Prescribing, recording, and reporting proton-beam therapy

Journal of the ICRU

Volumn 7, Issue 2, 2007, Pages 1-210

  DeLuca Jr , Paul M ^a   Wambersie, André ^a   Whitmore, Gordon ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

CALORIMETRY; CELL HETEROGENEITY; CHONDROSARCOMA; CHORDOMA; DOSIMETRY; ELECTRON THERAPY; EYE INJURY; HISTOGRAM; HUMAN; INTENSITY MODULATED RADIATION THERAPY; IONIZATION CHAMBER; LINEAR ENERGY TRANSFER; LIVER CANCER; LUNG NON SMALL CELL CANCER; MEDICAL RECORD; PARANASAL SINUS CARCINOMA; PATIENT POSITIONING; POSITRON EMISSION TOMOGRAPHY; PRESCRIPTION; PROTON THERAPY; QUALITY CONTROL; RADIATION ABSORPTION; RADIATION BEAM; RADIATION DOSE; RADIATION DOSE DISTRIBUTION; RADIATION RESPONSE; RADIOBIOLOGY; RADIOGRAPHY; RELATIVE BIOLOGIC EFFECTIVENESS; REVIEW; STEREOTACTIC RADIOSURGERY; SYNCHROTRON; TREATMENT PLANNING; UVEA MELANOMA; X RAY FILM;

EID: 47349105864     PISSN: 14736691     EISSN: 17423422     Source Type: Journal    
DOI: 10.1093/jicru/ndm021     Document Type: Review

References (614)

1. AAPM (1980) American Association of Physicists in Medicine: Task Group 18. Protocol for Neutron Beam Dosimetry, AAPM Report No. 7 (American Association of Physicists in Medicine: New York).
2. AAPM (1983) American Association of Physicists in Medicine. 'A protocol for the determination of absorbed dose from high-energy photon and electron beams.' Med. Phys. 10, 741-771.
3. AAPM (1986) American Association of Physicists in Medicine: Task Group 20. Protocol for Heavy Charged-Particle Therapy Beam Dosimetry, AAPM Report No. 16 (American Association of Physicists in Medicine: New York).
4. Agosteo, S., Birattari, C., Caravaggio, M., Silari, M. and Tosi, G. (1998) 'Secondary neutron and photon dose in proton therapy.' Radiother. Oncol. 48, 293-305.
5. AJCC (2002) American Joint Committee on Cancer. In Cancer Staging Manual, 6th edn, Greene, F. L., Page, D. L., Fleming, I. D., Fritz, A. G., Balch, C. M., Haller, D. G. and Morrow, M. Eds. (Springer: New York).
6. Almond, P. R. and Smathers, J. B. (1977) 'Physics intercomparisons for neutron radiation therapy.' Int. J. Radiat. Oncol. Biol. Phys. 3, 169-176.
7. Amaldi, U., Arduini, G., Cambrai, R., Campi, D., Gerardi, F., Gramatica, R., Leone, R., Manfredi, G., Ninis, M., Petrucci, G., Rossi, S., Sangaletti, L., Silari, M., Tosi, G., Vecchi, L. and Weiss, M. (1994) 'A hospital-based hadrontherapy facility for Italy,' pp. 329-339 in Hadrontherapy in Oncology, Amaldi, U. and Larsson, B. Eds (Elsevier Science B.V.: Amsterdam).
8. Amerio, S., Boriano, A., Bourhaleb, F., Cirio, R., Donetti, M., Fidanzio, A., Garelli, E., Giordanengo, S., Madon, E., Marchetto, F., Nastasi, U., Peroni, C., Piermattei, A., Sanz Freire, C. J., Sardo, A. and Trevisiol, E. (2004) 'Dosimetric characterization of a large area pixel-segmented ionization chamber.' Med. Phys. 31, 414-420.
9. Ando, K., Koike, S., Kawachi, K., Hiraoka, T., Ohara, H., Yokota, M., Inada, T., Hirokawa, Y., Sato, S. and Eguchi, K. (1985) 'Relative biological effectiveness of the therapeutic proton beams at NIRS and Tsukuba University.' Nippon Igaku Hoshasen Gakkai Zasshi, (Nippon Acta Radiologica) 45, 531-535.
10. Andreo, P. (1992) 'Absorbed dose beam quality factors for the dosimetry of high-energy photon beams.' Phys. Med. Biol. 37, 2189-2211.
11. Andreo, P. (2002) 'Role of the IAEA codes of practice in the radiation dosimetry chain,' pp. 21-33 in Proc. Int. Symp. on Standards and Codes of Practice in Medical Radiation Dosimetry. IAEA-CN-96 (International Atomic Energy Agency, Vienna).
12. Andreo, P., Nahum, A. and Brahme, A. (1986) 'Chamber-dependent wall correction factors in dosimetry.' Phys. Med. Biol. 31, 1189-1199.
13. Archambeau, J. O., Bennett, G. W., Levine, G. S., Cowen, R. and Akanuma, A. (1974) 'Proton radiation therapy.' Radiology 110, 445-457.
14. Attix, F. H. (1986) Introduction to Radiological Physics and Radiation Dosimetry (John Wiley: New York).
15. Austin-Seymour, M., Kalet, I., McDonald, J., Kromhout-Schiro, S., Jacky, J., Hummel, S. and Unger, J. (1995) 'Three dimensional planning target volumes: A model and a software tool.' Int. J. Radiat. Oncol. Biol. Phys., 33, 1073-1080.
16. Bacher, R., Blattmann, H., Boehringer, T., Coray, A., Egger, E., Pedroni, E., Phillips, M. and Scheib, S. (1989) 'Development and first results of discrete dynamic spot scanning with protons,' pp. 9-12 in Proc. Int. Heavy Particle Therapy Workshop (PTCOG/EORTC/ECNEU), PSI Report No. 69 (Paul Scherrer Institute, Villigen, Switzerland.
17. Balter, J. M., Ten Haken, R. K. and Lamm, K. L. (1996) 'Treatment setup verification,' pp. 471-493 in Teletherapy: Present and Future, Mackie, T. R. and Palta, J. R. Eds. (Advanced Medical Publishing: Madison, WI).
18. Bartolotta, A., Indovina, P. L., Onori, S. and Rosati, A. (1984) 'Dosimetry for Cobalt-60 gamma rays with alanine.' Radiat. Prot. Dosim. 9, 277-281.
19. Bartolotta, A., Onori, S. and Pantaloni, M. (1990) 'Alanine EPR dosimetry as a traveling dosimetric system for intercomparison purposes.' Radiat. Phys. Chem. 35, 708-712.
20. Bartolotta, A., Fattibene, P., Onori, S., Pantaloni, M. and Petetti, E. (1993) 'Sources of uncertainty in therapy level alanine dosimetry.' Appl. Radiat. Isot. 44, 13-17.
21. Baumert, B. G., Lomax, A. J., Miltchev, V. and Davis, J. B. (2001) 'A comparison of dose distributions of proton and photon beams in stereotactic conformal radiotherapy of brain lesions.' Int. J. Radiat. Oncol. Biol. Phys. 29, 1439-1449.
22. Baumert, B. G., Norton, I. A., Lomax, A. J. and Davis, J. B. (2004) 'Dose conformation of intensity-modulated stereotactic photon beams, proton beams, and intensity-modulated proton beams for intracranial lesions.' Int. J. Radiat. Oncol. Biol. Phys. 60, 1314-1324.
23. Beckham, W. A., Keall, P. J. and Siebers, J. V. (2002) 'A fluence-convolution method to calculate radiation therapy dose distributions that incorporate random set-up error.' Phys. Med. Biol. 47, 3465-3473.
24. Beeckman, W., Jongen, Y., Laisne, A. and Lannoye, G. (1991) 'Preliminary design of a reduced-cost proton therapy facility using a compact high field isochronous cyclotron.' Nucl. Instrum. Methods Phys. Res. B56/57, 1201-1204.
25. Belli, M., Cera, F., Cherubini, R., Haque, A. M. I., Ianzini, F., Moschini, G., Sapora, O., Simone, G., Tabocchini, M. A. and Tivero, P. (1993) 'Inactivation and mutation induction in V79 cells by low energy protons: re-evaluation of the results at the LNL facility.' Int. J. Radiat. Biol. 63, 331-337.
26. Bettega, D., Calzolari, P., Chauvel, P., Courdi, A., Herault, J., Iborra, N., Marchesini, R., Massariello, P., Poli, G. L. and Tallone, L. (2000) 'Radiobiological studies on the 65 MeV therapeutic proton beam at Nice using human tumour cells.' Int. J. Radiat. Biol. 76, 1297-1303.
27. Bichsel, H. (1995) 'Calculated Bragg curves for ionization chambers of different shapes.' Med. Phys. 22, 1721-1726.
28. Bilski, P., Budzanowski, M., Hoffmann, W., Molokanov, A., Olko, P. and Waligórski, M. P. R. (1997) 'Investigation of efficiency of thermoluminescence detectors for particle therapy beams.' Radiat. Prot. Dosim. 70, 501-504.
29. Binns, P. J. and Hough, J. H. (1997) 'Secondary dose exposures during 200 MeV proton therapy.' Radiat. Prot. Dosim. 70, 441-444.
30. Binns, P. J., Hough, J. H., Jones, D. T. L. and Schreuder, A. N. (1993) 'Microdose Spectra for Protons of Different LET.' In NAC Annual Report, NAC/AR/93-01 (National Accelerator Centre: Faure, South Africa 88).
31. BIPM (1981) Bureau International des Poids et Mesures. Recommendation R(I)-1, page R(I) 15 in BIPM Com. Cons. Étalons Mes. Ray. Ionisants (Section I) 6, (Offilib, Paris, France).
32. BIPM (2006) Bureau International des Poids et Mesures. The International System of Units (SI), 8th edn. (BIPM, Pavillon de Breteuil, Sèvres Cedex, France).
33. Björk, P., Knöös, T. and Nilsson, P. (2000) 'Comparative dosimetry of diode and diamond detectors in electron beams for intraoperative radiation therapy.' Med. Phys. 27, 2580-2588.
34. 60Co gamma-radiation using two cell lines.' Radiother. Oncol. 28, 44-51.
35. Blosser, H., Johnson, D., Lawton, D., Ronningen, R., Burleigh, R. and Gottschalk, B. (1991) Preliminary Design Study Exploring Building Features Required for a Proton Therapy Facility for Ontario Cancer Institute, Report MSUCL 76a (National Superconducting Cyclotron Laboratory, Michigan State University, East Lansing, MI).
