Molecular analysis of immunoglobulin variable genes in human immunodeficiency virus-related non-Hodgkin's lymphoma reveals implications for disease pathogenesis and histogenesis

Haematologica

Volumn 93, Issue 8, 2008, Pages 1178-1185

  Capello, Daniela ^a   Martini, Maurizio ^b   Gloghini, Annunziata ^c   Cerri, Michaela ^a   Rasi, Silvia ^a   Deambrogi, Clara ^a   Rossi, Davide ^a   Spina, Michele ^d   Tirelli, Umberto ^d   Larocca, Luigi Maria ^b   Carbone, Antonino ^c   Gaidano, Gianluca ^a  

^a UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^b CATHOLIC UNIVERSITY   (Italy)

^c NATIONAL CANCER INSTITUTE   (Italy)

^d CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

Author keywords

Histogenesis; HIV; Immunoglobulin genes; Lymphoma; Pathogenesis

Indexed keywords

ANTIGEN; B LYMPHOCYTE RECEPTOR; GENOMIC DNA; IMMUNOGLOBULIN;

ANTIGEN BINDING; ARTICLE; B CELL LYMPHOMA; BURKITT LYMPHOMA; CONTROLLED STUDY; GENE AMPLIFICATION; GENE REARRANGEMENT; GENE SEQUENCE; GENETIC ANALYSIS; HISTOGENESIS; HOST; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN TISSUE; IMMUNE DYSREGULATION; IMMUNOGLOBULIN GENE; IMMUNOSTIMULATION; LARGE CELL LYMPHOMA; MAJOR CLINICAL STUDY; MORPHOLOGY; PATHOGENESIS; PATHOLOGY; POLYMERASE CHAIN REACTION; PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA; SOMATIC HYPERMUTATION; STATISTICAL SIGNIFICANCE;

BATHING BEACHES; BURKITT LYMPHOMA; GENE AMPLIFICATION; GENE REARRANGEMENT; HIV INFECTIONS; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; LYMPHOMA, NON-HODGKIN; POLYMERASE CHAIN REACTION; RECEPTORS, ANTIGEN, B-CELL; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN;

EID: 48749086243     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: 10.3324/haematol.12705     Document Type: Article

References (53)

