메뉴 건너뛰기




Volumn 10, Issue 9, 2008, Pages 1787-1800

Focal adhesion kinase mediates the interferon-γ-inducible GTPase-induced phosphatidylinositol 3-kinase/Akt survival pathway and further initiates a positive feedback loop of NF-κB activation

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; DOXYCYCLINE; FOCAL ADHESION KINASE; GAMMA INTERFERON INDUCIBLE GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SMALL INTERFERING RNA;

EID: 48749113901     PISSN: 14625814     EISSN: 14625822     Source Type: Journal    
DOI: 10.1111/j.1462-5822.2008.01165.x     Document Type: Article
Times cited : (28)

References (64)
  • 1
    • 33646831500 scopus 로고    scopus 로고
    • NF-kappaB regulates phagocytic NADPH oxidase by inducing the expression of gp91phox
    • Anrather, J., Racchumi, G., and Iadecola, C. (2006) NF-kappaB regulates phagocytic NADPH oxidase by inducing the expression of gp91phox. J Biol Chem 281: 5657-5667.
    • (2006) J Biol Chem , vol.281 , pp. 5657-5667
    • Anrather, J.1    Racchumi, G.2    Iadecola, C.3
  • 2
    • 0038152988 scopus 로고    scopus 로고
    • Inhibition of NF-kappaB sensitizes A431 cells to epidermal growth factor-induced apoptosis, whereas its activation by ectopic expression of RelA confers resistance
    • Anto, R.J., Venkatraman, M., and Karunagaran, D. (2003) Inhibition of NF-kappaB sensitizes A431 cells to epidermal growth factor-induced apoptosis, whereas its activation by ectopic expression of RelA confers resistance. J Biol Chem 278: 25490-25498.
    • (2003) J Biol Chem , vol.278 , pp. 25490-25498
    • Anto, R.J.1    Venkatraman, M.2    Karunagaran, D.3
  • 3
    • 0031820706 scopus 로고    scopus 로고
    • Caspase activation and specific cleavage of substrates after coxsackievirus B3-induced cytopathic effect in HeLa cells
    • Carthy, C.M., Granville, D.J., Watson, K.A., Anderson, D.R., Wilson, J.E., Yang, D., et al. (1998) Caspase activation and specific cleavage of substrates after coxsackievirus B3-induced cytopathic effect in HeLa cells. J Virol 72: 7669-7675.
    • (1998) J Virol , vol.72 , pp. 7669-7675
    • Carthy, C.M.1    Granville, D.J.2    Watson, K.A.3    Anderson, D.R.4    Wilson, J.E.5    Yang, D.6
  • 4
    • 0033555070 scopus 로고    scopus 로고
    • Focal adhesion kinase in integrin-mediated signaling
    • Cary, L.A., and Guan, J.L. (1999) Focal adhesion kinase in integrin-mediated signaling. Front Biosci 4: D102-D113.
    • (1999) Front Biosci , vol.4
    • Cary, L.A.1    Guan, J.L.2
  • 5
    • 0032475851 scopus 로고    scopus 로고
    • Insulin-like growth factor I stimulates tyrosine phosphorylation of p130 (Cas), focal adhesion kinase, and paxillin. Role of phosphatidylinositol 3′-kinase and formation of a p130 (Cas) Crk complex
    • Casamassima, A., and Rozengurt, E. (1998) Insulin-like growth factor I stimulates tyrosine phosphorylation of p130 (Cas), focal adhesion kinase, and paxillin. Role of phosphatidylinositol 3′-kinase and formation of a p130 (Cas) Crk complex. J Biol Chem 273: 26149-26156.
    • (1998) J Biol Chem , vol.273 , pp. 26149-26156
    • Casamassima, A.1    Rozengurt, E.2
  • 6
    • 0942276399 scopus 로고    scopus 로고
    • CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation
    • Chandrasekar, B., Bysani, S., and Mummidi, S. (2004) CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation. J Biol Chem 279: 3188-3196.
    • (2004) J Biol Chem , vol.279 , pp. 3188-3196
    • Chandrasekar, B.1    Bysani, S.2    Mummidi, S.3
  • 7
    • 32344445820 scopus 로고    scopus 로고
    • CXCL8-induced FAK phosphorylation via CXCR1 and CXCR2: Cytoskeleton- and integrin-related mechanisms converge with FAK regulatory pathways in a receptor-specific manner
    • Cohen-Hillel, E., Yron, I., Meshel, T., Soria, G., Attal, H., and Ben-Baruch, A. (2006) CXCL8-induced FAK phosphorylation via CXCR1 and CXCR2: Cytoskeleton- and integrin-related mechanisms converge with FAK regulatory pathways in a receptor-specific manner. Cytokine 33: 1-16.