36. Blosser, H. G., Gelbke, G. K., Lawton, D., Marti, F., Vincent, J., York, R. C. and Zeller, A. (1993) Proposal to Construct a 250 MeV Superconducting Isochronous Cyclotron to Serve as an Advanced Cancer Treatment Facility and as a Manufacturing Prototype for Commercial Productions of such Cyclotrons, Report MSUCL-874 (National Superconducting Cyclotron Laboratory, Michigan State University, East Lansing, MI).
37. Boag, J. W. (1966) 'Ionization Chambers,' pp. 1-72 in Radiation Dosimetry, Vol. II, Attix, F. H. and Roesch, W. C. Eds. (Academic Press: New York).
38. Boag, J. W. and Wilson, T. (1952) 'The saturation curve at high ionization intensity.' Br. J. Appl. Phys. 3, 222-229.
39. Bolsi, A., Fogliata, A. and Cozzi, L. (2003) 'Radiotherapy of small intracranial tumours with different advanced techniques using photon and proton beams: a treatment planning study.' Radiother. Oncol. 68, 1-14.
40. Bonnett, D. E. (1993) 'Current developments in proton therapy: A review.' Phys. Med. Biol. 38, 1371-1392.
41. Boon, S. N. (1998) Dosimetry and quality control of scanning proton beams. Doctoral Thesis, Mathematics and Natural Sciences (Rijksuniversteit Groningen, The Netherlands).
42. Boon, S. N., van Luijk, P., Schippers, J. M., Meertens, H., Denis, J. M., Vynckier, S., Medin, J. and Grusell, E. (1998) 'Fast 2D phantom dosimetry for scanning proton beams.' Med. Phys. 25, 464-475.
43. Boon, S. N., van Luijk, P., Böhringer, T., Coray, A., Lomax, A., Pedroni, E., Schaffner, B. and Schippers, J. M. (2000) 'Performance of a fluorescent screen and CCD camera as a two-dimensional dosimetry system for dynamic treatment techniques.' Med. Phys. 27, 2198-2208.
44. Bortfeld, T. (2003) 'Physical optimization.' In Intensity-Modulated Radiation Therapy: The State of the Art, Palta, J. R. and Mackie, T. R. Eds. (Medical Physics Publishing: Madison, WI).
45. Bortfeld, T., Jokivarsi, K., Goitein, M., Kung, J. and Jiang, S. B. (2002) 'Effects of intra-fraction motion on IMRT dose delivery: Statistical analysis and simulation.' Phys. Med. Biol. 47, 2203-2220.
46. Bortfeld, T., Trofimov, A., Shipley, W. U., Chan, W. F. A., Adams, J., DeLaney, T. F., Kooy, H., Küfer, K.-H. and Monz, M. (2004) 'Advances in comparative proton therapy treatment planning at NPTC in Boston.' Proc. ESTRO 23, S122.
47. Boutillon, M. (1987) Values of g for photon energies. CCEMRI, Offilib Report (I) 85-18 (Comité Consultatif pour les Étalons de Measures des Rayonnements Ionisants, Offilib, Paris, France).
48. 60Co beam.' Phys. Med. Biol. 34, 1809-1821.
49. Boutillon, M. and Perroche-Roux, A. M. (1987) 'Re-evaluation of the W value for electrons in dry air.' Phys. Med. Biol. 32, 213-219.
50. Boyd, T. J., Crandall, K. R., Hamm, R. W., Hansborough, L. D., Hoeberling, R. F., Jameson, R. A., Knapp, E. A., Mueller, D. W., Potter, J. M., Stokes, R. H., Stovall, J. E., Sturgess, R. G., Swenson, D. A., Tallerico, P. J., Wangler, T. P. and Wilkerson, L. C. (1982) 'The PIGMI linear accelerator technology,' pp. 3-22 in Pion and Heavy Ion Radiotherapy: Pre-Clinical and Clinical Studies, Skarsgard, L. D. Ed. (Elsevier Science Publishing Co., Inc.: New York).
51. Bradshaw, W. W., Cadena, D. G., Jr., Crawford, G. W. and Spetzler, H. A.W. (1962) 'The use of alanine as a solid dosimeter.' Radiat. Res. 17, 11-21.
52. Brahme, A. (1984) 'Dosimetric precision requirements in radiation therapy.' Acta Radiol. Oncol. 23, 379-391.
53. Brahme, A., Källman, P. and Lind, B. K. (1989) 'Optimization of proton and heavy ion therapy using an adaptive inversion algorithm.' Radiother. Oncol. 15, 189-197.
54. Brede, H. J., Hecker, O. and Selbach, H. J. (1994) 'Measurement principles and experimental setup for determining the heat defect of water for high-energy protons, deuterons and alpha particles.' In Proc. NPL Calorimetry Workshop (National Physical Laboratory, Teddington, UK).
55. Brede, H. J., Hecker, O. and Hollnagel, R. (1997) 'Measurement of the heat defect in water and A-150 plastic for high-energy protons, deuterons, and alpha particles.' Radiat. Prot. Dosim. 70, 505-508.
56. Brede, H. J., Heinemann, E., Binns, P. J., Langen, K. M., Jones, D. T. L. and Schreuder, A. N. (1999) 'Water calorimetry and ionization chamber dosimetry in the proton therapy beam,' pp. 123-124 in National Accelerator Annual Report, March 1999 (National Accelerator Centre, Faure, South Africa).
57. Brede, H. J., Hecker, O. and Hollnagel, R. (2000) 'An absorbed dose to water calorimeter for collimated radiation fields.' Nucl. Instrum. Methods Phys. Res. A455, 721-732.
58. Brede, H. J., Greif, K-D., Hecker, O., Heeg, P., Heese, J., Jones, D. T. L., Kluge, H. and Schardt, D. (2006) 'Absorbed dose to water determination with ionization chamber dosimetry and calorimetry in restricted neutron, photon, proton and heavy-ion radiation fields.' Phys. Med. Biol. 51, 3667-3682.
59. Breuer, H. and Smit, B. J. (2000) Proton Therapy and Radiosurgery (Springer-Verlag: Berlin).
60. Broerse, J. J., Coppola, M. and Burger, G. (1978) A European Neutron Dosimetry Intercomparison Project (ENDIP): Results and Evaluation. EUR 6004 EN (Commission of the European Communities: Luxembourg).
61. Broerse, J. J., Mijnheer, B. J., Eenma, J. and Wootton, P. (1979) 'Dosimetry intercomparisons and protocols for therapeutic applications of fast neutron beams,' in pp. 117-123 High LET Radiations in Clinical Radiotherapy, Barendsen, G. W., Broerse, J. J. and Breur, K. Eds. (Pergamon Press: Oxford).
62. Broerse, J. J., Mijnheer, B. J. and Williams, J. R. (1981) 'European protocol for neutron dosimetry for external beam therapy. European Neutron Dosimetry Group (ECNEU).' Br. J. Radiol. 54, 882-898.
63. Brusasco, C., Cattai, A., Cirio, R., Dellacasa, G., Donetti, M., Isoardi, P., Marchetto, F., Peroni, C, Rolando, V., Ruspa, M., Solano, A. and Zambernardi, C. (1997) 'Strip ionization chambers as 3-D detector for hadron therapy.' Nucl. Instrum. Methods Phys. Res. A389, 499-512.
64. Brusasco, C., Voss, B., Schardt, D., Krämer, M. and Kraft, G. (2000) 'A dosimetry system for fast measurement of 3D depth-dose profiles in charged-particle tumor therapy with scanning techniques.' Nucl. Instrum. Methods Phys. Res. B168, 578-592.
65. 60Co beam and 62 MeV protons.' Phys. Med. XV, 71-77.
66. Bucciolini, M., Cuttone, G., Guasti, A., Lo Nigro, S., Mazzocchi, S., Raffaele, L., Sabini, M. G., Kacperek, A. and Egger, E. (2000) 'Check on the use of thermoluminescence detectors for proton dose distribution measurements.' Phys. Med. XVI, 117-120.
67. Bucciolini, M., Banci Buonamici, F., Mazzocchi, S., De Angelis, C., Onori, S. and Cirrone, G. A. P. (2003) 'Diamond detector versus silicon diode and ion chamber in photon beams of different energy and field size.' Med. Phys. 30, 2149-2154.
68. Bush, D. A., Slater, J. D., Shin, B. B., Cheek, G., Miller, D. W. and Slater, J. M. (2004a) 'Hypofractionated proton beam radiotherapy for stage I lung cancer.' Chest 126, 1198-1203.
69. Bush, D. A., Hillebrand, D. J., Slater, J. M. and Slater, J. D. (2004b) 'High-dose proton beam radiotherapy of hepatocellular carcinoma: preliminary results of a phase II trial.' Gastroenterol. 127 (Suppl. 1), S189-S193.
70. Butson, M. J., Cheung, T. and Yu, P. K. N. (2001) 'Radiochromic film dosimetry in water phantoms.' Phys. Med. Biol. 46, N27-N31.
71. Cambria, R., Hérault, J., Brassart, N., Silari, M. and Chauvel, P. (1997) 'Proton beam dosimetry: A comparison between the Faraday cup and an ionization chamber.' Phys. Med. Biol. 42, 1185-1196.
72. Carlsson, C. A. and Carlsson, G. A. (1970) 'Proton dosimetry: measurement of depth doses from 185-MeV protons by means of thermoluminescent LiF.' Radiat. Res. 42, 207-219.
73. Case, J. A., von Goeler, F., Rabin, M. S. Z. and Wagner, M. (1994) 'Effects of detector geometry and sensitivity on the shape of the Bragg peak.' Proton Therapy Co-Operative Group Meeting, Cambridge, MA.
74. Castro, J. R., Quivey, J. M., Lyman, J. T., Chen, G. T. Y., Phillips, T. L., Tobias, C. A. and Alpen, E. L. (1980) 'Current status of clinical particle radiotherapy at Lawrence Berkeley Laboratory.' Cancer 46, 633-641.
75. Caumes, J., Ostrowski, A., Steinschaden, K., Mancaux, M., Cance, M., Simeon, J. P., Sabattier, R. and Breteau, N. (1984) 'Direct calibration of ionization chambers with a TE calorimeter at the Orleans cyclotron neutron facility.' Strahlenther. 160, 127-128.
76. CCEMRI (1977) Comité Consultatif pour les Étalons de Mesures des Rayonnements Ionisants (Section I). Correction d'Humidité. CCEMRI R(I)-30 (Bureau International des Poids et Mesures, Sèvres, France).
77. CCEMRI (1985) Comité Consultatif pour les Étalons de Mesures des Rayonnements Ionisants (Section I). Effect of a change of stopping-power values on the W values recommended by ICRU for electrons in dry air. CCEMRI (I)/85-8 (Bureau International des Poids et Mesures, Sèvres, France).