1. Beral V, Peterman T, Berkelman R, Jaffe H. AIDS-associated non-Hodgkin lymphoma. Lancet 1991;337:805-9.
2. Levine AM. AIDS-related malignancies: the emerging epidemic. J Natl Cancer Inst 1993;85:1382-97.
3. Boshoff C, Weiss R. AIDS-related malignancies. Nat Rev Cancer 2002;2:373-82.
4. Kirk O, Pedersen C, Cozzi-Lepri A, Antunes F, Miller V, Gatell JM, et al. Non-Hodgkin lymphoma in HIV-infected patients in the era of highly active antiretroviral therapy. Blood 2001;98:3406-12.
5. Noy A. Update in HIV lymphoma. Curr Opin Oncol 2006;18:449-55.
6. Jaffe ES, Harris NL, Stein H, Vardiman JW, eds. World Health Organization Classification of Tumours, Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues. IARC Press: Lyon, 2001.
7. Martinez-Maza O, Crabb Breen E. B-cell activation and lymphoma in patients with HIV. Curr Opin Oncology 2002;14:528-32.
8. Carbone A, Gloghini A. AIDS-related lymphomas: from pathogenesis to pathology. Br J Haematol 2005;130:662-70.
9. Müller-Hermelink HK, Greiner A. Molecular analysis of human immunoglobulin heavy chain variable genes (IgVH) in normal and malignant B cells. Am J Pathol 1998;153:1341-6.
10. Küppers R, Klein U, Hansmann ML, Rajewsky K. Cellular origin of human B-cell lymphomas. N Engl J Med 1999;341:1520-9.
11. Stevenson FK, Sahota SS, Ottensmeier CH, Zhu D, Forconi F, Hamblin TJ. The occurrence and significance of V gene mutations in B cell-derived human malignancy. Adv Cancer Res 2001;83:81-116.
12. Lane H, Masur H, Edgar K, Whalen G, Rook A, Fauci A. Abnormalities of B-cell activation and immunoregulation in patients with the acquired immunodeficiency syndrome. N Engl J Med 1983;309:453-8.
13. Przybylski GK, Goldman J, Ng VL, McGrath MS, Herndier BG, Schenkein DP, et al. Evidence for early B-cell activation preceding the development of Epstein-Barr virus-negative acquired immunodeficiency syndrome-related lymphoma. Blood 1996;88:4620-9.
14. De Milito A, Nilsson A, Titanji K Thorstensson R, Reizenstein E, Narita M, et al. Mechanisms of hypergammaglobulinemia and impaired antigen-specific humoral immunity in HIV-1 infection. Blood 2004;103:2180-6.
15. Berberian L, Goodglick L, Kipps TJ, Braun J. Immunoglobulin VH3 gene products: natural ligands for HIV gp120. Science 1993;261:1588-91.
16. Joumpan L, Lambin P, Zouali M. Selective deficit in antibodies specific for the superantigen binding site of gp120 in HIV infection. FASEB J 1998;12:1473-80.
17. Ng VL, Hurt MH, Fein CL, Khayam-Bashi F, Marsh J, Nunes WM, et al. IgMs produced by two acquired immune deficiency syndrome lymphoma cell lines: Ig binding specificity and VH-gene putative somatic mutation analysis. Blood 1994;83:1067-78.
18. Riboldi P, Gaidano G, Schettino EW, Steger TG, Knowles DM, Dalla-Favera R, et al. Two acquired immunodeficiency syndrome-associated Burkitt's lymphomas produce specific anti-i IgM cold agglutinins using somatically mutated VH4-21 segments. Blood 1994;83:2952-61.
19. Roncella S, Cutrona G, Favre A, Ulivi M, Fais F, Signorini A, et al. Apoptosis of Burkitt's lymphoma cells induced by specific interaction of surface IgM with a self-antigen: implications for lymphomagenesis in acquired immunodeficiency syndrome. Blood 1996;88:599-608.
20. Bessudo A, Cherepakhin V, Johnson TA, Rassenti LZ, Feigal E, Kipps TJ. Favored use of immunoglobulin VH4 genes in AIDS-associated B-cell lymphoma. Blood 1996;88:252-60.
21. Delecluse HJ, Hummel M, Marafioti T, Anagnostopoulos I, Stein H. Common and HIV-related diffuse large B-cell lymphomas differ in their immunoglobulin gene mutation pattern. J Pathol 1999;188:133-8.
22. Julien S, Radosavljevic M, Labouret N, Camilleri-Broet S, Davi F, Raphael M, et al. AIDS primary central nervous system lymphoma. Molecular analysis of the expressed VH genes and possible implications for lymphomagenesis. J Immunol 1999;162:1551-8.
23. Cunto-Amesty G, Przybylski G, Honczarenko M, Monroe JG, Silberstein LE. Evidence that immunoglobulin specificities of AIDS-related lymphoma are not directed to HIV-related antigens. Blood 2000;95:1393-9.
24. Capello D, Cerri M, Muti G, Berra E, Oreste P, Deambrogi C, et al. Molecular histogenesis of posttransplantation lymphoproliferative disorders. Blood 2003;102:3775-85.
25. Küppers R, Hajadi M, Plank L, Rajewsky K, Hansmann M-L. Molecular Ig gene analysis reveals that monocytoid B cell lymphoma is a malignancy of mature B cells carrying somatically mutated V region genes and suggests that rearrangements of the kappa-deleting element (resulting in deletion of the kappa enhancers) abolishes somatic hypermutation in the human. Eur J Immunol 1996;26:1794-800.
26. Klein U, Küppers R, Rajewsky K. Variable gene analysis of B cell subsets derived from a 4-years-old child. Somatically mutated memory B cells accumulate in the peripheral blood already at young age. J Exp Med 1994;180:1383-93.
27. Kabat EA, Wu TT, Perry HM, Gottesman KS, Foeller C. Sequences of proteins of immunological interest. National Institute of Health (U.S.) publication; no. 91-3242. (5th ed.). Bethesda, MD.: U.S. Dept. of Health and Human Services Public Health Service National Institute of Health; 1991.
