The Human Heavy Chain Ig V Region Gene Repertoire Is Biased at All Stages of B Cell Ontogeny, Including Early Pre-B Cells

Journal of Immunology

Volumn 158, Issue 12, 1997, Pages 5824-5832

  Kraj, Piotr ^a,b   Rao, Sambasiva P ^c   Glas, Annuska M ^c   Hardy, Richard R ^d   Milner, Eric C B ^c   Silberstein, Leslie E ^a,e  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b INSTITUTE OF IMMUNOLOGY AND EXPERIMENTAL THERAPY   (Poland)

^c BENAROYA RESEARCH INSTITUTE   (United States)

^d FOX CHASE CANCER CENTER   (United States)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN;

ADULT; ARTICLE; B LYMPHOCYTE; CELL DIFFERENTIATION; FETUS; GENE REARRANGEMENT; GENETICS; HUMAN; IMMUNOGLOBULIN VARIABLE REGION; NEWBORN; PHYSIOLOGY;

ADULT; B-LYMPHOCYTES; CELL DIFFERENTIATION; FETUS; GENE REARRANGEMENT, B-LYMPHOCYTE; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; INFANT, NEWBORN;

EID: 0031570413     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (63)

1. Tonegawa, S. 1983. Somatic generation of antibody diversity. Nature 302:575.
2. H locus completed by analysis of the telomeric region of chromosome 14q. Nat. Genet. 7:162.
3. Matsuda, F., E. K. Shin, H. Nagaoka, R. Matsumara, M. Haino, Y. Fukita, S. Taka-ishi, T. Imai, J. H. Riley, R. Anand, E. Soeda, and T. Honjo. 1993. Structure and physical map of 64 variable segments in the 3′ 0.8-megabase region of the human immunoglobulin heavy-chain locus. Nat. Genet. 3:88.
4. Ravetch, J. V., U. Siebenlist, S. Korsmeyer, T. Waldmann, and P. Leder. 1981. Structure of the human immunoglobulin μ locus: characterization of embryonic and rearranged J and D genes. Cell 27:583.
5. Ichihara, Y., H. Matsuoka, and Y. Kurosawa. 1988. Organization of human immunoglobulin heavy chain diversity gene loci. EMBO J. 7:4141.
6. Walter, M. A., U. Surti, M. H. Hofker, and D. W. Cox. 1990. The physical organization of the human immunoglobulin heavy chain gene complex. EMBO J. 9:3303.
7. Siebenlist, U., J. V. Ravetch, S. Korsmeyer, T. Waldmann, and P. Leder. 1981. Human immunoglobulin D segments encoded in tandem multigenic families. Nature 294:631.
8. H genes may be the target of immune regulation. Int. Rev. Immunol. 8:147.
9. H-gene representation in autoantibodies reflects the normal B-cell repertoire. Immunol. Rev. 101:101.
10. Schroeder, H., Jr., and G. Dighiero. 1994. The pathogenesis of chronic lymphocytic leukemia: analysis of the antibody repertoire. Immunol. Today 15:288.
11. Schroeder, H. W., Jr., J. L. Hillson, and R. M. Perlmutter. 1987. Early restriction of the human antibody repertoire. Science 238:791.
12. Schroeder, H. W., and J. Y. Wang. 1990. Preferential utilization of conserved immunoglobulin heavy chain variable gene segments during human fetal life. Proc. Natl. Acad. Sci. USA 87:6146.
13. Hillson, J. L., I. R. Oppliger, E. H. Sasso, E. C. B. Milner, and M. H. Wener. 1992. Emerging human B cell repertoire: influence of development stage and interindividual variation. J. Immunol. 149:3741.
14. H gene in the expressed human B cell repertoire. J. Exp. Med. 177:409.
15. Klein, U., R. Kuppers, and K. Rajewsky. 1994. Variable region gene analysis of B cell subsets derived from a 4-year-old child: somatically mutated memory B cells accumulate in the peripheral blood already at young age. J. Exp. Med. 180:1383.