78. Cella, L., Lomax, A. and Miralbell, R. (2001) 'Potential role of intensity modulated proton beams in prostate cancer radiotherapy.' Int. J. Radiat. Oncol. Biol. Phys. 49, 217-223.
79. Censor, Y. (2003) 'Mathematical optimization for the inverse problem of intensity-modulated radiation therapy.' In Intensity Modulated Radiation Therapy: The State of the Art, Palta, J. R. and Mackie, T. R. Eds. (Medical Physics Publishing: Madison, WI).
80. Chadwick, M. B., Jones, D. T. L., Arendse, G. J., Cowley, A. A., Richter, W. A., Lawrie, J. J., Newman, R. T., Pilcher, J. V., Smit, F. D., Steyn, G. F., Koen, J. W. and Stander, J. A. (1999) 'Nuclear interaction cross sections for proton radiotherapy.' Nucl. Phys. A654, 1051c-1057c.
81. Chandna, S., Dwarakanath, B. S., Khaitan, D., Lazar Mathew, T. and Jain, V. (2002) 'Low-dose radiation hypersensitivity in human tumor cell lines: Effects of cell-cell contact and nutritional deprivation.' Radiat. Res. 157, 516-525.
82. Chapman, P. H., Ogilvy, C. S. and Butler, W. E. (1993) 'A new stereotactic alignment system for charged particle radiosurgery at the Harvard Cyclotron Laboratory, Boston,' pp. 105-108 in Stereotactictic Radiosurgery, Alexander, E., III, Loeffler, J. S. and Lunsford, L. D. Eds. (McGraw-Hill: New York).
83. Char, D. H., Quivey, J. M., Castro, J. R., Kroll, S. and Phillips, T. (1993) 'Helium ions versus iodine 125 brachytherapy in the management of uveal melanoma. A prospective, randomized, dynamically balanced trial.' Ophthalmology 100, 1547-1554.
84. Charpak, G. (1970) 'Evolution of the automatic spark chambers.' Ann. Rev. Nucl. Sci. 20, 195-254.
85. 60Co photon beams using ionometry and Fricke dosimetry.' Phys. Med. Biol. 42, 2053-2063.
86. Chen, G. T. (1988) 'Dose volume histograms in treatment planning.' Int. J. Radiat. Oncol. Biol. Phys. 14, 1319-1320.
87. Chen, G. T., Singh, R. P., Castro, J. R., Lyman, J. T. and Quivey, J. M. (1979) 'Treatment planning for heavy ion radiotherapy.' Int. J. Radiat. Oncol. Biol. Phys. 5, 1809-1819.
88. Chen, G. T. Y., Kung, J. H. and Beaudette, K. P. (2004) 'Artifacts in computed tomography scanning of moving objects.' Semin. Radiat. Oncol., 14, 19-26.
89. Cheung, T., Butson, M. J. and Yu, P. K. N. (2005) 'Post-irradiation colouration of GafChromic EBT radiochromic film.' Phys. Med. Biol. 50, N281-N285.
90. Chiba, T., Tokuuye, K., Matsuzaki, Y., Sugahara, S., Chuganji, Y., Kagei, K., Shoda, J., Hata, M., Abei, M., Igaki, H., Tanaka, N. and Akine, Y. (2005) 'Proton beam therapy for hepatocellular carcinoma: A retrospective review of 162 patients.' Clin. Cancer. Res. 11, 3799-3805.
91. Chu, W. T. (1995a) 'Ion beams for cancer treatment - a perspective.' Nucl. Instrum. Methods Phys. Res. B99, 835-838.
92. Chu, W. T (1995b) 'Radiation detectors', pp. 234-245 in Ion Beams in Tumor Therapy, Linz, U. Ed. (Chapman and Hall: Weinheim, Germany).
93. Chu, W., McEvoy, M., Nyman, M., Renner, T., Gonzales, B., Singh, R. P. and Stradner, R. (1985) 'Wobbler dosimetry for the biomedical program at the LBL BEVALAC.' IEEE Trans. Nucl. Sci. NS-32, 3324-3326.
94. Chu, W. T., Renner, T. R. and Ludewigt, B. A. (1989) 'Dynamic beam delivery for three-dimensional conformal therapy,' pp. 295-328 in EULIMA Workshop on the Potential Value of Light Ion Beam Therapy, Nice, France, Chauvel, P. and Wambersie, A. Eds. EUR 12165 EN (Commission of the European Communities: Luxembourg).
95. Chu, W. T., Ludewigt, B. A. and Renner, T. R. (1993) 'Instrumentation for treatment of cancer using proton and light-ion beams.' Rev. Sci. Instrum. 64, 2055-2122.
96. Ciesielski, B. and Wielopolski, L. (1994) 'The effects of dose and radiation quality on the shape and power saturation of the EPR signal in alanine.' Radiat. Res. 140, 105-111.
97. Cirio, R., Garelli, E., Schulte, R., Amerio, S., Boriano, A., Bourhaleb, F., Coutrakon, G., Donetti, M., Giordanengo, S., Koss, P., Madon, E., Marchetto, F., Nastasi, U., Peroni, C., Santuari, D., Sardo, A., Scielzo, G., Stasi, M. and Trevisiol, E. (2004) 'Two-dimensional and quasi-three-dimensional dosimetry of hadron and photon beams with the Magic Cube and the Pixel Ionization Chamber.' Phys. Med. Biol. 49, 3713-3724.
98. Cole, F., Livdahl, P. V., Mills, F. and Teng, L. (1987) 'Design and application of a proton therapy accelerator,' pp. 1985-1987 in Proc. 1987 IEEE Particle Accelerator Conference, Lindstrom, E. R. and Taylor, L. S. Eds. (IEEE Press, Piscataway, NJ).
99. Constable, I. J., Goitein, M., Koehler, A. M. and Schmidt, R. A. (1976) 'Small-field irradiation of monkey eyes with protons and photons.' Radiat. Res. 65, 304-314.
100. Constantinou, C., Harrington, J. C. and DeWerd, L. A. (1992) 'An electron density calibration phantom for CT-based treatment planning computers.' Med. Phys., 19, 325-327.
101. Coray, A., Pedroni, E., Boehringer, T., Lin, S., Lomax, A. and Goitein, G. (2002) 'Dosimetry with the scanned proton beam on the Paul Scherrer Institute gantry,' pp. 295-302 in Proc. Int. Symp. on Standards and Codes of Practice in Medical Radiation Dosimetry. IAEA-CN-96 (International Atomic Energy Agency, Vienna.).
102. Courant, E. D., Livingston, M. S. and Snyder, H. S. (1952) 'The strong-focusing synchrotron-a new high energy accelerator.' Phys. Rev. 88, 1190-1196.
103. Courdi, A., Brassart, N., Herault, J. and Chauvel, P. (1994) 'The depth-dependent radiation response of human melanoma cells exposed to 65 MeV protons.' Br. J. Radiol. 67, 800-804.
104. Coutrakon, G., Miller, D., Wong, J., Gere, L. and Binns, R. (1990) 'Characterization of the Loma Linda proton beam using a plastic scintillator and CCD camera readout.' Med. Phys. 17, 543 (Abstract).
105. Coutrakon, G., Miller, D., Kross, B. J., Anderson, D. F., DeLuca, P. M. Jr. and Siebers, J. (1991a) 'A beam intensity monitor for the Loma Linda cancer therapy proton accelerator.' Med. Phys. 18, 817-820.
106. Coutrakon, G., Bauman, M., Lesyna, D., Miller, D., Nusbaum, J., Slater, J., Johanning, J., Miranda, J., DeLuca, P. M. Jr., Siebers, J. and Ludewigt, B. (1991b) 'A prototype beam delivery system for the proton medical accelerator at Loma Linda.' Med. Phys. 18, 1093-1099.
107. Coutrakon, G., Hubbard, J., Johanning, J., Maudsley, G., Slaton, T. and Morton, P. (1994) 'A performance study of the Loma Linda proton medical accelerator.' Med. Phys. 21, 1691-1701.
108. Coutrakon, G., Cortese, J., Ghebremedhin, A., Hubbard, J., Johanning, J., Koss, P., Maudsley, G., Slater, C. R. and Zuccarelli, C. (1997) 'Microdosimetry spectra of the Loma Linda proton beam and relative biological effectiveness comparisons.' Med. Phys. 24, 1499-1506.
109. Cox, R., Thacker, J., Goodhead, D. T. and Munson, R. J. (1977) 'Mutation and inactivation of mammalian cells by various ionising radiations.' Nature 267, 425-427.
110. Crook, J. M., Raymond, Y., Salhani, D., Yang, H. and Esche, B. (1995) 'Prostate motion during standard radiotherapy as assessed by fiducial markers.' Radiother. Oncol. 37, 35-42.
111. Cumming, J. B. (1963) 'Monitor reactions for high energy proton beams.' Ann. Rev. Nucl. Sci. 13, 261-286.
112. Cuttone, G., Raffaele, L., Barone Tonghi, L., Rovelli, A., Sabini, M. G., Egger, E., Kacperek, A., Brai, M., Bartolotta, A., Teri, G., Onori, S. and Fattibene, P. (1999) 'First dosimetry intercomparison results for the CATANA Project.' Phys. Med. XV, 121-130.
113. Daftari, I., Castenadas, C., Petti, P. L., Singh, R. P. and Verhey, L. J. (1999) 'An application of GafChromic MD-55 film for 67.5 MeV clinical proton beam dosimetry.' Phys. Med. Biol. 44, 2735-2745.
114. Dantzig, G. B. (1963) Linear Programming and Extensions (Princeton University Press, Princeton, NJ).
115. Daures, J., Chauvenet, B. and Ostrowski, A. (1994) 'State-of the-art of calorimetry at LPRI.' In Proc. NPL Calorimetry Workshop (National Physical Laboratory, Teddington, UK).
116. De Angelis, C., Onori, S., Pacilio, M., Cirrone, G. A. P., Cuttone, G., Raffaele, L., Bucciolini, M. and Mazzocchi, S. (2002) 'An investigation of the operating characteristics of two PTW diamond detectors in photon and electron beams.' Med. Phys. 29, 248-254.
117. Debus, J., Schulz-Ertner, D., Schad, L., Essig, M., Rhein, B., Thillmann, C. O. and Wannenmacher, M. (2000) 'Stereotactic fractionated radiotherapy for chordomas and chondrosarcomas of the skull base.' Int. J. Radiat. Oncol. Biol. Phys., 47, 591-596.
118. de Kock, E. A. (2002) 'The robot-based patient positioning system for high precision radiotherapy at iThemba LABS.' In Particles 32, Abstracts of the 37th Proton Therapy Co-Operative Group Meeting, Cape Town, South Africa.
