Favored use of immunoglobulin V(H)4 genes in AIDS-associated B-cell lymphoma

Blood

Volumn 88, Issue 1, 1996, Pages 252-260

  Bessudo, Alberto ^b   Cherepakhin, Vladimir ^b   Johnson, Todd A ^b   Rassenti, Laura Z ^b   Feigal, Ellen ^b   Kipps, Thomas J ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; B CELL LYMPHOMA; CARCINOGENESIS; CLINICAL ARTICLE; GENE EXPRESSION; GENE REARRANGEMENT; HUMAN; HUMAN TISSUE; IMMUNOGLOBULIN VARIABLE REGION; LYMPH NODE BIOPSY; PRIORITY JOURNAL;

EID: 0029900823     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v88.1.252.bloodjournal881252     Document Type: Article

References (69)

1. Ziegler JL, Beckstead JA, Volberding PA, Abrams DI, Levine AM, Lukes RJ, Gill PS, Burkes RL, Meyer PR, Metroka CE, Mouradian J, Moore A, Riggs SA, Butler JJ, Cabanillas FC, Hersh E, Newell GR, Laubenstein LJ, Knowles D, Odajnyk C, Raphael B, Koziner B, Urmacher C, Clarkson BD: Non-Hodgkin's lymphoma in 90 homosexual men. Relation to generalized lymphadenopathy and the acquired immunodeficiency syndrome. N Engl J Med 311:565, 1984
2. Levine AM, Meyer PR, Begandy MK, Parker JW, Taylor CR, Irwin L, Lukes RJ: Development of B-cell lymphoma in homosexual men. Ann Intern Med 100:7, 1984
3. Ioachim HL, Cooper MC, Hellman GC: Lymphomas in men at high risk for acquired immune deficiency syndrome (AIDS). Cancer 56:2831, 1985
4. Serraino D, Salamina G, Franceschi S, Dubois D, La Vecchia C, Brunet JB, Ancelle-Park RA: The epidemiology of AIDS-associated non-Hodgkin's lymphoma in the World Health Organization European Region. Br J Cancer 66:912, 1992
5. Cremer KJ, Spring SB, Gruber J: Role of human immunodeficiency virus type 1 and other viruses in malignancies associated with acquired immunodeficiency disease syndrome. J Natl Cancer Inst 82:1016, 1990
6. Laurence J, Astrin SM: Human immunodeficiency virus induction of malignant transformation in human B lymphocytes. Proc Natl Acad Sci USA 88:7635, 1991
7. Montefiori DC, Zhou J, Shaff DI: CD4-independent binding of HIV-1 to the B lymphocyte receptor CR2 (CD21) in the presence of complement and antibody. Clin Exp Immunol 90:383, 1992
8. Karp JE, Broder S: The pathogenesis of AIDS lymphomas: a foundation for addressing the challenges of therapy and prevention. Leuk Lymphoma 8:167, 1992
9. Sarngadharan MG, Popovic M, Bruch L, Schupbach J, Gallo RC: Antibodies reactive with human T-lymphotropic retroviruses (HTLV-III) in the serum of patients with AIDS. Science 224:506, 1984
10. Robey WG, Safai B, Oroszlan S, Arthur LO, Gonda MA, Gallo RC, Fischinger PJ: Characterization of envelope and core structural gene products of HTLV-III with sera from AIDS patients. Science 228:593, 1985
11. Weber JN, Clapham PR, Weiss RA, Parker D, Roberts C, Duncan J, Weller I, Carne C, Tedder RS, Pinching AJ: Human immunodeficiency virus infection in two cohorts of homosexual men: Neutralising sera and association of anti-gag antibody with prognosis. Lancet 1:119, 1987
12. Levine AM, Liebman HA: The acquired immunodeficiency syndrome (AIDS), in Beutler E, Lichtman MA, Coller BS, Kipps TJ (eds): Williams Hematology, New York, NY, McGraw-Hill, 1995, p 975
13. Scott ME, Landay AL, Lint TF, Spear GT: In vivo decrease in the expression of complement receptor 2 on B-cells in HIV infection. AIDS 7:37, 1993
14. Martinez-Maza O, Crabb E, Mitsuyasu RT, Fahey JL, Giorgi JV: Infection with the human immunodeficiency virus (HIV) is associated with an in vivo increase in B lymphocyte activation and immaturity. J Immunol 138:3720, 1987
