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Volumn 24, Issue 10, 2003, Pages 504-507

Unravelling multiple ligand-activation binding sites using RASSL receptors

Author keywords

[No Author keywords available]

Indexed keywords

1 METHYL 3 INDOLECARBOXYLIC ACID [1 [2 (METHYLSULFONYLAMINO)ETHYL] 4 PIPERIDINYLMETHYL] ESTER; 2 (2 ETHOXY 1,4 BENZODIOXAN 2 YL) 2 IMIDAZOLINE; 2,3 DIHYDRO 3 ISOPROPYL 2 OXO 1 BENZIMIDAZOLECARBOXYLIC ACID 3ALPHA TROPANYLAMIDE; 4 AMINO 5 CHLORO 2 METHOXYBENZOIC ACID 2 (1 PIPERIDINYL)ETHYL ESTER; 4 AMINO 5 CHLORO 2 METHOXYBENZOIC ACID 2 (3,5 DIMETHYLPIPERIDINO)ETHYL ESTER; 5 CARBAMOYLTRYPTAMINE; 5 METHOXYTRYPTAMINE; 6 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 1H 3 BENZAZEPINE; ADRENALIN; ALPHA 2A ADRENERGIC RECEPTOR; ATIPAMEZOLE; BRIMONIDINE; CLONIDINE; DEXEFEROXAN; G PROTEIN COUPLED RECEPTOR; IDAZOXAN; LIGAND; MEDETOMIDINE; METOCLOPRAMIDE; OPIATE PEPTIDE; OXYMETAZOLINE; RECEPTORS ACTIVATED SOLELY BY SYNTHETIC LIGAND; SEROTONIN; SEROTONIN RECEPTOR; TALIPEXOLE; TEGASEROD; UNCLASSIFIED DRUG;

EID: 0141953281     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tips.2003.08.007     Document Type: Short Survey
Times cited : (17)

