Studying the effects of mobile phone use on the auditory system and the central nervous system: A review of the literature and future directions

European Archives of Oto-Rhino-Laryngology

Volumn 265, Issue 9, 2008, Pages 1011-1019

  Kaprana, A E ^a   Karatzanis, A D ^a   Prokopakis, E P ^a   Panagiotaki, I E ^a   Vardiambasis, I O ^b   Adamidis, G ^b   Christodoulou, P ^a   Velegrakis, G A ^a  

^a UNIVERSITY OF CRETE   (Greece)

^b TECHNOLOGICAL EDUCATIONAL INSTITUTE OF CRETE   (Greece)

Author keywords

Auditory system; Central nervous system; Electromagnetic fields; Electromagnetic radiation; Mobile phones

Indexed keywords

ACOUSTIC NEURINOMA; AUDITORY SYSTEM; BENIGN TUMOR; BRAIN CELL; BRAIN TUMOR; BREAST TUMOR; CANCER RISK; CARCINOGENESIS; CENTRAL NERVOUS SYSTEM; COLON CANCER; DISEASE ASSOCIATION; ELECTROMAGNETIC FIELD; ELECTROMAGNETIC RADIATION; GLIOMA; HUMAN; MEMBRANE CONDUCTANCE; MENINGIOMA; MOBILE PHONE; NERVE MEMBRANE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SKIN TUMOR; VESTIBULAR FUNCTION; VESTIBULAR SYSTEM;

CELLULAR PHONE; CENTRAL NERVOUS SYSTEM; ELECTROMAGNETIC FIELDS; HEARING; HUMANS; NEOPLASMS, RADIATION-INDUCED;

EID: 48349138591     PISSN: 09374477     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00405-008-0703-z     Document Type: Review

References (92)