15. Miedema F, Petit AJ, Terpstra FG, Schattenkerk JK, De Wolf F, Al BJ, Roos M, Lange JM, Danner SA, Goudsmit J, Schellekens PTA: Immunological abnormalities in human immunodeficiency virus (HIV)-infected asymptomatic homosexual men. HIV affects the immune system before CD4+ T helper cell depletion occurs. J Clin Invest 82:1908, 1988
16. Pascual V, Capra JD: Human immunoglobulin heavy-chain variable region genes: Organization, polymorphism, and expression. Adv Immunol 49:1, 1991
17. Tomlinson IM, Walter G, Marks JD, Llewelyn MB, Winter G: The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops. J Mol Biol 227:776, 1992
18. Guigou V, Cuisinier AM, Tonnelle C, Moinier D, Fougereau M, Fumoux F: Human immunoglobulin VH and VK repertoire revealed by in situ hybridization. Mol Immunol 27:935, 1990
19. Walter MA, Surti U, Hofker MH, Cox DW: The physical organization of the human immunoglobulin heavy chain gene complex. EMBO J 9:3303, 1990
20. Ng VL, Hurt MH, Fein CL, Khayam-Bashi F, Marsh J, Nunes WM, McPhaul LW, Feigal E, Nelson P, Herndier BG: IgMs produced by two acquired immune deficiency syndrome lymphoma cell lines: Ig binding specificity and VH-gene putative somatic mutation analysis. Blood 83:1067, 1994
21. Suzuki I, Pfister L, Glas A, Nottenburg C, Milner EC: Representation of rearranged VH gene segments in the human adult antibody repertoire. J Immunol 154:3902, 1995
22. Stewart AK, Schwartz RS: Immunoglobulin V regions and the B cell. Blood 83:1717, 1994
23. Berberian L, Goodglick L, Kipps TJ, Braun J: Immunoglobulin VH3 gene products: Natural ligands for HIV gp120. Science 261:1588, 1993
24. Marasco WA, Bagley J, Zani C, Posner M, Cavacini L, Haseltine WA, Sodroski J: Characterization of the cDNA of a broadly reactive neutralizing human anti-gp120 monoclonal antibody. J Clin Invest 90:1467, 1992
25. Wang H, Muller S, Zolla-Pazner S, Kohler H: Human monoclonal and polyclonal anti-human immunodeficiency virus-1 antibodies share a common clonotypic specificity. Eur J Immunol 22:1749, 1992
26. Boudet F, Girard M, Theze J, Zouali M: Antibodies of HIV-1 positive subjects and experimentally immunized primates and rodents bind to sequence divergent regions of the third variable domain (V3) of gp120. Int Immunol 4:283, 1992
27. Pratt LF, Szubin R, Carson DA, Kipps TJ: Molecular characterization of a supratypic cross reactive idiotype associated with IgM autoantibodies. J Immunol 147:2041, 1991
28. Southern EM: Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol 98:503, 1975
29. Rassenti LZ, Kipps TJ: Lack of extensive mutations in the VH5 genes used in common B cell chronic lymphocytic leukemia. J Exp Med 177:1039, 1993
30. Nomenclature Committee of the International Union of Biochemistry (NC-IUB): Nomenclature for incompletely specified bases in nucleic acid sequences. Recommendations 1984. Eur J Biochem 150:1, 1985
31. H gene repertoire by an anchored PCR-ELISA. Ann NY Acad Sci 764:463, 1995
32. Kipps TJ, Duffy SF: Relationship of the CD5 B cell to human tonsillar lymphocytes that express autoantibody-associated cross reactive idiotypes. J Clin Invest 87:2087, 1991
33. Smith TF, Waterman MS: Overlapping genes and information theory. J Theor Biol 91:379, 1981 (letter)
34. Chang B, Casali P: The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement. Immunol Today 15:367, 1994