    • (2006) Cytokine , vol.33 , pp. 1-16
    • Cohen-Hillel, E.1    Yron, I.2    Meshel, T.3    Soria, G.4    Attal, H.5    Ben-Baruch, A.6
  • 8
    • 0036893663 scopus 로고    scopus 로고
    • The function of gamma interferon-inducible GTP-binding protein IGTP in host resistance to Toxoplasma gondii is Stat1 dependent and requires expression in both hematopoietic and nonhematopoietic cellular compartments
    • Collazo, C.M., Yap, G.S., Hieny, S., Caspar, P., Feng, C.G., Taylor, G.A., and Sher, A. (2002) The function of gamma interferon-inducible GTP-binding protein IGTP in host resistance to Toxoplasma gondii is Stat1 dependent and requires expression in both hematopoietic and nonhematopoietic cellular compartments. Infect Immun 70: 6933-6939.
    • (2002) Infect Immun , vol.70 , pp. 6933-6939
    • Collazo, C.M.1    Yap, G.S.2    Hieny, S.3    Caspar, P.4    Feng, C.G.5    Taylor, G.A.6    Sher, A.7
  • 9
    • 0036839623 scopus 로고    scopus 로고
    • NF-kappa B and TNF-alpha: A positive autocrine loop in human lung mast cells?
    • Coward, W.R., Okayama, Y., Sagara, H., Wilson, S.J., Holgate, S.T., and Church, M.K. (2002) NF-kappa B and TNF-alpha: A positive autocrine loop in human lung mast cells? J Immunol 169: 5287-5293.
    • (2002) J Immunol , vol.169 , pp. 5287-5293
    • Coward, W.R.1    Okayama, Y.2    Sagara, H.3    Wilson, S.J.4    Holgate, S.T.5    Church, M.K.6
  • 11
    • 34548442100 scopus 로고    scopus 로고
    • Coxsackievirus B3 activates nuclear factor kappa B transcription factor via a phosphatidylinositol-3 kinase/protein kinase B-dependent pathway to improve host cell viability
    • Esfandiarei, M., Boroomand, S., Suarez, A., Si, X.N., Rahmani, M., and McManus, B. (2007) Coxsackievirus B3 activates nuclear factor kappa B transcription factor via a phosphatidylinositol-3 kinase/protein kinase B-dependent pathway to improve host cell viability. Cell Microbiol 9: 2358-2371.
    • (2007) Cell Microbiol , vol.9 , pp. 2358-2371
    • Esfandiarei, M.1    Boroomand, S.2    Suarez, A.3    Si, X.N.4    Rahmani, M.5    McManus, B.6
  • 13
    • 0037199972 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells
    • Guha, M., and Mackman, N. (2002) The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells. J Biol Chem 277: 32124-32132.
    • (2002) J Biol Chem , vol.277 , pp. 32124-32132
    • Guha, M.1    Mackman, N.2
  • 14
    • 0345826140 scopus 로고    scopus 로고
    • Cell type-specific expression of the IkappaB kinases determines the significance of phosphatidylinositol 3-kinase/Akt signaling to NF-kappa B activation
    • Gustin, J.A., Ozes, O.N., Akca, H., Pincheira, R., Mayo, L.D., Li, Q., et al. (2004) Cell type-specific expression of the IkappaB kinases determines the significance of phosphatidylinositol 3-kinase/Akt signaling to NF-kappa B activation. J Biol Chem 279: 1615-1620.
    • (2004) J Biol Chem , vol.279 , pp. 1615-1620
    • Gustin, J.A.1    Ozes, O.N.2    Akca, H.3    Pincheira, R.4    Mayo, L.D.5    Li, Q.6
  • 15
    • 0034861021 scopus 로고    scopus 로고
    • Gamma interferon-induced inhibition of Toxoplasma gondii in astrocytes is mediated by IGTP
    • Halonen, S.K., Taylor, G.A., and Weiss, L.M. (2001) Gamma interferon-induced inhibition of Toxoplasma gondii in astrocytes is mediated by IGTP. Infect Immun 69: 5573-5576.