1. Steele R, Hanzo L (1999) Mobile communications, 2nd edn. New York, Wiley
2. GF Pederson JB Anderson 1999 RF and ELF exposure from cellular phone handsets: TDMA and CDMA systems Radiat Prot Dosimetry 83 131
3. ER Adair BL Cobb KS Mylacraine SA Kelleher 1999 Human exposure at two radiofrequencies (450 and 2450 MHz): similarities and differences in physiological response Bioelectromagnetics 20 12
4. ICNIRP 1998 Guidelines for limiting exposure to time-varying electric, magnetic and electromagnetic fields (up to 300 GHz) Health Phys 74 4 494
5. ICNIRP 1998 Response to questions and comments on ICNIRP guidelines Health Phys 75 4 438
6. MH Repacholi 1998 Low level exposure to radiofrequency electromagnetic fields: health effects and research needs Bioelectromagnetics 19 1
7. IEGMP: Independent Expert Group on Mobile Phones (2000) Mobile phones and health. Chairman Professor Sir William Stewart
8. M Röösli M Moser Y Baldinini M Meier C Braun-Fahrländer 2004 Symptoms of ill health ascribed to electromagnetic field exposure: a questionnaire survey Int J Hyg Environ Health 207 2 141
9. Michel G (2004) Symptom reporting: exploration of situational and individual predictors. Ph.D. thesis, University of Fribourg, Switzerland
10. Hillert L, Berglind N, Arnetz BB, Bellander T (2001) Prevalence of self-reported hypersensitivity to electric or magnetic fields in population-based questionnaire survey. Scand J Work Environ Res 28(1):33
11. S Thomée M Eklöf E Gustafsson R Nilsson M Hagberg 2007 Prevalence of perceived stress, symptoms of depression and sleep disturbances in relation to information and communication technology (ICT) use among young adults: an explorative prospective study Comput Hum Behav 23 3 300 1321
12. CS Hung C Anderson JA Horne P McEvoy 2007 Mobile phone 'talk-mode' signal delays EEG-determined sleep onset Neurosci Lett 421 1 82 86
13. M Koivisto C Haarala CM Krause A Revonsuo M Laine H Hamalainen 2001 GSM phone signal does not produce subjective symptoms Bioelectromagnetics 22 3 212
14. D Dubreuil T Jay JM Edeline 2002 Does head only exposure to GSM-900 electromagnetic fields affect the performance of rats in spatial learning tasks? Behav Brain Res 129 1, 2 203 210
15. D Dubreuil T Jay JM Edeline 2003 Head-only exposure to GSM-900-MHz electromagnetic fields does not alter rat's memory in spatial and non-spatial tasks Behav Brain Res 145 1, 2 51 61
16. P Levallois R Neutra G Lee L Hristova 2002 Study of self reported hypersensitivity to electromagnetic fields in California Environ Health Perspect 110 Suppl 4 619
17. N Leitgeb J Schröttner 2003 Electrosensibility and electromagnetic hypersensitivity Bioelectromagnetics 24 6 387
18. G Abdel-Rassoul O Abou El-Fateh M Abou Salem A Michael F Farahat M El-Batanouny E Salem 2007 Neurobehavioral effects among inhabitants around mobile phone base stations Neurotoxicology 28 2 434 440
19. IEGMP 2000 Advisory Group on Non-ionising Radiation (AGNIR) (2003 Health effects from radiofrequency electromagnetic fields: report of an independent. Advisory Group Of Non-ionising Radiation Doc NRPB 14 1 77
20. MJ Schroemaker AJ Swerdlow A Ahlbom A Auvinen 2005 Mobile phone use and risk of acoustic neuroma: results of the interphone case-control study in five North European countries Br J Cancer 93 7 842 848
21. S Lönn A Ahlbom P Hall M Feychting 2004 Mobile phone use and risk of acoustic neuroma Epidemiology 15 653 659
22. H Lennart 2004 No association between mobile phone usage and development of acoustic neuroma Evid Based Healthc 8 213 215
23. L Hardell M Carlberg MK Hansson 2005 Case-control study on cellular and cordless telephones and the risk for acoustic neuroma or meningioma in patients diagnosed 2000-2003 Neuroepidemiology 25 3 120 128
24. HC Christensen J Schuz M Kosteljanetz 2004 Cellular telephone use and risk of acoustic neuroma Am J Epidemiol 159 277 283
25. C Johansen JD Boice JK McLaughlin 2001 Cellular telephones and cancer: anation wide cohort study in Denmark J Natl Cancer Inst 93 203 207
