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Volumn 9, Issue 7, 2008, Pages 881-893

Pharmacogenetics of Crohn's disease

Author keywords

AZA 6 MP; Crohn's disease; Glucocorticoids; Infliximab; Innovative therapies; Methotrexate; Pharmacogenetics

Indexed keywords

ABT 874; ADALIMUMAB; APILIMOD; AZATHIOPRINE; CALCINEURIN INHIBITOR; CERTOLIZUMAB PEGOL; CNTO 1275; CYTOKINE; DNA; FOLIC ACID; FONTOLIZUMAB; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; IMMUNOSUPPRESSIVE AGENT; INFLIXIMAB; INTERLEUKIN 12 ANTIBODY; INTERLEUKIN 6 ANTIBODY; J 695; MERCAPTOPURINE; METHOTREXATE; NATALIZUMAB; PLACEBO; PREDNISONE; RECOMBINANT GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; RECOMBINANT INTERLEUKIN 10; RITUXIMAB; STA 5326; STEROID; TACROLIMUS; TIOGUANINE; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; UNINDEXED DRUG; ANTIMETABOLITE; MONOCLONAL ANTIBODY; NUCLEIC ACID SYNTHESIS INHIBITOR;

EID: 49949093323     PISSN: 14622416     EISSN: 17448042     Source Type: Journal    
DOI: 10.2217/14622416.9.7.881     Document Type: Review
Times cited : (6)

References (136)
  • 1
    • 40049097245 scopus 로고    scopus 로고
    • What's new in inflammatory bowel disease in 2008?
    • Baumgart DC: What's new in inflammatory bowel disease in 2008? World J. Gastroenterol. 14, 329-330 (2008).
    • (2008) World J. Gastroenterol , vol.14 , pp. 329-330
    • Baumgart, D.C.1
  • 2
    • 0030954732 scopus 로고    scopus 로고
    • A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis facto α for Crohn's disease. Crohn's Disease cA2 Study Group
    • Targan SR, Hanauer SB, van Deventer SJ et al.: A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis facto α for Crohn's disease. Crohn's Disease cA2 Study Group. N. Engl. J. Med. 337, 1029-1035 (1997).
    • (1997) N. Engl. J. Med , vol.337 , pp. 1029-1035
    • Targan, S.R.1    Hanauer, S.B.2    van Deventer, S.J.3
  • 3
    • 0042736615 scopus 로고    scopus 로고
    • The incidence of alkaptonuria: A study in chemical individuality. 1902 [classical article]. Ya1e
    • Garrod AE: The incidence of alkaptonuria: a study in chemical individuality. 1902 [classical article]. Ya1e J. Biol. Med. 75, 221-231 (2002).
    • (2002) J. Biol. Med , vol.75 , pp. 221-231
    • Garrod, A.E.1
  • 4
    • 39149092661 scopus 로고    scopus 로고
    • Pharmacogenetics: Data, concepts and tools to improve drug discovery and drug treatment
    • Brockmoller J, Tzvetkov MV: Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment. Eur. J. Clin. Pharmacol. 64, 133-157 (2008).
    • (2008) Eur. J. Clin. Pharmacol , vol.64 , pp. 133-157
    • Brockmoller, J.1    Tzvetkov, M.V.2
  • 6
    • 0018290191 scopus 로고
    • National Cooperative Crohn's Disease Study: Results of drug treatment
    • Summers RW, Switz DM, Sessions JT et al.: National Cooperative Crohn's Disease Study: results of drug treatment. Gastroenterology 77, 847-869 (1979).
    • (1979) Gastroenterology , vol.77 , pp. 847-869
    • Summers, R.W.1    Switz, D.M.2    Sessions, J.T.3
  • 7
    • 2942557091 scopus 로고    scopus 로고
    • Treatment of inflammatory bowl disease with corticosteroids
    • 33, 171-189, vii
    • Katz JA: Treatment of inflammatory bowl disease with corticosteroids. Gastroenterol. Clin. North Am. 33, 171-189, vii (2004).
    • (2004) Gastroenterol. Clin. North Am
    • Katz, J.A.1
  • 8
    • 0034903792 scopus 로고    scopus 로고
    • The natural history of corticosteroid therapy for inflammatory bowel disease: A population-based study
    • Faubion WA, Loftus EV, Harmsen WS, Zinsmeister AR, Sandborn WJ: The natural history of corticosteroid therapy for inflammatory bowel disease: a population-based study. Gastroenterology 121, 255-260 (2001).
    • (2001) Gastroenterology , vol.121 , pp. 255-260
    • Faubion, W.A.1    Loftus, E.V.2    Harmsen, W.S.3    Zinsmeister, A.R.4    Sandborn, W.J.5
  • 10
    • 0033959944 scopus 로고    scopus 로고
    • High multidrug resistance (P-glycoprotein 170) expression in inflammatory bowel disease patients who fall medical therapy
    • Farell RJ, Murphy A, Long A et al.: High multidrug resistance (P-glycoprotein 170) expression in inflammatory bowel disease patients who fall medical therapy. Gastroenterology 118, 279-288 (2000).
    • (2000) Gastroenterology , vol.118 , pp. 279-288
    • Farell, R.J.1    Murphy, A.2    Long, A.3
  • 11
    • 0034724324 scopus 로고    scopus 로고
    • Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo
    • Hoffmeyer S, Burk O, von Richter O et al.: Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc. Natl Acad Sci. USA 97, 3473-3478 (2000).
    • (2000) Proc. Natl Acad Sci. USA , vol.97 , pp. 3473-3478
    • Hoffmeyer, S.1    Burk, O.2    von Richter, O.3
  • 12
    • 8844229534 scopus 로고    scopus 로고
    • Polymorphisms in multidrug resistance 1 (MDR1) gene are associated with refractory Crohn disease and ulcerative colitis
    • Potocnik U, Ferkolj I, Glavac D, Dean M: Polymorphisms in multidrug resistance 1 (MDR1) gene are associated with refractory Crohn disease and ulcerative colitis. Genes Immun. 5, 530-539 (2004).
    • (2004) Genes Immun , vol.5 , pp. 530-539
    • Potocnik, U.1    Ferkolj, I.2    Glavac, D.3    Dean, M.4
  • 13
    • 29744467435 scopus 로고    scopus 로고
    • Urcelay E, Mendoza JL. Martin MC. et al.: MDR1 gene: susceptibility in Spanish Crohn's disease and ulcerative colitis patients. Inflamm. Bowel Dis. 12, 33-37 (2006).
    • Urcelay E, Mendoza JL. Martin MC. et al.: MDR1 gene: susceptibility in Spanish Crohn's disease and ulcerative colitis patients. Inflamm. Bowel Dis. 12, 33-37 (2006).
  • 14
    • 33749020006 scopus 로고    scopus 로고
    • Absence of association between the multidrug resistance (MDR1) gene and inflammatory bowel disease
    • Oostenbrug LE, Dijkstra G, Nolte IM et al.: Absence of association between the multidrug resistance (MDR1) gene and inflammatory bowel disease. Scand. J. Gastroenterol. 41, 1174-1182 (2006).
    • (2006) Scand. J. Gastroenterol , vol.41 , pp. 1174-1182
    • Oostenbrug, L.E.1    Dijkstra, G.2    Nolte, I.M.3
  • 15
    • 23344449020 scopus 로고    scopus 로고
    • Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota
    • Elson CO, Cong Y, McCracken VJ, Dimmitt RA, Lorenz RG, Weaver CT: Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota. Immunol. Rev. 206, 260-276 (2005).
    • (2005) Immunol. Rev , vol.206 , pp. 260-276
    • Elson, C.O.1    Cong, Y.2    McCracken, V.J.3    Dimmitt, R.A.4    Lorenz, R.G.5    Weaver, C.T.6
  • 16
    • 33646757531 scopus 로고    scopus 로고
    • Associations of allelic variants of the multidrug resistance gene (ABCB1 or MDR1) and inflammatory bowel disease and their effects on disease behaviour: A case-control and meta-analysis study
    • Onnie CM. Fisher SA, Pattni R et al.: Associations of allelic variants of the multidrug resistance gene (ABCB1 or MDR1) and inflammatory bowel disease and their effects on disease behaviour: a case-control and meta-analysis study. Inflamm. Bowel Dis. 12, 263-271 (2006).
    • (2006) Inflamm. Bowel Dis , vol.12 , pp. 263-271
    • Onnie, C.M.1    Fisher, S.A.2    Pattni, R.3
  • 17
    • 33846644967 scopus 로고    scopus 로고
    • Polymorphisms of tumor necrosis factor-α but not MDR1 influence response to medical therapy in pediatric-onset inflammatory bowel disease
    • Cucchiara S, Latiano A, Palmieri O et al.: Polymorphisms of tumor necrosis factor-α but not MDR1 influence response to medical therapy in pediatric-onset inflammatory bowel disease. J. Pediatr. Gastroenterol. Nutr. 44, 171-179 (2007).
