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Volumn 86, Issue 9, 2008, Pages 2071-2082

Advanced glycation end products induce in vitro cross-linking of α-synuclein and accelerate the process of intracellular inclusion body formation

Author keywords

synuclein; AGEs; Lewy bodies; Parkinson's disease

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ALPHA SYNUCLEIN; RECOMBINANT PROTEIN; ROTENONE;

EID: 48249103154     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21644     Document Type: Article
Times cited : (80)

References (77)
  • 1
    • 0036468432 scopus 로고    scopus 로고
    • Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease
    • Auluck PK, Chan HYE, Trojanowski JQ, Lee VMY, Bonini NM. 2002. Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease. Science 295:865-868.
    • (2002) Science , vol.295 , pp. 865-868
    • Auluck, P.K.1    Chan, H.Y.E.2    Trojanowski, J.Q.3    Lee, V.M.Y.4    Bonini, N.M.5
  • 2
    • 4544341125 scopus 로고    scopus 로고
    • The journey: Parkinson's disease
    • Baker MG, Graham L. 2004. The journey: Parkinson's disease. Br Med J 329:611-614.
    • (2004) Br Med J , vol.329 , pp. 611-614
    • Baker, M.G.1    Graham, L.2
  • 6
    • 0022519244 scopus 로고
    • Uptake and accumulation of the vital dye hydroethidine in neoplastic cells
    • Bucana C, Saiki I, Nayar R. 1986. Uptake and accumulation of the vital dye hydroethidine in neoplastic cells. J Histochem Cytochem 34:1109-1115.
    • (1986) J Histochem Cytochem , vol.34 , pp. 1109-1115
    • Bucana, C.1    Saiki, I.2    Nayar, R.3
  • 7
    • 0032703915 scopus 로고    scopus 로고
    • Alpha-synuclein and Parkinson's disease
    • Burke RE. 1999. Alpha-synuclein and Parkinson's disease. Brain Res Bull 50:465-466.
    • (1999) Brain Res Bull , vol.50 , pp. 465-466
    • Burke, R.E.1
  • 8
    • 0032102455 scopus 로고    scopus 로고
    • The synucleins: A family of proteins involved in synaptic function, plasticity, neurodegeneration and disease
    • Clayton DF, George JM. 1998. The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease. Trends Neurosci 21:249-254.
    • (1998) Trends Neurosci , vol.21 , pp. 249-254
    • Clayton, D.F.1    George, J.M.2
  • 9
    • 0033215063 scopus 로고    scopus 로고
    • Synucleins in synaptic plasticity and neurodegenerative disorders
    • Clayton DF, George JM. 1999. Synucleins in synaptic plasticity and neurodegenerative disorders. J Neurosci Res 58:120-129.
    • (1999) J Neurosci Res , vol.58 , pp. 120-129
    • Clayton, D.F.1    George, J.M.2
  • 11
    • 34247359088 scopus 로고    scopus 로고
    • Methylglyoxal impairs glucose metabolism and leads to energy depletion in neuronal cells - protection by carbonyl scavengers
    • de Arriba SG, Stuchbury G, Yarin J, Burnell J, Loske C, Munch G. 2007. Methylglyoxal impairs glucose metabolism and leads to energy depletion in neuronal cells - protection by carbonyl scavengers. Neurobiol Aging 28:1044-1050.
    • (2007) Neurobiol Aging , vol.28 , pp. 1044-1050
    • de Arriba, S.G.1    Stuchbury, G.2    Yarin, J.3    Burnell, J.4    Loske, C.5    Munch, G.6
  • 13
    • 0032573597 scopus 로고    scopus 로고
    • Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments
    • El-Agnaf OM, Jakes R, Curran MD, Middleton D, Ingenito R, Bianchi E, Pessi A, Neill D, Wallace A. 1998. Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments. FEBS Lett 440:71-75.
    • (1998) FEBS Lett , vol.440 , pp. 71-75
    • El-Agnaf, O.M.1    Jakes, R.2    Curran, M.D.3    Middleton, D.4    Ingenito, R.5    Bianchi, E.6    Pessi, A.7    Neill, D.8    Wallace, A.9
  • 14
    • 0034704752 scopus 로고    scopus 로고
    • A Drosophila model of Parkinson's disease
    • Feany MB, Bender WW. 2000. A Drosophila model of Parkinson's disease. Nature 404:394-398.