26. S Hepworth M Schoemaker K Muir A Swerdlow MJ Van Tongeren P McKinney 2006 Mobile phone use and risk of glioma in adults: case-control study BMJ 332 883 887
27. Schüz J, Böhler E, Berg G, Schlehofer B et al Cellular phones, cordless phones, and the risks of glioma and meningioma (Interphone Study Group, Germany). Am J Epidemiol 2006;63(6):512-520. Epub Jan 27. Comment by Morgan in: Am J Epidemiol 2006;164:294-295. Author reply 295
28. A Lahkola A Auvinen J Raitanen 2007 Mobile phone use and risk of glioma in 5 North European countries Int J Cancer 120 1769 1775
29. A Auvinen M Hietanen R Luukkonen RS Koskela 2002 Brain tumors and salivary gland cancers among cellular telephone users Epidemiology 13 356 359
30. A Stang G Anastassiou W Ahrens K Bromen N Bornfeld K-H Jockel 2001 The possible role of radiofrequency radiation in the development of uveal melanoma Epidemiology 12 7 12
31. PD Inskip RE Tarone EE Hatch TC Wilcosky WR Shapiro RG Selker HA Fine PM Black JS Loeffler MS Linet 2001 Cellulartelephone use and brain tumors N Engl J Med 344 79 86
32. D Brusick R Albertini D McRee D Peterson G Williams P Hanawalt J Preston 1998 Genotoxicity of radiofrequency radiations Environ Mol Mutagen 32 1
33. L Verschaeve A Maes 1998 Genetic, carcinogenic and teratogenic effects of radiofrequency fields Mutat Res 410 141
34. Jokela K, Leszczynski D, Paile W, Salomaa S, Puranen L, Hyysalo P (1999) Radiation safety of handheld mobile phones and base stations. Stockholm, STUK, S161
35. JE Moulder LS Erdreich RS Malyapa J Merritt WF Pickard DZ Vijayalaxmi 1999 Cell phones and cancer: what is the evidence for a connection? Radiat Res 151 513
36. Royal Society of Canada Expert Panel Report (1999) A review of the potential health risks of radiofrequency fields from wireless telecommunication devices. An Expert Panel Report prepared at the request of the Royal Society of Canada for Health Canada. Ottawa, Royal Society of Canada, RSC.EPR, pp 99-101
37. S Asanami K Shimono 1999 High body temperature induces micronuclei in mouse bone marrow Mutat Res 390 79
38. JB Jorritsma AW Konings 1984 The occurrence of DNA strand breaks after hyperthermic treatments of mammalian cells with and without radiation Radiat Res 98 198
39. K Miura K Morimoto A Koizumi 1986 Effects of temperature on chemically induced sister-chromatid exchange in human lymphocytes Mutat Res 174 15
40. H Lai NP Singh 1995 Acute low-intensity microwave exposure increases DNA single-strand breaks in rat brain cells Bioelectromagnetics 16 207
41. H Lai NP Singh 1996 Single- and double-strand DNA breaks in rat brain cells after acute exposure to radiofrequency electromagnetic radiation Int J Radiat Biol 69 513
42. VJ McKelvey-Martin MHL Green P Schmezer BL Pool-Zobel MP De Méo A Collins 1993 The single cell gel electrophoresis assay (comet assay): a European review Mutat Res 288 47
43. RS Malyapa EW Ahern WL Straube EG Moros WF Pickard JL Roti Roti 1997 Measurement of DNA damage following exposure to 2450 MHz electromagnetic radiation Radiat Res 148 608
44. RS Malyapa EW Ahern WL Straube EG Moros WF Pickard JL Roti Roti 1997 Measurement of DNA damage following exposure to electromagnetic radiation in the cellular communications frequency band (835.62 and 847.74 MHz) Radiat Res 148 618
45. S Szmigielski A Szudzinski A Pietraszek M Bielec JK Wrembel 1982 Accelerated development of spontaneous and benzopyrene-induced skin cancer in mice exposed to 2450-MHz microwave radiation Bioelectromagnetics 3 179
46. A Szudzinski A Pietraszek M Janiak J Wrembel M Kalczek S Szmigielski 1982 Acceleration of the development of benzopyrene-induced skin cancer in mice by microwave radiation Arch Dermatol Res 274 303
47. Szmigielski S, Bielec M, Lipski S, Sokolska G (1988) Immunologic and cancer-related aspects of exposure to low-level microwave and radiofrequency fields. In: Marino AA (ed) Modern bioelectricity. New York, Marcel Dekker, p 861
48. A Maes M Collier U Van Gorp S Vandoninck L Verschaeve 1997 Cytogenetic effects of 935.2-MHz (GSM) microwaves alone and in combination with mitomycin C Mutat Res 393 151