    • (2007) J. Pediatr. Gastroenterol. Nutr , vol.44 , pp. 171-179
    • Cucchiara, S.1    Latiano, A.2    Palmieri, O.3
  • 18
    • 15144360854 scopus 로고    scopus 로고
    • A polymorphism in the glucocorticoid receptor gene may be associated with and increased sensitivity to glucocorticoids in vivo
    • Huizenga NA, Koper JW, de Lange P et al.: A polymorphism in the glucocorticoid receptor gene may be associated with and increased sensitivity to glucocorticoids in vivo. J. Clin. Endocrinol. Metab. 83, 144-151 (1998).
    • (1998) J. Clin. Endocrinol. Metab , vol.83 , pp. 144-151
    • Huizenga, N.A.1    Koper, J.W.2    de Lange, P.3
  • 19
    • 26244465447 scopus 로고    scopus 로고
    • Two polymorphisms in the glucocorticoid receptor gene directly affect glucocorticoid-regulated gene expression
    • Russcher H, Smit P, van den Akker EL et al.: Two polymorphisms in the glucocorticoid receptor gene directly affect glucocorticoid-regulated gene expression. J. Clin. Endocrinol. Metab. 90, 5804-5810 (2005).
    • (2005) J. Clin. Endocrinol. Metab , vol.90 , pp. 5804-5810
    • Russcher, H.1    Smit, P.2    van den Akker, E.L.3
  • 20
    • 34447546650 scopus 로고    scopus 로고
    • Gene-drug interaction at the glucocorticoid receptor increases risk of squamous cell skin cancer
    • Patel AS, Karagas MR, Perry AE, Spencer SK, Nelson HH: Gene-drug interaction at the glucocorticoid receptor increases risk of squamous cell skin cancer. J. Invest. Dermatol. 127, 1868-1870 (2007).
    • (2007) J. Invest. Dermatol , vol.127 , pp. 1868-1870
    • Patel, A.S.1    Karagas, M.R.2    Perry, A.E.3    Spencer, S.K.4    Nelson, H.H.5
  • 21
    • 0036789254 scopus 로고    scopus 로고
    • A polymorphism in the glucocorticoid receptor gene, which decreases sensitivity to glucocorticoids in vivo, is associated with low insulin and cholesterol levels
    • van Rossum EF. Koper JW, Huizenga NA et al.: A polymorphism in the glucocorticoid receptor gene, which decreases sensitivity to glucocorticoids in vivo, is associated with low insulin and cholesterol levels. Diabetes 51, 3128-3134 (2002).
    • (2002) Diabetes , vol.51 , pp. 3128-3134
    • van Rossum, E.F.1    Koper, J.W.2    Huizenga, N.A.3
  • 22
    • 33745512966 scopus 로고    scopus 로고
    • Glucocorticoid receptor polymorphisms in inflammatory bowel disease
    • Decorti G, De Iudicibus S, Stocco G et al.: Glucocorticoid receptor polymorphisms in inflammatory bowel disease. Gut 55, 1053-1054 (2006).
    • (2006) Gut , vol.55 , pp. 1053-1054
    • Decorti, G.1    De Iudicibus, S.2    Stocco, G.3
  • 23
    • 34548120895 scopus 로고    scopus 로고
    • Association of BclI polymorphism of the glucocorticoid receptor gene locus with response to glucocorticoids in inflammatory bowel disease
    • De Iudicibus S, Stocco G, Martelossi S et al.: Association of BclI polymorphism of the glucocorticoid receptor gene locus with response to glucocorticoids in inflammatory bowel disease. Gut 56, 1319-1320 (2007).
    • (2007) Gut , vol.56 , pp. 1319-1320
    • De Iudicibus, S.1    Stocco, G.2    Martelossi, S.3
  • 24
    • 33846171221 scopus 로고    scopus 로고
    • Macrophage migration inhibitory factor (MIF) -173G/C promoter polymorphism influences upper gastrointestinal tract involvement and disease activity in patients with Crohn's disease
    • Dambacher J, Staudinger T, Seiderer J et al.: Macrophage migration inhibitory factor (MIF) -173G/C promoter polymorphism influences upper gastrointestinal tract involvement and disease activity in patients with Crohn's disease. Inflamm. Bowel Dis. 13, 71-82 (2007).
    • (2007) Inflamm. Bowel Dis , vol.13 , pp. 71-82
    • Dambacher, J.1    Staudinger, T.2    Seiderer, J.3
  • 25
    • 34250212850 scopus 로고    scopus 로고
    • A polymorphism in the macrophage migration inhibitory factor gene is involved in the genetic predisposition of Crohn's disease and associated with cumulative steroid doses
    • Griga T, Wilkens C, Wirkus N, Epplen J, Schmiegel W, Klein W: A polymorphism in the macrophage migration inhibitory factor gene is involved in the genetic predisposition of Crohn's disease and associated with cumulative steroid doses. Hepatogastroenterology 54, 784-786 (2007).
    • (2007) Hepatogastroenterology , vol.54 , pp. 784-786
    • Griga, T.1    Wilkens, C.2    Wirkus, N.3    Epplen, J.4    Schmiegel, W.5    Klein, W.6
  • 26
    • 36749086523 scopus 로고    scopus 로고
    • Review article: The evidence base for interventions used to maintain remission in Crohn's disease
    • Akobeng AK: Review article: the evidence base for interventions used to maintain remission in Crohn's disease. Aliment. Pharmacol. Ther. 27, 11-18 (2008).
    • (2008) Aliment. Pharmacol. Ther , vol.27 , pp. 11-18
    • Akobeng, A.K.1
  • 27
    • 25844472389 scopus 로고    scopus 로고
    • Effects of azatthioprine and its metabolites on repair mechanisms of the intestinal epithelium in vitro
    • Schroll S, Sarlette A, Ahrens K, Manns MP, Goke M: Effects of azatthioprine and its metabolites on repair mechanisms of the intestinal epithelium in vitro. Regul. Pept. 131, 1-11 (2005).
    • (2005) Regul. Pept , vol.131 , pp. 1-11
    • Schroll, S.1    Sarlette, A.2    Ahrens, K.3    Manns, M.P.4    Goke, M.5
  • 29
    • 0037043658 scopus 로고    scopus 로고
    • Inflammatory bowel disease
    • Podolsky DK: Inflammatory bowel disease. N. Engl. J. Med. 347, 417-429 (2002).
    • (2002) N. Engl. J. Med , vol.347 , pp. 417-429
    • Podolsky, D.K.1
  • 31
    • 0036009619 scopus 로고    scopus 로고
    • The thiopurine S-methyltransferase gene locus - implications for clinical pharmacogenomics
    • McLeod HL, Siva C: The thiopurine S-methyltransferase gene locus - implications for clinical pharmacogenomics. Pharmacogenomics 3, 89-98 (2002).
    • (2002) Pharmacogenomics , vol.3 , pp. 89-98
    • McLeod, H.L.1    Siva, C.2
  • 32
    • 33748304132 scopus 로고    scopus 로고
    • Review article: Genetic susceptibility and application of genetic testing in clinical management of inflammatory bowel disease
    • Vermeire S: Review article: genetic susceptibility and application of genetic testing in clinical management of inflammatory bowel disease. Aliment. Pharmacol. Ther. 24(Suppl. 3), 2-10 (2006).
    • (2006) Aliment. Pharmacol. Ther , vol.24 , Issue.SUPPL. 3 , pp. 2-10
    • Vermeire, S.1
  • 33
    • 0033631649 scopus 로고    scopus 로고
    • Characterization of three new VNTR alleles in the promoter region of the TPMT gene
    • Alves S, Ferreira F, Prata MJ, Amorim A: Characterization of three new VNTR alleles in the promoter region of the TPMT gene. Hum. Mutat. 15, 121 (2000).
    • (2000) Hum. Mutat , vol.15 , pp. 121
    • Alves, S.1    Ferreira, F.2    Prata, M.J.3    Amorim, A.4
  • 34
    • 33947287144 scopus 로고    scopus 로고
    • Thiopurine treatment in inflammatory bowel disease: Clinical pharmacology and implication of phannacogenetically guided dosing
    • Teml A, Schaeffeler E, Herrlinger KR, Klotz U, Schwab M: Thiopurine treatment in inflammatory bowel disease: clinical pharmacology and implication of phannacogenetically guided dosing. Clin. Pharmacokinet. 46, 187-208 (2007).