    • (2001) Infect Immun , vol.69 , pp. 5573-5576
    • Halonen, S.K.1    Taylor, G.A.2    Weiss, L.M.3
  • 16
    • 0141565353 scopus 로고    scopus 로고
    • Activation of focal adhesion kinase by protein kinase C epsilon in neonatal rat ventricular myocytes
    • Heidkamp, M.C., Bayer, A.L., Scully, B.T., Eble, D.M., and Samarel, A.M. (2003) Activation of focal adhesion kinase by protein kinase C epsilon in neonatal rat ventricular myocytes. Am J Physiol Heart Circ Physiol 285: H1684-H1696.
    • (2003) Am J Physiol Heart Circ Physiol , vol.285
    • Heidkamp, M.C.1    Bayer, A.L.2    Scully, B.T.3    Eble, D.M.4    Samarel, A.M.5
  • 17
    • 22144444232 scopus 로고    scopus 로고
    • API2-MALT1 fusion protein induces transcriptional activation of the API2 gene through NF-kappaB binding elements: Evidence for a positive feed-back loop pathway resulting in unremitting NF-kappaB activation
    • Hosokawa, Y., Suzuki, H., Nakagawa, M., Lee, T.H., and Seto, M. (2005) API2-MALT1 fusion protein induces transcriptional activation of the API2 gene through NF-kappaB binding elements: Evidence for a positive feed-back loop pathway resulting in unremitting NF-kappaB activation. Biochem Biophys Res Commun 334: 51-60.
    • (2005) Biochem Biophys Res Commun , vol.334 , pp. 51-60
    • Hosokawa, Y.1    Suzuki, H.2    Nakagawa, M.3    Lee, T.H.4    Seto, M.5
  • 18
    • 0031044781 scopus 로고    scopus 로고
    • Focal adhesion kinase: At the crossroads of signal transduction
    • Ilic, D., Damsky, C.H., and Yamamoto, T. (1997) Focal adhesion kinase: at the crossroads of signal transduction. J Cell Sci 110 (Part 4): 401-407.
    • (1997) J Cell Sci , vol.110 , Issue.PART 4 , pp. 401-407
    • Ilic, D.1    Damsky, C.H.2    Yamamoto, T.3
  • 19
    • 6344255031 scopus 로고    scopus 로고
    • Paxillin serves as an ERK-regulated scaffold for coordinating FAK and Rac activation in epithelial morphogenesis
    • Ishibe, S., Joly, D., Liu, Z.X., and Cantley, L.G. (2004) Paxillin serves as an ERK-regulated scaffold for coordinating FAK and Rac activation in epithelial morphogenesis. Mol Cell 16: 257-267.
    • (2004) Mol Cell , vol.16 , pp. 257-267
    • Ishibe, S.1    Joly, D.2    Liu, Z.X.3    Cantley, L.G.4
  • 20
    • 7644232626 scopus 로고    scopus 로고
    • Transcriptional regulation of the MAIL gene in LPS-stimulated RAW264 mouse macrophages
    • Ito, T., Morimatsu, M., Oonuma, T., Shiina, T., Kitamura, H., and Syuto, B. (2004) Transcriptional regulation of the MAIL gene in LPS-stimulated RAW264 mouse macrophages. Gene 342: 137-143.
    • (2004) Gene , vol.342 , pp. 137-143
    • Ito, T.1    Morimatsu, M.2    Oonuma, T.3    Shiina, T.4    Kitamura, H.5    Syuto, B.6
  • 21
    • 0034658320 scopus 로고    scopus 로고
    • Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X (L) levels in vivo
    • Jones, R.G., Parsons, M., Bonnard, M., Chan, V.S., Yeh, W.C., Woodgett, J.R., and Ohashi, P.S. (2000) Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X (L) levels in vivo. J Exp Med 191: 1721-1734.
    • (2000) J Exp Med , vol.191 , pp. 1721-1734
    • Jones, R.G.1    Parsons, M.2    Bonnard, M.3    Chan, V.S.4    Yeh, W.C.5    Woodgett, J.R.6    Ohashi, P.S.7
  • 22
    • 0038578823 scopus 로고    scopus 로고
    • The PI-3 kinase/Akt pathway and T cell activation: Pleiotropic pathways downstream of PIP3
    • Kane, L.P., and Weiss, A. (2003) The PI-3 kinase/Akt pathway and T cell activation: Pleiotropic pathways downstream of PIP3. Immunol Rev 192: 7-20.
