BAY REGION BINDING SITE;
DRUG EFFICACY;
DRUG RECEPTOR BINDING;
PHARMACODYNAMICS;
PRIORITY JOURNAL;
PROTEIN FUNCTION;
REVIEW;
SIGNAL TRANSDUCTION;
WILD TYPE;
A single mutation in the 5-HT4 receptor (5-HT4-R D100(3.32)A) generates a Gs-coupled receptor activated exclusively by synthetic ligands (RASSL)
Claeysen S., et al. A single mutation in the 5-HT4 receptor (5-HT4-R D100(3.32)A) generates a Gs-coupled receptor activated exclusively by synthetic ligands (RASSL). J. Biol. Chem. 278:2003;699-702.
Modification of the β2-adrenergic receptor to engineer a receptor-effector complex for gene therapy
Small K.L., et al. Modification of the β2-adrenergic receptor to engineer a receptor-effector complex for gene therapy. J. Biol. Chem. 276:2001;31596-31601.
Three-dimensional models of α2A-adrenergic receptor complexes provide a structural explanation for ligand binding
Salminen T., et al. Three-dimensional models of α2A-adrenergic receptor complexes provide a structural explanation for ligand binding. J. Biol. Chem. 274:1999;23405-23413.
Heterogeneous ligand-mediated Ca2+ responses at wt and mutant α2A-adrenoceptors suggest multiple ligand activation binding sites at the α2A-adrenoceptor
Pauwels P.J., Colpaert F.C. Heterogeneous ligand-mediated Ca2+ responses at wt and mutant α2A-adrenoceptors suggest multiple ligand activation binding sites at the α2A-adrenoceptor. Neuropharmacology. 39:2000;2101-2111.
A 5-HT4 receptor transmembrane network implicated in the activity of inverse agonists but not agonists
Joubert L., et al. A 5-HT4 receptor transmembrane network implicated in the activity of inverse agonists but not agonists. J. Biol. Chem. 277:2002;25502-25511.
Conditional expression and signaling of a specifically designed Gi-coupled receptor in transgenic mice
Redfern C.H., et al. Conditional expression and signaling of a specifically designed Gi-coupled receptor in transgenic mice. Nat. Biotechnol. 17:1999;165-169.