119. Deasy, J. O., Chao, K. S. C. and Markman, J. (2001) 'Uncertainties in model-based outcome predictions for treatment planning.' Int. J. Radiat. Oncol. Biol. Phys. 51, 1389-1399.
120. Delacroix, S., Bridier, A., Mazal, A., Daures, J., Ostrowsky, A., Nauraye, C., Kacperek, A., Vynckier, S., Brassard, N. and Habrand, J. L. (1997) 'Proton dosimetry comparison involving ionometry and calorimetry.' Int. J. Radiat. Oncol. Biol. Phys. 37, 711-718.
121. Dendale, R., Lumbroso-Le Rouic, L., Noel, G., Feuvret, L., Levy, C., Delacroix, S., Meyer, A., Nauraye, C., Mazal, A., Mammar, H., Garcia, P., D'Hermies, F., Frau, E., Plancher, C., Asselain, B., Schlienger, P., Mazeron, J. J. and Desjardins, L. (2006) 'Proton beam radiotherapy for uveal melanoma: Results of Curie Institut-Orsay Proton Therapy Center (ICPO).' Int. J. Radiat. Oncol. Biol. Phys. 65, 780-787.
122. Dieckmann, K., Georg, D., Bogner, J., Zehetmayer, M., Petersch, B., Chorvat, M., Weitmann, H. and Potter, R. (2006) 'Optimizing linac-based stereotactic radiotherapy of uveal melanomas: 7 years clinical experience.' Int. J. Radiat. Oncol. Biol. Phys. 66, S47-S52.
123. Dobler, B. and Bendl, R. (2002) 'Precise modelling of the eye for proton therapy of intra-ocular tumours.' Phys. Med. Biol. 47, 593-613.
124. Domen, S. R. (1980) 'Absorbed dose water calorimeter.' Med. Phys. 7, 157-159.
125. Domen, S. R. (1987) 'Advances in calorimetry for radiation dosimetry,' pp. 245-320 in The Dosimetry of Ionizing Radiation, Vol. II, Kase, K. R., Bjarngard, B. E. and Attix, F. H. Eds. (Academic Press: Orlando, FL).
126. Domen, S. R. (1994) 'A sealed water calorimeter for measuring absorbed dose.' J. Res. Natl. Inst. Stand. Technol. 99, 121-141.
127. Domen, S. R. and Lamperti, P. J. (1974) 'A heat-loss compensated calorimeter: Theory, design, and performance.' J. Res. Natl. Bur. Stand. 78A, 595-610.
128. Drzymala, R. E., Mohan, R., Brewster, L., Chu, J., Goitein, M., Harms, W. and Urie, M. (1991) 'Dose-volume histograms.' Int. J. Radiat. Oncol. Biol. Phys. 21, 71-78.
129. Dudley, R. A. (1966) 'Dosimetry with photographic emulsions,' pp. 325-387. in Radiation Dosimetry, Vol. II, Attix, F. H. and Roesch, W. C. Eds. (Academic Press: New York).
130. DuSautoy, A. R. (1996) 'The UK primary standard calorimeter for photon-beam absorbed dose measurement.' Phys. Med. Biol. 41, pp. 137-151.
131. Ebert, P. J., Hardy, K. A. and Cadena, J. D. G. (1965) 'Energy dependence of free radical production in alanine.' Radiat. Res. 26, 178-197.
132. Egger, E., Schalenbourg, A., Zografos, L., Bercher, L., Boehringer, T., Chamot, L. and Goitein, G. (2001) 'Maximizing local tumor control and survival after proton beam radiotherapy of uveal melanoma.' Int. J. Radiat. Oncol. Biol. Phys. 51, 138-147.
133. Enghardt, W., Debus, J., Haberer, T., Hasch, B. G., Hinz, R., Jäkel, O., Krämer, M., Lauckner, K., Pawelke, J. and Pönisch, F. (1999) 'Positron emission tomography for quality assurance of cancer therapy with light ion beams.' Nucl. Phys. A654, 1047c-1050c.
134. Enghardt, W., Crespo, P., Fiedler, F., Hinz, R., Parodi, K., Pawelke, J. and Pönisch, F. (2004) 'Charged hadron tumour therapy monitoring by means of PET.' Nucl. Instrum. Methods. Phys. Res. A525, 284-288.
135. Falkmer, S., Fors, B., Larsson, B., Lindell, A., Naeslund, J. and Stenson, S. (1962) 'Pilot study on proton irradiation of human carcinoma.' Acta Radiol. 58, 33-51.
136. Fattibene, P., Calicchia, A., d'Errico, F., De Angelis, C., Egger, E. and Onori, S. (1996) 'Preliminary assessment of LiF and alanine detectors for the dosimetry of proton therapy beams.' Radiat. Prot. Dosim. 66, 305-309.
137. Fidanzio, A., Azario, L., De Angelis, C., Pacilio, M., Onori, S. and Piermattei, A. (2002) 'Radiochromic film dosimetry for a 62 MeV clinical proton beam.' Phys. Med. XV111, 15-23.
138. Field, S. B. (1977) 'Early and late normal tissue damage after fast neutrons.' Int. J. Radiat. Oncol. Biol. Phys. 3, 203-210.
139. Fitzek, M. M., Thornton, A. F., Rabinov, J. D., Lev, M. H., Pardo, F. S., Munzenrider, J. E., Okunieff, P., Bussiere, M., Braun, I., Hochberg, F. H., Hedley-Whyte, E. T., Liebsch, N. J. and Harsh, G. R. (1999) 'Accelerated fractionated proton/photon irradiation to 90 cobalt gray equivalent for glioblastoma multiforme: results of a phase II prospective trial.' J. Neurosurg. 91, 251-260.
140. Fleming, D. M. and Glass, W. A. (1969) 'Endothermic processes in tissue-equivalent plastic.' Radiat. Res. 37, 316-322.
141. Fogliata, A., Bolsi, A. and Cozzi, L. (2002) 'Critical appraisal of treatment techniques based on conventional photon beams, intensity modulated photon beams and proton beams for therapy of intact breast.' Radiother. Oncol. 62, 137-145.
142. Fong, P. M., Keil, D. C., Does, M. D. and Gore, J. C. (2001) 'Polymer gels for magnetic resonance imaging of radiation dose distributions at normal room atmosphere.' Phys. Med. Biol. 46, 3105-3113.
143. Fontenot, J. D., Newhauser, W. D. and Titt, U. (2005) 'Design tools for proton therapy nozzles based on the double-scattering foil technique.' Radiat. Prot. Dosim. 116, 211-215.
144. Ford, E. C., Mageras, G. S., Yorke, E. and Ling, C. C. (2003) 'Respiration-correlated spiral CT: A method of measuring respiratory-induced anatomic motion for radiation treatment planning.' Med. Phys. 30, 88-97.
145. Fowler, J. F. (1981) Nuclear Particles in Cancer Treatment (Adam Hilger Ltd.: Bristol, UK).
146. Fraass, B., Doppke, K., Hunt, M., Kutcher, G., Starkschall, G., Stern, R. and Van Dyke, J. (1998) 'American Association of Physicists in Medicine Radiation Therapy Committee, Task Group 53: Quality assurance for clinical radiotherapy treatment planning.' Med. Phys. 25, 1773-1829.
147. Fukumoto, S., Endo, K., Muto, K., Akisada, M., Kitagawa, T., Inada, T., Tsujii, H., Maruhashi, A., Hayakawa, Y., Takada, Y. and Tada, J. (1989) 'Tsukuba Medical Proton Synchrotron,' p. 70 in Heavy Particle Therapy Workshop (PTCOG, EORTC, ECNEU), PSI Report No. 69 (Paul Scherrer Institute, Villigen, Switzerland).
148. Fukumura, A., Kanai, T., Kanematsu, N., Yusa, K., Maruhashi, A., Nohtomi, A., Nishio, T., Shimbo, M., Akagi, T., Yanou, T., Fukuda, S., Hasegawa, T., Kusano, Y. and Masuda, Y. (2002) 'Proton beam dosimetry: protocol and intercomparison in Japan,' pp. 321-326 in Proc. Int. Symp. on Standards and Codes of Practice in Medical Radiation Dosimetry, IAEA-CN-96 (International Atomic Energy Agency, Vienna.
149. Gall, K. P., Verhey, L., Alonso, J., Castro, J., Collier, J. M., Chu, W., Daftari, I., Goitein, M., Kubo, H., Ludewigt, B., Munzenrider, J., Petti, P., Renner, T., Rosenthal, S., Smith, A., Staples, J., Suit, H. and Thornton, A. (1993a) 'State of the art? New proton medical facilities for the Massachusetts General Hospital and the University of California Davis Medical Center.' Nucl. Instrum. Methods Phys. Res. B79, 881-884.
150. Gall, K. P., Verhey, L. J. and Wagner, M. (1993b) 'Computer-assisted positioning of radiotherapy patients using implanted radiopaque fiducials.' Med. Phys. 20, 1153-1159.
151. Gall, K., Rosenthal, S. K. and Smith, A. R. (1994) 'Proton dosimetry protocol comparisons,' pp. 231-233 in Proc. NIRS International Seminar on the Application of Heavy Ion Accelerators to Radiation Therapy of Cancer in Connection with XXI PTCOG Meeting, Kanai, T. and Takada, E. Eds. NIRS-M-103/HIMAC-008 (National Institute of Radiological Sciences, Chiba, Japan. 231-233).
152. ion).' Med. Phys. 13, 751-754.
153. Geso, M., Ackerly, T. and Patterson, W. (2004) 'Improving radiochromic film's sensitivity by wrapping it with UV phosphor.' Med. Phys. 31, 1014-1016.
154. Glimelius, B., Ask, A., Bjelkengren, G., Bjork-Eriksson, T., Blomquist, E., Johansson, B., Karlsson, M. and Zackrisson, B. (2005) 'Number of patients potentially eligible for proton therapy.' Acta Oncol. 44, 836-849.
155. Goitein, M. (1977) 'The measurement of tissue heterodensity to guide
156. Goitein, M. (1978a) 'Compensation for inhomogeneities in charged particle radiotherapy using computed tomography.' Int. J. Radiat. Oncol. Biol. Phys. 4, 499-508.
157. Goitein, M. (1978b) 'A technique for calculating the influence of thin inhomogeneities on charged particle beams.' Med. Phys. 5, 258-264.
158. Goitein, M. (1980) 'Calculation of the uncertainty in the dose delivered in radiation therapy.' J. Am. Med. Assoc. 244, 1347-1350.
159. Goitein, M. (1982a) 'Limitations of two-dimensional treatment planning programs.' Med. Phys. 9, 580-586.
160. Goitein, M. (1982b) 'Applications of computed tomography in radiotherapy treatment planning,' pp. 195-293 in Progress in Medical Radiation Physics, Vol. I, Orton, C. G. Ed. (Plenum Press, New York).