    • (2003) Immunol Rev , vol.192 , pp. 7-20
    • Kane, L.P.1    Weiss, A.2
  • 23
    • 0034084163 scopus 로고    scopus 로고
    • Phosphorylation meets ubiquitination: The control of NF-[kappa]B activity
    • Karin, M., and Ben-Neriah, Y. (2000) Phosphorylation meets ubiquitination: The control of NF-[kappa]B activity. Annu Rev Immunol 18: 621-663.
    • (2000) Annu Rev Immunol , vol.18 , pp. 621-663
    • Karin, M.1    Ben-Neriah, Y.2
  • 25
    • 0033514987 scopus 로고    scopus 로고
    • From myocarditis to cardiomyopathy: Mechanisms of inflammation and cell death: Learning from the past for the future
    • Kawai, C. (1999) From myocarditis to cardiomyopathy: Mechanisms of inflammation and cell death: Learning from the past for the future. Circulation 99: 1091-1100.
    • (1999) Circulation , vol.99 , pp. 1091-1100
    • Kawai, C.1
  • 26
    • 1042266663 scopus 로고    scopus 로고
    • Down-regulation of the tumor suppressor PTEN by the tumor necrosis factor-alpha/nuclear factor-kappaB (NF-kappaB)-inducing kinase/NF-kappaB pathway is linked to a default IkappaB-alpha autoregulatory loop
    • Kim, S., Domon-Dell, C., Kang, J., Chung, D.H., Freund, J.N., and Evers, B.M. (2004) Down-regulation of the tumor suppressor PTEN by the tumor necrosis factor-alpha/nuclear factor-kappaB (NF-kappaB)-inducing kinase/ NF-kappaB pathway is linked to a default IkappaB-alpha autoregulatory loop. J Biol Chem 279: 4285-4291.
    • (2004) J Biol Chem , vol.279 , pp. 4285-4291
    • Kim, S.1    Domon-Dell, C.2    Kang, J.3    Chung, D.H.4    Freund, J.N.5    Evers, B.M.6
  • 27
    • 0141994828 scopus 로고    scopus 로고
    • Selenite-induced survival of HuH7 hepatoma cells involves activation of focal adhesion kinase-phosphatidylinositol 3-kinase-Akt pathway and Rac1
    • Lee, Y.C., Tang, Y.C., Chen, Y.H., Wong, C.M., and Tsou, A.P. (2003) Selenite-induced survival of HuH7 hepatoma cells involves activation of focal adhesion kinase-phosphatidylinositol 3-kinase-Akt pathway and Rac1. J Biol Chem 278: 39615-39624.
    • (2003) J Biol Chem , vol.278 , pp. 39615-39624
    • Lee, Y.C.1    Tang, Y.C.2    Chen, Y.H.3    Wong, C.M.4    Tsou, A.P.5
  • 28
    • 33645116785 scopus 로고    scopus 로고
    • NF-kappa B activation as a pathological mechanism of septic shock and inflammation
    • Liu, S.F., and Malik, A.B. (2006) NF-kappa B activation as a pathological mechanism of septic shock and inflammation. Am J Physiol Lung Cell Mol Physiol 290: L622-L645.
    • (2006) Am J Physiol Lung Cell Mol Physiol , vol.290
    • Liu, S.F.1    Malik, A.B.2
  • 29
    • 0033961280 scopus 로고    scopus 로고
    • Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB
    • Madrid, L.V., Wang, C.Y., Guttridge, D.C., Schottelius, A.J., Baldwin, A.S., Jr, and Mayo, M.W. (2000) Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB. Mol Cell Biol 20: 1626-1638.
    • (2000) Mol Cell Biol , vol.20 , pp. 1626-1638
    • Madrid, L.V.1    Wang, C.Y.2    Guttridge, D.C.3    Schottelius, A.J.4    Baldwin, A.S.5    Mayo, M.W.6
  • 30
    • 0035941298 scopus 로고    scopus 로고
    • Internalin B activates nuclear factor-kappa B via Ras, phosphoinositide 3-kinase, and Akt
    • Mansell, A., Khelef, N., Cossart, P., and O'Neill, L.A. (2001) Internalin B activates nuclear factor-kappa B via Ras, phosphoinositide 3-kinase, and Akt. J Biol Chem 276: 43597-43603.
    • (2001) J Biol Chem , vol.276 , pp. 43597-43603
    • Mansell, A.1    Khelef, N.2    Cossart, P.3    O'Neill, L.A.4
  • 31
    • 33646010041 scopus 로고    scopus 로고
    • Roles for NF-kappaB in nerve cell survival, plasticity, and disease
    • Mattson, M.P., and Meffert, M.K. (2006) Roles for NF-kappaB in nerve cell survival, plasticity, and disease. Cell Death Differ 13: 852-860.