16. H gene segments in the human adult antibody repertoire. J. Immunol. 154:3902.
17. H4.21) Ig gene segment in the normal adult human peripheral blood B cell repertoire. J. Immunol. 154:6406.
18. H genes. Science 227:1597.
19. H gene segments in pre-B-cell lines. Nature 311:727.
20. Arnold, L. W., C. A. Pennell, S. K. McCray, and S. H. Clarke. 1994. Development of B-1 cells: segregation of phosphatidyl choline-specific B cells to the B-1 population occurs after immunoglobulin gene expression. J. Exp. Med. 179:1585.
21. H11 in the Ly-1 cell lineage. J. Exp. Med. 172:371.
22. Huetz, F., L. Carlsson, U. C. Tornberg, and D. Holmberg. 1993. V-region directed selection in differentiating B lymphocytes. EMBO J. 12:1819.
23. Willems van Dijk, K., H. W. Schroeder, R. G. Perlmutter, and E. C. B. Milner. 1992. Chromosomal organization of the heavy chain variable region gene segments comprising the human fetal antibody repertoire. Proc. Natl. Acad. Sci. USA 89:10430.
24. Gu, H., D. Tarlinton, W. Müller, K. Rajewsky, and I. Förster. 1991. Most peripheral B cells in mice are ligand selected. J. Exp. Med. 173:1357.
25. Keyna, V., G. B. Beck-Engeser, J. Jongstra, S. E. Applequist, and H. M. Jack. 1995. Surrogate light chain dependent selection of Ig heavy chain V regions. J. Immunol. 155:5536.
26. Brezinschek, H. P., R. I. Brezinschek, and P. E. Lipsky. 1995. Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction. J. Immunol. 155:190.
27. + B cells. Immunogenetics 42:342.
28. Loken, M. R., V. O. Shah, K. L. Dattilio, and C. I. Civin. 1987. Flow cytometric analysis of human bone marrow. II. Normal B lymphocyte development. Blood 70:1316.
29. H4 gene family. J. Immunol. 150:2858.
30. H locus. J. Immunol. 146:2547.
31. Wood, W. I., J. Gitschier, L. A. Lasky, and R. M. Lawn. 1985. Base composition independent hybridization in tetramethylammonium chloride: a method for oligonucleotide screening of highly complex gene libraries. Proc. Natl. Acad. Sci. USA 82:1585.
32. H4 gene family. J. Immunol. 146:3646.
33. H3 genes. J. Immunol. 145:2751.
34. H4 germline genes. Eur. J. Immunol. 22:1075.
35. Banchereau, J., and F. Rousset. 1992. Human B lymphocytes: phenotype, proliferation, and differentiation. Adv. Immunol. 52:125.
36. Terstapen, L. W., S Johnsen, I. M. Segers-Nolten, and M. R. Loken. 1990. Identification and characterization of plasma cells in normal human bone marrow by high resolution flow cytometry. Blood 76:1739.
37. H genes. Ann. NY Acad. Sci. USA 764:50.
38. H gene locus is duplicated. Scand. J. Immunol. 31:593.
39. Huang, S. C., R. Jiang, A. M. Glas, and E. C. B. Milner. 1996. Non-stochastic utilization of Ig V region genes in unselected human peripheral B cells. Mol. Immunol. 33:553.
40. H3 gene. J. Clin. Invest. 96:1591.
41. H gene 51p1 is proportional to its germline copy number. J. Clin. Invest. 97:2074.
42. H6 encoded IgM antibodies in early ontogeny. J. Immunol. 150:161.
43. H4) using deletional analysis and pulse field gel electrophoresis. J. Immunol 148:2923.
44. Pascual, V., L. Verkruyse, M. L. Casey, and J. D. Capra. 1993. Analysis of the Ig H chain gene segment utilization in human fetal liver: revisiting the "proximal utilization hypothesis." J. Immunol. 151:4164.