161. Goitein, M. (1983) 'Non standard deviations.' Med. Phys. 10, 709-711.
162. Goitein, M. (1985) 'Calculation of the uncertainty in the dose delivered in radiation therapy.' Med. Phys. 12, 608-612.
163. Goitein, M. (1992) 'The comparison of treatment plans.' Semin. Radiat. Oncol., 2, 246-256.
164. Goitein, M. (1995) 'Lessons to be learned from proton beam therapy,' pp. 667-672 in Proc. 5th Int. Meeting on Progress in Radio-Oncology (ICRO, Ocombining double acute accentGRO 5), Salzburg, Austria (Monduzzi Editore S. P. A., Bologna, Italy.
165. Goitein, M. (2005) 'The cell's-eye view: Assessing dose in four dimensions.' Int. J. Radiat. Oncol. Biol. Phys. 62, 951-953.
166. Goitein, M. and Abrams, M. (1983) 'Multi-dimensional treatment planning: I. Delineation of anatomy.' Int. J. Radiat. Oncol. Biol. Phys. 9, 777-787.
167. Goitein, M. and Chen, G. T. Y. (1983) 'Beam scanning for heavy charged particle radiotherapy.' Med. Phys. 10, 831-840.
168. Goitein, M. and Miller, T. (1983) 'Planning proton therapy of the eye.' Med. Phys. 10, 275-283.
169. Goitein, M. and Schultheiss, T. E. (1985) 'Strategies for treating possible tumor extensions: Some theoretical considerations.' Int. J. Radiat. Oncol. Biol. Phys. 11, 1519-1528.
170. Goitein, M., Gentry, R. and Koehler, A. M. (1983a) 'Energy of proton accelerator necessary for treatment of choroidal melanomas.' Int. J. Radiat. Oncol. Biol. Phys. 9, 259-260.
171. Goitein, M., Abrams, M., Rowell, D., Pollari, H. and Wiles, J. (1983b) 'Multi-dimensional treatment planning: II. Beam's-eye view, back projection, and projection through CT sections.' Int. J. Radiat. Oncol. Biol. Phys. 9, 789-797.
172. Goitein, M., Chen, G. T. Y., Ting, J. Y., Schneider, R. J. and Sisterson, J. M. (1978) 'Measurements and calculations of the influence of thin inhomogeneities on charged particle beams.' Med. Phys. 5, 265-273.
173. Goitein, M., Lomax, A. J. and Pedroni, E. S. (2002) 'Treating cancer with protons.' Phys. Today 55, 45-51.
174. Goitein, M., Suit, H. D., Gragoudas, E., Koehler, A. M. and Wilson, R. (1985) 'Potential for low-LET chargedparticle radiation therapy in cancer.' Radiat. Res. 104, S297-S309.
175. Gore, J. C., Kang, Y. S. and Schulz, R. J. (1984) 'Measurement of radiation dose distributions by nuclear magnetic resonance (NMR) imaging.' Phys. Med. Biol. 29, 1189-1197.
176. Gottschalk, B. (1983) 'Charge-balancing current integrator with large dynamic range.' Nucl. Instrum. Methods 207, 417-421.
177. Gottschalk, B. (2003) 'On the characterization of spreadout Bragg peaks and the definition of 'Depth' and 'Modulation". http://huhepl.harvard.edu/ ~gottschalk/BGdocs.zip/SOBP.pdf.
178. Gottschalk, B., Platais, R. and Paganetti, H. (1999) 'Nuclear interactions of 160 MeV protons stopping in copper: A test of Monte Carlo nuclear models.' Med. Phys. 26, 2597-2601.
179. Graffman, S. (1975) On the Evaluation of New Irradiation Modalities in Tumor Therapy: An Experimental and Clinical Study with Special Reference to High Energy Protons, Umeä University Medical Dissertations, New Series No. 1 (Umeä University, Sweden).
180. Graffman, S., Brahme, A. and Larsson, B. (1985) 'Proton radiotherapy with the Uppsala cyclotron. Experience and plans.' Strahlenther. 161, 764-770.
181. Gragoudas, E. S., Goitein, M., Koehler, A. M., Verhey, L., Tepper, J., Suit, H. D., Brockhurst, R. and Constable, I. J. (1977) 'Proton irradiation of small choroidal malignant melanomas.' Am. J. Opthalmol. 83, 665-673.
182. Gragoudas, E. S., Goitein, M., Verhey, L., Suit, H. D. and Koehler, A. M. (1980) 'Proton beam irradiation: An alternative to enucleation for intraocular melanomas.' Opthalmol. 87, 571-581.
183. Gragoudas, E. S., Lane, A. M., Egan, K. M. and Li, W. (2002a) 'Long term risk of local failure after proton therapy for choroidal/ciliary body melanoma.' Trans. Am. Ophthmol. Soc. 100, 43-49.
184. Gragoudas, E., Li, W., Goitein, M., Lane, A. M. and Egan, K. M. (2002b) 'Evidence-based estimates of outcome in patients irradiated for intraocular melanoma.' Arch. Ophthalmol. 120, 1665-1671.
185. Grégoire, V., Coche, E., Cosnard, G., Hamoir, M. and Reychler, H. (2000) 'Selection and delineation of lymph node target volumes in head and neck conformal radiotherapy. Proposal for standardizing terminology and procedure based on the surgical experience.' Radiother. Oncol. 56, 135-150.
186. Grégoire, V., Pötter, R. and Wambersie, A. (2004) 'General principles for prescribing, recording and reporting a therapeutic irradiation.' Radiother. Oncol. 73 (Suppl. 2), S57-S61.
187. Grusell, E. and Medin, J. (2000) 'General characteristics of the use of silicon diode detectors for clinical dosimetry in proton beams.' Phys. Med. Biol. 45, 2573-2582.
188. Grusell, E., Montelius, A., Brahme, A., Rikner, G. and Russell, K. (1994) 'A general solution to charged particle beam flattening using an optimized dual-scattering-foil technique, with application to proton therapy beams.' Phys. Med. Biol. 39, 2201-2216.
189. Grusell, E., Isacsson, U., Montelius, A. and Medin, J. (1995) 'Faraday cup dosimetry in a proton beam without collimation.' Phys. Med. Biol. 40, 1831-1840.
190. Guerra, A. S., Laitano, R. F. and Pimpinella, M. (1996) 'Characteristics of the absorbed dose to water standard at ENEA.' Phys. Med. Biol. 41, 657-674.
191. Gueulette, J., Grégoire, V., Octave-Prignot, M. and Wambersie, A. (1996) 'Measurements of radiobiological effectiveness in the 85 MeV proton beam produced at the cyclotron CYCLONE of Louvain-la-Neuve, Belgium.' Radiat. Res. 145, 70-74.
192. Gueulette, J., Böhm, L., Slabbert, J. P., De Coster, B. M., Rutherfoord, G. S., Ruifrok, A., Octave-Prignot, M., Binns, P. J., Schreuder, A. N., Symons, J. E., Scalliet, P. and Jones, D. T. L. (2000) 'Proton relative biological effectiveness (RBE) for survival in mice after thoracic irradiation with fractionated doses.' Int. J. Radiat. Oncol. Biol. Phys. 47, 1051-1058.
193. Gueulette, J., Octave-Prignot, M., De Coster, B-M., Wambersie, A. and Grégoire, V. (2004) 'Intestinal crypt cell regeneration in mice: a biological system for quality assurance in non-conventional radiation therapy.' Radiother. Oncol. 73 (Suppl. 2), 148-154.
194. Gueulette, J., Blattmann, H., Pedroni, E., Coray, A., De Coster, B. M., Mahy, P., Wambersie, A. and Goitein, G. (2005) 'Relative biologic effectiveness determination in mouse intestine for scanning proton beam at Paul Scherrer Institute, Switzerland. Influence of motion.' Int. J. Radiat. Oncol. Biol. Phys., 62, 838-845.
195. Gulbrandsen, T. and Madsen, C. B. (1962) 'Radiation dosimetry by means of semiconductor.' Acta Radiol. 58, 226-232.
196. Guo, P. Y., Adamovics, J. A. and Oldham, M. (2006) 'Characterization of a new radiochromic three-dimensional dosimeter.' Med. Phys. 33, 1338-1345.
197. Guru Prasad, S., Parthasaradhi, K. and Bloomer, W. D. (1997) 'Effective atomic numbers of composite materials for total and partial interaction processes for photons, electrons, and protons.' Med. Phys. 24, 883-885.
198. Gustavsson, H., Bäck, S. Å. J., Medin, J., Grusell, E. and Olsson, L. E. (2004) 'Linear energy transfer dependence of a normoxic polymer gel dosimeter investigated using proton beam absorbed dose measurements.' Phys. Med. Biol. 49, 3847-3855.
199. Haberer, T., Becher, W., Schardt, D. and Kraft, G. (1993) 'Magnetic scanning system for heavy ion therapy.' Nucl. Instrum. Methods Phys. Res. A330, 296-305.
200. Hall, E. J. (2006) 'Intensity-modulated radiation therapy, protons, and the risk of second cancers.' Int. J. Radiat. Oncol. Biol. Phys. 65, 1-7.
201. Hamm, R. W., Crandall, K. R. and Potter, J. (1991) 'Preliminary design of a dedicated proton therapy linac,' p. 2583 in IEEE Particle Accelerator Conference: Accelerator Science and Technology, Lawrence Berkeley Laboratory, Berkeley, CA, Lizama, L. and Chew, J. Eds. (IEEE Press, Piscataway, NJ).
202. Hanley, J., Debois, M. M., Mah, D., Mageras, G. S., Raben, A., Rosenzweig, K., Mychalczak, B., Schwartz, L. H., Gloeggler, P. J., Lutz, W., Ling, C. C., Leibel, S. A., Fuks, Z. and Kutcher, G. J. (1999) 'Deep inspiration breath-hold technique for lung tumors: The potential value of target immobilization and reduced lung density in dose escalation.' Int. J. Radiat. Oncol. Biol. Phys. 45, 603-611.
203. Hansen, J. W. and Olsen, K. J. (1985) 'Theoretical and experimental radiation effectiveness of the free radical dosimeter alanine to irradiation with heavy charged particles.' Radiat. Res. 104, 15-27.
204. Hansen, J. W. and Olsen, K. J. (1989) 'Predicting decay in free-radical concentration in L-α-alanine following high-LET radiation exposure.' Appl. Radiat. Isot. 40, 935-939.
205. Hashemian, R., Foster, C. C., Murray, K. M., Landolt, R. L., Shaw, S. M. and Bloch, C. (2003) 'Measurement of W/e for protons in air.' 39th Meeting of the Particle Therapy Co-Operative Group, San Francisco, CA.