    • (2006) Cell Death Differ , vol.13 , pp. 852-860
    • Mattson, M.P.1    Meffert, M.K.2
  • 32
    • 0037119428 scopus 로고    scopus 로고
    • Akt is a downstream target of NF-kappa B
    • Meng, F., Liu, L., Chin, P.C., and D'Mello, S.R. (2002) Akt is a downstream target of NF-kappa B. J Biol Chem 277: 29674-29680.
    • (2002) J Biol Chem , vol.277 , pp. 29674-29680
    • Meng, F.1    Liu, L.2    Chin, P.C.3    D'Mello, S.R.4
  • 33
    • 11244258882 scopus 로고    scopus 로고
    • Focal adhesion kinase: In command and control of cell motility
    • Mitra, S.K., Hanson, D.A., and Schlaepfer, D.D. (2005) Focal adhesion kinase: In command and control of cell motility. Nat Rev Mol Cell Biol 6: 56-68.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 56-68
    • Mitra, S.K.1    Hanson, D.A.2    Schlaepfer, D.D.3
  • 34
    • 0033517189 scopus 로고    scopus 로고
    • NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase
    • Ozes, O.N., Mayo, L.D., Gustin, J.A., Pfeffer, S.R., Pfeffer, L.M., and Donner, D.B. (1999) NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 401: 82-85.
    • (1999) Nature , vol.401 , pp. 82-85
    • Ozes, O.N.1    Mayo, L.D.2    Gustin, J.A.3    Pfeffer, S.R.4    Pfeffer, L.M.5    Donner, D.B.6
  • 35
    • 33645983982 scopus 로고    scopus 로고
    • The NF-kappaB-mediated control of the JNK cascade in the antagonism of programmed cell death in health and disease
    • Papa, S., Bubici, C., Zazzeroni, F., Pham, C.G., Kuntzen, C., Knabb, J.R., et al. (2006) The NF-kappaB-mediated control of the JNK cascade in the antagonism of programmed cell death in health and disease. Cell Death Differ 13: 712-729.
    • (2006) Cell Death Differ , vol.13 , pp. 712-729
    • Papa, S.1    Bubici, C.2    Zazzeroni, F.3    Pham, C.G.4    Kuntzen, C.5    Knabb, J.R.6
  • 36
    • 0037509990 scopus 로고    scopus 로고
    • Focal adhesion kinase: The first ten years
    • Parsons, J.T. (2003) Focal adhesion kinase: The first ten years. J Cell Sci 116: 1409-1416.
    • (2003) J Cell Sci , vol.116 , pp. 1409-1416
    • Parsons, J.T.1
  • 37
    • 33646001448 scopus 로고    scopus 로고
    • Dissection of the NF-kappaB signalling cascade in transgenic and knockout mice
    • Pasparakis, M., Luedde, T., and Schmidt-Supprian, M. (2006) Dissection of the NF-kappaB signalling cascade in transgenic and knockout mice. Cell Death Differ 13: 861-872.
    • (2006) Cell Death Differ , vol.13 , pp. 861-872
    • Pasparakis, M.1    Luedde, T.2    Schmidt-Supprian, M.3
  • 38
    • 33845768987 scopus 로고    scopus 로고
    • Integrating cell-signalling pathways with NF-kappaB and IKK function
    • Perkins, N.D. (2007) Integrating cell-signalling pathways with NF-kappaB and IKK function. Nat Rev Mol Cell Biol 8: 49-62.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 49-62
    • Perkins, N.D.1
  • 39
    • 33645971047 scopus 로고    scopus 로고
    • Good cop, bad cop: The different faces of NF-kappaB
    • Perkins, N.D., and Gilmore, T.D. (2006) Good cop, bad cop: The different faces of NF-kappaB. Cell Death Differ 13: 759-772.
    • (2006) Cell Death Differ , vol.13 , pp. 759-772
    • Perkins, N.D.1    Gilmore, T.D.2
  • 40
    • 0037424498 scopus 로고    scopus 로고
    • The role of focal adhesion kinase-phosphatidylinositol 3-kinase-akt signaling in hepatic stellate cell proliferation and type I collagen expression
    • Reif, S., Lang, A., Lindquist, J.N., Yata, Y., Gabele, E., Scanga, A., et al. (2003) The role of focal adhesion kinase-phosphatidylinositol 3-kinase-akt signaling in hepatic stellate cell proliferation and type I collagen expression. J Biol Chem 278: 8083-8090.
