Genotoxicity of radiofrequency radiation

Environmental and Molecular Mutagenesis

Volumn 32, Issue 1, 1998, Pages 1-16

  Brusick, David ^a   Albertini, Richard ^a   McRee, Donald ^a   Peterson, Donald ^a   Williams, Gary ^a   Hanawalt, Phillip ^a   Preston, Julian ^a  

^a UK   (United States)

Author keywords

Aberrations; Genotoxicity; Microwave; Mutation; Radiowave

Indexed keywords

CHO CELL; CHROMOSOME ABERRATION; DATA BASE; DNA DAMAGE; DROSOPHILA MELANOGASTER; GENE MUTATION; GENOTOXICITY; MICROWAVE RADIATION; NONHUMAN; REVIEW; SALMONELLA TYPHIMURIUM; SISTER CHROMATID EXCHANGE;

DROSOPHILA MELANOGASTER; MELANOGASTER; SALMONELLA TYPHIMURIUM; TYPHIMURIUM;

EID: 0031927718     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2280(1998)32:1<1::AID-EM1>3.0.CO;2-Q     Document Type: Review

References (88)

1. Alam MT, Barthakur N, Lambert NC, Kasatiya SS (1978):Cytological effects of microwave radiation in Chinese hamster cells in vitro. Can J Genet Cytol 20:23-30.
2. Anderstem B, Hamnerius Y, Hussain S, Ehrenberg L (1983):Studies of possible genetic effects in bacteria of high frequency electromagnetic fields. Hereditas 98:11-32.
3. Asanami S, Shimono K (1997):High body temperature induces micronuclei in mouse bone marrow. Mutat Res 390:79-83.
4. Averbeck D, Dardalhon M, Berteaud AJ (1976):Microwaves action in procaryotic and eukaryotic cells and a possible interaction with X-rays. J Microw Power 11:143-144.
5. Balcer-Kubiczek EK, Harrison GH (1985):Evidence for microwave carcinogenesis in vitro. Carcinogenesis 6:859-864.
6. Balcer-Kubiczek EK, Harrison GH (1989):Induction of neoplastic transformation in C3H/10T 1/2 cells by 2.45-GHz microwaves and phorbol ester. Radiat Res 117:531-537.
7. Balcer-Kubiczek EK, Harrison GH (1991):Neoplastic transformation of C3H/10T 1/2 cells following exposure to 120-Hz modulated 2.45-GHz microwaves and phorbol ester tumor promoter. Radial Res 126:65-72.
8. Banerjee R, Goldfeder A, Mitra J (1983):Sister chromatid exchanges and chromosome aberrations induced by radio sensitizing agents in bone marrow cells of treated tumor-bearing mice. JNCI 70:517-521.
9. Baranski S, Debiec H, Kwarecki K, Mezykowski T (1976):Influence of microwaves on genetical processes of Aspergillus nidulans. J Microw Power 11:146-147.
10. Beechey CV, Brooker D, Kowalczuk CI, Saunders RD, Searle AG (1986):Cytogenic effects of microwave irradiation on male germ cells of the mouse. Int J Radiat Biol 50:909-918.
11. Berman E, Carter HB, House D (1980):Tests for mutagenesis and reproduction in male rats exposed to 2,450-MHz (CW) microwaves. Bioelectromagnetics 1:65-76.
12. Berteaud AJ, Dardalhon M, Rebcyrotte N, Averbeck DM (1975):Action d'un rayonnement electromagnetique a longueur d'onde millimetrique sur la croissance bacterienne (Effect of an electromagnetic microwave radiation on the growth of bacteria).
13. Blackman CF, Surles MC, Benane SG (1976):The effect of microwave exposure on bacteria:Mutation induction. In Johnson CC, Shore M (eds):"Biological Effects of Electromagnetic Waves." Washington, DC:US Food and Drug Administration (FDA), (USNC/URSI Annual Meeting - Selected Papers, Oct. 20-23, 1975, Boulder, CO) Vol. 1:406-413.
14. Blevins RD, Crenshaw RC, Houghland AE, Clark CE (1980):The effects of microwave radiation and heat on specific mutants of Salmonella typhimurium LT2. Radiat Res 82:511-517.
