Salivary gland B cell lymphoproliferative disorders in Sjögren's syndrome present a restricted use of antigen receptor gene segments similar to those used by hepatitis C virus-associated non-Hodgkin's lymphomas

European Journal of Immunology

Volumn 32, Issue 3, 2002, Pages 903-910

  De Re, Valli ^a   De Vita, Salvatore ^b   Gasparotto, Daniela ^a   Marzotto, Alessandra ^a   Carbone, Antonino ^a   Ferraccioli, Gianfranco ^b   Boiocchi, Mauro ^a  

^a CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

^b UNIVERSITY OF UDINE   (Italy)

Author keywords

Autoimmunity; Hepatitis C virus; IgR; Lymphoproliferation

Indexed keywords

IMMUNOGLOBULIN M; LYMPHOCYTE ANTIGEN RECEPTOR; RHEUMATOID FACTOR;

ADULT; AGED; AMINO ACID SEQUENCE; ANTIBODY COMBINING SITE; ANTIGEN BINDING; ANTIGEN SPECIFICITY; ARTICLE; B LYMPHOCYTE; CELL CLONE; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; CROSS REACTION; CRYOGLOBULINEMIA; DISEASE ASSOCIATION; FEMALE; GENE EXPRESSION; GENE SEQUENCE; HEPATITIS C; HUMAN; HUMAN CELL; IMMUNOGLOBULIN VARIABLE REGION; LYMPHOCYTE ACTIVATION; LYMPHOPROLIFERATIVE DISEASE; MALE; MOLECULAR CLONING; MOLECULAR MIMICRY; NONHODGKIN LYMPHOMA; NUCLEOTIDE SEQUENCE; POLYCLONAL ACTIVATION; PRIORITY JOURNAL; RECEPTOR GENE; SALIVARY GLAND; SEQUENCE HOMOLOGY; SJOEGREN SYNDROME;

ADULT; AGED; AMINO ACID SEQUENCE; AUTOANTIBODIES; AUTOIMMUNE DISEASES; CELL TRANSFORMATION, NEOPLASTIC; CLONE CELLS; COMPLEMENTARITY DETERMINING REGIONS; CROSS REACTIONS; DISEASE PROGRESSION; FEMALE; GENE REARRANGEMENT, B-LYMPHOCYTE; GENES, IMMUNOGLOBULIN; HEPACIVIRUS; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN KAPPA-CHAINS; IMMUNOGLOBULIN VARIABLE REGION; LYMPHOCYTE ACTIVATION; LYMPHOMA, B-CELL; LYMPHOMA, NON-HODGKIN; LYMPHOPROLIFERATIVE DISORDERS; MALE; MIDDLE AGED; MOLECULAR MIMICRY; MOLECULAR SEQUENCE DATA; PAROTID NEOPLASMS; POLYMERASE CHAIN REACTION; RECEPTORS, ANTIGEN, B-CELL; RHEUMATOID FACTOR; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SIALADENITIS; SJOGREN'S SYNDROME;

EID: 0036207634     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200203)32:3<903::AID-IMMU903>3.0.CO;2-D     Document Type: Article

References (44)