    • (2007) Clin. Pharmacokinet , vol.46 , pp. 187-208
    • Teml, A.1    Schaeffeler, E.2    Herrlinger, K.R.3    Klotz, U.4    Schwab, M.5
  • 35
    • 0036790212 scopus 로고    scopus 로고
    • Thiopurine methyltransferase activity and the use of azathioprine in inflammatory bowel disease
    • Ansari A, Hassan C, Duiey J et al.: Thiopurine methyltransferase activity and the use of azathioprine in inflammatory bowel disease. Aliment. Pharmacol. Ther. 16, 1743-1750 (2002).
    • (2002) Aliment. Pharmacol. Ther , vol.16 , pp. 1743-1750
    • Ansari, A.1    Hassan, C.2    Duiey, J.3
  • 36
    • 0034093057 scopus 로고    scopus 로고
    • Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy
    • Colombet JF, Ferrari N, Debuysere H et al.: Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy. Gastroenterology 118, 1025-1030 (2000).
    • (2000) Gastroenterology , vol.118 , pp. 1025-1030
    • Colombet, J.F.1    Ferrari, N.2    Debuysere, H.3
  • 37
    • 12144285961 scopus 로고    scopus 로고
    • Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase)
    • Marinaki AM; Ansari A, Duley JA et al. Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase). Pharmacogenetics 14, 181-187 (2004).
    • (2004) Pharmacogenetics , vol.14 , pp. 181-187
    • Marinaki, A.M.1    Ansari, A.2    Duley, J.A.3
  • 38
    • 0036202803 scopus 로고    scopus 로고
    • 6-MP metabolite profiles provide a biochemical explanation for 6-MP resistance in patients with inflammatory bowel disease
    • Dubinsky MC, Yang H, Hassard PV et al.: 6-MP metabolite profiles provide a biochemical explanation for 6-MP resistance in patients with inflammatory bowel disease. Gastroenterology 122, 904-915 (2002).
    • (2002) Gastroenterology , vol.122 , pp. 904-915
    • Dubinsky, M.C.1    Yang, H.2    Hassard, P.V.3
  • 39
    • 0346998117 scopus 로고    scopus 로고
    • Early modular hyperplasia of the liver occurring with inflammatory bowel diseases in association with thioguanine therapy
    • Shastri S, Dubinsky MC, Fred Poordad F, Vasiliauskas EA, Geller SA: Early modular hyperplasia of the liver occurring with inflammatory bowel diseases in association with thioguanine therapy. Arch. Pathol. Lab. Med. 129, 49-53 (2004).
    • (2004) Arch. Pathol. Lab. Med , vol.129 , pp. 49-53
    • Shastri, S.1    Dubinsky, M.C.2    Fred Poordad, F.3    Vasiliauskas, E.A.4    Geller, S.A.5
  • 40
    • 0043168014 scopus 로고    scopus 로고
    • 6-thioguanine can cause serious liver injury in inflammatory bowel disease patients
    • Dubinsky MC, Vasiliauskas EA, Singh H et al.: 6-thioguanine can cause serious liver injury in inflammatory bowel disease patients. Gastroenterology 125, 298-303 (2003).
    • (2003) Gastroenterology , vol.125 , pp. 298-303
    • Dubinsky, M.C.1    Vasiliauskas, E.A.2    Singh, H.3
  • 41
    • 0036076821 scopus 로고    scopus 로고
    • TPMT in the treatment of Crohn's disease with azathioprine
    • Leonard L: TPMT in the treatment of Crohn's disease with azathioprine. Gut 51, 143-146 (2002).
    • (2002) Gut , vol.51 , pp. 143-146
    • Leonard, L.1
  • 42
    • 17644381606 scopus 로고    scopus 로고
    • Thiopurine methyltransferase enzyme activity determination before treatment of inflammatory bowel disease with azathioprine: Effect on cost and adverse events
    • Sayani FA, Prosser C, Bailey RJ, Jacobs P, Fedorak RN: Thiopurine methyltransferase enzyme activity determination before treatment of inflammatory bowel disease with azathioprine: effect on cost and adverse events. Can. J Gastroenterol. 19, 147-151 (2005).
    • (2005) Can. J Gastroenterol , vol.19 , pp. 147-151
    • Sayani, F.A.1    Prosser, C.2    Bailey, R.J.3    Jacobs, P.4    Fedorak, R.N.5
  • 43
    • 34247159530 scopus 로고    scopus 로고
    • Assessment of thiopurine methyltransferase enzyme activity is superior to genotype in predicting myelosuppression following azathioprine therapy in patients with inflammatory bowel disease
    • Winter JW, Gaffney D, Shapiro D et al.: Assessment of thiopurine methyltransferase enzyme activity is superior to genotype in predicting myelosuppression following azathioprine therapy in patients with inflammatory bowel disease. Aliment. Pharmacol. Ther. 25, 1069-1077 (2007).
    • (2007) Aliment. Pharmacol. Ther , vol.25 , pp. 1069-1077
    • Winter, J.W.1    Gaffney, D.2    Shapiro, D.3
  • 44
    • 33947357078 scopus 로고    scopus 로고
    • Current use of pharmacogenetic testing: A national survey of thiopurine methyltransferase testing prior to azathioprine prescription
    • Fargher EA, Tricker K, Newman W et al.: Current use of pharmacogenetic testing: a national survey of thiopurine methyltransferase testing prior to azathioprine prescription. J. Clin, Pharm. Ther. 32, 187-195 (2007).
    • (2007) J. Clin, Pharm. Ther , vol.32 , pp. 187-195
    • Fargher, E.A.1    Tricker, K.2    Newman, W.3
  • 45
    • 0036820724 scopus 로고    scopus 로고
    • Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency
    • Sumi S, Marinaki AM, Arenas M et al.: Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency. Hum. Genet. 111, 360-367 (2002).
    • (2002) Hum. Genet , vol.111 , pp. 360-367
    • Sumi, S.1    Marinaki, A.M.2    Arenas, M.3
  • 46
    • 28044446081 scopus 로고    scopus 로고
    • Association of inosine triphosphatase 94C>A and thiopurine S-methyltransferase deficiency with adverse events and study drop-outs under azathioprine therapy in a prospective Crohn disease study
    • von Ahsen N, Armstrong VW, Behrens C et al.: Association of inosine triphosphatase 94C>A and thiopurine S-methyltransferase deficiency with adverse events and study drop-outs under azathioprine therapy in a prospective Crohn disease study. Clin. Chem. 51, 2282-2288 (2005).
    • (2005) Clin. Chem , vol.51 , pp. 2282-2288
    • von Ahsen, N.1    Armstrong, V.W.2    Behrens, C.3
  • 47
    • 9244237558 scopus 로고    scopus 로고
    • Lack of association between the ITPA 94C>A polymorphism and adverse effects from azathioprine
    • Gearry RB, Roberts RL, Barclay ML, Kennedy MA: Lack of association between the ITPA 94C>A polymorphism and adverse effects from azathioprine. Pharmacogenetics 14, 779-781 (2004).
    • (2004) Pharmacogenetics , vol.14 , pp. 779-781
    • Gearry, R.B.1    Roberts, R.L.2    Barclay, M.L.3    Kennedy, M.A.4
  • 48
    • 15444367938 scopus 로고    scopus 로고
    • ITPA genotyping test does not Improve detection of Crohn's disease patients at risk of azathioprine/6-mercaptopurine induced myelosuppression
    • Allorge D, Harridan R, Broly F, Libersa C, Colombel JF: ITPA genotyping test does not Improve detection of Crohn's disease patients at risk of azathioprine/6-mercaptopurine induced myelosuppression. Gut 54, 565 (2005).
    • (2005) Gut , vol.54 , pp. 565
    • Allorge, D.1    Harridan, R.2    Broly, F.3    Libersa, C.4    Colombel, J.F.5
  • 49
    • 0033910990 scopus 로고    scopus 로고
    • Glutathione S-transferase polymorphisms and colorectal cancer: A HuGE review
    • Cotton SC, Sharp L, Little J, Brockton N: Glutathione S-transferase polymorphisms and colorectal cancer: a HuGE review. Am. J. Epidermiol. 151, 7-32 (2000).
    • (2000) Am. J. Epidermiol , vol.151 , pp. 7-32
    • Cotton, S.C.1    Sharp, L.2    Little, J.3    Brockton, N.4
  • 50
    • 33846136090 scopus 로고    scopus 로고
    • Glutathione-S-transferase genotypes and the adverse effects of azathioprine in young patients with inflammatory bowel disease
    • Stocco G, Martelossi S, Barabino A et al.: Glutathione-S-transferase genotypes and the adverse effects of azathioprine in young patients with inflammatory bowel disease. Inflamm. Bowel Dis. 13, 57-64 (2007).
    • (2007) Inflamm. Bowel Dis , vol.13 , pp. 57-64
    • Stocco, G.1    Martelossi, S.2    Barabino, A.3
  • 51
    • 34249047036 scopus 로고    scopus 로고
    • MDR1 polymorphisms and response to azathioprine therapy in patients with Crohn's disease
    • Mendoza JL, Urcelay E, Lana R et al.: MDR1 polymorphisms and response to azathioprine therapy in patients with Crohn's disease Inflamm. Bowel Dis. 13, 585-590 (2007).