15. Brown RF, Marshall SV (1982):Sister chromatid exchange in marrow cells of mice exposed to RFR (400, 800, and 1200 MhzCW) (meeting abstract). In Bioelectromagnetics Society (BEMS):"4th Bioelectromagnetics Society Annual Meeting - Abstracts." Los Angeles, June 28 - July 2, 1982, p 51, Abstr. No. G31.
16. Brusick DJ (1994):An assessment of the genetic toxicity of atrazine:Relevance to human health and environmental effects. Mutat Res 317-144.
17. Cain et al. (1997):Bioelectromagnetics 18:237-243.
18. Cairnie AB, Harding RK (1981):Cytological studies in mouse testis irradiated with 2.45-GHz continuous-wave microwaves. Radiat Res 87:100-108.
19. Chen KM, Samuel A, Hoopingarner R (1974):Chromosomal aberrations of living cells induced by microwave radiation. Environ Lett 6:37-46.
20. Ciaravino V, Meltz ML, Erwin DN (1987):Effects of radiofrequency radiation and simultaneous exposure with mitomycin C on the frequency of sister chromatid exchanges in Chinese hamster ovary cells. Environ Mutagen 9:393-399.
21. Ciaravino V, Meltz, ML, Erwin DN (1991):Absence of a synergistic effect between moderate-power radio-frequency electromagnetic radiation and adriamycin on cell-cycle progression and sister-chromatid exchange. Bioelectromagnetics 12:289-298.
22. Cleary SF, Liu LM, Merchant RE (1990):Glioma proliferation modulated in vitro by isothermal radiofrequency radiation exposure. Radiat Res 121:38-45.
23. Comptes Rendus Hebdomadaires des Seances de l'Academe des Sciences (Ser D -Sciences Naturelles) 281(21):43-846.
24. Corelli JC, Gutmann RJ, Kohazi S, Levy J (1977):Effects of 2.6-4.0 Ghz microwave radiation on E-coli B. J Microw 12:141-144.
25. Dardalon M, Averbeck D, Berteaud AJ (1981):Studies on possible genetic effects of microwaves in procaryotic and eukaryotic cells. Radiat Environ Biophys 20:37-51.
26. Dutta SK, Nelson WH (1978):Lack of generic effects of short duration low power density 2.45 GHz CW and 8.5-9.6 GHz pulsed electromagnetic radiation on selected microbial tester strains. Environ Mutagen Soc - Ann Meet Program Abstr 9th:69-70.
27. Dutta SK, Nelson WH, Blackmun CF, Brusick DJ (1978):Effects of chronic non-thermal exposures of pulsed microwaves on a repair-deficient mutant of Escherichia coli. Mutat Res 53:91-92.
28. Dutta SK, Nelson WH, Blackman CF, Brusick DJ (1979a):Lack of microbial genetic response to 2.45-GHz CW and 8.5- to 9.6-GHz pulsed microwaves. J Microw Power 14:275-280.
29. Dutta SK, Hossain MA, Ho HS, Blackman CF (1979b):Effects of 8.6-GHx pulsed electromagnetic radiation on an Escherichia coli repair-deficient mutant. In Stuchly SS (ed):"Electromagnetic Fields in Biological Systems." Edmonton, AB:IMPI Ltd., (Symposium, June 28-39, 1978, Ottawa, ON) pp 76-95.
30. Elmer-Dewit P (1993):Dialing "P" for Panic. Time, February 8:42.
31. Garaj-Vrhovac V, Horvat D, Koren Z (1990a):The effect of microwave radiation on the cell genome. Mutat Res 243:87-93.
32. Garaj-Vrhovac V, Fucic A, Horvat D (1990b):Comparison of chromosome aberration and micronucleus induction in human lymphocytes after occupational exposure to vinyl chloride monomer and microwave radiation. Periodicum Biologorium 92:411-416.
