-
1
-
-
0034691171
-
v-Crk activates the phosphoinositide 3-kinase/AKT pathway in transformation
-
Akagi T, Shishido T, Murata K, Hanafusa H (2000) v-Crk activates the phosphoinositide 3-kinase/AKT pathway in transformation. Proc Natl Acad Sci USA 97: 7290-7295
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 7290-7295
-
-
Akagi, T.1
Shishido, T.2
Murata, K.3
Hanafusa, H.4
-
2
-
-
0031127305
-
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα
-
Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB, Cohen P (1997) Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα. Curr Biol 7: 261-269
-
(1997)
Curr Biol
, vol.7
, pp. 261-269
-
-
Alessi, D.R.1
James, S.R.2
Downes, C.P.3
Holmes, A.B.4
Gaffney, P.R.5
Reese, C.B.6
Cohen, P.7
-
3
-
-
0036363390
-
Splice variants of human β1 integrins: Origin, biosynthesis and functions
-
Armulik A (2002) Splice variants of human β1 integrins: Origin, biosynthesis and functions. Front Biosci 7: D219-d227
-
(2002)
Front Biosci
, vol.7
-
-
Armulik, A.1
-
4
-
-
0034627799
-
Expression of integrin subunit β1B in integrin β1-deficient GD25 cells does not interfere with αVβ3 functions
-
Armulik A, Svineng G, Wennerberg K, Fassler R, Johansson S (2000) Expression of integrin subunit β1B in integrin β1-deficient GD25 cells does not interfere with αVβ3 functions. Exp Cell Res 254: 55-63
-
(2000)
Exp Cell Res
, vol.254
, pp. 55-63
-
-
Armulik, A.1
Svineng, G.2
Wennerberg, K.3
Fassler, R.4
Johansson, S.5
-
5
-
-
2542481699
-
The integrin β1 subunit transmembrane domain regulates P13K-dependent tyrosine phosphorylation of CAS
-
Armulik A, Velling T, Johansson S (2004) The integrin β1 subunit transmembrane domain regulates P13K-dependent tyrosine phosphorylation of CAS. Mol Biol Cell 15: 2558-2567
-
(2004)
Mol Biol Cell
, vol.15
, pp. 2558-2567
-
-
Armulik, A.1
Velling, T.2
Johansson, S.3
-
6
-
-
0037392942
-
The specificities of protein kinase inhibitors: An update
-
Bain J, McLauchlan H, Elliott M, Cohen P (2003) The specificities of protein kinase inhibitors: An update. Biochem J 371: 199-204
-
(2003)
Biochem J
, vol.371
, pp. 199-204
-
-
Bain, J.1
McLauchlan, H.2
Elliott, M.3
Cohen, P.4
-
7
-
-
0033816156
-
Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors
-
Buchdunger E, Cioffi CL, Law N, Stover D, Ohno-Jones S, Druker BJ, Lydon NB (2000) Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors. J Pharmacol Exp Ther 295: 139-145
-
(2000)
J Pharmacol Exp Ther
, vol.295
, pp. 139-145
-
-
Buchdunger, E.1
Cioffi, C.L.2
Law, N.3
Stover, D.4
Ohno-Jones, S.5
Druker, B.J.6
Lydon, N.B.7
-
9
-
-
0042195824
-
Talin forges the links between integrins and actin
-
Calderwood DA, Ginsberg MH (2003) Talin forges the links between integrins and actin. Nat Cell Biol 5: 694-697
-
(2003)
Nat Cell Biol
, vol.5
, pp. 694-697
-
-
Calderwood, D.A.1
Ginsberg, M.H.2
-
10
-
-
0029979722
-
Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3-kinase
-
Chen HC, Appeddu PA, Isoda H, Guan JL (1996) Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3-kinase. J Biol Chem 271: 26329-26334
-
(1996)
J Biol Chem
, vol.271
, pp. 26329-26334
-
-
Chen, H.C.1
Appeddu, P.A.2
Isoda, H.3
Guan, J.L.4
-
11
-
-
0035943677
-
Regulation of Akt/PKB activation by tyrosine phosphorylation
-
Chen R, Kim O, Yang J, Sato K, Eisenmann KM, McCarthy J, Chen H, Qiu Y (2001) Regulation of Akt/PKB activation by tyrosine phosphorylation. J Biol Chem 276: 31858-31862
-
(2001)
J Biol Chem
, vol.276
, pp. 31858-31862
-
-
Chen, R.1
Kim, O.2
Yang, J.3
Sato, K.4
Eisenmann, K.M.5
McCarthy, J.6
Chen, H.7
Qiu, Y.8
-
12
-
-
0028173980
-
Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK
-
Cobb BS, Schaller MD, Leu TH, Parsons JT (1994) Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK. Mol Cell Biol 14: 147-155
-
(1994)
Mol Cell Biol
, vol.14
, pp. 147-155
-
-
Cobb, B.S.1
Schaller, M.D.2
Leu, T.H.3
Parsons, J.T.4
-
13
-
-
0029807471
-
Akt is a direct target of the phosphatidylinositol 3-kinase. Activation by growth factors, v-src and v-Ha-ras, in Sf9 and mammalian cells
-
Datta K, Bellacosa A, Chan TO, Tsichlis PN (1996) Akt is a direct target of the phosphatidylinositol 3-kinase. Activation by growth factors, v-src and v-Ha-ras, in Sf9 and mammalian cells. J Biol Chem 271 30835-30839
-
(1996)
J Biol Chem
, vol.271
, pp. 30835-30839
-
-
Datta, K.1
Bellacosa, A.2
Chan, T.O.3
Tsichlis, P.N.4
-
14
-
-
0028985980
-
Lack of β1 integrin gene in embryonic stem cells affects morphology, adhesion, and migration but not integration into the inner cell mass of blastocysts
-
Fassler R, Pfaff M, Murphy J, Noegel AA, Johansson S, Timpl R, Albrecht R (1995) Lack of β1 integrin gene in embryonic stem cells affects morphology, adhesion, and migration but not integration into the inner cell mass of blastocysts. J Cell Biol 128: 979-988
-
(1995)
J Cell Biol
, vol.128
, pp. 979-988
-
-
Fassler, R.1
Pfaff, M.2
Murphy, J.3
Noegel, A.A.4
Johansson, S.5
Timpl, R.6
Albrecht, R.7
-
15
-
-
0033847250
-
The SH3 domain directs acto-myosin-dependent targeting of v-Src to focal adhesions via phosphatidylinositol 3-kinase
-
Fincham VJ, Brunton VG, Frame MC (2000) The SH3 domain directs acto-myosin-dependent targeting of v-Src to focal adhesions via phosphatidylinositol 3-kinase. Mol Cell Biol 20: 6518-6536
-
(2000)
Mol Cell Biol
, vol.20
, pp. 6518-6536
-
-
Fincham, V.J.1
Brunton, V.G.2
Frame, M.C.3
-
16
-
-
1842584776
-
Newest findings on the oldest oncogene; how activated src does it
-
Frame MC (2004) Newest findings on the oldest oncogene; how activated src does it. J Cell Sci 117: 989-998
-
(2004)
J Cell Sci
, vol.117
, pp. 989-998
-
-
Frame, M.C.1
-
17
-
-
0036022143
-
Involvement of P13-kinase and its association with c-Src in PTH-stimulated rat enterocytes
-
Gentili C, Morelli S, Russo De Boland A (2002) Involvement of P13-kinase and its association with c-Src in PTH-stimulated rat enterocytes. J Cell Biochem 86: 773-783
-
(2002)
J Cell Biochem
, vol.86
, pp. 773-783
-
-
Gentili, C.1
Morelli, S.2
Russo, D.3
Boland, A.4
-
18
-
-
0036629339
-
Role of the β1-integrin cytoplasmic tail in mediating invasin-promoted internalization of Yersinia
-
Gustavsson A, Armulik A, Brakebusch C, Fassler R, Johansson S, Fallman M (2002) Role of the β1-integrin cytoplasmic tail in mediating invasin-promoted internalization of Yersinia. J Cell Sci 115 2669-2678
-
(2002)
J Cell Sci
, vol.115
, pp. 2669-2678
-
-
Gustavsson, A.1
Armulik, A.2
Brakebusch, C.3
Fassler, R.4
Johansson, S.5
Fallman, M.6
-
19
-
-
0029120440
-
Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice
-
Ilic D et al (1995) Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature 377: 539-544
-
(1995)
Nature
, vol.377
, pp. 539-544
-
-
Ilic, D.1
-
20
-
-
0036170771
-
Integrin α 2 β 1 promotes activation of protein phosphatase 2A and dephosphorylation of Akt and glycogen synthase kinase 3β
-
Ivaska J, Nissinen L, Immonen N, Eriksson JE, Kahari VM, Heino J (2002) Integrin α 2 β 1 promotes activation of protein phosphatase 2A and dephosphorylation of Akt and glycogen synthase kinase 3β. Mol Cell Biol 22: 1352-1359
-
(2002)
Mol Cell Biol
, vol.22
, pp. 1352-1359
-
-
Ivaska, J.1
Nissinen, L.2
Immonen, N.3
Eriksson, J.E.4
Kahari, V.M.5
Heino, J.6
-
21
-