    • (2007) Inflamm. Bowel Dis , vol.13 , pp. 585-590
    • Mendoza, J.L.1    Urcelay, E.2    Lana, R.3
  • 52
    • 0034463305 scopus 로고    scopus 로고
    • Recombinant human interleukin 10 in the treatment of patients with mild to moderately active Crohn's disease. The Interleukin 10 Inflammatory Bowel Disease Cooperative Study Group
    • Fedorak RN, Gangl A, Elson CO et al.: Recombinant human interleukin 10 in the treatment of patients with mild to moderately active Crohn's disease. The Interleukin 10 Inflammatory Bowel Disease Cooperative Study Group. Gastroenterology 119, 1473-1482 (2000).
    • (2000) Gastroenterology , vol.119 , pp. 1473-1482
    • Fedorak, R.N.1    Gangl, A.2    Elson, C.O.3
  • 53
    • 0037268202 scopus 로고    scopus 로고
    • Methotrexate for induction of remission in refractory Crohn's disease
    • Rev. CD003459
    • Alfadhli AA, McDonald JW, Feagan BG: Methotrexate for induction of remission in refractory Crohn's disease. Cochrane Database Syst. Rev. CD003459 (2003).
    • (2003) Cochrane Database Syst
    • Alfadhli, A.A.1    McDonald, J.W.2    Feagan, B.G.3
  • 54
    • 46049088744 scopus 로고    scopus 로고
    • Use of methotrexate in refractory Crohn's disease: The Edinburgh experience
    • Din S, Dahele A, Fennel J et al.: Use of methotrexate in refractory Crohn's disease: The Edinburgh experience. Inflamm. Bowel Dis. 14(6), 756-762 (2008).
    • (2008) Inflamm. Bowel Dis , vol.14 , Issue.6 , pp. 756-762
    • Din, S.1    Dahele, A.2    Fennel, J.3
  • 55
    • 38449094689 scopus 로고    scopus 로고
    • Understanding the mechanisms of action of methotrexate: Implications for the treatment of rheumatoid arthritis
    • Tian H, Cronstein BN: Understanding the mechanisms of action of methotrexate: implications for the treatment of rheumatoid arthritis. Bull. NYU Hosp. Jt Dis. 65, 168-173 (2007).
    • (2007) Bull. NYU Hosp. Jt Dis , vol.65 , pp. 168-173
    • Tian, H.1    Cronstein, B.N.2
  • 56
    • 0035985787 scopus 로고    scopus 로고
    • Molecular action of methotrexate in inflammatory diseases
    • Chan ES, Cronstein BN: Molecular action of methotrexate in inflammatory diseases. Arthritis Res. 4, 266-273 (2002).
    • (2002) Arthritis Res , vol.4 , pp. 266-273
    • Chan, E.S.1    Cronstein, B.N.2
  • 57
    • 39449121672 scopus 로고    scopus 로고
    • Recent insights in the pharmacological actions of methotrexate in the treatment of rheumatoid arthritis
    • Wessels JA Huizinga TW, Guchelaar HJ: Recent insights in the pharmacological actions of methotrexate in the treatment of rheumatoid arthritis. Rheumatology 47, 249-255 (2008).
    • (2008) Rheumatology , vol.47 , pp. 249-255
    • Wessels, J.A.1    Huizinga, T.W.2    Guchelaar, H.J.3
  • 59
    • 0032810850 scopus 로고    scopus 로고
    • Increased prevalence of methylenetetrahydrofolate reductase C677T variant in patients with inflammatory bowel disease, and its clinical implications
    • Mahmud N, Molloy A, McPartlin J et al.: Increased prevalence of methylenetetrahydrofolate reductase C677T variant in patients with inflammatory bowel disease, and its clinical implications. Gut 45, 389-394 (1999).
    • (1999) Gut , vol.45 , pp. 389-394
    • Mahmud, N.1    Molloy, A.2    McPartlin, J.3
  • 60
    • 0037110469 scopus 로고    scopus 로고
    • Polymorphism G80A in the reduced folate carrier gene and its relationship to methotrexate plasma levels and outcome of childhood acute lymphoblastic leukemia
    • Laverdiere C, Chiasson S, Costea I, Moghrabi A, Krajinovic M: Polymorphism G80A in the reduced folate carrier gene and its relationship to methotrexate plasma levels and outcome of childhood acute lymphoblastic leukemia. Blood 100, 3832-3834 (2002).
    • (2002) Blood , vol.100 , pp. 3832-3834
    • Laverdiere, C.1    Chiasson, S.2    Costea, I.3    Moghrabi, A.4    Krajinovic, M.5
  • 61
    • 9244264949 scopus 로고    scopus 로고
    • Contribution of common polymorphisms in reduced folate carrier and γ-glutamylhydrolase to methotrexate polyglutamate levels in patients with rheumatoid arthritis
    • Dervieux T, Kremer J, Lein DO et al.: Contribution of common polymorphisms in reduced folate carrier and γ-glutamylhydrolase to methotrexate polyglutamate levels in patients with rheumatoid arthritis. Pharmacogenetics 14, 733-739 (2004).
    • (2004) Pharmacogenetics , vol.14 , pp. 733-739
    • Dervieux, T.1    Kremer, J.2    Lein, D.O.3
  • 62
    • 4444376725 scopus 로고    scopus 로고
    • Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis
    • Dervieux T, Furst D, Lein DO et al.: Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis. Arthritis Rheum. 50, 2766-2774 (2004).
    • (2004) Arthritis Rheum , vol.50 , pp. 2766-2774
    • Dervieux, T.1    Furst, D.2    Lein, D.O.3
  • 63
    • 33749370785 scopus 로고    scopus 로고
    • Relationship between genetic variants in the adenosine pathway and outcome of methotrexate treatment in patients with recent-onset rheumatoid arthritis
    • Wessels JA, Kooloos WM, de Jonge R et al.: Relationship between genetic variants in the adenosine pathway and outcome of methotrexate treatment in patients with recent-onset rheumatoid arthritis. Arthritis Rheum. 54, 2830-2839 (2006).
    • (2006) Arthritis Rheum , vol.54 , pp. 2830-2839
    • Wessels, J.A.1    Kooloos, W.M.2    de Jonge, R.3
  • 65
    • 34447508090 scopus 로고    scopus 로고
    • A clinical pharmacogenetic model to predict the efficacy of methotrexate monotherapy in recent-onset rheumatoid arthritis
    • Wessels JA, van der Kooij SM, le Cessie S et al.: A clinical pharmacogenetic model to predict the efficacy of methotrexate monotherapy in recent-onset rheumatoid arthritis. Arthritis Rheum. 56, 1765-1775 (2007).
    • (2007) Arthritis Rheum , vol.56 , pp. 1765-1775
    • Wessels, J.A.1    van der Kooij, S.M.2    le Cessie, S.3
  • 66
    • 0032953631 scopus 로고    scopus 로고
    • Tacrolimus: The drug for the turn of the millennium?
    • Ruzicka T, Assmann T, Homey B: Tacrolimus: the drug for the turn of the millennium? Arch. Dermatol. 135, 574-580 (1999).
    • (1999) Arch. Dermatol , vol.135 , pp. 574-580
    • Ruzicka, T.1    Assmann, T.2    Homey, B.3
  • 67
    • 0032447773 scopus 로고    scopus 로고
    • Steroid-unresponsive acute attacks of inflammatory bowel disease: Immunomodulation by tacrolimus (FK506)
    • Fellermann K, Ludwig D, Stah M, David-Walek T, Stange EF: Steroid-unresponsive acute attacks of inflammatory bowel disease: immunomodulation by tacrolimus (FK506). Am. J. Gastroenterol. 93, 1860-1866 (1998).
    • (1998) Am. J. Gastroenterol , vol.93 , pp. 1860-1866
    • Fellermann, K.1    Ludwig, D.2    Stah, M.3    David-Walek, T.4    Stange, E.F.5
  • 68
    • 0041665068 scopus 로고    scopus 로고
    • Tacrolimus for the treatment of fistulas in patients with Crohn's disease: A randomized, placebo-controlled trial
    • Sandborn WJ, Present DH, Isaacs KL et al.: Tacrolimus for the treatment of fistulas in patients with Crohn's disease: a randomized, placebo-controlled trial. Gastroenterology 125, 380-388 (2003).
    • (2003) Gastroenterology , vol.125 , pp. 380-388
    • Sandborn, W.J.1    Present, D.H.2    Isaacs, K.L.3
  • 69
    • 34249324777 scopus 로고    scopus 로고
    • Medium-term results of oral tacrolimus treatment in refractory inflammatory bowel disease
    • Ng SC, Arebi N, Kamm MA: Medium-term results of oral tacrolimus treatment in refractory inflammatory bowel disease. Inflamm. Bowel Dis. 13, 129-134 (2007).