33. Garaj-Vrhovac V, Horvat D, Koren Z (1991):The relationship between colony-forming ability, chromosome aberrations and incidence of micronuclei in V79 Chinese hamster cells exposed to microwave radiation. Mutat Res 263:143-149.
34. Garaj-Vrhovac V, Fucic A, Horvat D (1992):The correlation between the frequency of micronuclei and specific chromosome aberrations in human lymphocytes exposed to microwave radiation in vitro. Mutat Res 281:181-186.
35. Carson OM, McRobert TL, Campbell LJ, Hocking BA, Gordon I (1991):A chromosomal study of workers with long-term exposure to radiofrequency radiation. Med J Aust 155:289-292.
36. Goud SN, Usha Rani MV, Reddy PP, Reddi OS, Rao MS, Saxena VK (1982):Genetic effects of microwave radiation in mice. Mutat Res 103:39-42.
37. Haider T, Knasmueller S, Kundi M, Haider M (1994):Clastogenic effects of radiofrequency radiations on chromosomes of Tradescantia. Mutat Res 324:65-68.
38. Hamnerius Y, Olofsson H, Rasmuson A, Rasmuson B (1979):A negative test for mutagenic action of microwave radiation in Drosophila melanogaster. Mutat Res 68:217-224.
39. Humnerius Y, Rasmuson A, Rasmuson B (1985):Biological effects of high-frequency electromagnetic fields on Salmonella typhimurium and Drosophila melanogaster. Bioelectromagnetics 6:405-414.
40. Huang AT, Engle ME, Elder JA, Kinn JB, Ward TR (1977):The effect of microwave radiation (2450 MHz) on the morphology and chromosomes of lymphocytes. Radio Sci 12:173-177.
41. Ivasvhuk et al. (1997):Bioelectromagnetics 18:223-229.
42. Janes ED, Leach WM, Mills WA, Moore RT, Shore ML (1969):Effects of 2450 MHz, microwaves on protein synthesis and on chromosomes in Chinese hamsters. Non-Ionizing Radiat 1:125-130.
43. Kerbacher JJ, Meltz ML, Erwin DN (1990):Influence of radiofrequency radiation on chromosome aberrations in CHO cells and its interaction with DNA-damaging agents. Radiat Res 123:311-319.
44. Khalil AM, Qassem WF, Suleiman MM (1993):A preliminary study on the radiofrequency field-induced cytogenetic effects in cultured human lymphocytes, Dirasat 20:121-130.
45. Kirkland DJ, Dean SW (1994):On the need for confirmation of negative genotoxicity results in vitro and on the usefulness of mammalian cell mutation tests in a core battery:Experiences of a contract research laboratory. Mutagenesis 9:491-501.
46. Lai H, Singh NP (1995):Acute low-intensity microwave exposure increases DNA single-strand breaks in rat brain cells. Bioelectromagnetics (in press).
47. Leonard A, Berteaud AJ, Bruyere A (1983):An evaluation of the mutagenic, carcinogenic and teratogenic potential of microwaves. Mutat Res 123:31-46.
48. Lloyd DC, Saunders RD, Finnon P, Kowalczuk CI (1984):No clastogenic effect from in vitro microwave irradiation of Go human lymphocytes. Int J Radiat Biol 46:135-141.
49. Lloyd DC, Saunders DC, Moquet JE, Kowalczuk CI (1986):Absence of chromosomal damage in human lymphocytes exposed to microwave radiation with hyperthermia. Bioelectromagnetics 7:235-237.
50. Maes A, Verschaeve L, Arroyo A, de Wagter C, Vercruyssen L (1993):In vitro cytogenetic effects of 2450 MHz waves on human peripheral blood lymphocytes. Bioelectromagnetics 14:495-501.
51. Maes A, Collier M, Slaets D, Verschaeve L (1995):Cytogenetic effects of microwaves from mobile communication frequencies (954 MHz). Electro Magnetobiol 14:91-98.