    • (2000) Nature , vol.404 , pp. 394-398
    • Feany, M.B.1    Bender, W.W.2
  • 15
    • 0034017710 scopus 로고    scopus 로고
    • Alpha-synuclein and Parkinson's disease: Selective neurodegenerative effect of alpha-synuclein fragment on dopaminergic neurons in vitro and in vivo
    • Forloni G, Bertani I, Calella AM, Thaler F, Invernizzi R. 2000. Alpha-synuclein and Parkinson's disease: selective neurodegenerative effect of alpha-synuclein fragment on dopaminergic neurons in vitro and in vivo. Ann Neurol 47:632-640.
    • (2000) Ann Neurol , vol.47 , pp. 632-640
    • Forloni, G.1    Bertani, I.2    Calella, A.M.3    Thaler, F.4    Invernizzi, R.5
  • 16
    • 0029981526 scopus 로고    scopus 로고
    • Neuropathology of Parkinson's disease
    • Forno LS. 1996. Neuropathology of Parkinson's disease. J Neuropathol Exp Neurol 55:259-272.
    • (1996) J Neuropathol Exp Neurol , vol.55 , pp. 259-272
    • Forno, L.S.1
  • 17
    • 0033669319 scopus 로고    scopus 로고
    • In situ and in vitro study of colocalization and segregation of alpha-synuclein, ubiquitin, and lipids in Lewy bodies
    • Gai WP, Yuan HX, Li XQ, Power JT, Blumbergs PC, Jensen PH. 2000. In situ and in vitro study of colocalization and segregation of alpha-synuclein, ubiquitin, and lipids in Lewy bodies. Exp Neurol 166:324-333.
    • (2000) Exp Neurol , vol.166 , pp. 324-333
    • Gai, W.P.1    Yuan, H.X.2    Li, X.Q.3    Power, J.T.4    Blumbergs, P.C.5    Jensen, P.H.6
  • 18
    • 0033583215 scopus 로고    scopus 로고
    • Mutant and wild type human alpha-synucleins assemble into elongated filaments with distinct morphologies in vitro
    • Giasson BI, Uryu K, Trojanowski JQ, Lee VM. 1999. Mutant and wild type human alpha-synucleins assemble into elongated filaments with distinct morphologies in vitro. J Biol Chem 274:7619-7622.
    • (1999) J Biol Chem , vol.274 , pp. 7619-7622
    • Giasson, B.I.1    Uryu, K.2    Trojanowski, J.Q.3    Lee, V.M.4
  • 20
    • 0035951869 scopus 로고    scopus 로고
    • A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly
    • Giasson BI, Murray IV, Trojanowski JQ, Lee VM. 2001. A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly. J Biol Chem 276:2380-2386.
    • (2001) J Biol Chem , vol.276 , pp. 2380-2386
    • Giasson, B.I.1    Murray, I.V.2    Trojanowski, J.Q.3    Lee, V.M.4
  • 21
    • 0343527226 scopus 로고    scopus 로고
    • Alpha-synuclein immunoreactivity in dementia with Lewy bodies: Morphological staging and comparison with ubiquitin immunostaining
    • Gomez-Tortosa E, Newell K, Irizarry MC, Sanders JL, Hyman BT. 2000. Alpha-synuclein immunoreactivity in dementia with Lewy bodies: morphological staging and comparison with ubiquitin immunostaining. Acta Neuropathol 99:352-357.
    • (2000) Acta Neuropathol , vol.99 , pp. 352-357
    • Gomez-Tortosa, E.1    Newell, K.2    Irizarry, M.C.3    Sanders, J.L.4    Hyman, B.T.5
  • 22
    • 0030250041 scopus 로고    scopus 로고
    • Carbon dioxide enhancement of peroxynitrite-mediated protein tyrosine nitration
    • Gow A, Duran D, Thom SR, Ischiropoulos H. 1996. Carbon dioxide enhancement of peroxynitrite-mediated protein tyrosine nitration. Arch Biochem Biophys 333:42-48.
    • (1996) Arch Biochem Biophys , vol.333 , pp. 42-48
    • Gow, A.1    Duran, D.2    Thom, S.R.3    Ischiropoulos, H.4
  • 24
    • 26944477762 scopus 로고    scopus 로고
    • A delivery strategy for rotenone microspheres in an animal model of Parkinson's disease
    • Huang J, Liu H, Gu W, Yan Z, Xu Z, Yang Y, Zhu X, Li Y. 2006. A delivery strategy for rotenone microspheres in an animal model of Parkinson's disease. Biomaterials 27:937-946.