206. Harsh, G. R., Thornton, A. F., Chapman, P. H., Bussière, M. R., Rabinov, J. D. and Loeffler, J. S. (2002) 'Proton beam stereotactic radiosurgery of vestibular schwannomas.' Int. J. Radiat. Oncol. Biol. Phys. 54, 35-44.
207. Hayakawa, Y. and Schechtman, H. (1988) 'Comments on the value of the average energy per ion pair formed in air for a proton beam recommended by the American Association of Physicists in Medicine.' Med. Phys. 15, 778.
208. Hazle, J. D., Hefner, L., Nyerick, C. E., Wilson, L. and Boyer, A. L. (1991) 'Dose-response characteristics of a ferrous-sulfate-doped gelatin system for determining radiation absorbed dose distribution by magnetic resonance imaging (Fe MRI).' Phys. Med. Biol. 36, 1117-1125.
209. Heese, J., Kluge, H., Fuchs, H., Heufelder, J., Cordinil, D., Morgenstern, H., Nausner, M., Bechrakis, M., Hinkelbein, J. and Foerster, M. H. (2002) 'The proton facility at HMI.' Particles 32, Abstracts of the 37th Proton Therapy Co-Operative Group Meeting, Cape Town.
210. Hilts, M., Jirasek, A., Audet, C. and Duzenli, C. (2000) 'X-ray CT polymer gel dosimetry: Applications in stereotactic radiosurgery and proton therapy.' Radiother. Oncol. 56, (Suppl. 1), S80 (Abstract).
211. Hiraoka, T., Omata, K., Fukumura, A. and Takeshita, M. (1997) 'Dosimetry of particle beams with different walled ionization chambers.' Med. Phys. 24, 1051 (Abstract).
212. Hiramoto, K. and Nishi, M. (1992) 'Resonant beam extraction scheme with constant separatrix.' Nucl. Instrum. Meth. Phys. Res. A322, 154-160.
213. Hishikawa, Y., Kagawa, K., Murakami, M., Sakai, H., Akagi, T. and Abe, M. (2002) 'Usefulness of positron-emission tomographic images after proton therapy.' Int. J. Radiat. Oncol. Biol. Phys. 53, 1388-1391.
214. Hohlfield, K. (1988) 'The standard DIN 6800: Procedures for absorbed dose determination in radiology by the ionization method,' pp. 13-22 in Dosimetry in Radiotherapy, IAEA-SM-298/31 (International Atomic Energy Agency, Vienna) pp. 13-22.
215. Hong, L., Goitein, M., Bucciolini, M., Comiskey, R., Gottschalk, B., Rosenthal, S., Serago, C. and Urie, M. (1996) 'A pencil beam algorithm for proton dose calculations.' Phys. Med. Biol. 41, 1305-1330.
216. Hong, T. S., Ritter, M. A., Tome, W. A. and Harari, P. M. (2005) 'Intensity-modulated radiation therapy: Emerging cancer treatment technology.' Br. J. Cancer 92, 1819-1824.
217. Hoppe, B. S., Stegman, L. D., Zelefsky, M. J., Rosenzweig, K. E., Wolden, S. L., Patel, S. G., Shah, J. P., Kraus, D. H. and Lee, N. Y. (2007) 'Treatment of nasal cavity and paranasal sinus cancer with modern radiotherapy techniques in the postoperative setting: the MSKCC experience.' Int. J. Radiat. Oncol. Biol. Phys. 67, 691-702.
218. Hoyer, M., Roed, H., Hansen, A. T., Ohlhuis, L., Petersen, J., Nellemann, H., Berthelsen, A. K., Grau, C., Engelholm, S. A. and von der Masse, H. (2006) 'Prospective study on stereotactic radiotherapy of limited-stage non-small-cell lung cancer.' Int. J. Radiat. Oncol. Biol. Phys. 66, S128-S135.
219. Hsiung-Stripp, D. C., McDonough, J., Masters, H. M., Levin, W. P., Hahn, S. M., Jones, H. A. and Metz, J. M. (2001) 'Comparative treatment planning between proton and x-ray therapy in pancreatic cancer.' Med. Dosim. 26, 255-259.
220. Hug, E. B., Fitzek, M. M., Liebsch, N. J. and Munzenrider, J. E. (1995) 'Locally challenging osteo- and chondrogenic tumors of the axial skeleton: Results of combined proton and photon radiation therapy using three-dimensional treatment planning.' Int. J. Radiat. Oncol. Biol. Phys. 31, 467-476.
221. IAEA (1997a) International Atomic Energy Agency. Absorbed Dose Determination in Photon and Electron Beams: An International Code of Practice, Technical Report Series No. 277, 2nd edn (International Atomic Energy Agency: Vienna).
222. IAEA (1997b) International Atomic Energy Agency. The Use of Plane Parallel Ionization Chambers in High Energy Electron and Photon Beams: An International Code of Practice for Dosimetry, Technical Reports Series No. 381 (International Atomic Energy Agency: Vienna).
223. IAEA (2000) International Atomic Energy Agency. Absorbed Dose Determination in External Beam Radiotherapy. An International Code of Practice for Dosimetry Based on Standards of Absorbed Dose to Water, Technical Reports Series No. 398 (International Atomic Energy Agency: Vienna). Revised and updated version (V.11b, 23 April, 2004): http://wwwnaweb.iaea.org/nahu/dmrp/ pdf_files/COPV11b.pdf.
224. IAEA (2004) International Atomic Energy Agency. Commissioning and Quality Assurance of Computerized Planning Systems for Radiation Treatment of Cancer, Technical Reports Series No. 430 (International Atomic Energy Agency: Vienna).
225. ICRP (1991) International Commission on Radiological Protection. 1990 Recommendations of the International Commission on Radiological Protection, ICRP Publication 60, Anns. ICRP 21, 1-3 (Elsevier Science B. V.: Amsterdam).
226. ICRU (1976) International Commission on Radiation Units and Measurements. Determination of Absorbed Dose in a Patient Irradiated by Beams of X or Gamma Rays in Radiotherapy Procedures, ICRU Report 24 (International Commission on Radiation Units and Measurements: Bethesda, MD).
227. ICRU (1977) International Commission on Radiation Units and Measurements. Neutron Dosimetry for Biology and Medicine, ICRU Report 26 (International Commission on Radiation Units and Measurements: Bethesda, MD).
228. ICRU (1978) International Commission on Radiation Units and Measurements. An International Neutron Dosimetry Intercomparison, ICRU Report 27 (International Commission on Radiation Units and Measurements: Bethesda, MD).
229. ICRU (1979) International Commission on Radiation Units and Measurements. Average Energy Required to Produce an Ion Pair, ICRU Report 31 (International Commission on Radiation Units and Measurements: Bethesda, MD).
230. ICRU (1984) International Commission on Radiation Units and Measurements, Stopping Powers for Electrons and Positrons, ICRU Report 37 (International Commission on Radiation Units and Measurements: Bethesda, MD).
231. ICRU (1989) International Commission on Radiation Units and Measurements. Clinical Neutron Dosimetry Part 1: Determination of Absorbed Dose in a Patient Treated by External Beams of Fast Neutrons, ICRU Report 45 (International Commission on Radiation Units and Measurements: Bethesda, MD).
232. ICRU (1993a) International Commission on Radiation Units and Measurements, Stopping Powers and Ranges for Protons and Alpha Particles, ICRU Report 49 (International Commission on Radiation Units and Measurements: Bethesda, MD).
233. ICRU (1993b) International Commission on Radiation Units and Measurements. Prescribing, Recording, and Reporting Photon Beam Therapy, ICRU Report 50, (International Commission on Radiation Units and Measurements: Washington, DC).
234. ICRU (1998) International Commission on Radiation Units and Measurements. Clinical Proton Dosimetry Part 1: Beam Production, Beam Delivery and Measurement of Absorbed Dose, ICRU Report 59 (International Commission on Radiation Units and Measurements: Bethesda, MD).
235. ICRU (1999) International Commission on Radiation Units and Measurements. Prescribing, Recording, and Reporting Photon Beam Therapy (Supplement to ICRU Report 50), ICRU Report 62 (International Commission on Radiation Units and Measurements: Bethesda, MD).
236. ICRU (2000) International Commission on Radiation Units and Measurements. Nuclear Data for Neutron and Proton Radiotherapy and for Radiation Protection, ICRU Report 63 (International Commission on Radiation Units and Measurements: Bethesda, MD).
237. ICRU (2001) International Commission on Radiation Units and Measurements. Dosimetry of High-Energy Photon Beams Based on Standards of Absorbed Dose to Water, ICRU Report 64 (Nuclear Technology Publishing: Ashford, UK).
238. ICRU (2004) International Commission on Radiation Units and Measurements. Prescribing, Recording, and Reporting Electron Beam Therapy, ICRU Report 71, J. ICRU 4(1) (Oxford University Press: Oxford, UK).
239. ISO (1995) International Organization for Standardization. Guide to the Expression of Uncertainty in Measurement, 2nd edn. Published by ISO in the name of BIPM, IEC, IFCC, IUPAC, IUPAP and OIML (International Organization for Standardization: Geneva).
240. iTL (2001) iThemba Laboratory for Accelerator-Based Sciences. The Quality Control Programme for the iThemba LABS Proton Therapy Facility, Internal Report (iThemba LABS: Somerset West, South Africa).
241. Jaffray, D. A. (2003) 'X-ray-guided IMRT.' In Intensity Modulated Radiation Therapy: The State of the Art, Palta, J. R. and Mackie, T. R. Eds. (Medical Physics Publishing: Madison, WI).
242. JASTRO (2004) Japanese Association of Therapeutical Radiation Oncology. Guidelines of Physical and Technological Quality Assurance for Particle Beam Therapy.
243. Jesse, W. P. and Sadauskis, J. (1952) 'Alpha-particle ionization in mixtures of the noble gases.' Phys. Rev. 88, 417-418.
244. Jesse, W. P. and Sadauskis, J. (1953) 'Alpha-particle ionization in pure gases and the average energy to make an ion pair.' Phys. Rev. 90, 1120-1121.
245. Jiang, H. and Paganetti, H. (2004) 'Adaptation of GEANT4 to Monte Carlo dose calculations based on CT data.' Med. Phys., 31, 2811-2818.
246. Jiang, H., Wang, B., Xu, X. G., Suit, H. D. and Paganetti, H. (2005) 'Simulation of organ-specific patient effective dose due to secondary neutrons in proton radiation treatment.' Phys. Med. Biol. 50, 4337-4353.