52. Manikowska E, Luciani JM, Servantie B, Czerski P, Obrenovitch J, Stahl A (1979):Effects of 9.4 GHz microwave exposure on meiosis in mice. Experientia 35:388-390.
53. Manikowska-Czerska E, Czerski P, Leach WM (1985):Effects of 2.45 GHz microwaves on meiotic chromosomes of male CBA/CAY mice. J Hered 76:71-73.
54. Marec F, Ondracek J, Brunnhofer V (1985):The effect of repeated microwave irradiation on the frequency of sex-linked recessive lethal mutations in Drosophila melanogaster. Mutat Res 157:163-167.
55. McKelvey-Martin VJ, Green MHL, Schmezer P, Pool-Zobel BL, De Meo MP, Collins A (1993):The single cell gel electrophoresis assay (comet assay):A European review. Mutat Res 288:47-63.
56. McLees BD, Finch ED, Albright ML (1972):An examination of regenerating hepatic tissue subjected to radio-frequency irradiation. J Appl Physiol 32:78-85.
57. McRee DI, MacNichols G, Livingston GK (1981):Incidence of sister chromatid exchange in bone marrow cells of the mouse following microwave exposure. Radiat Res 85:340-348.
58. Meltz ML, Walker KA, Erwin DN (1987):Radiofrequency (microwave) radiation exposure of mammalian cells during UV-induced DNA repair synthesis. Radiat Res 110:255-266.
59. Meltz ML, Eagan P, Erwin DN (1989):Absence of mutagenic interaction between microwaves and mitomycin C in mammalian cells. Environ Mol Mutagen 13:294-303.
60. Meltz ML, Eagan P, Erwin DN (1990a):Proflavin and microwave radiation:Absence of a mutagenic interaction. Bioelectromagnetics 11:149-157.
61. Meltz ML, Holahan PK, Smith ST, Kerbacher JJ, Ciaravino V (1990b):Interaction of inoning radiation, genetically active chemicals, and radiofrequency radiation in human and rodent cells. Department of Radiology, University of Texas Health Science Center. USAF-SAM-TR-90-18.
62. Mezykowski T, Bal J, Debiec H, Kwarecki K (1980):Response of Aspergillus nidulans and Physarium polycephalum in microwave irradiation. J Microw Power 15:75-80.
63. Mittler S (1975):Non-thermal radio waves and genetic damage in Drosophila melanogaster. Mutat Res 31:316.
64. Mittler S (1976):Failure of 2- and 10-meter radio waves to induce genetic damage in Drosophila melanogaster. Environ Res 11:326-330.
65. Mittler S (1977):Failure of chronic exposure to nonthermal FM radio waves to mutate Drosophila. J Hered 68:257-258.
66. Pay TL, Beyer EC, Reichelderfer CF (1972):Microwave effects on reproductive capacity and genetic transmission in Drosophila melanogaster. J Microw Power 14:275-280.
67. Repacholi MH, Basten A, Gebski V, Noonan D, Finnie J, Harris AW, (1997):Lymphomas in Eu-pim 1 transgenic mice exposed to pulsed 900 Mhz electromagnetic fields. Radiat Res 147:631-640.
68. Roti, Roti et al. (1996):Bioelectromagnetics Society, 18th Annual Meeting, Victoria British Columbia, June 9-14, Abstract.
69. Sagripanti J-L, Swicord ML (1986):DNA structural changes caused by microwave radiation. Int J Radiat Biol 50:47-50.
70. Salford LG, Brun A, Persson BR, Eberhardt J (1993):Experimental studies of brain tumor development during exposure to continuous and pulsed 915 MHz radiofrequency radiation. Bioelectrochem Bioenerg 30:313-318.
71. Sarkar S, Ali S, Behari J (1994):Effect of low power microwave on the mouse genome:A direct DNA analysis. Mutat Res 320:141-147.
72. Saunders RD, Darby SC, Kowalczuk CI (1983):Dominant lethal studies in male mice after exposure to 2.45 GHz microwave radiation. Mutat Res 117:345-356.