49. RY Wu H Chiang BJ Shao NG Li YD Fu 1994 Effects of 2.45 GHz microwave radiation and phorbol ester 12-O-tetradecanoylphorbol-13-acetate on dimethylhydrazine-induced colon cancer in mice Bioelectromagnetics 15 531
50. K Imaida M Taki T Yamaguchi T Ito S Watanabe K Wake A Aimoto Y Kamimura N Ito T Shirai 1998 Lack of promoting effects of the electromagnetic near-field used for cellular phones (929.2 MHz) on rat liver carcinogenesis in a medium-term liver bioassay Carcinogenesis 19 311
51. K Imaida M Taki S-i Watanabe Y Kamimura T Ito T Yamaguchi N Ito T Shirai 1998 The 1.5 GHz electromagnetic near-field used for cellular phones does not promote rat liver carcinogenesis in a mediumterm liver bioassay Jpn J Cancer Res 89 995
52. WR Adey CV Byus CD Cain RJ Higgins RA Jones CJ Kean N Kuster A MacMurray RB Stagg G Zimmerman JL Phillips W Haggren 1999 Spontaneous and nitrosourea-induced primary tumours in Fischer 344 rats chronically exposed to 836 MHz modulated microwaves Radiat Res 152 293
53. RS Malyapa EW Ahern C Bi WL Straube M LaRegina WF Pickard JL Roti Roti 1998 DNA damage in rat brain cells after in vivo exposure to 2450 MHz electromagnetic radiation and various methods of euthanasia Radiat Res 149 637
54. C Oysu M Topak O Celik HB Yilmaz AA Sahin 2005 Effects of the acute exposure to the electromagnetic field of mobile phones on human auditory brainstem responses Eur Arch Otorhinolaryngo 262 10 839 843
55. O Ozturan T Erdem MC Miman MT Kalcioglu S Oncel 2002 Effects of the electromagnetic field of mobile telephones on hearing Acta Otolaryngol 122 3 289
56. A Noritoshi E Hiroyuki O Shingo Y Kaoru K Yoshitsugu U Yoshikazu 2003 Thirty minutes mobile phone use has no short-term adverse effects on central auditory pathways Clin Neurophysiol 114 8 1390 1394
57. SA Counter 1993 Neurobiological effects of extensive transcranial electromagnetic stimulation in an animal model Electroencephalogr Clin Neurophysiol Evoked Potentials Sect 89 5 341 348
58. L Kellenyi G Thuroczy B Faludy L Lenard 1999 Effects of mobile GSM radiotelephone exposure on the auditory brainstem response (ABR) Neurobiology 7 79 81
59. FJ Garcia Callejo F Garcia Callejo J Pena Santamaria I Alonso Castaneira E Sebastian Gil J Marco Algarra 2005 Hearing level and intensive use of mobile phones Acta Otorrinolaringol Esp 56 5 187 191
60. V Kerekhanjanarong P Supiyaphun J Naratricoon P Laungpitackchumpon 2005 The effect of mobile phone to audiologic system J Med Assoc Thai 88 Suppl 4 S231 S234
61. MF Oktay S Dasdag 2006 Effects of intensive and moderate cellular phone use on hearing function Electromagn Biol Med 25 1 13 21
62. HC Davidson ME Lutman 2007 Survey of mobile phone use and their chronic effects on the hearing of a student population Int J Audiol 46 3 113 118
63. HW Pau U Sievert S Eggert W Wild 2005 Can electromagnetic field emitted by mobile phones stimulate the vestibular organ? Otolaryngol Head Neck Surg 132 1 43 9
64. U Sievert S Eggert HW Pau 2005 Can mobile phone emissions affect auditory functions of cochlea or brain stem? Otolaryngol Head Neck Surg 132 451 455
65. GM Van Leeuewen JJ Lagendijk BJ Van Leersum 1999 Calculation of change in brain temperatures due to exposure to a mobile phone Phys Med Biol 44 2367 2379
66. AL Mausset-Bonnefont H Hirbec X Bonnefont A Privat J Vignon R de Sèze 2004 Acute exposure to GSM 900-MHz electromagnetic fields induces glial reactivity and biochemical modifications in the rat brain Neurobiol Dis 17 3 445 454
67. E Brillaud A Piotrowski R de Seze 2007 Effect of an acute 900 MHz GSM exposure on glia in the rat brain: a time-dependent study Toxicology 238 1 23 33
68. Q Wang ZJ Cao XT Bai 2005 Effect of 900 MHz electromagnetic fields on the expression of GABA receptor of cerebral cortical neurons in postnatal rats Wei Sheng Yan Jiu 34 5 546 548
69. S Xu W Ning Z Xu S Zhou H Chiang J Luo 2006 Chronic exposure to GSM 1800-MHz microwaves reduces excitatory synaptic activity in cultured hippocampal neurons Neurosci Lett 398 253 257