    • (2006) Biomaterials , vol.27 , pp. 937-946
    • Huang, J.1    Liu, H.2    Gu, W.3    Yan, Z.4    Xu, Z.5    Yang, Y.6    Zhu, X.7    Li, Y.8
  • 25
    • 0032147208 scopus 로고    scopus 로고
    • Biological tyrosine nitration: A pathophysiological function of nitric oxide and reactive oxygen species
    • Ischiropoulos H. 1998. Biological tyrosine nitration: a pathophysiological function of nitric oxide and reactive oxygen species. Arch Biochem Biophys 356:1-11.
    • (1998) Arch Biochem Biophys , vol.356 , pp. 1-11
    • Ischiropoulos, H.1
  • 26
    • 0035976959 scopus 로고    scopus 로고
    • Alpha-synuclein affects the MAPK pathway and accelerates cell death
    • Iwata A, Maruyama M, Kanazawa I, Nukina N. 2001. Alpha-synuclein affects the MAPK pathway and accelerates cell death. J Biol Chem 276:45320-45329.
    • (2001) J Biol Chem , vol.276 , pp. 45320-45329
    • Iwata, A.1    Maruyama, M.2    Kanazawa, I.3    Nukina, N.4
  • 27
    • 0031899172 scopus 로고    scopus 로고
    • Oxidative mechanisms in nigral cell death in Parkinson's disease
    • Jenner P. 1998. Oxidative mechanisms in nigral cell death in Parkinson's disease. Mov Disord 13 Suppl 1:24-34.
    • (1998) Mov Disord , vol.13 , Issue.SUPPL. 1 , pp. 24-34
    • Jenner, P.1
  • 29
    • 0037744714 scopus 로고    scopus 로고
    • Lewy body densities in the entorhinal and anterior cingulate cortex predict cognitive deficits in Parkinson's disease
    • Kovari E, Gold G, Herrmann FR, Canuto A, Hof PR, Bouras C, Giannakopoulos P. 2003. Lewy body densities in the entorhinal and anterior cingulate cortex predict cognitive deficits in Parkinson's disease. Acta Neuropathol 106:83-88.
    • (2003) Acta Neuropathol , vol.106 , pp. 83-88
    • Kovari, E.1    Gold, G.2    Herrmann, F.R.3    Canuto, A.4    Hof, P.R.5    Bouras, C.6    Giannakopoulos, P.7
  • 31
    • 1542373544 scopus 로고    scopus 로고
    • Differential effects of "advanced glycation endproducts" and beta-amyloid peptide on glucose utilization and ATP levels in the neuronal cell line SH-SY5Y
    • Kuhla B, Loske C, Garcia De Arriba S, Schinzel R, Huber J, Munch G. 2004. Differential effects of "advanced glycation endproducts" and beta-amyloid peptide on glucose utilization and ATP levels in the neuronal cell line SH-SY5Y. J Neural Transm 111:427-439.
    • (2004) J Neural Transm , vol.111 , pp. 427-439
    • Kuhla, B.1    Loske, C.2    Garcia De Arriba, S.3    Schinzel, R.4    Huber, J.5    Munch, G.6
  • 32
    • 0037173006 scopus 로고    scopus 로고
    • Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53→Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice
    • Lee MK, Stirling W, Xu Y, Xu X, Qui D, Mandir AS, Dawson TM, Copeland NG, Jenkins NA, Price DL. 2002. Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53→Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice. Proc Natl Acad Sci U S A 99:8968-8973.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 8968-8973
    • Lee, M.K.1    Stirling, W.2    Xu, Y.3    Xu, X.4    Qui, D.5    Mandir, A.S.6    Dawson, T.M.7    Copeland, N.G.8    Jenkins, N.A.9    Price, D.L.10
  • 34
    • 0034489853 scopus 로고    scopus 로고
    • Alpha-synuclein and Parkinson's disease
    • Lucking CB, Brice A. 2000. Alpha-synuclein and Parkinson's disease. Cell Mol Life Sci 57:1894-1908.
