Cdc7 kinases (DDKs) and checkpoint responses: Lessons from two yeasts

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 532, Issue 1-2, 2003, Pages 21-27

  Duncker, Bernard P ^a   Brown, Grant W ^b  

^a UNIVERSITY OF WATERLOO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Cdc7 Hsk1; Checkpoint; Dbf4 Dfp1; DDK; Origin of replication; Replication fork; Saccharomyces cerevisiae; Schizosaccharomyces pombe

Indexed keywords

CYCLIN DEPENDENT KINASE 7;

CELL CYCLE S PHASE; COMPARATIVE STUDY; DATA ANALYSIS; DNA DAMAGE; DNA REPLICATION; GENOTOXICITY; MICROORGANISM; MUTANT; NONHUMAN; ORTHOLOGY; PRIORITY JOURNAL; REVIEW; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE; YEAST;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE;

EID: 0344413644     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2003.08.007     Document Type: Review

References (37)

1. Kelly T.J., Brown G.W. Regulation of chromosome replication. Ann. Rev. Biochem. 69:2000;829-880.
2. Bell S.P., Dutta A. DNA replication in eukaryotic cells. Ann. Rev. Biochem. 71:2002;333-374.
3. Culotti J., Hartwell L.H. Genetic control of the cell division cycle in yeast. 3. Seven genes controlling nuclear division. Exp. Cell Res. 67:1971;389-401.
4. Cheng L., Collyer T., Hardy C.F. Cell cycle regulation of DNA replication initiator factor Dbf4p. Mol. Cell Biol. 19:1999;4270-4278.
5. Pasero P., Duncker B.P., Schwob E., Gasser S.M. A role for the Cdc7 kinase regulatory subunit Dbf4p in the formation of initiation-competent origins of replication. Genes Dev. 13:1999;2159-2176.
6. Weinreich M., Stillman B. Cdc7p-Dbf4p kinase binds to chromatin during S phase and is regulated by both the APC and the RAD53 checkpoint pathway. EMBO J. 18:1999;5334-5346.
7. Sclafani R.A. Cdc7p-Dbf4p becomes famous in the cell cycle. J. Cell Sci. 113:2000;2111-2117.
8. Masai H., Arai K. Cdc7 kinase complex: a key regulator in the initiation of DNA replication. J. Cell Physiol. 190:2002;287-296.
9. Sipiczki M. Where does fission yeast sit on the tree of life? Genome Biol. 1:2000;1011.1-1011.4.
10. Brown G.W., Kelly T.J. Purification of Hsk1, a minichromosome maintenance protein kinase from fission yeast. J. Biol. Chem. 273:1998;22083-22090.
11. Brown G.W., Kelly T.J. Cell cycle regulation of Dfp1, an activator of the Hsk1 protein kinase. Proc. Natl. Acad. Sci. U.S.A. 96:1999;8443-8448.
12. Takeda T., Ogino K., Matsui E., Cho M.K., Kumagai H., Miyake T., Arai K., Masai H. A fission yeast gene, him1+/dfp1+, encoding a regulatory subunit for Hsk1 kinase, plays essential roles in S-phase initiation as well as in S-phase checkpoint control and recovery from DNA damage. Mol. Cell Biol. 19:1999;5535-5547.
13. Snaith H.A., Brown G.W., Forsburg S.L. Schizosaccharomyces pombe Hsk1 is a potential Cds1p target required for genome integrity. Mol. Cell Biol. 20:2000;7922-7932.
14. Lei M., Kawasaki Y., Young M.R., Kihara M., Sugino A., Tye B.K. Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis. Genes Dev. 11:1997;3365-3374.
15. Takeda T., Ogino K., Tatebayashi K., Ikeda H., Arai K., Masai H. Regulation of checkpoint signaling, and maintenance of mitotic chromosome structures during S phase by Hsk1. Mol. Biol. Cell. 12:2001;1257-1274.
16. + is uniquely required for chromosome stability following alkylation damage during S phase. Mol. Cell. Biol. 22:2002;4477-4490.
17. Kihara M., Nakai W., Asano S., Suzuki A., Kitada K., Kawasaki Y., Johnston L.H., Sugino A. Characterization of the yeast Cdc7p/Dbf4p complex purified from insect cells: its protein kinase activity is regulated by Rad53p. J. Biol. Chem. 275:2000;35051-35062.