    • (2003) J Biol Chem , vol.278 , pp. 8083-8090
    • Reif, S.1    Lang, A.2    Lindquist, J.N.3    Yata, Y.4    Gabele, E.5    Scanga, A.6
  • 42
    • 0035948579 scopus 로고    scopus 로고
    • Biochemical signals and biological responses elicited by the focal adhesion kinase
    • Schaller, M.D. (2001) Biochemical signals and biological responses elicited by the focal adhesion kinase. Biochim Biophys Acta 1540: 1-21.
    • (2001) Biochim Biophys Acta , vol.1540 , pp. 1-21
    • Schaller, M.D.1
  • 43
    • 3142521875 scopus 로고    scopus 로고
    • Control of motile and invasive cell phenotypes by focal adhesion kinase
    • Schlaepfer, D.D., Mitra, S.K., and Ilic, D. (2004) Control of motile and invasive cell phenotypes by focal adhesion kinase. Biochim Biophys Acta 1692: 77-102.
    • (2004) Biochim Biophys Acta , vol.1692 , pp. 77-102
    • Schlaepfer, D.D.1    Mitra, S.K.2    Ilic, D.3
  • 44
    • 33748506089 scopus 로고    scopus 로고
    • Human IRGM induces autophagy to eliminate intracellular mycobacteria
    • Singh, S.B., Davis, A.S., Taylor, G.A., and Deretic, V. (2006) Human IRGM induces autophagy to eliminate intracellular mycobacteria. Science 313: 1438-1441.
    • (2006) Science , vol.313 , pp. 1438-1441
    • Singh, S.B.1    Davis, A.S.2    Taylor, G.A.3    Deretic, V.4
  • 45
    • 0033038491 scopus 로고    scopus 로고
    • Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit
    • Sizemore, N., Leung, S., and Stark, G.R. (1999) Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit. Mol Cell Biol 19: 4798-4805.
    • (1999) Mol Cell Biol , vol.19 , pp. 4798-4805
    • Sizemore, N.1    Leung, S.2    Stark, G.R.3
  • 46
    • 0033538078 scopus 로고    scopus 로고
    • FAK is the upstream signal protein of the phosphatidylinositol 3-kinase-Akt survival pathway in hydrogen peroxide-induced apoptosis of a human glioblastoma cell line
    • Sonoda, Y., Watanabe, S., Matsumoto, Y., Aizu-Yokota, E., and Kasahara, T. (1999) FAK is the upstream signal protein of the phosphatidylinositol 3-kinase-Akt survival pathway in hydrogen peroxide-induced apoptosis of a human glioblastoma cell line. J Biol Chem 274: 10566-10570.
    • (1999) J Biol Chem , vol.274 , pp. 10566-10570
    • Sonoda, Y.1    Watanabe, S.2    Matsumoto, Y.3    Aizu-Yokota, E.4    Kasahara, T.5
  • 47
    • 0034717285 scopus 로고    scopus 로고
    • Anti-apoptotic role of focal adhesion kinase (FAK). Induction of inhibitor-of-apoptosis proteins and apoptosis suppression by the overexpression of FAK in a human leukemic cell line, HL-60
    • Sonoda, Y., Matsumoto, Y., Funakoshi, M., Yamamoto, D., Hanks, S.K., and Kasahara, T. (2000) Anti-apoptotic role of focal adhesion kinase (FAK). Induction of inhibitor-of-apoptosis proteins and apoptosis suppression by the overexpression of FAK in a human leukemic cell line, HL-60. J Biol Chem 275: 16309-16315.
    • (2000) J Biol Chem , vol.275 , pp. 16309-16315
    • Sonoda, Y.1    Matsumoto, Y.2    Funakoshi, M.3    Yamamoto, D.4    Hanks, S.K.5    Kasahara, T.6
  • 48
    • 0038784379 scopus 로고    scopus 로고
    • CD40 induces human multiple myeloma cell migration via phosphatidylinositol 3-kinase/AKT/NF-kappa B signaling
    • Tai, Y.T., Podar, K., Mitsiades, N., Lin, B., Mitsiades, C., Gupta, D., et al. (2003) CD40 induces human multiple myeloma cell migration via phosphatidylinositol 3-kinase/AKT/NF-kappa B signaling. Blood 101: 2762-2769.