References (14)
  • 1
    • 0035083109 scopus 로고    scopus 로고
    • Inverse, protean, and ligand-selective agonism: Matters of receptor conformation
    • Kenakin T. Inverse, protean, and ligand-selective agonism: matters of receptor conformation. FASEB J. 15:2001;598-611.
    • (2001) FASEB J. , vol.15 , pp. 598-611
    • Kenakin, T.1
  • 2
    • 0035423643 scopus 로고    scopus 로고
    • Engineering receptors activated solely by synthetic ligands (RASSLs)
    • Scearce-Levie K., et al. Engineering receptors activated solely by synthetic ligands (RASSLs). Trends Pharmacol. Sci. 22:2001;414-420.
    • (2001) Trends Pharmacol. Sci. , vol.22 , pp. 414-420
    • Scearce-Levie, K.1
  • 3
    • 0031940393 scopus 로고    scopus 로고
    • Controlling signaling with a specifically designed Gi-coupled receptor
    • Coward P., et al. Controlling signaling with a specifically designed Gi-coupled receptor. Proc. Natl. Acad. Sci. U. S. A. 95:1998;352-357.
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 352-357
    • Coward, P.1
  • 4
    • 0037428475 scopus 로고    scopus 로고
    • A single mutation in the 5-HT4 receptor (5-HT4-R D100(3.32)A) generates a Gs-coupled receptor activated exclusively by synthetic ligands (RASSL)
    • Claeysen S., et al. A single mutation in the 5-HT4 receptor (5-HT4-R D100(3.32)A) generates a Gs-coupled receptor activated exclusively by synthetic ligands (RASSL). J. Biol. Chem. 278:2003;699-702.
    • (2003) J. Biol. Chem. , vol.278 , pp. 699-702
    • Claeysen, S.1
  • 5
    • 0033862570 scopus 로고    scopus 로고
    • Disparate ligand-mediated Ca2+ responses by wild-type, mutant Ser200Ala and Ser204Ala α2A-adrenoceptor: Gα15 fusion proteins: Evidence for multiple ligand-activation binding sites
    • Pauwels P.J., Colpaert F.C. Disparate ligand-mediated Ca2+ responses by wild-type, mutant Ser200Ala and Ser204Ala α2A-adrenoceptor: Gα15 fusion proteins: evidence for multiple ligand-activation binding sites. Br. J. Pharmacol. 130:2000;1505-1512.
    • (2000) Br. J. Pharmacol. , vol.130 , pp. 1505-1512
    • Pauwels, P.J.1    Colpaert, F.C.2
  • 6
    • 0034672622 scopus 로고    scopus 로고
    • Diverse signalling by 5-hydroxytryptamine (5-HT) receptors
    • Pauwels P.J. Diverse signalling by 5-hydroxytryptamine (5-HT) receptors. Biochem. Pharmacol. 60:2000;1743-1750.
    • (2000) Biochem. Pharmacol. , vol.60 , pp. 1743-1750
    • Pauwels, P.J.1
  • 7
    • 0024519931 scopus 로고
    • Structural basis of β-adrenergic receptor function
    • Strader C.D., et al. Structural basis of β-adrenergic receptor function. FASEB J. 3:1989;1825-1832.
    • (1989) FASEB J. , vol.3 , pp. 1825-1832
    • Strader, C.D.1
  • 8
    • 0035943605 scopus 로고    scopus 로고
    • Modification of the β2-adrenergic receptor to engineer a receptor-effector complex for gene therapy
    • Small K.L., et al. Modification of the β2-adrenergic receptor to engineer a receptor-effector complex for gene therapy. J. Biol. Chem. 276:2001;31596-31601.
    • (2001) J. Biol. Chem. , vol.276 , pp. 31596-31601
    • Small, K.L.1
  • 9
    • 0033551828 scopus 로고    scopus 로고
    • Three-dimensional models of α2A-adrenergic receptor complexes provide a structural explanation for ligand binding
    • Salminen T., et al. Three-dimensional models of α2A-adrenergic receptor complexes provide a structural explanation for ligand binding. J. Biol. Chem. 274:1999;23405-23413.
    • (1999) J. Biol. Chem. , vol.274 , pp. 23405-23413
    • Salminen, T.1
  • 10
    • 0033837404 scopus 로고    scopus 로고
    • Heterogeneous ligand-mediated Ca2+ responses at wt and mutant α2A-adrenoceptors suggest multiple ligand activation binding sites at the α2A-adrenoceptor
    • Pauwels P.J., Colpaert F.C. Heterogeneous ligand-mediated Ca2+ responses at wt and mutant α2A-adrenoceptors suggest multiple ligand activation binding sites at the α2A-adrenoceptor. Neuropharmacology. 39:2000;2101-2111.
    • (2000) Neuropharmacology , vol.39 , pp. 2101-2111
    • Pauwels, P.J.1    Colpaert, F.C.2
  • 11
    • 0027283546 scopus 로고
    • Partial agonists, full agonists, antagonists: Dilemmas of definition
    • Hoyer D., Boddeke H.W. Partial agonists, full agonists, antagonists: dilemmas of definition. Trends Pharmacol. Sci. 14:1993;270-275.
    • (1993) Trends Pharmacol. Sci. , vol.14 , pp. 270-275
    • Hoyer, D.1    Boddeke, H.W.2
  • 12
    • 0036468505 scopus 로고    scopus 로고
    • Mechanisms of inverse agonism at G-protein-coupled receptors
    • Strange P.G. Mechanisms of inverse agonism at G-protein-coupled receptors. Trends Pharmacol. Sci. 23:2002;89-95.
    • (2002) Trends Pharmacol. Sci. , vol.23 , pp. 89-95
    • Strange, P.G.1
  • 13
    • 0037067318 scopus 로고    scopus 로고
    • A 5-HT4 receptor transmembrane network implicated in the activity of inverse agonists but not agonists
    • Joubert L., et al. A 5-HT4 receptor transmembrane network implicated in the activity of inverse agonists but not agonists. J. Biol. Chem. 277:2002;25502-25511.
    • (2002) J. Biol. Chem. , vol.277 , pp. 25502-25511
    • Joubert, L.1
  • 14
    • 0032966673 scopus 로고    scopus 로고
    • Conditional expression and signaling of a specifically designed Gi-coupled receptor in transgenic mice
    • Redfern C.H., et al. Conditional expression and signaling of a specifically designed Gi-coupled receptor in transgenic mice. Nat. Biotechnol. 17:1999;165-169.
    • (1999) Nat. Biotechnol. , vol.17 , pp. 165-169
    • Redfern, C.H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.