247. Jirasek, A. and Duzenli, C. (2002) 'Relative effectiveness of polyacrylamide gel dosimeters applied to proton beams: Fourier transform Raman observations and track structure calculations.' Med. Phys. 29, 569-577.
248. Jones, A. Z., Bloch, C. D., Hall, E. R., Hashemian, R., Klein, S. B., von Przewoski, B., Murray, K. M. and Foster, C. C. (1999) 'Comparison of Indiana University Cyclotron Facility Faraday cup proton dosimetry with radiochromic films, a calorimeter, and a calibrated ion chamber.' IEEE Trans. Nucl. Sci. 46, 1762-1765.
249. Jones, D. T. L. (1995) 'The NAC particle therapy facilities,' pp. 350-359 in Ion Beams in Tumor Therapy, Linz, U. Ed. (Chapman and Hall:Weinheim, Germany).
250. Jones, D. T. L. (1996) 'Proton dosimetry intercomparison performed at the NAC,' p. 116 in National Accelerator Centre Annual Report, March (National Accelerator Centre: Faure, South Africa).
251. Jones, D. T. L. (1999) 'Present status and future trends of heavy particle therapy,' pp. 13-20 in Proc. 15th Int. Conf. on Cyclotrons and their Applications, Baron, E. and Lieuvin, M. Eds. (Institute of Physics Publishing: Bristol, UK.
252. Jones, D. T. L. (2001a) 'Overview of hadron therapy: rationales, present status and future prospects.' Radiochim. Acta 89, 235-244.
253. Jones, D. T. L. (2001b) 'Fast neutron and proton therapy sources.' Radiochim. Acta 89, 265-277.
254. Jones, D. T. L. (2001c) 'Proton therapy: the promise of precision.' Bull. Int. Radiat. Phys. Soc. 15 (3/4), 4-13.
255. Jones, D. T. L. (2001d) 'Reference dosimetry for fast neutron and proton therapy.' Radiochim. Acta 89, 279-287.
256. Jones, D. T. L. (2006) 'The w-value in air for proton therapy beams.' Radiat. Phys. Chem. 75, 541-550.
257. Jones, D. T. L. and Schreuder, A. N. (2001) 'Magnetically scanned proton therapy beams: rationales and principles.' Radiat. Phys. Chem. 61, 615-618.
258. Jones, D. T. L., Kacperek, A., Vynckier, S., Mazal, A., Delacroix, S. and Nauraye, C. (1992) 'A European proton dosimetry intercomparison,' pp. 61-63 in National Accelerator Centre Annual Report, NAC/AR/92-01 (National Accelerator Centre: Faure, South Africa).
259. Jones, D. T. L., Schreuder, A. N., Symons, J. E., Vynckier, S., Hayakawa, Y. and Maruhashi, A. (1994a) 'Proton dosimetry intercomparison at NAC,' pp. 94-95 in National Accelerator Centre Annual Report, NAC/AR/94-01 (National Accelerator Centre: Faure, South Africa).
260. Jones, D. T. L., Schreuder, A. N., Symons, J. E., Vynckier, S., Kacperek, A., Mazal, A., Delacroix, S., Nauraye, C., Bridier, A., Wagner, M., Beatty, J., Gall, K. and Hayakawa, Y. (1994b) 'National Accelerator Centre: proton dosimetry protocol intercomparisons,' p. 230 in Proc. NIRS International Seminar on the Application of Heavy Ion Accelerator to Radiation Therapy of Cancer in Connection with XXI PTCOG Meeting, Kanai, T. and Takada, E. Eds. NIRS-M-103/HIMAC-008 (National Institute of Radiological Sciences: Chiba, Japan).
261. Jones, D. T. L., Schreuder, A. N. and Symons, J. E. (1995) 'Use of stereophotogrammetry in proton radiation therapy,' pp. 138-153 in Proc. Int. Symp. on Photogrammetry in Engineering Surveying, Rüther, H. Ed. (University of Cape Town: South Africa.
262. Kacperek, A. (2003) 'Low-energy proton therapy: QA protocol.' Internal Report (Douglas Cyclotron, Clatterbridge Centre for Oncology: Clatterbridge, UK).
263. Kacperek, A. and Bonnett, D. E. (1990) 'Development of a Faraday cup for proton beam dosimetry at the MRC Cyclotron Unit at Clatterbridge Hospital,' pp. 53-56 in Proc. Int. Heavy Particle Therapy Workshop (PTCOG/EORTC/ECNEU), Blattmann, H. Ed. PSI-Bericht Nr. 69 (Paul Scherrer Institute: Villigen, Switzerland.
264. Kacperek, A., Egger, E., Barone Tonghi, L., Cuttone, G., Raffaele, L., Rovelli, A., Sabini, M. G., Tabarelli De Fatis, P., Luraschi, F. and Marzoli, L. (2002) 'Proton dosimetry intercomparison using parallel-plate ionization chambers in a proton eye therapy beam,' pp. 311-319 in Proc. Int. Symp. on Standards and Codes of Practice in Medical Radiation Dosimetry. IAEA-CN-96 (International Atomic Energy Agency: Vienna.
265. Kacperek, A., Vynckier, S., Bridier, A., Hérault, J. and Bonnett, D. E. (1991) 'A small scale European proton dosimetry intercomparison,' pp. 76-79 in Proc. Proton Radiotherapy Workshop, Blattmann, H. Ed. PSIBericht Nr. 111 (Paul Scherrer Institute, Villigen, Switzerland.
266. Kagawa, K., Murakami, M., Hishikawa, Y., Abe, M., Akagi, T., Yanou, T., Kagiya, G., Furusawa, Y., Ando, K., Nojima, K., Aoki, M. and Kanai, T. (2002) 'Preclinical biological assessment of proton and carbon ion beams at Hyogo Ion Beam Medical Center.' Int. J. Radiat. Oncol. Biol. Phys. 54, 928-938.
267. Kanai, T., Kawachi, K., Kumamoto, Y., Ogawa, H., Yamada, T. and Matsuzawa, H. (1980) 'Spot scanning system for proton radiotherapy.' Med. Phys. 7, 365-369.
268. Kanai, T., Kawachi, K., Matsuzawa, H. and Inada, T. (1983) 'Three-dimensional beam scanning for proton therapy.' Nucl. Instrum. Methods 214, 491-496.
269. Kanai, T., Endo, M., Minohara, S., Miyahara, N., Koyama-ito, H., Tomura, H., Matsufuji, N., Futami, Y., Fukumura, A., Hiraoka, T., Furusawa, Y., Ando, K., Suzuki, M., Soga, F. and Kawachi, K. (1999) 'Biophysical characteristics of HIMAC clinical irradiation system for heavy-ion radiation therapy.' Int. J. Radiat. Oncol. Biol. Phys. 44, 201-210.
270. Kanai, T., Fukumura, A., Kusano, Y., Shimbo, M. and Nishio, T. (2004) 'Cross-calibration of ionization chambers in proton and carbon beams.' Phys. Med. Biol. 49, 771-781.
271. Kanematsu, N., Matsufuji, N., Kohno, R., Minohara, S. and Kanai, T. (2003) 'A CT calibration method based on the polybinary tissue model for radiotherapy treatment planning.' Phys. Med. Biol. 48, 1053-1064.
272. Kapchinskii, I. M. and Teplyakov, V. A. (1970) 'Linear ion accelerator with spatially homogeneous strong focusing.' Prib. Tekh. Eksp. 19, 19-22.
273. Karzmark, C. J. (1964) 'Secondary emission monitor as a linear accelerator electron beam dose monitor.' Rev. Sci. Instrum. 35, 1646-1652.
274. Kavanaugh, B. D., Schefter, T. E., Cardenes, H. R., Stieber, V. W., Raben, D., Timmerman, R. D., McCarter, M. C., Burri, S., Nedzi, L. A., Sawyer, T. E. and Gaspar, L. E. (2006) 'Interim analysis of a prospective phase I/II trial of SBRT for liver metastases.' Acta Oncol. 45, 848-855.
275. Khoroshkov, V. S., Goldin, L. L., Onosovsky, K. K. and Klenov, G. I. (1991) 'Soviet project of proton therapy facility with several treatment rooms,' pp. 37-42 in Proc. Proton Radiotherapy Workshop, Blattmann, H. Ed. PSI-Bericht Nr. 111 (Paul Scherrer Institute: Villigen, Switzerland.
276. Khrunov, V. S., Martynov, S. S., Vatnitsky, S. M., Ermakov, I. A., Chervjakov, A. M., Karlin, D. L., Fominych, V. I. and Tarbeyev, Yu. V. (1990) 'Diamond detectors in relative dosimetry of photon, electron and proton radiation fields.' Radiat. Prot. Dosim. 33, 155-157.
277. Kjellberg, R. N. (1979) 'Stereotactic Bragg peak proton radiosurgery results,' pp. 233-241 in Stereotactic Cerebral Irradiation: INSERM Symposium No. 12, Szikla, G. Ed. (Elsevier/North Holland Press: Amsterdam.
278. Kjellberg, R. N., Koehler, A. M., Preston, W. M. and Sweet, W. H. (1962a) 'Stereotaxic instrument for use with the Bragg peak of a proton beam.' Confin. Neurol. 22, 183-189.
279. Kjellberg, R. N., Sweet, W. H., Preston, W. M. and Koehler, A. M. (1962b) 'The Bragg peak of a proton beam in intracranial therapy of tumors.' Trans. Am. Neurol. Soc. 87, 216-218.
280. Kjellberg, R. N., Shintani, A., Frantz, A. G. and Kliman, B. (1968) 'Proton-beam therapy in acromegaly.' New Eng. J. Med. 278, 689-695.
281. Kjellberg, R. N., Hanamura, T., Davis, K. R., Lyons, S. L. and Adams, R. D. (1983) 'Bragg-peak proton-beam therapy for arteriovenous malformations of the brain.' N Engl. J. Med. 309, 269-274.
282. Klassen, N. V. and Ross, C. K. (1991) 'Absorbed dose calorimetry using various aqueous solutions.' Radiat. Phys. Chem., 38, 95-104.
283. Klevenhagen, S. C. (1977a) 'The non-linearity of the temperature response of silicon p-n junction radiation detectors operated in the DC mode.' Phys. Med. Biol. 22, 353-358.
284. Klevenhagen, S. C. (1977b) 'Transient processes in the DC circuit of p-n junction silicon radiation detectors.' Phys. Med. Biol. 22, 773-779.
285. Knoll, G. F. (1989) Radiation Detection and Measurement (John Wiley, New York).
286. Knöös, T., Kristensen, I. and Nilsson, P. (1998) 'Volumetric and dosimetric evaluation of radiation treatment plans: Radiation conformity index.' Int. J. Radiat. Oncol. Biol. Phys. 42, 1169-1176.
