Proteolysis of Human Calcitonin in Excised Bovine Nasal Mucosa: Elucidation of the Metabolic Pathway by Liquid Secondary Ionization Mass Spectrometry (LSIMS) and Matrix Assisted Laser Desorption Ionization Mass Spectrometry (MALDI)

Pharmaceutical Research

Volumn 13, Issue 11, 1996, Pages 1679-1685

  Lang, Steffen R ^a,b   Staudenmann, Werner ^a   James, Peter ^a   Manz, Hans Jörg ^b   Kessler, Rudolf ^b   Galli, Bruno ^b   Moser, Hans Peter ^c   Rummelt, Andreas ^c   Merkle, Hans P ^a  

^a ETH ZURICH   (Switzerland)

^b CIBA GEIGY LTD   (Switzerland)

^c Sandoz Pharma Ltd   (Switzerland)

Author keywords

Human calcitonin; LC MS; LSIMS; MALDI MS; Metabolic pathway mass spectrometry; Nasal metabolism; Nasal mucosa; Peptide metabolism; Salmon calcitonin

Indexed keywords

CALCITONIN; SALCATONIN;

ARTICLE; CATTLE; DRUG METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IONIZATION; LASER; MASS; MASS SPECTROMETRY; NONHUMAN; NOSE MUCOSA; PRIORITY JOURNAL; PROTEIN DEGRADATION;

AMINO ACID SEQUENCE; ANIMALS; CALCITONIN; CATTLE; FLUORESCEIN-5-ISOTHIOCYANATE; HUMANS; MOLECULAR SEQUENCE DATA; NASAL MUCOSA; PEPTIDE HYDROLASES; SALMON; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SPECTROMETRY, MASS, SECONDARY ION;

EID: 0030453146     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016492723930     Document Type: Article

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