    • (2007) Inflamm. Bowel Dis , vol.13 , pp. 129-134
    • Ng, S.C.1    Arebi, N.2    Kamm, M.A.3
  • 70
    • 33947506701 scopus 로고    scopus 로고
    • Topical tacrolimus in the treatment of perianal Crohn's disease: Exploratory randomized controlled trial
    • Hart AL, Plamondon S, Kamm MA: Topical tacrolimus in the treatment of perianal Crohn's disease: exploratory randomized controlled trial. Inflamm. Bowel Dis. 13, 245-253 (2007).
    • (2007) Inflamm. Bowel Dis , vol.13 , pp. 245-253
    • Hart, A.L.1    Plamondon, S.2    Kamm, M.A.3
  • 71
    • 0242351679 scopus 로고    scopus 로고
    • Pharmacokinetic interaction between corticosteroids and tacrolimus after renal transplantation
    • Anglicheau D, Flamant M, Schlageter MH et al.: Pharmacokinetic interaction between corticosteroids and tacrolimus after renal transplantation. Nephrol. Dial. Transplant. 18, 2409-2414 (2003).
    • (2003) Nephrol. Dial. Transplant , vol.18 , pp. 2409-2414
    • Anglicheau, D.1    Flamant, M.2    Schlageter, M.H.3
  • 72
    • 34548083672 scopus 로고    scopus 로고
    • Cytochrome P450 3A polymorphisms and immunosuppressive drugs: An update
    • Anglicheau D, Legendre C, Beaune P, Thervet E: Cytochrome P450 3A polymorphisms and immunosuppressive drugs: an update. Pharmacogenomics 8, 835-849 (2007).
    • (2007) Pharmacogenomics , vol.8 , pp. 835-849
    • Anglicheau, D.1    Legendre, C.2    Beaune, P.3    Thervet, E.4
  • 73
    • 12344334846 scopus 로고    scopus 로고
    • Clinical aspects of the MDR1 (ABCB1) gene polymorphism
    • Etchelbaum M, Fromm MF, Schwab M: Clinical aspects of the MDR1 (ABCB1) gene polymorphism. Ther. Drug Monit. 26, 180-185 (2004).
    • (2004) Ther. Drug Monit , vol.26 , pp. 180-185
    • Etchelbaum, M.1    Fromm, M.F.2    Schwab, M.3
  • 74
    • 0041831261 scopus 로고    scopus 로고
    • Genetic polymorphisms of the CYP3A4, CYP3A5, and MDR-1 genes and pharmacokinetics of the calcineurin inhibitors cyclosporine and tacrolimus
    • Hesselink DA, van Schaik RH, van der Heiden IP et al.: Genetic polymorphisms of the CYP3A4, CYP3A5, and MDR-1 genes and pharmacokinetics of the calcineurin inhibitors cyclosporine and tacrolimus. Clin. Pharmacol. Ther. 74, 245-254 (2003).
    • (2003) Clin. Pharmacol. Ther , vol.74 , pp. 245-254
    • Hesselink, D.A.1    van Schaik, R.H.2    van der Heiden, I.P.3
  • 75
    • 0038304548 scopus 로고    scopus 로고
    • Association of the multidrug resistance-1 gene single-nucleotide polymorphisms with the tacrolimus dose requirements in renal transplant recipients
    • Anglicheau D, Verstuyft C, Laurent-Puig P et al.: Association of the multidrug resistance-1 gene single-nucleotide polymorphisms with the tacrolimus dose requirements in renal transplant recipients. J. Am. Soc. Nephrol. 14, 1889-1896 (2003).
    • (2003) J. Am. Soc. Nephrol , vol.14 , pp. 1889-1896
    • Anglicheau, D.1    Verstuyft, C.2    Laurent-Puig, P.3
  • 76
    • 12144286933 scopus 로고    scopus 로고
    • The effect of CYP3A5 and MDR1 (ABCB1) polymorphisms on cyclosporine and tacrolimus dose requirements and trough blood levels in stable renal transplant patients
    • Haufroid V, Mourad M, van Kerckhove V et al.: The effect of CYP3A5 and MDR1 (ABCB1) polymorphisms on cyclosporine and tacrolimus dose requirements and trough blood levels in stable renal transplant patients. Pharmacogenetics 14, 147-154 (2004).
    • (2004) Pharmacogenetics , vol.14 , pp. 147-154
    • Haufroid, V.1    Mourad, M.2    van Kerckhove, V.3
  • 77
    • 33846621036 scopus 로고    scopus 로고
    • Potential role of pharmacogenetics in anti-TNF treatment of rheumatoid arthritis and Crohn's disease
    • Kooloos WM, de Jong DJ, Huizinga TW, Guchelaar HJ: Potential role of pharmacogenetics in anti-TNF treatment of rheumatoid arthritis and Crohn's disease. Drug Discov. Today 12, 125-131 (2007).
    • (2007) Drug Discov. Today , vol.12 , pp. 125-131
    • Kooloos, W.M.1    de Jong, D.J.2    Huizinga, T.W.3    Guchelaar, H.J.4
  • 78
    • 0037282538 scopus 로고    scopus 로고
    • Azathioprine and anti-TNFα therapies in Crohn's disease: A review of pharmacology, clinical efficacy and safety
    • Arnott ID, Watts D, Satsangi J: Azathioprine and anti-TNFα therapies in Crohn's disease: a review of pharmacology, clinical efficacy and safety. Pharmacol. Res. 47, 1-10 (2003).
    • (2003) Pharmacol. Res , vol.47 , pp. 1-10
    • Arnott, I.D.1    Watts, D.2    Satsangi, J.3
  • 79
    • 0032833517 scopus 로고    scopus 로고
    • Efficacy and safety of retreatment with anti-tumor necrosis factor antibody (infliximab) to maintain remission in Crohn's disease
    • Rutgeerts P, D'Haens G, Targan S et al.: Efficacy and safety of retreatment with anti-tumor necrosis factor antibody (infliximab) to maintain remission in Crohn's disease. Gastroenterology 117, 761-769 (2004).
    • (2004) Gastroenterology , vol.117 , pp. 761-769
    • Rutgeerts, P.1    D'Haens, G.2    Targan, S.3
  • 80
    • 0033529049 scopus 로고    scopus 로고
    • Infliximab for the treatment of fistulas in patients with Crohn's disease
    • Present DH, Rutgeerts P, Targan S et al.: Infliximab for the treatment of fistulas in patients with Crohn's disease. N. Engl. J. Med. 340, 1398-1405 (1999).
    • (1999) N. Engl. J. Med , vol.340 , pp. 1398-1405
    • Present, D.H.1    Rutgeerts, P.2    Targan, S.3
  • 81
    • 0037018761 scopus 로고    scopus 로고
    • Maintenance infliximab for Crohn's disease: The ACCENT I randomised trial
    • Hanauer SB, Feagan BG, Lichtenstein GR et al.: Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial. Lancet 359, 1541-1549 (2002).
    • (2002) Lancet , vol.359 , pp. 1541-1549
    • Hanauer, S.B.1    Feagan, B.G.2    Lichtenstein, G.R.3
  • 82
    • 10744221312 scopus 로고    scopus 로고
    • Infliximab maintenance therapy for fistulizing Crohn's disease
    • Sands BE, Anderson FH, Bernstein CN et al.: Infliximab maintenance therapy for fistulizing Crohn's disease. N. Engl. J. Med. 350, 876-885 (2004).
    • (2004) N. Engl. J. Med , vol.350 , pp. 876-885
    • Sands, B.E.1    Anderson, F.H.2    Bernstein, C.N.3
  • 83
    • 0036726041 scopus 로고    scopus 로고
    • Predictors of response to infliximab in patients with Crohn's disease
    • Parsi MA, Achkar JP, Richardson S et al.: Predictors of response to infliximab in patients with Crohn's disease. Gastroenterology 123, 707-713 (2002).
    • (2002) Gastroenterology , vol.123 , pp. 707-713
    • Parsi, M.A.1    Achkar, J.P.2    Richardson, S.3
  • 84
    • 0036732707 scopus 로고    scopus 로고
    • Demographic and clinical parameters influencing the short-term outcome of anti-tumor necrosis factor (infliximab) treatment in Crohn's diiease
    • Vermeire S, Louis E, Carbonez A et al.: Demographic and clinical parameters influencing the short-term outcome of anti-tumor necrosis factor (infliximab) treatment in Crohn's diiease. Am. J. Gastroenterol. 97, 2357-2363 (2002).