    • (2003) Blood , vol.101 , pp. 2762-2769
    • Tai, Y.T.1    Podar, K.2    Mitsiades, N.3    Lin, B.4    Mitsiades, C.5    Gupta, D.6
  • 49
    • 33745903422 scopus 로고    scopus 로고
    • Coxsackievirus myocarditis: Interplay between virus and host in the pathogenesis of heart disease
    • Tam, P.E. (2006) Coxsackievirus myocarditis: Interplay between virus and host in the pathogenesis of heart disease. Viral Immunol 19: 133-146.
    • (2006) Viral Immunol , vol.19 , pp. 133-146
    • Tam, P.E.1
  • 50
    • 34047256441 scopus 로고    scopus 로고
    • IRG proteins: Key mediators of interferon-regulated host resistance to intracellular pathogens
    • Taylor, G.A. (2007) IRG proteins: Key mediators of interferon-regulated host resistance to intracellular pathogens. Cell Microbiol 9: 1099-1107.
    • (2007) Cell Microbiol , vol.9 , pp. 1099-1107
    • Taylor, G.A.1
  • 51
    • 0030978494 scopus 로고    scopus 로고
    • The inducibly expressed GTPase localizes to the endoplasmic reticulum, independently of GTP binding
    • Taylor, G.A., Stauber, R., Rulong, S., Hudson, E., Pei, V., Pavlakis, G.N., et al. (1997) The inducibly expressed GTPase localizes to the endoplasmic reticulum, independently of GTP binding. J Biol Chem 272: 10639-10645.
    • (1997) J Biol Chem , vol.272 , pp. 10639-10645
    • Taylor, G.A.1    Stauber, R.2    Rulong, S.3    Hudson, E.4    Pei, V.5    Pavlakis, G.N.6
  • 53
    • 1142298755 scopus 로고    scopus 로고
    • p47 GTPases: Regulators of immunity to intracellular pathogens
    • Taylor, G.A., Feng, C.G., and Sher, A. (2004) p47 GTPases: Regulators of immunity to intracellular pathogens. Nat Rev Immunol 4: 100-109.
    • (2004) Nat Rev Immunol , vol.4 , pp. 100-109
    • Taylor, G.A.1    Feng, C.G.2    Sher, A.3
  • 54
    • 11344254134 scopus 로고    scopus 로고
    • beta1-Integrins induce phosphorylation of Akt on serine 473 independently of focal adhesion kinase and Src family kinases
    • Velling, T., Nilsson, S., Stefansson, A., and Johansson, S. (2004) beta1-Integrins induce phosphorylation of Akt on serine 473 independently of focal adhesion kinase and Src family kinases. EMBO Rep 5: 901-905.
    • (2004) EMBO Rep , vol.5 , pp. 901-905
    • Velling, T.1    Nilsson, S.2    Stefansson, A.3    Johansson, S.4
  • 55
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-Kinase AKT pathway in human cancer
    • Vivanco, I., and Sawyers, C.L. (2002) The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2: 489-501.
    • (2002) Nat Rev Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 56
    • 3543023861 scopus 로고    scopus 로고
    • Focal adhesion kinase is upstream of phosphatidylinositol 3-kinase/Akt in regulating fibroblast survival in response to contraction of type I collagen matrices via a beta 1 integrin viability signaling pathway
    • Xia, H., Nho, R.S., Kahm, J., Kleidon, J., and Henke, C.A. (2004) Focal adhesion kinase is upstream of phosphatidylinositol 3-kinase/Akt in regulating fibroblast survival in response to contraction of type I collagen matrices via a beta 1 integrin viability signaling pathway. J Biol Chem 279: 33024-33034.
    • (2004) J Biol Chem , vol.279 , pp. 33024-33034
    • Xia, H.1    Nho, R.S.2    Kahm, J.3    Kleidon, J.4    Henke, C.A.5
  • 57
    • 0037409464 scopus 로고    scopus 로고
    • FAK overexpression upregulates cyclin D3 and enhances cell proliferation via the PKC and PI3-kinase-Akt pathways
    • Yamamoto, D., Sonoda, Y., Hasegawa, M., Funakoshi-Tago, M., Aizu-Yokota, E., and Kasahara, T. (2003) FAK overexpression upregulates cyclin D3 and enhances cell proliferation via the PKC and PI3-kinase-Akt pathways. Cell Signal 15: 575-583.