70. E Lopez-Martin JL Relova-Quinteiro R Gallego-Gomez M Peleteiro-Fernandez FJ Jorge-Barreiro FJ Ares-Pena 2006 GSM radiation triggers seizures and increases cerebral c-Fos positivity in rats pretreated with subconvulsive doses of picrotoxin Neurosci Lett 398 139 144
71. Kolomytkin O, Yurinska M, Zharikov S, Kuznetsov V, Zharikova A (1994) Response of brain receptor systems to microwave energy exposure. In: Frey AH (ed) On the nature of electromagnetic field interactions with biological systems. R.G. Landes, Austin, pp 195-206
72. Yasser M Moustafa RM Moustafa A Belacy SH Abou-El-Ela FM Ali 2001 Effects of acute exposure to the radiofrequency fields of cellular phones on plasma lipid peroxide and antioxidase activities in human erythrocytes J Pharm Biomed Anal 26 4 605 608
73. S Pacini M Ruggiero I Sardi S Aterini F Gulisano M Gulisano 2002 Exposure to global system for mobile communication (GSM) cellular phone radiofrequency alters gene expression, proliferation and morphology of human skin fibroblasts Oncol Res 13 19 24
74. R Sattler M Tymianski 2000 Molecular mechanisms of calcium-dependent excitotoxicity J Mol Med 78 3 13
75. PW French R Penny JA Laurence DR McKenzie 2001 Mobile phones, heat shock proteins and cancer Differentiation 67 93 97
76. D Leszczynski S Joenvaara J Reivinen R Kuokka 2002 Non thermal activation of the hsp27/p38MAPK stress pathway by mobile phone radiation in human endothelial cells: modecular mechanism for cancer and blood-brain barrier-related effects Differentiation 70 120 129
77. WJ Koroshetz JV Bonventre 1994 Heat shock response in the central nervous system Experientia 50 1085 1091
78. SL Arber JC Lin 1984 Microwave enhancement of membrane conductance: effect of EDTA, caffeine and tetracaine Physiol Chem Phys Med NMR 16 469
79. SL Arber JC Lin 1985 Microwave induced changes in nerve cells: effects of modulation and temperature Bioelectromagnetics 6 257
80. DI McRee H Wachtel 1980 The effects of microwave radiation on the vitality of isolated frog sciatic nerves Radiat Res 82 536
81. RL Seaman H Wachtel 1978 Slow and rapid responses to CW and pulsed microwave radiation by individual Aplysia pacemakers J Microwave Power 13 77
82. H Wachtel R Seaman W Joines 1975 Effects of low-intensity microwaves on isolated neurons Ann N Y Acad Sci 247 46
83. CR Gandhi DH Ross 1989 Microwave induced stimulation of 32P incorporation into phosphoinotides of rat brain synaptosomes Radiat Environ Biophys 28 223
84. F Ferreri G Curcio P Pasqualetti L De Gennaro R Fini PM Rossini 2006 Mobile phone emissions and human brain excitability Ann Neurol 60 188 196
85. CM Krause CH Bjornberg M Pesonen A Hulten T Liesivuori M Koivisto A Revonsuo M Laine H Hamalainen 2006 Mobile phone effects on children's event-related oscillatory EEG during an auditory memory task Int J Radiat Biol 82 6 443 450
86. CC Papageorgiou ED Nanou VG Tsiafakis E Kapareliotis KA Kontoangelos CN Capsalis AD Rabavilas CR Soldatos 2006 Acute mobile phone effects on pre-attentive operation Neurosci Lett 397 99 103
87. K Yuasa N Arai S Okabe Y Tarusawa T Nojima R Hanajima Y Terao Y Ugawa 2006 Effects of thirty minutes mobile phone use on the human sensory cortex Clin Neurophysiol 117 900 905
88. CM Krause M Pesonen C Haarala Bjornberg H Hamalainen 2007 Effects of pulsed and continuous wave 902 MHz mobile phone exposure on brain oscillatory activity during cognitive processing Bioelectromagnetics 28 296 308
89. F Vecchio C Babiloni F Ferreri G Curcio R Fini C Del Percio PM Rossini 2007 Mobile phone emission modulates interhemispheric functional coupling of EEG alpha rhythms Eur J Neurosci 25 6 1908 1913
90. CS Hung C Anderson JA Horne P McEvoy 2007 Mobile phone 'talk-mode' signal delays EEG determined sleep onset Neurosci Lett 421 1 82 86
91. JE Muscat M Hinsvark M Malkin 2006 Mobile telephones and rates of brain cancer Neuroepidemiology 27 1 55 56
92. JE Muscat MG Maklin RE Shire 2002 Handheld cellular telephones and risk of acoustic neuroma Neurology 58 1304 1306