18. Dohrmann P.R., Oshiro G., Tecklenburg M., Sclafani R.A. RAD53 regulates DBF4 independently of checkpoint function in Saccharomyces cerevisiae. Genetics. 151:1999;965-977.
19. Duncker B.P., Shimada K., Tsai-Pflugfelder M., Pasero P., Gasser S.M. An N-terminal domain of Dbf4p mediates interaction with both origin recognition complex (ORC) and Rad53p and can deregulate late origin firing. Proc. Natl. Acad. Sci. U.S.A. 99:2002;16087-16092.
20. Masai H., Arai K. Dbf4 motifs: conserved motifs in activation subunits for Cdc7 kinases essential for S-phase. Biochem. Biophys. Res. Commun. 275:2000;228-232.
21. Hardy C.F.J., Pautz A. A novel role for Cdc5p in DNA replication. Mol. Cell. Biol. 16:1996;6775-6782.
22. Dowell S.J., Romanowski P., Diffley J.F.X. Interaction of Dbf4, the Cdc7 protein kinase regulatory subunit, with yeast replication origins in vivo. Science. 265:1994;1243-1246.
23. Ogino K., Takeda T., Matsui E., Iiyama H., Taniyama C., Arai K., Masai H. Bipartite binding of a kinase activator activates Cdc7-related kinase essential for S phase. J. Biol. Chem. 276:2001;31376-31387.
24. Pike B.L., Yongkiettrakul S., Tsai M., Heierhorst J. Diverse but overlapping functions of the two forkhead-associated (FHA) domains in Rad53 checkpoint kinase activation. J. Biol. Chem. 278:2003;30421-30424.
25. Raghuraman M.K., Winzeler E.A., Collingwood D., Hunt S., Wodieka L., Conway A., Lockhart D.J., Davis R.W., Brewer B.J., Fangman W.L. Replication dynamics of the yeast genome. Science. 294:2001;115-121.
26. Kim S., Huberman J.A. Regulation of replication timing in fission yeast. EMBO J. 20:2001;6115-6126.
27. Bousset K., Diffley J.F.X. The Cdc7 protein kinase is required for origin firing during S phase. Genes Dev. 12:1998;480-490.
28. Donaldson A.D., Fangman W.L., Brewer B.J. Cdc7 is required throughout the yeast S phase to activate replication origins. Genes Dev. 12:1998;491-501.
29. Santocanale C., Diffley J.F. A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication. Nature. 395:1998;615-618.
30. Shirahige K., Hori Y., Shiraishi K., Yamashita M., Takahashi K., Obuse C., Tsurimoto T., Yoshikawa H. Regulation of DNA-replication origins during cell-cycle progression. Nature. 395:1998;618-621.
31. Tercero J.A., Longhese M.P., Diffley J.F.X. A central role for DNA replication forks in checkpoint activation and response. Mol. Cell. 11:2003;1323-1336.
32. Lopes M., Cotta-Ramusino C., Pellicoli A., Liberi G., Plevani P., Muzi-Falconi M., Newlon C.S., Foiani M. The DNA replication checkpoint response stabilizes stalled replication forks. Nature. 412:2001;557-561.
33. Tercero J.A., Diffley J.F.X. Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint. Nature. 412:2001;553-557.
34. Paciotti V., Clerici M., Scotti M., Lucchini G., Longhese M.P. Characterization of mec1 kinase-deficient mutants and of new hypomorphic mec1 alleles impairing subsets of the DNA damage response pathway. Mol. Cell. Biol. 21:2001;3913-3925.
35. Nougarede R., Della Seta F., Zarzov P., Schwob E. Hierarchy of S-phase-promoting factors: yeast Dbf4-Cdc7 kinase requires prior S-phase cyclin-dependent kinase activation. Mol. Cell. Biol. 20:2000;3795-3806.
36. Costanzo V., Shechter D., Lupardus P.J., Cimprich K.A., Gottesman M., Gautier J. An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication. Mol. Cell. 11:2003;203-213.
37. J.M. Kim, M. Yamada, H. Masai, Functions of mammalian Cdc7 kinase (DDK) in initiation, Mut. Res., this issue.