A Gq/11-coupled mutant histamine H1 receptor F435A activated solely by synthetic ligands (RASSL)

Journal of Biological Chemistry

Volumn 280, Issue 41, 2005, Pages 34741-34746

  Bruysters, Martijn ^a   Jongejan, Aldo ^a   Akdemir, Atilla ^a   Bakker, Remko A ^a   Leurs, Rob ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; COMPUTER SIMULATION; MOLECULAR DYNAMICS; MUTAGENESIS;

BINDING POCKETS; MUTANTS; POTENCY; PROTEIN-COUPLED RECEPTORS;

PROTEINS;

2 (2 PYRIDYL)ETHYLAMINE; 2 (3 CHLOROPHENYL)HISTAMINE; 2 (3 TRIFLUOROMETHYLPHENYL)HISTAMINE; 2 (3,4 DICHLOROPHENYL)HISTAMINE; 2 (CYCLOHEXYL)HISTAMINE; 2 (ETHYLCYCLOHEXYL)HISTAMINE; 2 (METHYLCYCLOHEXYL)HISTAMINE; 2 PHENYLHISTAMINE; G PROTEIN COUPLED RECEPTOR; HISTAMINE; HISTAMINE AGONIST; HISTAMINE H1 RECEPTOR; HISTAPRODIFEN; LISURIDE; MUTANT PROTEIN; PROTEIN RASSL; SUPRAHISTAPRODIFEN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ENGINEERING; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

ANIMALS; CATTLE; CERCOPITHECUS AETHIOPS; COS CELLS; CRYSTALLOGRAPHY, X-RAY; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; GENES, REPORTER; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HISTAMINE; HUMANS; HYDROGEN-ION CONCENTRATION; LIGANDS; MODELS, CHEMICAL; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; NF-KAPPA B; PHENYLALANINE; PROTEIN BINDING; PROTEIN ENGINEERING; RECEPTORS, HISTAMINE H1; RECEPTORS, OPIOID, KAPPA; TRANSFECTION;

EID: 27144529199     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M504165200     Document Type: Article

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