Common and HIV-related diffuse large B-cell lymphomas differ in their immunoglobulin gene mutation pattern

Journal of Pathology

Volumn 188, Issue 2, 1999, Pages 133-138

  Delecluse, H J ^a   Hummel, M ^a   Marafioti, T ^a   Anagnostopoulos, I ^a   Stein, H ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

B cell lymphomas; Epstein Barr virus; Human immunodeficiency virus; Immunoglobulin gene rearrangement; Somatic mutations

Indexed keywords

ARTICLE; B CELL LYMPHOMA; CANCER RISK; CLINICAL ARTICLE; EPSTEIN BARR VIRUS; GENE MUTATION; GENE REARRANGEMENT; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL;

GENE REARRANGEMENT; HERPESVIRUS 4, HUMAN; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LYMPHOMA, AIDS-RELATED; LYMPHOMA, B-CELL; LYMPHOMA, LARGE-CELL, DIFFUSE; MUTATION; POLYMERASE CHAIN REACTION;

EID: 0033055145     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9896(199906)188:2<133::AID-PATH349>3.0.CO;2-Y     Document Type: Article

References (37)

1. Beral V, Peterman T, Berkelman R, Jaffe H. AIDS-associated non-Hodgkin lymphoma. Lancet 1991; 337: 805-809.
2. Levine AM. Acquired immunodeficiency syndrome-related lymphoma. Blood 1992; 80: 8-20.
3. Nalesnik MA. Lymphoproliferative disease in organ transplant recipients. Springer Semin Immunopathol 1991; 13: 199-216.
4. Knowles DM, Chadburn A. Lymphadenopathy and the lymphoid neoplasms associated with the acquired immune deficiency syndrome (AIDS). In: Knowles DM, ed. Neoplastic Hematopathology. Baltimore: Williams and Walker, 1992: 773-835.
5. Offit K, Jhanwar SC, Ladanyi M, Filippa DA, Chaganti RSK. Cytogenetic analysis of 434 consecutively ascertained specimens of non-Hodgkin's lymphoma: correlations between recurrent aberrations, histology, and exposure to cytotoxic treatment. Genes Chromosom Cancer 1991; 3: 189-201.
6. Subar M, Neri A, Inghirami G, Knowles DM, Dalla-Favera R. Frequent c-myc oncogene activation and infrequent presence of Epstein-Barr virus genome in AIDS-associated lymphoma. Blood 1988; 72: 667-671.
7. Ballerini P, Gaidano G, Gong JZ, et al. Multiple genetic lesions in acquired immunodeficiency syndrome-related non-Hodgkin's lymphoma. Blood 1993; 81: 166-176.
8. McGrath MS, Shiramizu B, Meeker TC, Kaplan LD, Herndier B. AIDS-associated polyclonal lymphoma: identification of a new HIV-associated disease process. J Acquir Immune Defic Syndr 1991; 4: 408-415.
9. Shiramizu B, Herndier B, Meeker T, Kaplan L, McGrath M. Molecular and immunophenotypic characterization of AIDS-associated, Epstein-Barr virus-negative, polyclonal lymphoma. J Clin Oncol 1992; 10: 383-389.
10. Hamilton Dutoit SJ, Rea D, Raphael M, et al. Epstein-Barr virus-latent gene expression and tumor cell phenotype in acquired immunodeficiency syndrome-related non-Hodgkin's lymphoma. Correlation of lymphoma phenotype with three distinct patterns of viral latency. Am J Pathol 1993; 143: 1072-1085.
11. Hummel M, Anagnostopoulos I, Korbjuhn P, Stein H. Epstein-Barr virus in B-cell non-Hodgkin's lymphomas: unexpected infection patterns and different infection incidence in low-and high-grade types. J Pathol 1995; 175: 263-271.
12. Young L, Alfieri C, Hennessy K, et al. Expression of Epstein-Barr virus transformation-associated genes in tissues of patients with EBV lymphoproliferative disease. N Engl J Med 1989; 321: 1080-1085.
13. Locker J, Nalesnik MA. Molecular genetic analysis of lymphoid tumors arising after organ transplantation. Am J Pathol 1989; 135: 977-987.
14. Delecluse HJ, Rouault JP, Ffrench M, Dureau G, Magaud JP, Berger F. Post-transplant lymphoproliferative disorders with genetic abnormalities commonly found in malignant tumours. Br J Haematol 1995; 89: 90-97.
15. Tamaru J, Hummel M, Marafioti T, et al. Burkitt's lymphomas express VH genes with a moderate number of antigen-selected somatic mutations. Am J Pathol 1995; 147: 1398-1407.
16. Hummel M, Tamaru J, Kalvelage B, Stein H. Mantle cell (previously centrocytic) lymphomas express VH genes with no or very little somatic mutations like the physiologic cells of the follicle mantle. Blood 1994; 84: 403-407.
17. Harris NL, Jaffe ES, Stein H, et al. A revised European-American classification of lymphoid neoplasms: a proposal from the international lymphoma study group. Blood 1994; 84: 1361-1392.