    • (2002) Am. J. Gastroenterol , vol.97 , pp. 2357-2363
    • Vermeire, S.1    Louis, E.2    Carbonez, A.3
  • 85
    • 0035050836 scopus 로고    scopus 로고
    • ANCA pattern and LTA haplotype relationship to clinical responses to anti-TNF antibody treatment in Crohn's disease
    • Taylor KD, Plevy SE, Yang H et al.: ANCA pattern and LTA haplotype relationship to clinical responses to anti-TNF antibody treatment in Crohn's disease. Gastroenterology 120, 1347-1355 (2001).
    • (2001) Gastroenterology , vol.120 , pp. 1347-1355
    • Taylor, K.D.1    Plevy, S.E.2    Yang, H.3
  • 86
    • 0035978533 scopus 로고    scopus 로고
    • A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
    • Ogura Y, Bonen DK, Inohara N et al.: A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411, 603-606 (2001).
    • (2001) Nature , vol.411 , pp. 603-606
    • Ogura, Y.1    Bonen, D.K.2    Inohara, N.3
  • 87
    • 11144279151 scopus 로고    scopus 로고
    • Differential effects of NOD2 variants on Crohn's disease risk and phenotype in diverse populations: A metaanalysis
    • Economou M, Trikalinos TA, Loizou KT, Tsianos EV, Ioannidis JP: Differential effects of NOD2 variants on Crohn's disease risk and phenotype in diverse populations: a metaanalysis. Am. J. Gastroenterol. 99, 2393-2404 (2004).
    • (2004) Am. J. Gastroenterol , vol.99 , pp. 2393-2404
    • Economou, M.1    Trikalinos, T.A.2    Loizou, K.T.3    Tsianos, E.V.4    Ioannidis, J.P.5
  • 88
    • 0037458665 scopus 로고    scopus 로고
    • Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease
    • Inohara N, Ogura Y, Fontalba A et al.: Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease. J. Biol. Chem. 278, 5509-5512 (2003).
    • (2003) J. Biol. Chem , vol.278 , pp. 5509-5512
    • Inohara, N.1    Ogura, Y.2    Fontalba, A.3
  • 89
    • 0012722659 scopus 로고    scopus 로고
    • Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection
    • Girardin SE, Boneca IG, Viala J et al.: Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J. Biol. Chem. 278, 8869-8872 (2003).
    • (2003) J. Biol. Chem , vol.278 , pp. 8869-8872
    • Girardin, S.E.1    Boneca, I.G.2    Viala, J.3
  • 90
    • 0036151047 scopus 로고    scopus 로고
    • Infliximab treatment induces apoptosis of lamina propria T lymphocytes in Crohn's disease
    • ten Hove T, van Montfrans C, Peppelenbosch MP, van Deventer SJ: Infliximab treatment induces apoptosis of lamina propria T lymphocytes in Crohn's disease. Gut 50, 206-211 (2002).
    • (2002) Gut , vol.50 , pp. 206-211
    • ten Hove, T.1    van Montfrans, C.2    Peppelenbosch, M.P.3    van Deventer, S.J.4
  • 91
    • 0034754480 scopus 로고    scopus 로고
    • Infliximab induces apoptosis in monocytes from patients with chronic active Crohn's disease by using a caspase-dependent pathway
    • Lugering A, Schmidt M, Lugering N, Pauels HG, Domschke W, Kucharzik T: Infliximab induces apoptosis in monocytes from patients with chronic active Crohn's disease by using a caspase-dependent pathway. Gastroenterology 121, 1145-1157 (2001).
    • (2001) Gastroenterology , vol.121 , pp. 1145-1157
    • Lugering, A.1    Schmidt, M.2    Lugering, N.3    Pauels, H.G.4    Domschke, W.5    Kucharzik, T.6
  • 92
    • 0035895992 scopus 로고    scopus 로고
    • Nod2, a Nod1/ Apaf-1 family member that is restricted to monocytes and activates NF-κB
    • Ogura Y, Inohara N, Benito A, Chen FF, Yamaoka S, Nunez G: Nod2, a Nod1/ Apaf-1 family member that is restricted to monocytes and activates NF-κB. J. Biol. Chem. 276, 4812-4818 (2001).
    • (2001) J. Biol. Chem , vol.276 , pp. 4812-4818
    • Ogura, Y.1    Inohara, N.2    Benito, A.3    Chen, F.F.4    Yamaoka, S.5    Nunez, G.6
  • 93
    • 50149103373 scopus 로고    scopus 로고
    • MDP-induced apoptosis of monocytes is mediated by NOD2/CARD15
    • Beynon VE, Maier K, Faussner A et al.: MDP-induced apoptosis of monocytes is mediated by NOD2/CARD15. Gastroenterology 132 (Suppl. 2), A555 (2007).
    • (2007) Gastroenterology , vol.132 , Issue.SUPPL. 2
    • Beynon, V.E.1    Maier, K.2    Faussner, A.3
  • 94
    • 0036305537 scopus 로고    scopus 로고
    • NOD2/CARD15 does not influence response to infliximab in Crohn's disease
    • Vermeire S, Louis E, Rutgeerts P et al.: NOD2/CARD15 does not influence response to infliximab in Crohn's disease. Gastroenterology 123, 106-111 (2002).
    • (2002) Gastroenterology , vol.123 , pp. 106-111
    • Vermeire, S.1    Louis, E.2    Rutgeerts, P.3
  • 95
    • 18644366895 scopus 로고    scopus 로고
    • Response to infliximab treatment in Crohn's disease is not associated with mutations in the CARD15 (NOD2) gene: An analysis in 534 patients from two multicenter, prospective GCP-level trials
    • Mascheretti S, Hampe J, Croucher PJ et al.: Response to infliximab treatment in Crohn's disease is not associated with mutations in the CARD15 (NOD2) gene: an analysis in 534 patients from two multicenter, prospective GCP-level trials. Pharmacogenetics 12, 509-515 (2002).
    • (2002) Pharmacogenetics , vol.12 , pp. 509-515
    • Mascheretti, S.1    Hampe, J.2    Croucher, P.J.3
  • 96
    • 0036367145 scopus 로고    scopus 로고
    • Pharmacogenetic investigation of the TNF/TNF-receptor system in patients with chronic active Crohn's disease treated with infliximab
    • Mascheretti S, Hampe J, Kuhbacher T et al.: Pharmacogenetic investigation of the TNF/TNF-receptor system in patients with chronic active Crohn's disease treated with infliximab. Pharmacogenomics J. 2, 127-136 (2002).
    • (2002) Pharmacogenomics J , vol.2 , pp. 127-136
    • Mascheretti, S.1    Hampe, J.2    Kuhbacher, T.3
  • 97
    • 4043140020 scopus 로고    scopus 로고
    • Tumour necrosis factor-α receptor 1 and 2 polymorphisms in inflammatory bowel disease and their association with response to infliximab
    • Pierik M, Vermeire S, Steen KV et al.: Tumour necrosis factor-α receptor 1 and 2 polymorphisms in inflammatory bowel disease and their association with response to infliximab. Aliment. Pharmacol. Ther. 20, 303-310 (2004).
    • (2004) Aliment. Pharmacol. Ther , vol.20 , pp. 303-310
    • Pierik, M.1    Vermeire, S.2    Steen, K.V.3
  • 98
    • 33750622795 scopus 로고    scopus 로고
    • Analysis of linkage between lymphotoxin α haplotype and polymorphisms in 5′-flanking region of tumor necrosis factor α gene associated with efficacy of infliximab for Crohn's disease patients
    • Ozeki T, Furuya Y, Nagano C et al.: Analysis of linkage between lymphotoxin α haplotype and polymorphisms in 5′-flanking region of tumor necrosis factor α gene associated with efficacy of infliximab for Crohn's disease patients. Mutat. Res. 602, 170-174 (2006).
    • (2006) Mutat. Res , vol.602 , pp. 170-174
    • Ozeki, T.1    Furuya, Y.2    Nagano, C.3
  • 99
    • 33645904838 scopus 로고    scopus 로고
    • Lymphotoxin α gene in Crohn's disease patients: Absence of implication in the response to infliximab in a large cohort study
    • Dideberg V, Louis E, Farnir F et al.: Lymphotoxin α gene in Crohn's disease patients: absence of implication in the response to infliximab in a large cohort study. Pharmacogenet. Genomics. 16, 369-373 (2006).
    • (2006) Pharmacogenet. Genomics , vol.16 , pp. 369-373
    • Dideberg, V.1    Louis, E.2    Farnir, F.3
  • 100
    • 33749010045 scopus 로고    scopus 로고
    • The TNF/ADAM 17 system: Implication of an ADAM 17 haplotype in the clinical response to infliximab in Crohn's disease
    • Dideberg V, Theatre E, Farnir F et al.: The TNF/ADAM 17 system: implication of an ADAM 17 haplotype in the clinical response to infliximab in Crohn's disease. Pharmacogenet. Genomics. 16, 727-734 (2006).