-
0037938847
-
Interaction between Src and a C-terminal proline-rich motif of Akt is required for Akt activation
-
Jiang T, Qiu Y (2003) Interaction between Src and a C-terminal proline-rich motif of Akt is required for Akt activation. J Biol Chem 278: 15789-15793
-
(2003)
J Biol Chem
, vol.278
, pp. 15789-15793
-
-
Jiang, T.1
Qiu, Y.2
-
22
-
-
0021350062
-
Substrate adhesion of rat hepatocytes: On the mechanism of attachment to fibronectin
-
Johansson S, Höök M (1984) Substrate adhesion of rat hepatocytes: on the mechanism of attachment to fibronectin. J Cell Biol 98 810-817
-
(1984)
J Cell Biol
, vol.98
, pp. 810-817
-
-
Johansson, S.1
Höök, M.2
-
23
-
-
0033522510
-
Src family kinases are required for integrin but not PDGFR signal transduction
-
Klinghoffer RA, Sachsenmaier C, Cooper JA, Soriano P (1999) Src family kinases are required for integrin but not PDGFR signal transduction. EMBO J 18: 2459-2471
-
(1999)
EMBO J
, vol.18
, pp. 2459-2471
-
-
Klinghoffer, R.A.1
Sachsenmaier, C.2
Cooper, J.A.3
Soriano, P.4
-
24
-
-
0032486386
-
Integrins regulate the association and phosphorylation of paxillin by c-Abl
-
Lewis JM, Schwartz MA (1998) Integrins regulate the association and phosphorylation of paxillin by c-Abl. J Biol Chem 273: 14225-14230
-
(1998)
J Biol Chem
, vol.273
, pp. 14225-14230
-
-
Lewis, J.M.1
Schwartz, M.A.2
-
25
-
-
0033002997
-
Induced focal adhesion kinase (FAK), expression in FAK-null cells enhances cell spreading and migration requiring both auto- and activation loop phosphorylation sites and inhibits adhesion-dependent tyrosine phosphorylation of Pyk2
-
Owen JD, Ruest PJ, Fry DW, Hanks SK (1999) Induced focal adhesion kinase (FAK), expression in FAK-null cells enhances cell spreading and migration requiring both auto- and activation loop phosphorylation sites and inhibits adhesion-dependent tyrosine phosphorylation of Pyk2. Mol Cell Biol 19: 4806-4818
-
(1999)
Mol Cell Biol
, vol.19
, pp. 4806-4818
-
-
Owen, J.D.1
Ruest, P.J.2
Fry, D.W.3
Hanks, S.K.4
-
26
-
-
0038719715
-
Specific β1 integrin site selectively regulates Akt/protein kinase B signaling via local activation of protein phosphatase 2A
-
Pankov R, Cukierman E, Clark K, Matsumoto K, Hahn C, Poulin B, Yamada KM (2003) Specific β1 integrin site selectively regulates Akt/protein kinase B signaling via local activation of protein phosphatase 2A. J Biol Chem 278: 18671-18681
-
(2003)
J Biol Chem
, vol.278
, pp. 18671-18681
-
-
Pankov, R.1
Cukierman, E.2
Clark, K.3
Matsumoto, K.4
Hahn, C.5
Poulin, B.6
Yamada, K.M.7
-
27
-
-
0037509990
-
Focal adhesion kinase: The first ten years
-
Parsons JT (2003) Focal adhesion kinase: The first ten years. J Cell Sci 116: 1409-1416
-
(2003)
J Cell Sci
, vol.116
, pp. 1409-1416
-
-
Parsons, J.T.1
-
28
-
-
0035920145
-
Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: Critical roles for kinase activity and amino-acids arginine 211 and serine 343
-
Persad S, Attwell S, Gray V, Mawji N, Deng JT, Leung D, Yan J, Sanghera J, Walsh MP, Dedhar S (2001) Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: Critical roles for kinase activity and amino-acids arginine 211 and serine 343. J Mol Chem 276: 27462-27469
-
(2001)
J Mol Chem
, vol.276
, pp. 27462-27469
-
-
Persad, S.1
Attwell, S.2
Gray, V.3
Mawji, N.4
Deng, J.T.5
Leung, D.6
Yan, J.7
Sanghera, J.8
Walsh, M.P.9
Dedhar, S.10
-
29
-
-
0032513019
-
Integrin β cytoplasmic domains differentially bind to cytoskeletal proteins
-
Pfaff M, Liu S, Erle DJ, Ginsberg MH (1998) Integrin β cytoplasmic domains differentially bind to cytoskeletal proteins. J Biol. Chem 273: 6104-6109.