    • (2000) Cell Mol Life Sci , vol.57 , pp. 1894-1908
    • Lucking, C.B.1    Brice, A.2
  • 35
    • 0034840664 scopus 로고    scopus 로고
    • Involvement of microglial receptor for advanced glycation endproducts (RAGE) in Alzheimer's disease: Identification of a cellular activation mechanism
    • Lue LF, Walker DG, Brachova L, Beach TG, Rogers J, Schmidt AM, Stern DM, Yan SD. 2001. Involvement of microglial receptor for advanced glycation endproducts (RAGE) in Alzheimer's disease: identification of a cellular activation mechanism. Exp Neurol 171:29-45.
    • (2001) Exp Neurol , vol.171 , pp. 29-45
    • Lue, L.F.1    Walker, D.G.2    Brachova, L.3    Beach, T.G.4    Rogers, J.5    Schmidt, A.M.6    Stern, D.M.7    Yan, S.D.8
  • 36
    • 19944424142 scopus 로고    scopus 로고
    • Preventing activation of receptor for advanced glycation endproducts in Alzheimer's disease
    • Lue LF, Yan SD, Stern DM, Walker DG. 2005. Preventing activation of receptor for advanced glycation endproducts in Alzheimer's disease. Curr Drug Targets CNS Neurol Disord 4:249-266.
    • (2005) Curr Drug Targets CNS Neurol Disord , vol.4 , pp. 249-266
    • Lue, L.F.1    Yan, S.D.2    Stern, D.M.3    Walker, D.G.4
  • 38
    • 0037166267 scopus 로고    scopus 로고
    • Biochemical characterization of the core structure of alpha-synuclein filaments
    • Miake H, Mizusawa H, Iwatsubo T, Hasegawa M. 2002. Biochemical characterization of the core structure of alpha-synuclein filaments. J Biol Chem 277:19213-19219.
    • (2002) J Biol Chem , vol.277 , pp. 19213-19219
    • Miake, H.1    Mizusawa, H.2    Iwatsubo, T.3    Hasegawa, M.4
  • 39
    • 0029738444 scopus 로고    scopus 로고
    • The receptor for advanced glycation end products (RAGE) is a central mediator of the interaction of AGE-beta2microglobulin with human mononuclear phagocytes via an oxidant-sensitive pathway. Implications for the pathogenesis of dialysis-related amyloidosis
    • Miyata T, Hori O, Zhang J, Yan SD, Ferran L, Iida Y, Schmidt AM. 1996. The receptor for advanced glycation end products (RAGE) is a central mediator of the interaction of AGE-beta2microglobulin with human mononuclear phagocytes via an oxidant-sensitive pathway. Implications for the pathogenesis of dialysis-related amyloidosis. J Clin Invest 98:1088-1094.
    • (1996) J Clin Invest , vol.98 , pp. 1088-1094
    • Miyata, T.1    Hori, O.2    Zhang, J.3    Yan, S.D.4    Ferran, L.5    Iida, Y.6    Schmidt, A.M.7
  • 40
    • 0032527056 scopus 로고    scopus 로고
    • Advanced glycation endproducts are associated with Hirano bodies in Alzheimer's disease
    • Munch G, Cunningham AM, Riederer P, Braak E. 1998a. Advanced glycation endproducts are associated with Hirano bodies in Alzheimer's disease. Brain Res 796:307-310.
    • (1998) Brain Res , vol.796 , pp. 307-310
    • Munch, G.1    Cunningham, A.M.2    Riederer, P.3    Braak, E.4
  • 41
    • 0031719122 scopus 로고    scopus 로고
    • Advanced glycation end products in neurodegeneration: More than early markers of oxidative stress?
    • Munch G, Gerlach M, Sian J, Wong A, Riederer P. 1998b. Advanced glycation end products in neurodegeneration: more than early markers of oxidative stress? Ann Neurol 44(Suppl 1):S85-S88.
    • (1998) Ann Neurol , vol.44 , Issue.SUPPL. 1
    • Munch, G.1    Gerlach, M.2    Sian, J.3    Wong, A.4    Riederer, P.5
  • 43
    • 0034468706 scopus 로고    scopus 로고
    • Crosslinking of alpha-synuclein by advanced glycation end-products - an early pathophysiological step in Lewy body formation?
    • Munch G, Luth HJ, Wong A, Arendt T, Hirsch E, Ravid R, Riederer P. 2000. Crosslinking of alpha-synuclein by advanced glycation end-products - an early pathophysiological step in Lewy body formation? J Chem Neuroanat 20:253-257.