    • (2006) Pharmacogenet. Genomics , vol.16 , pp. 727-734
    • Dideberg, V.1    Theatre, E.2    Farnir, F.3
  • 101
    • 41749085264 scopus 로고    scopus 로고
    • Genetic polymorphisms of TNF receptor superfamily 1A and 1B (TNFRSF1A and TNFRSF1B) affect responses to infliximab in Crohn's disease patients in Japan
    • Matsukura H, Ikeda S, Yoshimura N, Takazoe M, Muramatsu M: Genetic polymorphisms of TNF receptor superfamily 1A and 1B (TNFRSF1A and TNFRSF1B) affect responses to infliximab in Crohn's disease patients in Japan. Aliment. Pharmacol. Ther. 27(9), 765-770 (2008).
    • (2008) Aliment. Pharmacol. Ther , vol.27 , Issue.9 , pp. 765-770
    • Matsukura, H.1    Ikeda, S.2    Yoshimura, N.3    Takazoe, M.4    Muramatsu, M.5
  • 102
    • 0036306951 scopus 로고    scopus 로고
    • Lack of common NOD2 variants in Japanese patients with Crohn's disease
    • Inoue N, Tamura K, Kinouchi Y et al.: Lack of common NOD2 variants in Japanese patients with Crohn's disease. Gastroenterology 123, 86-91 (2002).
    • (2002) Gastroenterology , vol.123 , pp. 86-91
    • Inoue, N.1    Tamura, K.2    Kinouchi, Y.3
  • 103
    • 27944464550 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease
    • Yamazaki K, McGovern D, Ragoussis J et al.: Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease. Hum. Mol. Genet. 14, 3499-3506 (2005).
    • (2005) Hum. Mol. Genet , vol.14 , pp. 3499-3506
    • Yamazaki, K.1    McGovern, D.2    Ragoussis, J.3
  • 104
    • 26244456815 scopus 로고    scopus 로고
    • Polymorphisms in apoptosis genes predict response to infliximab therapy in luminal and fistulizing Crohn's disease
    • Hlavaty T, Pierik M, Henckaerts L et al.: Polymorphisms in apoptosis genes predict response to infliximab therapy in luminal and fistulizing Crohn's disease. Aliment. Pharmacol. Ther. 22, 613-626 (2005).
    • (2005) Aliment. Pharmacol. Ther , vol.22 , pp. 613-626
    • Hlavaty, T.1    Pierik, M.2    Henckaerts, L.3
  • 105
    • 34247638361 scopus 로고    scopus 로고
    • Predictive model for the outcome of infliximab therapy in Crohn's disease based on apoptotic pharmacogenetic index and clinical predictors
    • Hlavaty T, Ferrante M, Henckaerts L, Pierik M, Rutgeerts P, Vermeire S: Predictive model for the outcome of infliximab therapy in Crohn's disease based on apoptotic pharmacogenetic index and clinical predictors. Inflamm. Bowel Dis. 13, 372-379 (2007).
    • (2007) Inflamm. Bowel Dis , vol.13 , pp. 372-379
    • Hlavaty, T.1    Ferrante, M.2    Henckaerts, L.3    Pierik, M.4    Rutgeerts, P.5    Vermeire, S.6
  • 106
    • 0642373290 scopus 로고    scopus 로고
    • Two immunoglobulin G fragment C receptor polymorphisms independently predict response to rituximab in patients with follicular lymphoma
    • Weng WK, Levy R: Two immunoglobulin G fragment C receptor polymorphisms independently predict response to rituximab in patients with follicular lymphoma. J. Clin. Oncol. 21, 3940-3947 (2003).
    • (2003) J. Clin. Oncol , vol.21 , pp. 3940-3947
    • Weng, W.K.1    Levy, R.2
  • 107
    • 12144287977 scopus 로고    scopus 로고
    • Association between polymorphism in IgG Fc receptor IIIa coding gene and biological response to infliximab in Crohn's disease
    • Louis E, El Ghoul Z, Vermeire S et al.: Association between polymorphism in IgG Fc receptor IIIa coding gene and biological response to infliximab in Crohn's disease. Aliment. Pharmacol. Ther. 19, 511-519 (2004).
    • (2004) Aliment. Pharmacol. Ther , vol.19 , pp. 511-519
    • Louis, E.1    El Ghoul, Z.2    Vermeire, S.3
  • 108
    • 29144473531 scopus 로고    scopus 로고
    • No association between C-reactive protein gene polymorphisms and decrease of C-reactive protein serum concentration after infliximab treatment in Crohn's disease
    • Willot S, Vermeire S, Ohresser M et al.: No association between C-reactive protein gene polymorphisms and decrease of C-reactive protein serum concentration after infliximab treatment in Crohn's disease. Pharmacogenet. Genomics 16, 37-42 (2006).
    • (2006) Pharmacogenet. Genomics , vol.16 , pp. 37-42
    • Willot, S.1    Vermeire, S.2    Ohresser, M.3
  • 109
    • 32044451548 scopus 로고    scopus 로고
    • Human anti-tumor necrosis factor monoclonal antibody (adalimumab) in Crohn's disease: The CLASSIC-I trial
    • Hanauer SB, Sandborn WJ, Rutgeerts P et al.: Human anti-tumor necrosis factor monoclonal antibody (adalimumab) in Crohn's disease: the CLASSIC-I trial. Gastroenterology 130, 323-333 (2006).
    • (2006) Gastroenterology , vol.130 , pp. 323-333
    • Hanauer, S.B.1    Sandborn, W.J.2    Rutgeerts, P.3
  • 110
    • 34249281002 scopus 로고    scopus 로고
    • Adalimumab for maintenance treatment of Crohn's disease: Results of the CLASSIC II trial
    • Sandborn WJ, Hanauer SB, Rutgeerts P et al.: Adalimumab for maintenance treatment of Crohn's disease: results of the CLASSIC II trial. Gut 56, 1232-1239 (2007).
    • (2007) Gut , vol.56 , pp. 1232-1239
    • Sandborn, W.J.1    Hanauer, S.B.2    Rutgeerts, P.3
  • 111
    • 33846242958 scopus 로고    scopus 로고
    • Adalimumab for maintenance of clinical response and remission in patients with Crohn's disease: The CHARM trial
    • Colombel JF, Sandborn WJ, Rutgeerts P et al.: Adalimumab for maintenance of clinical response and remission in patients with Crohn's disease: the CHARM trial. Gastroenterology 132, 52-65 (2007).
    • (2007) Gastroenterology , vol.132 , pp. 52-65
    • Colombel, J.F.1    Sandborn, W.J.2    Rutgeerts, P.3
  • 112
    • 34447523749 scopus 로고    scopus 로고
    • Certolizumab pegol for the treatment of Crohn's disease
    • Sandborn WJ, Feagan BG, Stoinov, S et al.: Certolizumab pegol for the treatment of Crohn's disease. N. Engl. J. Med. 357, 228-238 (2007).
    • (2007) N. Engl. J. Med , vol.357 , pp. 228-238
    • Sandborn, W.J.1    Feagan, B.G.2    Stoinov, S.3
  • 113
    • 34447515607 scopus 로고    scopus 로고
    • Maintenance therapy with certolizumab pegol for Crohn's disease
    • Schreiber S, Khaliq-Kareemi M, Lawrance IC et al.: Maintenance therapy with certolizumab pegol for Crohn's disease. N. Engl. J. Med. 357, 239-250 (2007).
    • (2007) N. Engl. J. Med , vol.357 , pp. 239-250
    • Schreiber, S.1    Khaliq-Kareemi, M.2    Lawrance, I.C.3
  • 114
    • 33746176176 scopus 로고    scopus 로고
    • Fontolizumab, a humanised anti-interferon γ antibody, demonstrates safety and clinical activity in patients with moderate to severe Crohn's disease
    • Hommes DW, Mikhajlova TL, Stoinov S et al.: Fontolizumab, a humanised anti-interferon γ antibody, demonstrates safety and clinical activity in patients with moderate to severe Crohn's disease. Gut 55, 1131-1137 (2006).
    • (2006) Gut , vol.55 , pp. 1131-1137
    • Hommes, D.W.1    Mikhajlova, T.L.2    Stoinov, S.3
  • 115
    • 33746132472 scopus 로고    scopus 로고
    • A dose escalating, placebo controlled, double blind, single dose and multidose, safety and tolerability study of fontolizumab, a humanised anti-interferon γ antibody, in patients with moderate to severe Crohn's disease
    • Reinisch W, Hommes DW, van Assche G et al.: A dose escalating, placebo controlled, double blind, single dose and multidose, safety and tolerability study of fontolizumab, a humanised anti-interferon γ antibody, in patients with moderate to severe Crohn's disease. Gut 55, 1138-1144 (2006).