-
(1998)
J Biol. Chem
, vol.273
, pp. 6104-6109
-
-
Pfaff, M.1
Liu, S.2
Erle, D.J.3
Ginsberg, M.H.4
-
30
-
-
0037424498
-
The role of focal adhesion kinase-phosphatidylinositol 3-kinase-akt signaling in hepatic stellate cell proliferation and type I collagen expression
-
Reif S, Lang A, Lindquist JN, Yata Y, Gabele E, Scanga A, Brenner DA, Rippe RA (2003) The role of focal adhesion kinase-phosphatidylinositol 3-kinase-akt signaling in hepatic stellate cell proliferation and type I collagen expression. J Biol Chem 278: 8083-8090
-
(2003)
J Biol Chem
, vol.278
, pp. 8083-8090
-
-
Reif, S.1
Lang, A.2
Lindquist, J.N.3
Yata, Y.4
Gabele, E.5
Scanga, A.6
Brenner, D.A.7
Rippe, R.A.8
-
31
-
-
0031594784
-
β1-integrin cytoplasmic subdomains involved in dominant negative function
-
Retta SF, Balzac F, Ferraris P, Belkin AM, Fässler R, Humphries MJ, De Leo G, Silengo L, Tarone G (1998) β1-integrin cytoplasmic subdomains involved in dominant negative function. Mol Biol Cell 9: 715-731
-
(1998)
Mol Biol Cell
, vol.9
, pp. 715-731
-
-
Retta, S.F.1
Balzac, F.2
Ferraris, P.3
Belkin, A.M.4
Fässler, R.5
Humphries, M.J.6
De Leo, G.7
Silengo, L.8
Tarone, G.9
-
32
-
-
0035947577
-
Src family kinases are required for integrin-mediated but not for G protein-coupled receptor stimulation of focal adhesion kinase autophosphorylation at Tyr-397
-
Salazar EP, Rozengurt E (2001) Src family kinases are required for integrin-mediated but not for G protein-coupled receptor stimulation of focal adhesion kinase autophosphorylation at Tyr-397. J Biol Chem 276: 17788-17795
-
(2001)
J Biol Chem
, vol.276
, pp. 17788-17795
-
-
Salazar, E.P.1
Rozengurt, E.2
-
33
-
-
0028350859
-
Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src
-
Schaller MD, Hildebrand JD, Shannon JD, Fox JW, Vines RR, Parsons JT (1994) Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src. Mol Cell Biol 14: 1680-1688
-
(1994)
Mol Cell Biol
, vol.14
, pp. 1680-1688
-
-
Schaller, M.D.1
Hildebrand, J.D.2
Shannon, J.D.3
Fox, J.W.4
Vines, R.R.5
Parsons, J.T.6
-
34
-
-
0028609382
-
Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase
-
Schlaepfer DD, Hanks SK, Hunter T, van der Geer P (1994) Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature 372: 786-791
-
(1994)
Nature
, vol.372
, pp. 786-791
-
-
Schlaepfer, D.D.1
Hanks, S.K.2
Hunter, T.3
van der Geer, P.4
-
35
-
-
0035875975
-
Differential regulation of cell migration and cell cycle progression by FAK complexes with Src, P13K, Grb7 and Grb2 in focal contacts
-
Shen TL, Guan JL (2001) Differential regulation of cell migration and cell cycle progression by FAK complexes with Src, P13K, Grb7 and Grb2 in focal contacts. FEBS Lett 499: 176-181
-
(2001)
FEBS Lett
, vol.499
, pp. 176-181
-
-
Shen, T.L.1
Guan, J.L.2
-
36
-
-
0032820782
-
Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration
-
Sieg DJ, Hauck CR, Schlaepfer DD (1999) Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration. J Cell Sci 112: 2677-2691
-
(1999)
J Cell Sci
, vol.112
, pp. 2677-2691
-
-
Sieg, D.J.1
Hauck, C.R.2
Schlaepfer, D.D.3
-
37
-
-
0141865705
-
Talin binding to integrin β tails: A final common step in integrin activation
-
Tadokoro S, Shattil SJ, Eto K, Tai V, Liddington RC, de Pereda JM, Ginsberg MH, Calderwood DA (2003) Talin binding to integrin β tails: A final common step in integrin activation. Science 302: 103-106
-
(2003)
Science
, vol.302
, pp. 103-106
-
-
Tadokoro, S.1
Shattil, S.J.2
Eto, K.3
Tai, V.4
Liddington, R.C.5
de Pereda, J.M.6
Ginsberg, M.H.7
Calderwood, D.A.8
-
38
-
-
0037666792
-
Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation
-
Troussard AA, Mawji NM, Ong C, Mui A, St-Arnaud R, Dedhar S (2003) Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation. J Biol Chem 278: 22374-22378
-
(2003)
J Biol Chem
, vol.278
, pp. 22374-22378
-
-
Troussard, A.A.1
Mawji, N.M.2
Ong, C.3
Mui, A.4
St-Arnaud, R.5
Dedhar, S.6
-
39
-
-
0033942173
-
The cytoplasmic tyrosines of integrin subunit β1 are involved in focal adhesion kinase activation
-
Wennerberg K, Armulik A, Sakai T, Karlsson M, Fassler R, Schaefer EM, Mosher DF, Johansson S (2000) The cytoplasmic tyrosines of integrin subunit β1 are involved in focal adhesion kinase activation. Mol Cell Biol 20: 5758-5765
-
(2000)
Mol Cell Biol
, vol.20
, pp. 5758-5765
-
-
Wennerberg, K.1
Armulik, A.2
Sakai, T.3
Karlsson, M.4
Fassler, R.5
Schaefer, E.M.6
Mosher, D.F.7
Johansson, S.8
-
40
-
-
0029671372
-
β1 integrin-dependent and -independent polymerization of fibronectin
-
Wennerberg K, Lohikangas L, Gullberg D, Pfaff M, Johansson S, Fassler R (1996) β1 integrin-dependent and -independent polymerization of fibronectin. J Cell Biol 132: 227-238
-
(1996)
J Cell Biol
, vol.132
, pp. 227-238
-
-
Wennerberg, K.1
Lohikangas, L.2
Gullberg, D.3
Pfaff, M.4
Johansson, S.5
Fassler, R.6
-
41
-
-
0037018155
-
Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension
-
Woodring PJ, Litwack ED, O'Leary DD, Lucero GR, Wang JY, Hunter T (2002) Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension. J Cell Biol 156: 879-892.
-
(2002)
J Cell Biol
, vol.156
, pp. 879-892
-
-
Woodring, P.J.1
Litwack, E.D.2
O'Leary, D.D.3
Lucero, G.R.4
Wang, J.Y.5
Hunter, T.6
-
42
-
-
0037131377
-
N-ethylmaleimide inhibits platelet-derived growth factor BB-stimulated Akt phosphorylation via activation of protein phosphatase 2A
-
Yellaturu CR, Bhanoori M, Neeli I, Rao GN (2002) N-ethylmaleimide inhibits platelet-derived growth factor BB-stimulated Akt phosphorylation via activation of protein phosphatase 2A. J Biol Chem 277: 40148-40155
-
(2002)
J Biol Chem
, vol.277
, pp. 40148-40155
-
-
Yellaturu, C.R.1
Bhanoori, M.2
Neeli, I.3
Rao, G.N.4
|