    • (2000) J Chem Neuroanat , vol.20 , pp. 253-257
    • Munch, G.1    Luth, H.J.2    Wong, A.3    Arendt, T.4    Hirsch, E.5    Ravid, R.6    Riederer, P.7
  • 44
    • 4944267025 scopus 로고    scopus 로고
    • Cross-linking of ubiquitin, HSP27, parkin, and alpha-synuclein by gamma-glutamyl-epsilon-lysine bonds in Alzheimer's neurofibrillary tangles
    • Nemes Z, Devreese B, Steinert PM, Van Beeumen J, Fesus L. 2004. Cross-linking of ubiquitin, HSP27, parkin, and alpha-synuclein by gamma-glutamyl-epsilon-lysine bonds in Alzheimer's neurofibrillary tangles. FASEB J 18:1135-1137.
    • (2004) FASEB J , vol.18 , pp. 1135-1137
    • Nemes, Z.1    Devreese, B.2    Steinert, P.M.3    Van Beeumen, J.4    Fesus, L.5
  • 45
    • 0038711511 scopus 로고    scopus 로고
    • Effects of oxidative and nitrative challenges on alpha-synuclein fibrillogenesis involve distinct mechanisms of protein modifications
    • Norris EH, Giasson BI, Ischiropoulos H, Lee VM. 2003. Effects of oxidative and nitrative challenges on alpha-synuclein fibrillogenesis involve distinct mechanisms of protein modifications. J Biol Chem 278:27230-27240.
    • (2003) J Biol Chem , vol.278 , pp. 27230-27240
    • Norris, E.H.1    Giasson, B.I.2    Ischiropoulos, H.3    Lee, V.M.4
  • 46
    • 7244253283 scopus 로고    scopus 로고
    • Peroxidative aggregation of α-synuclein requires tyrosines
    • Olteanu A, Pielak GJ. 2004. Peroxidative aggregation of α-synuclein requires tyrosines. Protein Sci 13:2852-2856.
    • (2004) Protein Sci , vol.13 , pp. 2852-2856
    • Olteanu, A.1    Pielak, G.J.2
  • 47
    • 0035834655 scopus 로고    scopus 로고
    • Exposure to long chain polyunsaturated fatty acids triggers rapid multimerization of synucleins
    • Perrin RJ, Woods WS, Clayton DF, George JM. 2001. Exposure to long chain polyunsaturated fatty acids triggers rapid multimerization of synucleins. J Biol Chem 276:41958-41962.
    • (2001) J Biol Chem , vol.276 , pp. 41958-41962
    • Perrin, R.J.1    Woods, W.S.2    Clayton, D.F.3    George, J.M.4
  • 48
    • 0028231251 scopus 로고
    • A new flow cytometric assay for the evaluation of phagocytosis and the oxidative burst in whole blood
    • Perticarari S, Presani G, Banfi E. 1994. A new flow cytometric assay for the evaluation of phagocytosis and the oxidative burst in whole blood. J Immunol Methods 170:117-124.
    • (1994) J Immunol Methods , vol.170 , pp. 117-124
    • Perticarari, S.1    Presani, G.2    Banfi, E.3
  • 50
    • 34247130917 scopus 로고    scopus 로고
    • Effect of 4-hydroxy-2-nonenal modification on α-synuclein aggregation
    • Qin Z, Hu D, Han S, Reaney SH, Di Monte DA, Fink AL. 2007. Effect of 4-hydroxy-2-nonenal modification on α-synuclein aggregation. J Biol Chem 282:5862-5870.
    • (2007) J Biol Chem , vol.282 , pp. 5862-5870
    • Qin, Z.1    Hu, D.2    Han, S.3    Reaney, S.H.4    Di Monte, D.A.5    Fink, A.L.6
  • 51
    • 26444478269 scopus 로고    scopus 로고
    • Advanced glycation end products and RAGE: A common thread in aging, diabetes, neurodegeneration, and inflammation
    • Ramasamy R, Vannucci SJ, Yan SS, Herold K, Yan SF, Schmidt AM. 2005. Advanced glycation end products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation. Glycobiology 15:16R-28R.
    • (2005) Glycobiology , vol.15
    • Ramasamy, R.1    Vannucci, S.J.2    Yan, S.S.3    Herold, K.4    Yan, S.F.5    Schmidt, A.M.6
  • 53
    • 0034695098 scopus 로고    scopus 로고
    • The biology of the receptor for advanced glycation end products and its ligands
    • Schmidt AM, Yan SD, Yan SF, Stern DM. 2000. The biology of the receptor for advanced glycation end products and its ligands. Biochim Biophys Acta 1498:99-111.