35. Matsuda F, Shin EK, Nagaoka H, Matsumura R, Haino M, Fukita Y, Taka-ishi S, Imai T, Riley JH, Anand R: Structure and physical map of 64 variable segments in the 3′0.8-megabase region of the human immunoglobulin heavy-chain locus. Nat Genet 3:88, 1993
36. Van der Maarel S, Van Dijk KW, Alexander CM, Sasso EH, Bull A, Milner EC: Chromosomal organization of the human VH4 gene family. Location of individual gene segments. J Immunol 150:2858, 1993
37. Kabat E, Wu TT, Perry HM, Gottesman KS, Foeller C: Sequences of Proteins of Immunological Interest (ed 5). Bethesda, MD, U.S. Department of Health and Human Services, 1991
38. Ravetch JV, Siebenlist U, Korsmeyer S, Waldmann T, Leder P: Structure of the human immunoglobulin mu locus: Characterization of embryonic and rearranged J and D genes. Cell 27:583, 1981
39. Schroeder HW Jr, Hillson JL, Perlmutter RM: Early restriction of the human antibody repertoire. Science 238:791, 1987
40. Schroeder HW Jr, Wang JY: Preferential utilization of conserved immunoglobulin heavy chain variable gene segments during human fetal life. Proc Natl Acad Sci USA 87:6146, 1990
41. Bird J, Galili N, Link M, Stites D, Sklar J: Continuing rearrangement but absence of somatic hypermutation in immunoglobulin genes of human B cell precursor leukemia. J Exp Med 168:229, 1988
42. Pascual V, Randen I, Thompson K, Sioud M, Førre Ø, Natvig J, Capra JD: The complete nucleotide sequences of the heavy chain variable regions of six monospeciflc rheumatoid factors derived from Epstein-Barr virus-transformed B cells isolated from the synovial tissue of patients with rheumatoid arthritis. Further evidence that some autoantibodies are unmutated copies of germ line genes. J Clin Invest 86:1320, 1990
43. Yamada M, Wasserman R, Reichard BA, Shane S, Caton AJ, Rovera G: Preferential utilization of specific immunoglobulin heavy chain diversity and joining segments in adult human peripheral blood B lymphocytes. J Exp Med 173:395, 1991
44. Huang C, Stewart AK, Schwartz RS, Stollar BD: Immunoglobulin heavy chain gene expression in peripheral blood B lymphocytes. J Clin Invest 89:1331, 1992
45. Huang C, Stollar BD: A majority of Ig H chain cDNA of normal human adult blood lymphocytes resembles cDNA for fetal Ig and natural autoantibodies. J Immunol 151:5290, 1993
46. Fumoux F, Guigou V, Blaise D, Maraninchi D, Fougereau M, Schiff C: Reconstitution of human immunoglobulin VH repertoire after bone marrow transplantation mimics B-cell ontogeny. Blood 81:3153, 1993
47. Logtenberg T, Young FM, van Es J, Gmelig-Meyling FH, Berman JE, Alt FW: Frequency of VH-gene utilization in human EBV-transformed B-cell lines: The most JH-proximal VH segment encodes autoantibodies. J Autoimmun 2:203, 1989
48. Berberian L, Valles-Ayoub Y, Sun N, Martinez-Maza O, Braun J: A VH clonal deficit in human immunodeficiency virus-positive individuals reflects a B-cell maturational arrest (published erratum appears in Blood 78:1899, 1991). Blood 78:175, 1991
49. David D, Demaison C, Bani L, Zouali M, Theze J: Selective variations in vivo of VH3 and VH1 gene family expression in peripheral B cell IgM, IgD and IgG during HIV infection. Eur J Immunol 25:1524, 1995
50. Bessudo A, Rassenti L, Feigal E, Kipps TJ: Immunoglobulin VH gene repertoire of patients with AIDS. Blood 86:929a, 1995 (suppl 1)
51. H4 Ig gene family by diffuse large-cell lymphoma. Blood 86:3072, 1995
52. Schutte ME, Van Es JH, Silberstein LE, Logtenberg T: VH4.21-encoded natural autoantibodies with anti-i specificity mirror those associated with cold hemagglutinin disease. J Immunol 151:6569, 1993