    • (2003) Cell Signal , vol.15 , pp. 575-583
    • Yamamoto, D.1    Sonoda, Y.2    Hasegawa, M.3    Funakoshi-Tago, M.4    Aizu-Yokota, E.5    Kasahara, T.6
  • 58
    • 0035957951 scopus 로고    scopus 로고
    • Interferon alpha/beta promotes cell survival by activating nuclear factor kappa B through phosphatidylinositol 3-kinase and Akt
    • Yang, C.H., Murti, A., Pfeffer, S.R., Kim, J.G., Donner, D.B., and Pfeffer, L.M. (2001) Interferon alpha/beta promotes cell survival by activating nuclear factor kappa B through phosphatidylinositol 3-kinase and Akt. J Biol Chem 276: 13756-13761.
    • (2001) J Biol Chem , vol.276 , pp. 13756-13761
    • Yang, C.H.1    Murti, A.2    Pfeffer, S.R.3    Kim, J.G.4    Donner, D.B.5    Pfeffer, L.M.6
  • 59
    • 0033515431 scopus 로고    scopus 로고
    • Viral myocarditis: Identification of five differentially expressed genes in coxsackievirus B3-infected mouse heart
    • Yang, D., Yu, J., Luo, Z., Carthy, C.M., Wilson, J.E., Liu, Z., and McManus, B.M. (1999) Viral myocarditis: Identification of five differentially expressed genes in coxsackievirus B3-infected mouse heart. Circ Res 84: 704-712.
    • (1999) Circ Res , vol.84 , pp. 704-712
    • Yang, D.1    Yu, J.2    Luo, Z.3    Carthy, C.M.4    Wilson, J.E.5    Liu, Z.6    McManus, B.M.7
  • 60
    • 0041731897 scopus 로고    scopus 로고
    • RelA control of IkappaBalpha phosphorylation: A positive feedback loop for high affinity NF-kappaB complexes
    • Yang, L., Ross, K., and Qwarnstrom, E.E. (2003) RelA control of IkappaBalpha phosphorylation: A positive feedback loop for high affinity NF-kappaB complexes. J Biol Chem 278: 30881-30888.
    • (2003) J Biol Chem , vol.278 , pp. 30881-30888
    • Yang, L.1    Ross, K.2    Qwarnstrom, E.E.3
  • 61
    • 23044457308 scopus 로고    scopus 로고
    • Inhibition of glycogen synthase kinase 3beta suppresses coxsackievirus-induced cytopathic effect and apoptosis via stabilization of beta-catenin
    • Yuan, J., Zhang, J., Wong, B.W., Si, X., Wong, J., Yang, D., and Luo, H. (2005) Inhibition of glycogen synthase kinase 3beta suppresses coxsackievirus-induced cytopathic effect and apoptosis via stabilization of beta-catenin. Cell Death Differ 12: 1097-1106.
    • (2005) Cell Death Differ , vol.12 , pp. 1097-1106
    • Yuan, J.1    Zhang, J.2    Wong, B.W.3    Si, X.4    Wong, J.5    Yang, D.6    Luo, H.7
  • 63
    • 0041355437 scopus 로고    scopus 로고
    • Overexpression of interferon-gamma-inducible GTPase inhibits coxsackievirus B3-induced apoptosis through the activation of the phosphatidylinositol 3-kinase/Akt pathway and inhibition of viral replication
    • Zhang, H.M., Yuan, J., Cheung, P., Luo, H., Yanagawa, B., Chau, D., et al. (2003) Overexpression of interferon-gamma-inducible GTPase inhibits coxsackievirus B3-induced apoptosis through the activation of the phosphatidylinositol 3-kinase/Akt pathway and inhibition of viral replication. J Biol Chem 278: 33011-33019.
    • (2003) J Biol Chem , vol.278 , pp. 33011-33019
    • Zhang, H.M.1    Yuan, J.2    Cheung, P.3    Luo, H.4    Yanagawa, B.5    Chau, D.6
  • 64
    • 1942486873 scopus 로고    scopus 로고
    • NF-kappaB-mediated IAP expression induces resistance of intestinal epithelial cells to apoptosis after polyamine depletion
    • Zou, T., Rao, J.N., Guo, X., Liu, L., Zhang, H.M., Strauch, E.D., et al. (2004) NF-kappaB-mediated IAP expression induces resistance of intestinal epithelial cells to apoptosis after polyamine depletion. Am J Physiol Cell Physiol 286: C1009-C1018.
    • (2004) Am J Physiol Cell Physiol , vol.286
    • Zou, T.1    Rao, J.N.2    Guo, X.3    Liu, L.4    Zhang, H.M.5    Strauch, E.D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.