A comparison of aroclor 1254-induced and uninduced rat liver microsomes to human liver microsomes in phenytoin O-deethylation, coumarin 7-hydroxylation, tolbutamide 4-hydroxylation, S-mephenytoin 4′-hydroxylation, chloroxazone 6-hydroxylation and testosterone 6β-hydroxylation

Chemico-Biological Interactions

Volumn 134, Issue 3, 2001, Pages 243-249

  Easterbrook, Judy ^a   Fackett, Drew ^a   Li, Albert P ^a  

^a In Vitro Technologies Inc   (United States)

Author keywords

Aroclor 1254; Cytochrome P450; Drug metabolism; Enzyme induction; Genotoxicity assays; Liver microsomes; Species comparisons; Xenobiotic metabolism

Indexed keywords

AROCLOR 1254; CHLORZOXAZONE; COUMARIN; CYTOCHROME P450 1A2; CYTOCHROME P450 2A6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; CYTOCHROME P450 ISOENZYME; DEXTROMETHORPHAN; MEPHENYTOIN; PHENACETIN; TESTOSTERONE; TOLBUTAMIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DRUG HYDROXYLATION; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME INDUCTION; HUMAN; HUMAN TISSUE; LIVER MICROSOME; LIVER TOXICITY; MALE; MUTAGEN TESTING; MUTAGENICITY; NONHUMAN; RAT; SPECIES DIFFERENCE;

ANIMALS; AROCLOR 1254; CELL FRACTIONATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; ISOENZYMES; MALE; MICROSOMES, LIVER; RATS; RATS, SPRAGUE-DAWLEY; SPECIES SPECIFICITY; SUBSTRATE SPECIFICITY;

EID: 0035897708     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(01)00159-4     Document Type: Article

References (16)

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10. Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily
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13. Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450 IIE1
14. Human liver microsomal steroid metabolism and identification of the major microsomal steroid hormone 6-hydroxylase cytochrome P450 enzyme
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