    • (2000) Biochim Biophys Acta , vol.1498 , pp. 99-111
    • Schmidt, A.M.1    Yan, S.D.2    Yan, S.F.3    Stern, D.M.4
  • 54
    • 39049184161 scopus 로고    scopus 로고
    • Optimization of the Tet-On system for inducible expression of RAGE
    • Shaikh S, Nicholson LF. 2006. Optimization of the Tet-On system for inducible expression of RAGE. J Biomol Techniq 17:283-292.
    • (2006) J Biomol Techniq , vol.17 , pp. 283-292
    • Shaikh, S.1    Nicholson, L.F.2
  • 55
  • 56
    • 0037104723 scopus 로고    scopus 로고
    • An in vitro model of Parkinson's disease: Linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage
    • Sherer TB, Betarbet R, Stout AK, Lund S, Baptista M, Panov AV, Cookson MR, Greenamyre JT. 2002b. An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage. J Neurosci 22:7006-7015.
    • (2002) J Neurosci , vol.22 , pp. 7006-7015
    • Sherer, T.B.1    Betarbet, R.2    Stout, A.K.3    Lund, S.4    Baptista, M.5    Panov, A.V.6    Cookson, M.R.7    Greenamyre, J.T.8
  • 57
    • 0037402801 scopus 로고    scopus 로고
    • Selective microglial activation in the rat rotenone model of Parkinson's disease
    • Sherer TB, Betarbet R, Kim JH, Greenamyre JT. 2003. Selective microglial activation in the rat rotenone model of Parkinson's disease. Neurosci Lett 341:87-90.
    • (2003) Neurosci Lett , vol.341 , pp. 87-90
    • Sherer, T.B.1    Betarbet, R.2    Kim, J.H.3    Greenamyre, J.T.4
  • 58
    • 33646416155 scopus 로고    scopus 로고
    • Differential autocrine modulation of atrial and ventricular potassium currents and of oxidative stress in diabetic rats
    • Shimoni Y, Hunt D, Chen K, Emmett T, Kargacin G. 2006. Differential autocrine modulation of atrial and ventricular potassium currents and of oxidative stress in diabetic rats. Am J Physiol Heart Circ Physiol 290:H1879-H1888.
    • (2006) Am J Physiol Heart Circ Physiol , vol.290
    • Shimoni, Y.1    Hunt, D.2    Chen, K.3    Emmett, T.4    Kargacin, G.5
  • 60
    • 29644434199 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity
    • Smith WW, Jiang H, Pei Z, Tanaka Y, Morita H, Sawa A, Dawson VL, Dawson TM, Ross CA. 2005. Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity. Hum Mol Genet 14:3801-3811.
    • (2005) Hum Mol Genet , vol.14 , pp. 3801-3811
    • Smith, W.W.1    Jiang, H.2    Pei, Z.3    Tanaka, Y.4    Morita, H.5    Sawa, A.6    Dawson, V.L.7    Dawson, T.M.8    Ross, C.A.9
  • 61
    • 0034674652 scopus 로고    scopus 로고
    • Dityrosine cross-linking promotes formation of stable alpha-synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies
    • Souza JM, Giasson BI, Chen Q, Lee VMY, Ischiropoulos H. 2000. Dityrosine cross-linking promotes formation of stable alpha-synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies. J Biol Chem 275:18344-18349.
    • (2000) J Biol Chem , vol.275 , pp. 18344-18349
    • Souza, J.M.1    Giasson, B.I.2    Chen, Q.3    Lee, V.M.Y.4    Ischiropoulos, H.5
  • 63
    • 0032568534 scopus 로고    scopus 로고
    • Alpha-synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies
    • Spillantini MG, Crowther RA, Jakes R, Hasegawa M, Goedert M. 1998. Alpha-synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies. Proc Natl Acad Sci U S A 95:6469-6473.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 6469-6473
    • Spillantini, M.G.1    Crowther, R.A.2    Jakes, R.3    Hasegawa, M.4    Goedert, M.5
  • 64
    • 0037205095 scopus 로고    scopus 로고
    • Tyrosine 125 of alpha-synuclein plays a critical role for dimerization following nitrative stress
    • Takahashi T, Yamashita H, Nakamura T, Nagano Y, Nakamura S. 2002. Tyrosine 125 of alpha-synuclein plays a critical role for dimerization following nitrative stress. Brain Res 938:73-80.