73. Saunders RD, Kowalczuk CI, Beechey CV, Dunford R (1988):Studies of the induction of dominant lethals and translocations in male mice after chronic exposure to microwave radiation. Int J Radiat Biol 53:983-992.
74. Shelby MD, Erexson GL, Hook GJ, Tice RR (1993):Evaluation of a three-exposure mouse bone marrow micronucleus protocol:Results with 49 chemicals. Environ Mol Mutagen 21:160-179.
75. Stagg et al (1997):Bioelectromagnetics 18:230-231.
76. Swicord ML, Czerski P (1984):Strong interactions of radiofrequency fields with nucleic acids. In Adey WR, Lawrence AF (eds):"Nonlinear Electrodynamics in Biological Systems." New York:Plenum Press, pp 36-57.
77. Szmigielski S, Szudezenki A, Pietraszek A, Bielec B, Janiak M, Wrembel JK (1982):Accelerated development of spontaneous and benzopyrene-induced skin cancer in mice exposed to 2450 MHz microwave radiation. Bioelectromagnetics 3:179-191.
78. Varma MM, Traboulay EA Jr (1976):Evaluation of dominant lethal test and DNA studies in measuring mutagenicity caused by non-ionizing radiation. In Johnson CC, Shore M (eds):"Biological Effects of Electromagnetic Waves." Washington, DC:US Food and Drug Administration (PDA), (USNC/URSI Annual Meeting - Selected Papers, Oct. 20-23, 1975, Boulder, CO) Vol. 1:386-396.
79. Varma MM, Traboulay EA (1977):Comparison of native and microwave irradiated DNA. Experientia 33:1649-1650.
80. Varma MM, Dage EL, Joshi SR (1976):Mutagenicity induced by non-ionizing radiation in swiss male mice. In Johnson CC, Shore M (eds):"Biological Effects of Electromagnetic Waves." Washington, DC:US Food and Drug Administration (PDA), (USNC/URSI Annual Meeting - Selected Papers, Oct. 20-23, 1975, Boulder, CO) Vol. 1:397-405.
81. Verschaeve L, Slaets D, Van Gorp U, Maes A, Vankerkom L (1998):In vitro and in vivo genetic effects of microwaves form mobile telephone frequencies in human and rat peripheral blood lymphocytes. In press.
82. WHO (1993):"Environmental Health Criteria 137:Electromagnetic Fields (300 Hz to 300 GHz)." Geneva:World Health Organization, pp 80-180.
83. Wolff S, James TL, Young GB, Margulis AR, Bodycote J, Afzal V (1985):Magnetic resonance imaging:Absence of in vitro cytogenic damage. JN Radiol 155:163-165.
84. Wu RY, Ghiang H, Shao BJ (1989):The effects of 2.54 GHz radiation on DMH-induced colon cancer in mice (meeting abstract). In Bioelectromagnetics Society (BEMS):"11th Bioelectromagnetics Society Annual Meeting - Abstracts." Tucson, AZ:June 18-22, 1989, Abstr. No. P-2-34.
85. Yao KTS (1976):Cytogenetic consequences of microwave incubation of mammalian cells in culture. Genetics 83:S84.
86. Yao KT (1978):Microwave radiation-induced chromosomal aberrations in corneal epithelium of Chinese hamsters. J Hered 69:409-412.
87. Yao KTS (1982):Cytogenic consequences of microwave irradiation on mammalian cells incubated in vitro. J Hered 73:133-138.
88. Yao KTS, Jiles MM (1970):Effects of 2450 MHz microwave radiation on cultivated rat kangaroo cells. In Cleary SF (ed):"Biological Effects and Health Implications of Microwave Radiation." Medical College of Virginia Symposium - Proceedings, 1969, pp 123-133. Department of Health, Education, and Welfare, US (DHEW), Public Health Service, Environmental Health Service, Bureau of Radiology.