45. Cuisinier, A. M., L. Gauthier, L. Boubli, M. Fougereau, and C. Tonnelle. 1993. Mechanisms that generate human immunoglobulin diversity operate from the 8th week of gestation in fetal liver. Eur. J. Immunol. 23:110.
46. Karasuyama, H., A. Kudo, and F. Melchers. 1990. The protein encoded by the V preB and lambda-5 pre-B cell specific genes can associate with each other and with mu heavy chain. J. Exp. Med. 172:969.
47. H81 X gene segments evidences a dependence of B cell clonal maturation on the structure of nascent H chains. J. Immunol. 147:1406.
48. Decker, D. J., G. H. Kline, T. A. Hayden, S. N. Zaharevitz, and N. R. Klinman. 1995. Heavy chain V gene-specific elimination of B cells during the pre-B cell to B cell transition. J. Immunol. 154:4924.
49. H structure of the mu/surrogate L chain receptor. EMBO J. 15:1524.
50. Goodnow, C. C., J. Crosbie, S. Adelstein, T. B. Lavoie, S. J. Smith-Gill, R. A. Brink, H. Pritchard-Briscoe, J. S. Wotherspoon, R. H. Loblay, K. Raphael, R. J. Trent, and A. Basten. 1988. Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature 334:676.
51. Goodnow, C. C. 1992. Transgenic mice and analysis of B cell tolerance. Annu. Rev. Immunol 10:489.
52. Hartley, S. B., J. Crosbie, R. Brink, A. B. Kantor, A. Basten, and C. C. Goodnow. 1991. Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane bound antigens. Nature 353:765.
53. Russell, D. M., Z. Dembic, G. Morahan, J. F. A. P. Miller, K. Burki, and D. Nemazee. 1991. Peripheral deletion of self reactive B cells. Nature 354:308.
54. Nemazee, D. A., and K. Burki. 1989. Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes. Nature 337:562.
55. Friedman, D. F., E. A. Cho, J. Goldman, C. E. Carmack, E. C. Besa, R. R. Hardy, and L. E. Silberstein. 1991. The role of clonal selection in the pathogenesis of an autoreactive human B cell lymphoma. J. Exp. Med. 174:525.
56. 2 erythrocyte autoantibodies. J. Exp. Med. 169:1631.
57. Friedman, D. F., J. S. Moore, J. Erikson, J. Manz, J. Goldman, P. C. Nowell, and L. E. Silberstein. 1992. Variable region gene analysis of an isotype-switched (IgA) variant of chronic lymphocytic leukemia. Blood 80:2287.
58. Silberstein, L. E., L. C. Jefferies, J. Goldman, D. F. Friedman, J. S. Moore, P. C. Nowell, D. Roelcke, W. Pruzanski, J. Roudier, and G. J. Silverman. 1991. Variable region gene analysis of pathologic human autoantibodies to the related i and I red blood cell antigens. Blood 73:2372.
59. H and D segments on chromosomes 15q11.2 and 16p11.2. Hum. Mol Genet. 3:853.
60. Guelpa-Fonlupt, V., C. Tonnelle, D. Blaise, M. Fougereau, and F. Fumoux. 1994. Discrete early pro-B and pre-B stages in normal human bone marrow as defined by surface pseudo-light chain expression. Eur. J. Immunol. 24:257.
61. Lassoued, K., C. A. Nunez, L. Billips, H. Kubagawa, R. C. Monteiro, T. W. Lebien, and M. D. Cooper. 1993. Expression of surrogate light chain receptors is restricted to a late stage in pre-B cell differentiation. Cell 73:73.
62. Sanz, E., and A. de la Hera. 1996. A novel anti-V pre-B antibody identifies immunoglobulin-surrogate receptors on the surface of human pro-B cells. J. Exp. Med. 183:2693.
63. Melchers, F., D. Haasner, U. Grawunder, C. Kalberer, H. Karasuyama, T. Winkler, and A. G. Rolink. 1994. Roles of IgH and L chain and of surrogate H and L chains in the development of cells of the B lymphocyte lineage. Annu. Rev. Immunol. 12:209.