    • (2006) Gut , vol.55 , pp. 1138-1144
    • Reinisch, W.1    Hommes, D.W.2    van Assche, G.3
  • 116
    • 11144358366 scopus 로고    scopus 로고
    • A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease
    • Ito H, Takazoe M, Fukuda Y et al.: A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease. Gastroenterology 126, 989-996 (2004).
    • (2004) Gastroenterology , vol.126 , pp. 989-996
    • Ito, H.1    Takazoe, M.2    Fukuda, Y.3
  • 117
    • 0034464148 scopus 로고    scopus 로고
    • Safety and efficacy of recombinant human interleukin 10 in chronic active Crohn's disease. Crohn's Disease IL-10 Cooperative Study Group
    • Schreiber S, Fedorak RN, Nielsen OH et al.: Safety and efficacy of recombinant human interleukin 10 in chronic active Crohn's disease. Crohn's Disease IL-10 Cooperative Study Group. Gastroenterology 119, 1461-1472 (2000).
    • (2000) Gastroenterology , vol.119 , pp. 1461-1472
    • Schreiber, S.1    Fedorak, R.N.2    Nielsen, O.H.3
  • 118
    • 33744933432 scopus 로고    scopus 로고
    • A Phase I trial with transgenic bacteria expressing Interleukin-10 in Crohn's disease
    • Braat H, Rottiers P, Hommes DW et al.: A Phase I trial with transgenic bacteria expressing Interleukin-10 in Crohn's disease. Clin. Gastroenterol. Hepatol. 4, 754-759 (2006).
    • (2006) Clin. Gastroenterol. Hepatol , vol.4 , pp. 754-759
    • Braat, H.1    Rottiers, P.2    Hommes, D.W.3
  • 119
    • 8344284998 scopus 로고    scopus 로고
    • Anti-interleukin-12 antibody for active Crohn's disease
    • Mannon PJ, Fuss IJ, Mayer L et al.: Anti-interleukin-12 antibody for active Crohn's disease. N. Engl. J. Med. 351, 2069-2079 (2004).
    • (2004) N. Engl. J. Med , vol.351 , pp. 2069-2079
    • Mannon, P.J.1    Fuss, I.J.2    Mayer, L.3
  • 120
    • 33646397611 scopus 로고    scopus 로고
    • IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6
    • Yen D, Cheung J, Scheerens H et al.: IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J. Clin. Invest. 116, 1310-1316 (2006).
    • (2006) J. Clin. Invest , vol.116 , pp. 1310-1316
    • Yen, D.1    Cheung, J.2    Scheerens, H.3
  • 121
    • 33750505009 scopus 로고    scopus 로고
    • Interleukin-23 drives innate and T cell-mediated intestinal inflammation
    • Hue S, Ahern P, Buonocore S et al.: Interleukin-23 drives innate and T cell-mediated intestinal inflammation. J. Exp. Med. 203, 2473-2483 (2006).
    • (2006) J. Exp. Med , vol.203 , pp. 2473-2483
    • Hue, S.1    Ahern, P.2    Buonocore, S.3
  • 122
    • 33845340501 scopus 로고    scopus 로고
    • A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
    • Duerr RH, Taylor KD, Brant SR et al.: A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 314, 1461-1463 (2006).
    • (2006) Science , vol.314 , pp. 1461-1463
    • Duerr, R.H.1    Taylor, K.D.2    Brant, S.R.3
  • 123
    • 33745553245 scopus 로고    scopus 로고
    • A Phase 1/2A trial of STA 5326, an oral interleukin-12/23 inhibitor, in patients with active moderate to severe Crohn's disease
    • Burakoff R, Barish CF, Riff D et al.: A Phase 1/2A trial of STA 5326, an oral interleukin-12/23 inhibitor, in patients with active moderate to severe Crohn's disease. Inflamm. Bowel Dis. 12, 558-565 (2006).
    • (2006) Inflamm. Bowel Dis , vol.12 , pp. 558-565
    • Burakoff, R.1    Barish, C.F.2    Riff, D.3
  • 124
    • 33646695671 scopus 로고    scopus 로고
    • Rationale and safety of anti-interleukin-23 and anti-interleukin-17A therapy
    • Bowman EP, Chackerian AA, Cua, DJ Rationale and safety of anti-interleukin-23 and anti-interleukin-17A therapy. Curr. Opin. Infect. Dis. 19, 245-252 (2006).
    • (2006) Curr. Opin. Infect. Dis , vol.19 , pp. 245-252
    • Bowman, E.P.1    Chackerian, A.A.2    Cua, D.J.3
  • 125
    • 40049108461 scopus 로고    scopus 로고
    • Immunopathogenesis of inflammatory bowel disease
    • Shih DQ, Targan SR: Immunopathogenesis of inflammatory bowel disease. World J. Gastroenterol. 14, 390-400 (2008).
    • (2008) World J. Gastroenterol , vol.14 , pp. 390-400
    • Shih, D.Q.1    Targan, S.R.2
  • 126
    • 27644441529 scopus 로고    scopus 로고
    • Natalizumab induction and maintenance therapy for Crohn's disease
    • Sandborn WJ, Colombel JF, Enns R et al.: Natalizumab induction and maintenance therapy for Crohn's disease. N. Engl. J. Med. 353, 1912-1925 (2005).
    • (2005) N. Engl. J. Med , vol.353 , pp. 1912-1925
    • Sandborn, W.J.1    Colombel, J.F.2    Enns, R.3
  • 128
    • 0036241068 scopus 로고    scopus 로고
    • Immunostimulatory DNA ameliorates experimental and spontaneous murine colitis
    • Rachmilewitz D, Karmeli F, Takabayashi K et al.: Immunostimulatory DNA ameliorates experimental and spontaneous murine colitis. Gastroenterology 122, 1428-1441 (2002).
    • (2002) Gastroenterology , vol.122 , pp. 1428-1441
    • Rachmilewitz, D.1    Karmeli, F.2    Takabayashi, K.3
  • 129
    • 10744233159 scopus 로고    scopus 로고
    • Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis
    • Rachmilewitz D, Katakura K, Karmeli F et al.: Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis. Gastroenterology 126, 520-528 (2004).
    • (2004) Gastroenterology , vol.126 , pp. 520-528
    • Rachmilewitz, D.1    Katakura, K.2    Karmeli, F.3
  • 130
    • 33344466383 scopus 로고    scopus 로고
    • Defective acute inflammation in Crohn's disease: A clinical investigation
    • Marks DJ, Harbord MW, MacAllister R et al.: Defective acute inflammation in Crohn's disease: a clinical investigation. Lancet 367, 668-678 (2006).
    • (2006) Lancet , vol.367 , pp. 668-678
    • Marks, D.J.1    Harbord, M.W.2    MacAllister, R.3
  • 131
    • 0035978651 scopus 로고    scopus 로고
    • Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
    • Hugot JP, Chamaillard M, Zouali H et al.: Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411, 599-603 (2001).
    • (2001) Nature , vol.411 , pp. 599-603
    • Hugot, J.P.1    Chamaillard, M.2    Zouali, H.3
  • 132
    • 35449000411 scopus 로고    scopus 로고
    • Has toll-like receptor 4 been prematurely dismissed as an inflammatory bowel disease gene? Association study combined with meta-analysis shows strong evidence for association
    • Browning BL, Huebner C, Petermann I et al.: Has toll-like receptor 4 been prematurely dismissed as an inflammatory bowel disease gene? Association study combined with meta-analysis shows strong evidence for association. Am. J. Gastroenterol. 102, 2504-2512 (2007).
    • (2007) Am. J. Gastroenterol , vol.102 , pp. 2504-2512
    • Browning, B.L.1    Huebner, C.2    Petermann, I.3
  • 134
    • 33846627302 scopus 로고    scopus 로고
    • A genome-wide association scan of nonsynonymous SNPs Identifies a susceptibility variant for Crohn disease in ATG16L1
    • Hampe J, Franke A, Rosenstiel P et al.: A genome-wide association scan of nonsynonymous SNPs Identifies a susceptibility variant for Crohn disease in ATG16L1. Nat. Genet. 39, 207-211 (2007).
    • (2007) Nat. Genet , vol.39 , pp. 207-211
    • Hampe, J.1    Franke, A.2    Rosenstiel, P.3
  • 135
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
    • Welcome Trust Case Control Consortium
    • Welcome Trust Case Control Consortium: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447, 661-678 (2007).
    • (2007) Nature , vol.447 , pp. 661-678
  • 136
    • 35648958802 scopus 로고    scopus 로고
    • Diagnostics of Inflammatory bowel disease
    • Nikolaus S, Schreiber S: Diagnostics of Inflammatory bowel disease. Gastroenterology 133, 1670-1689 (2007).
    • (2007) Gastroenterology , vol.133 , pp. 1670-1689
    • Nikolaus, S.1    Schreiber, S.2


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