    • (2002) Brain Res , vol.938 , pp. 73-80
    • Takahashi, T.1    Yamashita, H.2    Nakamura, T.3    Nagano, Y.4    Nakamura, S.5
  • 66
    • 5444228135 scopus 로고    scopus 로고
    • Cellular pathology of Parkinson's disease: Astrocytes, microglia and inflammation
    • Teismann P, Schulz JB. 2004. Cellular pathology of Parkinson's disease: astrocytes, microglia and inflammation. Cell Tissue Res 318:149-161.
    • (2004) Cell Tissue Res , vol.318 , pp. 149-161
    • Teismann, P.1    Schulz, J.B.2
  • 67
    • 0033624416 scopus 로고    scopus 로고
    • Do neuronal inclusions kill the cell?
    • Terry RD. 2000. Do neuronal inclusions kill the cell? J Neural Transm Suppl 59:91-93.
    • (2000) J Neural Transm , Issue.SUPPL. 59 , pp. 91-93
    • Terry, R.D.1
  • 68
    • 15544365143 scopus 로고    scopus 로고
    • Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures
    • Testa CM, Sherer TB, Greenamyre JT. 2005. Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures. Brain Res Mol Brain Res 134:109-118.
    • (2005) Brain Res Mol Brain Res , vol.134 , pp. 109-118
    • Testa, C.M.1    Sherer, T.B.2    Greenamyre, J.T.3
  • 70
    • 0032568935 scopus 로고    scopus 로고
    • Acrolein is a product of lipid peroxidation reaction. Formation of free acrolein and its conjugate with lysine residues in oxidized low density hpoproteins
    • Uchida K, Kanematsu M, Morimitsu Y, Osawa T, Noguchi N, Niki E. 1998. Acrolein is a product of lipid peroxidation reaction. Formation of free acrolein and its conjugate with lysine residues in oxidized low density hpoproteins. J Biol Chem 273:16058-16066.
    • (1998) J Biol Chem , vol.273 , pp. 16058-16066
    • Uchida, K.1    Kanematsu, M.2    Morimitsu, Y.3    Osawa, T.4    Noguchi, N.5    Niki, E.6
  • 71
    • 0037014618 scopus 로고    scopus 로고
    • Amino acid determinants of α-synuclein aggregation: Putting together pieces of the puzzle
    • Uversky VN, Fink AL. 2002. Amino acid determinants of α-synuclein aggregation: putting together pieces of the puzzle. FEBS Lett 522:9-13.
    • (2002) FEBS Lett , vol.522 , pp. 9-13
    • Uversky, V.N.1    Fink, A.L.2
  • 73
    • 9644297858 scopus 로고    scopus 로고
    • Rotenone induces apoptosis via activation of bad in human dopaminergic SH-SY5Y cells
    • Watabe M, Nakaki T. 2004. Rotenone induces apoptosis via activation of bad in human dopaminergic SH-SY5Y cells. J Pharmacol Exp Ther 311:948-953.
    • (2004) J Pharmacol Exp Ther , vol.311 , pp. 948-953
    • Watabe, M.1    Nakaki, T.2
  • 74
    • 0035153678 scopus 로고    scopus 로고
    • Advanced glycation end products, their receptors and diabetic angiopathy
    • Wautier JL, Guillausseau PJ. 2001. Advanced glycation end products, their receptors and diabetic angiopathy. Diabetes Metab 27:535-542.
    • (2001) Diabetes Metab , vol.27 , pp. 535-542
    • Wautier, J.L.1    Guillausseau, P.J.2
  • 76
    • 0347381138 scopus 로고    scopus 로고
    • Glycation, inflammation, and RAGE: A scaffold for the macrovascular complications of diabetes and beyond
    • Yan SF, Ramasamy R, Naka Y, Schmidt AM. 2003. Glycation, inflammation, and RAGE: a scaffold for the macrovascular complications of diabetes and beyond. Circ Res 93:1159-1169.
    • (2003) Circ Res , vol.93 , pp. 1159-1169
    • Yan, S.F.1    Ramasamy, R.2    Naka, Y.3    Schmidt, A.M.4


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