1. Sjogren's syndrome (Sicca syndrome): Current issues
2. Immunohistologic analysis of lymphoid infiltrates in primary Sjogren's syndrome using monoclonal antibodies
3. Treatment of the patient with Sjogren's syndrome
4. Sjogren's syndrome: Autoimmune epithelitis
5. Clonal salivary gland infiltrates associated with myoepithelial sialadenitis (Sjogren's syndrome) begin as nonmalignant antigen-selected expansions
6. Molecular characterization of a major autoantibody-associated cross-reactive idiotype in Sjogren's syndrome
7. Antigen-driven clonal proliferation of B cells within the target tissue of an autoimmune disease. The salivary glands of patients with Sjogren's syndrome
8. High frequency of light chain restriction in labial gland biopsies of Sjogren's syndrome detected by in situ hybridization
9. Clinical evolution, and morbidity and mortality of primary Sjogren's syndrome
10. Clonal evolution of a follicular lymphoma: Evidence for antigen selection
11. Pre-malignant and malignant lymphoproliferations in an HCV-infected type II mixed cryoglobulinemic patient are sequential phases of an antigen-driven pathological process
12. Sequence analysis of the immunoglobulin antigen receptor of hepatitis C virus-associated non-Hodgkin lymphomas suggests that the malignant cells occur mainly in type II cryoglobulinemia
13. Somatic hypermutation, clonal diversity, and preferential expression of the VH 51p1/VL kv325 immunoglobulin gene combination in hepatitis C virus-associated immunocytomas
14. Clonal evolution of B cells in transformation from low-to-high-grade lymphoma
15. Characterization of prelymphomatous stages of B cell lymphoproliferation in Sjogren's syndrome
16. Ongoing Ig gene hypermutation in salivary gland mucosa-associated lymphoid tissue-type lymphomas
17. Salivary gland mucosa-associated lymphoid tissue lymphoma immunoglobulin V(H) genes show frequent use of V1-69 with distinctive CDR3 features
18. The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement
19. The maturation of the immune response
20. Salivary gland lymphomas in patients with Sjogren's syndrome may frequently develop from rheumatoid factor B cells
21. Differences in mutational patterns between rheumatoid factors in health and disease are related to variable heavy chain family and germ-line gene usage
22. A role for hepatitis C virus infection in type II cryoglobulinemia
23. The aetiology of mixed cryoglobulinaemia associated with hepatitis C virus infection
24. V(H)1-69 gene is preferentially used by hepatitis C virus-associated B cell lymphomas and by normal B cells responding to the E2 viral antigen
25. Hepatitis C virus infection, mixed cryoglobulinemia, and non-Hodgkin's lymphoma: An emerging picture
26. Hepatitis C virus within a malignant lymphoma lesion in the course of type II mixed cryoglobulinemia
27. Characterization of overt B-cell lymphomas in patients with hepatitis C virus infection
28. Hepatitis C virus and mixed cryoglobulinaemia
29. Detection and distribution of hepatitis C virus-related proteins in lymph nodes of patients with type II mixed cryoglobulinemia and neoplastic or non-neoplastic lymphoproliferation
30. Regression of monoclonal B-cell expansion in patients affected by mixed cryoglobulinemia responsive to alpha-interferon therapy
31. Gastric mucosa as an additional extrahepatic localization of hepatitis C virus: Viral detection in gastric low-grade lymphoma associated with auto-immune disease and in chronic gastritis
32. Structure of human IgM rheumatoid factor Fab bound to its autoantigen IgGFc reveals a novel topology of antibody-antigen inter-action
33. The structure and origin of rheumatoid factors
34. Hepatitis C virus infection mimicking primary Sjogren syndrome. A clinical and immunologic description of 35 cases
35. Lymphomas in patients with Sjogren's syndrome: Review of the literature and physiopathologic
36. Immunohistochemistry of minor salivary gland biopsy specimens from patients with Sjogren's syndrome with and without hepatitis C virus infection
37. In situ detection of hepatitis C virus RNA in salivary glands
38. Sialadenitis histologically resembling Sjogren syndrome in mice transgenic for hepatitis C virus envelope genes
39. Complete molecular remissions induced by patient-specific vaccination plus granulocyte-monocyte colony-stimulating factor against lymphoma
40. Tumor-specific idiotype vaccines in the treatment of patients with B-cell lymphoma-long-term results of a clinical trial
41. Preliminary criteria for the classification of Sjogren's syndrome. Results of a prospective concerted action supported by the European Community
42. Pathologic feature of lymphoid proliferations of salivary glands: Lymphoepithelial sialadenitis vs low-grade-B-cell lymphoma of MALT-type
43. The relevance of VDJ PCR protocols in detecting B-cell clonal expansion in lymphomas and other lymphoproliferative disorders
44. Oligoclonal non-neoplastic B cell expansions is the key feature of type II mixed cryoglobulinemia