18. Norton AJ, Jordan S, Yeomans P. Brief, high-temperature heat denaturation (pressure cooking): a simple and effective method of antigen retrieval for routinely processed tissues. J Pathol 1994; 173: 371-379.
19. Cordell JL, Falini B, Erber WN, et al. Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes). J Histochem Cytochem 1984; 32: 219-229.
20. Lerner MR, Andrews NC, Miller G, Steitz JA. Two small RNAs encoded by Epstein-Barr virus and complexed with protein are precipitated by antibodies from patients with systemic lupus erythematosus. Proc Natl Acad Sci U S A 1981; 78: 805-809.
21. Howe JG, Steitz JA. Localization of Epstein-Barr virus-encoded small RNAs by in situ hybridization. Proc Natl Acad Sci U S A 1986; 83: 9006-9010.
22. Khan G, Coates PJ, Kangro HO, Slavin G. Epstein-Barr virus (EBV) encoded small RNAs: targets for detection by in situ hybridization with oligonucleotide probes. J Clin Pathol 1992: 45: 616-620.
23. Korbjuhn P, Anagnostopoulos I, Hummel M, et al. Frequent latent Epstein-Barr virus infection of neoplastic T cells and bystander B cells in human immunodeficiency virus-negative European peripheral pleomorphic T-cell lymphomas. Blood 1993; 82: 217-223.
24. Tamaru J, Hummel M, Zemlin M, Kalvelage B, Stein H. Hodgkin's disease with a B-cell phenotype often shows a VDJ rearrangement and somatic mutalions in the VH genes. Blood 1994; 84: 708-715.
25. Trainer KJ, Brisco MJ, Wan JH, Neoh S, Grist S, Morley AA. Gene rearrangement in B-and T-lymphoproliferative disease detected by the polymerase chain reaction. Blood 1991; 78: 192-196.
26. Delecluse HJ, Anagnostopoulos I, Dallenbach F, et al. Plasmablastic lymphomas of the oral cavity: a new entity associated with the human immunodeficiency virus infection. Blood 1997; 89: 1413-1420.
27. Hsu FJ, Levy R. Preferential use of the VH4 Ig gene family by diffuse large-cell lymphoma. Blood 1995; 86: 3072-3082.
28. Küppers R, Rajewsky K, Hansmann ML. Diffuse large cell lymphomas are derived from mature B cells carrying V region genes with a high load of somatic mutation and evidence of selection for antibody expression. Eur J Immunol 1997; 27: 1398-1405.
29. Brezinschek HP, Brezinschek RI, Lipsky PE. Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction. J Immunol 1995; 155: 190-202.
30. Zelenetz AD, Chen TT, Levy R. Clonal expansion in follicular lymphoma occurs subsequent to antigenic selection. J Exp Med 1992; 176: 1137-1148.
31. Bahler DW, Levy R. Clonal evolution of a follicular lymphoma: evidence for antigen selection. Proc Natl Acad Sci U S A 1992; 89: 6770-6774.
32. Hanto DW, Frizzera G, Gajl-Peczalska KJ, et al. Epstein-Barr virus-induced B-cell lymphoma after renal transplantation: acyclovir therapy and transition from polyclonal to monoclonal B-cell proliferation. N Engl J Med 1982; 306: 913-918.
33. Pelicci PG, Knowles DM, Arlin ZA, et al. Multiple monoclonal B cell expansions and c-myc oncogene rearrangements in acquired immune deficiency syndrome-related lymphoproliferative disorders. Implications for lymphomagenesis. J Exp Med 1986; 164: 2049-2060.
34. Cen H, Williams PA, McWillians HP, Breinig MC, Ho M, McKnight JL. Evidence for restricted Epstein-Barr virus latent gene expression and anti-EBNA antibody response in solid organ transplant recipients with posttransplant lymphoproliferative disorders. Blood 1993; 81: 1393-1403.
35. Delecluse HJ, Kremmer E, Rouault JP, Cour C, Bornkamm GW. Berger F. The expression of Epstein-Barr virus latent proteins is related to the pathological features of post-transplant lymphoproliferative disorders. Am J Pathol 1995; 146: 1113-1120.
36. Kempkes B, Zimber-Strobl U, Eissner G, et al. EBNA2-estrogen receptor fusion proteins complement the EBNA2 deficient Epstein-Barr virus strain P3HRI in transformation of primary B cells but suppress growth of human B cell lymphomas cell lines. J Gen Virol 1996; 77: 227-237.
37. Jochner N, Eick D, Zimber-Strobl U. Pawlita M, Bornkamm GW, Kempkes B. Epstein-Barr nuclear antigen 2 is a transcriptional suppressor of the immunoglobulin mu gene: implications for the expression of the translocated c-MYC gene in Burkitt's lymphoma cells. EMBO J 1996; 15: 375-382.