The HIV Tat protein transduction domain improves the biodistribution of β-glucuronidase expressed from recombinant viral vectors

Nature Biotechnology

Volumn 19, Issue 7, 2001, Pages 640-644

  Xia, Haibin ^a   Mao, Qinwen ^a   Davidson, Beverly L ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; CELLS; DISEASES; GENE TRANSFER; PROTEINS;

PROTEIN TRANSDUCTION DOMAIN (PTD);

BIOTECHNOLOGY;

BETA GLUCURONIDASE; CHIMERIC PROTEIN; HYBRID PROTEIN; LYSOSOME ENZYME; MANNOSE 6 PHOSPHATE; TRANSACTIVATOR PROTEIN; VIRUS VECTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STRAIN 3T3; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG UPTAKE; GENE EXPRESSION; GENE THERAPY; GENETIC DISORDER; GENETIC TRANSDUCTION; HELA CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; IN VITRO STUDY; IN VIVO STUDY; MOUSE; MUCOPOLYSACCHARIDOSIS TYPE 7; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; TREATMENT OUTCOME; VIRUS RECOMBINANT;

3T3 CELLS; ADENOVIRIDAE; AMINO ACID MOTIFS; ANIMALS; BRAIN DISEASES; CYTOPLASM; ENDOCYTOSIS; GENE PRODUCTS, TAT; GENE THERAPY; GENETIC VECTORS; GENOTYPE; GLUCURONIDASE; HELA CELLS; HUMANS; IN SITU HYBRIDIZATION; LYSOSOMES; MANNOSEPHOSPHATES; MICE; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RECOMBINATION, GENETIC; TISSUE DISTRIBUTION;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0034941801     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/90242     Document Type: Article

References (15)

1. Prevalence of lysosomal storage disorders
2. Enzyme replacement therapy for murine mucopolysaccharidosis type VII leads to improvements in behavior and auditory function
3. Intracranial injection of recombinant adeno-associated virus improves cognitive function in a murine model of mucopolysaccharidosis type VII
4. In vivo protein transduction: Delivery of a biologically active protein into the mouse
5. Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells
6. Tat-mediated delivery of heterologous proteins into cells
7. Cell internalization of the third helix of the antennapedia homeodomain is receptor-independent
8. Extensive β-glucuronidase activity in murine CNS after adenovirus mediated gene transfer to brain
9. Endocytosis and targeting of exogenous HIV-1 tat protein
10. Systemic and central nervous system correction of lysosomal storage in mucopolysaccharidosis type VII mice
11. Systemic hyperosmolality improves β-glucuronidase distribution pathology in murine MPS VII brain following intraventricular gene transfer
12. Recombinant AAV type 2, 4 and 5 vectors: Transduction of variant cell types and regions in the mammalian CNS
13. A simple method for the rapid generation of recombinant adenovirus vectors
14. Beta-glucuronidase deficiency mucopolysaccharidosis: Methods for enzymatic diagnosis
15. Enzyme replacement therapy for murine mucopolysaccharidosis type VII