53. Riboldi P, Gaidano G, Schettino EW, Steger TG, Knowles DM, Dalla-Favera R, Casali P: Two acquired immunodeficiency syndrome-associated Burkitt's lymphomas produce specific anti-i IgM cold agglutinins using somatically mutated VH4-21 segments. Blood 83:2952, 1994
54. Jukes TH, King JL: Evolutionary nucleotide replacements in DNA. Nature 281:605, 1979
55. Shlomchik MJ, Marshak-Rothstein A, Wolfowicz CB, Rothstein TL, Weigert MG: The role of clonal selection and somatic mutation in autoimmunity. Nature 328:805, 1987
56. Rajewsky K, Förster I, Cumano A: Evolutionary and somatic selection of the antibody repertoire in the mouse. Science 238:1088, 1987
57. Weiss U, Zoebelein R, Rajewsky K: Accumulation of somatic mutants in the B cell compartment after primary immunization with a T cell-dependent antigen. Eur J Immunol 22:511, 1992
58. Chang B, Casali P: A sequence analysis of human germline Ig VH and VL genes. The CDR1s of a major proportion of VH, but not VL, genes display a high inherent susceptibility to amino acid replacement. Ann N Y Acad Sci 764:170, 1995
59. Sanz I, Wang SS, Meneses G, Fischbach M: Molecular characterization of human Ig heavy chain DIR genes. J Immunol 152:3958, 1994
60. Andris JS, Johnson S, Zolla-Pazner S, Capra JD: Molecular characterization of five human anti-human immunodeficiency virus type 1 antibody heavy chains reveals extensive somatic mutation typical of an antigen-driven immune response. Proc Natl Acad Sci USA 88:7783, 1991
61. Moran MJ, Andris JS, Matsumato Y, Capra JD, Hersh EM: Variable region genes of anti-HIV human monoclonal antibodies: Non-restricted use of the V gene repertoire and extensive somatic mutation. Mol Immunol 30:1543, 1993
62. Bagley J, Dillon PJ, Rosen C, Robinson J, Sodroski J, Marasco WA: Structural characterization of broadly neutralizing human monoclonal antibodies against the CD4 binding site of HIV-1 gp120. Mol Immunol 31:1149, 1994
63. Barbas CF, Collet TA, Amberg W, Roben P, Binley JM, Hoekstra D, Cababa D, Jones TM, Williamson RA, Pilkington GR: Molecular profile of an antibody response to HIV-1 as probed by combinatorial libraries. J Mol Biol 230:812, 1993
64. Robinson WEJ, Kawamura T, Gorny MK, Lake D, Xu JY, Matsumoto Y, Sugano T, Masuho Y, Mitchell WM, Hersh E: Human monoclonal antibodies to the human immunodeficiency virus type 1 (HIV-1) transmembrane glycoprotein gp41 enhance HIV-1 infection in vitro. Proc Natl Acad Sci USA 87:3185, 1990
65. Ditzel HJ, Barbas SM, Barbas CF, Burton DR: The nature of the autoimmune antibody repertoire in human immunodeficiency virus type 1 infection. Proc Natl Acad Sci USA 91:3710, 1994
66. Andris JS, Capra JD: The molecular structure of human antibodies specific for the human immunodeficiency virus. J Clin Immunol 15:17, 1995
67. Kodaira M, Kinashi T, Umemura I, Matsuda F, Noma T, Ono Y, Honjo T: Organization and evolution of variable region genes of the human immunoglobulin heavy chain. J Mol Biol 190:529, 1986
68. Shen A, Humphries C, Tucker P, Blattner F: Human heavy-chain variable region gene family nonrandomly rearranged in familial chronic lymphocytic leukemia. Proc Natl Acad Sci USA 84:8563, 1987
69. Cook GP, Tomlinson IM, Walter G, Riethman H, Carter NP, Buluwela L, Winter G, Rabbitts TH: A map of the human immunoglobulin VH locus completed by analysis of the telomeric region of chromosome 14q. Nat Genet 7:162, 1994