Exposure to Global System for Mobile Communication (GSM) Cellular Phone Radiofrequency Alters Gene Expression, Proliferation, and Morphology of Human Skin Fibroblasts

Oncology Research

Volumn 13, Issue 1, 2002, Pages 19-24

  Pacini, Stefania ^a   Ruggiero, Marco ^a,b   Sardi, Iacopo ^a   Aterini, Stefano ^a   Gulisano, Franca ^a   Gulisano, Massimo ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b Dept of Exp Pathology and Oncology ^*  (Italy)

Author keywords

Cell growth; Cellular phone; Gene expression; Nonionizing radiation

Indexed keywords

CYCLINE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BAX; TRANSFORMING GROWTH FACTOR BETA;

APOPTOSIS; ARTICLE; CELL CYCLE G2 PHASE; CELL GROWTH; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; ELECTROMAGNETIC FIELD; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; MASS COMMUNICATION; MITOGENICITY; MITOSIS; MOBILE PHONE; PRIORITY JOURNAL; RADIATION; RADIOFREQUENCY; SIGNAL TRANSDUCTION; SKIN FIBROBLAST; CELL CYCLE; CELL DIVISION; CELL LINE; CYTOLOGY; FIBROBLAST; GENE EXPRESSION REGULATION; RADIATION EXPOSURE; RADIOFREQUENCY RADIATION; SCANNING ELECTRON MICROSCOPY; SKIN; ULTRASTRUCTURE;

CELL CYCLE; CELL DIVISION; CELL LINE; CELLULAR PHONE; FIBROBLASTS; GENE EXPRESSION REGULATION; HUMANS; MICROSCOPY, ELECTRON, SCANNING; RADIO WAVES; SKIN;

EID: 0036362840     PISSN: 09650407     EISSN: None     Source Type: Journal    
DOI: 10.3727/096504002108747926     Document Type: Article

References (12)

1. Fritze, K.; Wiessner, C.; Kuster, N.; Sommer, C.; Gass, P.; Hermann, D. M.; Kiessling, M.; Hossmann, K. A. Effect of global system for mobile communication microwave exposure on the genomic response of the rat brain. Neuroscience 81:627-639; 1997.
2. Goswami, P. C.; Albee, L. D.; Parsian, A. J.; Baty, J. D.; Moros, E. G.; Pickard, W. F.; Roti Roti, J. L.; Hunt, C. R. Proto-oncogene mRNA levels and activities of multiple transcription factors in C3H 10T 1/2/ murine embryonic fibroblasts exposed to 835.62 and 847.74 MHz cellular phone communication frequency radiation. Radiat. Res. 151:300-309; 1999.
3. Ivaschuk, O. I.; Jones, R. A.; Ishida-Jones, T.; Haggren, W.; Adey, W. R.; Phillips, J. L. Exposure of nerve growth factor-treated PC12 rat pheochromocytoma cells to a modulated radiofrequency field at 836.55 MHz: Effects on c-jun and c-fos expression. Bioelectromagnetics 18:223-229; 1997.
4. Malyapa, R. S.; Ahern, E. W.; Straube, W. L.; Moros, E. G.; Pickard, W. F.; Roti Roti, J. L. Measurement of DNA damage after exposure to electromagnetic radiation in the cellular phone communication frequency band (835.62 and 847.74 MHz). Radiat Res. 148:618-627; 1997.
5. Morrissey, J. J.; Raney, S.; Heasley, E.; Rathinavelu, P.; Dauphinee, M. ; Fallon, J. H. Iridium exposure increases c-fos expression in the mouse brain only at levels which likely result in tissue heating. Neuroscience 92: 1539-1546; 1999.
6. Butler, M. The characteristics and growth of cultured cells. In: Butler M., ed. Mammalian cells biotechnology. A practical approach. New York: Oxford University Press; 1991:1-25.
7. Zhao, Y. L.; Johnson, P. G.; Jahreis, G. P.; Hui, S. W. Increased DNA synthesis in INIT/10T1/2 cells after exposure to a 60 Hz magnetic field: A magnetic field or a thermal effect? Radiat. Res. 151:201-208; 1999.
8. Pacini, S.; Aterini, S.; Ruggiero, C.; Pacini, P.; Gulisano, M.; Ruggiero, M. Influence of static magnetic field on the antiproliferative effect of vitamin D on human breast cancer cells. Oncol. Res. 11:265-271; 1999.
9. Ruggiero, M.; Casamassima, F.; Magnelli, L.; Pacini, S.; Pierce, J. H.; Greenberger, J. S.; Chiarugi, V. P. Mitogenic signal transduction: A common target for oncogenes that induce resistance to ionizing radiations. Biochem. Biophys. Res. Commun. 183:652-658; 1992.
10. Ruggiero, M.; Wang, M. L.; Pierce, J. H. Mitogenic signal transduction in normal and transformed 32D hematopoietic cells. FEBS Lett. 291:203-207; 1991.
11. Gulisano, M.; Pacini, S.; Ruggiero, M.; Pacini, A.; Delrio, A. N.; Pacini, P. In vitro effects of some differentiation inductors in metaplastic epithelium of the human nasal cavity. Cell Tissue Res. 285:119-125; 1996.
12. Lau, W.; Lai, P. B.; Leung, M. F.; Leung, B. C.; Wong, N.; Chen, G.; Leung, T. W.; Liew, C. T. Differential gene expression of hepatocellular carcinoma using cDNA microarray analysis. Oncol. Res. 12:59-69; 2000.