28. Corpet F. Multiple sequence alignment with hierarchical clustering. Nucl Acids Res 1988;16:10881-90.
29. Brezinschek H-P, Foster SJ, Brezinschek RI, Dörner T, Domiati-Saad R, Lipsky PE. Analysis of the human VH gene repertoire. J Clin Invest 1997;99:2488-501.
30. Foster SJ, Brezinschek H-P, Brezinschek RI, Lipsky PE. Molecular mechanism and selective influences that shape the kappa gene repertoire of IgM B cells. J Clin Invest 1997;99:1614-27.
31. Farner NL, Dörner T, Lipsky PE. Molecular mechanisms and selection influence the generation of the human V lambda J lambda repertoire. J Immunol;1999:162:2137-45.
32. Chang B, Casali P. The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement. Immunol Today 1994;15:367-73.
33. Lossos IS, Tibshirani N, Narasimhan B, Levy R. The inference of antigen selection on Ig genes. J Immunol 2000;165:5122-6.
34. Suzuki I, Pfister L, Glas A, Nottenburg C, Milner EC. Representation of rearranged VH gene segments in the human adult antibody repertoire. J Immunol 1995;154:3902-11.
35. Kraj P, Rao SP, Glas AM, Hardy RR, Milner ECB, Silberstein LE. The human heavy chain IgV region gene repertoire is biased at all stages of B cell ontogeny, including early pre-B cells. J Immunol 1997;158:5824-32.
36. Berberian L, Valles-Ayoub Y, Sun N, Martinez-Maza O, Braun J. A VH clonal deficit in human immunodeficiency virus-positive individuals reflects a B-cell maturation arrest. Blood 1991;78:175-9.
37. David D, Demaison C, Bani L, Zouali M, Theze J. Selective variations in vivo of VH3 and VH1 gene family expression in peripheral B cell IgM, IgD and IgG during HIV infection. Eur J Immunol 1995;25:1524-8.
38. + B cells. Immunogenetics 1995;42:342-52.
39. David D, Demaison C, Bani L, Theze J. Progressive decrease in VH3 gene family expression in plasma cells of HIV-infected patients. Int Immunol 1996;8:1329-33.
40. Wisnewski A, Cavacini L, Posner M. Human antibody variable region gene usage in HIV-1 infection. J Acquir Immune Defic Syndr Hum Retrovirol 1996;11:31-8.
41. Bessudo A, Rassenti L, Havlir D, Richman D, Feigal E, Kipps TJ. Aberrant and unstable expression of immunoglobulin genes in persons infected with human immunodeficiency virus. Blood 1998;92:1317-23.
42. Scamurra RW, Miller DJ, Abrahamsen M, Kapur V, Wahl SM, Milner ECB, et al. Impact of HIV-1 infection on VH3 gene repertoire of naïve human B cells. J Immunol 2000;164:5482-91.
43. Pascual V, Victor K, Lelsz D, Spellerberg MB, Hamblin TJ, Thompson KM, et al. Nucleotide sequence analysis of the V regions of two IgM cold agglutinins. Evidence that the VH4-21 gene segment is responsible for the major cross-reactive idiotype. J Immunol 1991;146:4385-91.
44. Pugh-Bernard AE, Silverman GJ, Cappione AJ, Villano ME, Ryan DH, Insel RA, et al. Regulation of inherently autoreactive VH4-34 B cells in the maintenance of human B cell tolerance. J Clin Invest 2001;108:1061-70.
45. Potter KN, Hobby P, Klijn S, Stevenson FK, Sutton BJ. Evidence for involvement of a hydrophobic patch in framework region 1 of human V4-34-encoded Igs in recognition of the red blood cell I antigen. J Immunol 2002;169:3777-82.
46. Mockridge CI, Rahman A, Buchan S, Hamblin T, Isemberg DA, Stevenson FK, et al. Common patterns of B cell perturbation and expanded V4-34 immunoglobulin gene usage in autoimmunity and infection. Autoimmunity 2004;37:9-15.
47. Montesinos-Rongen M, Kuppers R, Schluter D, Spieker T, Roost DV, Schaller C, et al. Primary central nervous system lymphomas are derived from germinal-center B cells and show a preferential usage of the V4-34 gene segment. Am J Pathol 1999;155:2077-86.
48. De Re V, De Vita S, Gasparotto D, Marzotto A, Carbone A, Ferraccioli G, et al. Salivary gland B cell lymphoproliferative disorders in Sjögren's syndrome present a restricted use of antigen receptor gene segments similar to those used by hepatitis C virus-associated non-Hodgkin's lymphomas. Eur J Immunol 2002;32:903-10.
49. Stevenson FK, Caligaris-Cappio F. Chronic lymphocytic leukemia: revelations from the B-cell receptor. Blood 2004;103:4389-95.
50. Brauninger A, Spieker T, Mottok A, Baur AS, Küppers R, Hansmann ML. Epstein-Barr virus (EBV)-positive lymphoproliferations in post-transplant patients show immunoglobulin V gene mutation patterns suggesting interference of EBV with normal B cell differentiation processes. Eur J Immunol 2003;33:1593-602.
51. Timms JM, Bell A, Flavell JR, Rickinson AB, Traverse-Glehen A, Berger F, et al. Target cells of Epstein-Barr-virus (EBV)-positive post-transplant lymphoproliferative disease: similarities to EBV-positive Hodgkin's lymphoma. Lancet 2003; 361:217-23.
52. Brauninger A, Schmitz R, Bechtel D, Renneè C, Hansmann M-L, Kuppers R. Molecular biology of Hodgkin's and Reed/Sternberg cells in Hodgkin's lymphoma. In J Cancer 2006;118:1853-61.
53. Bellan C, Lazzi S, Hummel M, Palummo N, de Santi M, Amato T, et al. Immunoglobulin gene analysis reveals 2 distinct cells of origin for EBV-positive and EBV-negative Burkitt lymphomas. Blood 2005;106:1031-6.