287. Koehler, A. M. (1967) 'Dosimetry of proton beams using small silicon diodes.' Radiat. Res. (Suppl. 7), 53-63.
288. Koehler, A. M. (1987) 'Preliminary design study for a corkscrew gantry,' pp. 147-158 in Proc. Fifth Proton Therapy Co-Operative Group Meeting: International Workshop on Biomedical Accelerators. Lawrence Berkeley Laboratory, Dec 1-2, 1986, Publication LBL-22962 (Lawrence Berkeley Laboratory: Berkeley, CA.
289. Koehler, A. M. and Preston, W. M. (1972) 'Protons in radiation therapy. Comparative dose distributions for protons, photons, and electrons.' Radiology 104, 191-195.
290. Koehler, A. M., Schneider, R. J. and Sisterson, J. M. (1975) 'Range modulators for protons and heavy ions.' Nucl. Instrum. Methods 131, 437-440.
291. Koehler, A. M., Schneider, R. J. and Sisterson, J. M. (1977) 'Flattening of proton dose distributions for large-field radiotherapy.' Med. Phys. 4, 297-301.
292. Kogelnik, H. D. (1997) 'Hadrontherapy - do we need it?,' pp. 12-27 in Advances in Hadrontherapy, Amaldi, U., Larsson, B. and Lemoigne, Y. Eds. (Elsevier Science B. V.: Amsterdam).
293. Kooy, H. M. (2002) 'Clinical commissioning of Gantry 1 at the Northeast Proton Therapy Center,' in Particles 31: Abstracts of the 36th Proton Therapy Co-Operative Group Meeting, Catania, Italy.
294. Kooy, H. M., Schaefer, M., Rosenthal, S. and Bortfeld, T. (2003) 'Monitor unit calculations for range-modulated spread-out Bragg peak fields.' Phys. Med. Biol. 48, 2797-2808.
295. 11C reaction from 95 to 200 MeV.' Int. J. Appl. Radiat. Isot. 44, 1173-1175.
296. Kostjuchenko, V., Nichiporov, D. and Luckjashin, V. (2001) 'A compact ridge filter for spread out Bragg peak production in pulsed proton clinical beams.' Med. Phys. 28, 1427-1430.
297. Kubo, H. and Brown, D. E. (1984) 'Calorimeter dose determinations by direct voltage measurements on a Wheatstone-type bridge circuit.' Phys. Med. Biol. 29, 885-889.
298. Kubo, H. and Brown, D. E. (1986) 'Absorbed dose calorimetry: Bridge nulling and voltage analysis techniques.' Phys. Med. Biol. 13, 242-247.
299. Kubo, H., Kageyama, Y. and Kai Lo, K. (1989) 'Construction of a calorimeter prototype with a high sensitivity pulsed signal detection circuit.' Phys. Med. Biol. 34, 1119-1123.
300. Laitano, R. F. (1997) 'Reference dosimetry of proton beams for radiotherapy.' Phys. Med. XII (Suppl. 1), 75-79.
301. Laitano, R. F. (1998) 'Absolute measurement methods for proton beam dosimetry.' Riv. Nuovo Cimento 21, 1-58.
302. Laitano, R. F. and Rosetti, M. (2000) 'Proton stopping powers averaged over beam energy spectra.' Phys. Med. Biol. 45, 3025-3043.
303. Laitano, R. F., Rosetti, M. and Frisoni, M. (1996) 'Effects of nuclear interactions on energy and stopping power in proton beam dosimetry' Nucl. Instrum. Meth. Phys. Res. A376, 466-476.
304. Langen, K. M. and Jones, D. T. L. (2001) 'Organ motion and its management.' Int. J. Radiat. Oncol. Biol. Phys. 50, 265-278.
305. Larsson, B. (1961) 'Pre-therapeutic physical experiments with high energy protons.' Br. J. Radiol. 34, 143-151.
306. Larsson, B. (1967) 'Radiological properties of beams of high-energy protons.' Radiat. Res. (Suppl. 7), 304-311.
307. Larsson, B. and Sarby, B. (1987) 'Equipment for radiation surgery using narrow 185 MeV proton beams. Dosimetry and design.' Acta Oncol. 26, 143-158.
308. Larsson, B., Leksell, L., Rexed, B., Sourander, P., Mair, W. and Andersson, B. (1958) 'The high-energy proton beam as a neurosurgical tool.' Nature 182, 1222-1223.
309. Larsson, B., Leksell, L., Rexed, B. and Sourander, P. (1959) 'Effect of high energy protons on the spinal cord.' Acta Radiol. 51, 52-64.
310. Larsson, B., Leksell, L. and Rexed, B. (1963) 'The use of high energy protons for cerebral surgery in man.' Acta Chir. Scand. 125, 1-7.
311. Larsson, B., Graffman, S. and Jung, B. (1965) 'Fixation of Carbon-11 in the cells of proton-irradiated blood.' Nature 207, 543-544.
312. Laughlin, J. S. and Jenna, S. (1966) 'Calorimetry,' pp. 389-441 in Radiation Dosimetry, Vol. II, Attix, F. H. and Roesch, W. C. Eds. (Academic Press: New York).
313. Lawrence, J. H. (1957) 'Proton irradiation of the pituitary.' Cancer 10, 795-798.
314. Leksell, L. (1951) 'The stereotaxic method and radiosurgery of the brain.' Acta. Chir. Scand. 102, 316-319.
315. Leksell, L., Larsson, B., Andersson, B., Rexed, B., Sourander, P. and Mair, W. (1960) 'Lesions in the depth of the brain produced by a beam of high energy protons.' Acta Radiol. 54, 251-264.
316. Lesyna, D. (2004) 'An automated patient registration system for precision daily set-up for proton beam therapy,' in Particles 34, Abstracts of the 40th Proton Therapy Co-Operative Group Meeting Proton Therapy, Paris, France.
317. Li, Q., Groezinger, S. O., Haberer, T., Rietzel, E. and Kraft, G. (2004) 'Online compensation for target motion with scanned particle beams: Simulation environment.' Phys. Med. Biol. 49, 3029-3046.
318. Lin, R., Hug, E. B., Schaefer, R. A., Miller, D. W., Slater, J. M. and Slater, J. D. (2000) 'Conformal proton radiation therapy of the posterior fossa: A study comparing protons with three-dimensional planned photons in limiting dose to auditory structures.' Int. J. Radiat. Oncol. Biol. Phys. 48, 1219-1226.
319. Lin, S., Blattmann, H., Boehringer, T., Coray, A., Kohli, M. and Pedroni, E. (1994) 'Preparatory work for proton therapy beam dosimetry system at PSI,' pp. 481-487 in Hadrontherapy in Oncology, Amaldi, U. and Larsson, B. Eds. (Elsevier Science B. V.: Amsterdam).
320. Ling, C. C., Yorke, E., Amols, H., Mechalakos, J., Erdi, Y., Leibel, S., Rosenzweig, K. and Jackson, A. (2004) 'High-tech will improve radiotherapy of NSCLC: A hypothesis waiting to be validated.' Int. J. Radiat. Oncol. Biol. Phys. 60, 3-7.
321. Lomax, A. (1999) 'Intensity modulated methods for proton therapy.' Phys. Med. Biol. 44, 185-205.
322. Lomax, A. J. (2001) 'Methods for assessing the effects of inter- and intra-fraction position errors in radiotherapy.' Radiother. Oncol. 61 (Suppl. 1), S22 (abstract).
323. Lomax, A. J., Boehringer, T., Coray, A., Egger, E., Goitein, G., Grossmann, M., Juelke, P., Lin, S., Pedroni, E., Rohrer, B., Roser, W., Rossi, B., Siegenthaler, B., Stadelmann, O., Stauble, H., Vetter, C. and Wisser, L. (2001) 'Intensity modulated proton therapy: A clinical example.'Med. Phys. 28, 317-324.
324. Lomax, A. J., Goitein, M. and Adams, J. (2003) 'Intensity modulation in radiotherapy: photons versus protons in the paranasal sinus.' Radiother. Oncol. 66, 11-18.
325. Lomax, A. J., Böhringer, T., Bolsi, A., Coray, D., Emert, F., Goitein, G., Jermann, M., Lin, S., Pedroni, E., Rutz, H., Stadelmann, O.,
326. Loncol, T., Cosgrove, V., Denis, J. M., Gueulette, J., Mazal, A., Menzel, H. G., Pihet, P. and Sabattier, R. (1994) 'Radiobiological effectiveness of radiation beams with broad LET spectra: Microdosimetric analysis using biological weighting factors.' Radiat. Prot. Dosim. 52, 347-352.
327. Loncol, Th., Vynckier, S. and Wambersie, A. (1996) 'Thermoluminescence in proton and fast neutron therapy beams.' Radiat. Prot. Dosim. 66, 299-304.
328. Lorin, S., Grusell, E., Tilly, N., Medin, J., Blom, M., Ziemann, V., Reistad, D. and Glimelius, B. (2000) 'Development of a compact proton scanning system in Uppsala with a moveable second magnet.' Phys. Med. Biol. 45, 1151-1163.
329. Low, D. A., Nystrom, M., Kalinin, E., Parikh, P., Dempsey, J. F., Bradley, J. D., Mutic, S., Wahab, S. H., Islam, T., Christensen, G., Politte, D. G. and Whiting, B. R. (2003) 'A method for the reconstruction of four-dimensional synchronized CT scans acquired during free breathing.' Med. Phys. 30, 1254-1263.
330. Luchin, Y. I., Vatnitsky, S. M., Miller, D. W., Kostyuchenko, V. I., Nichiporov, D. F., Slater, J. D. and Slater, J. M. (2000) 'The use of radiochromic film in treatment verification of proton radiosurgery.' J. Radiosurg. 3, 69-75.
331. Lyman, J. (1985) 'Complication probability as assessed from dose-volume histograms.' Radiat. Res. 104, S13-S19.
332. Maccabee, H. D., Madhvanath, U. and Raju, M. R. (1969) 'Tissue activation studies with alpha-particle beams.' Phys. Med. Biol. 14, 213-224.
333. Mageras, G. S., Kutcher, G. J., Leibel, S. A., Zelefsky, M. J., Melian, E., Mohan, R. and Fuks, Z. (1996) 'A method of incorporating organ motion uncertainties into three-dimensional conformal treatment plans.' Int. J. Radiat. Oncol. Biol. Phys. 35, 333-342.
334. Mah, D., Hanley, J., Rosenzweig, K. E., Yorke, E., Braban, L., Ling, C. C., Leibel, S. A. and Mageras, G. (2000) 'Technical aspects of the deep inspirational breath-hold technique in the treatment of thoracic cancer.' Int. J. Radiat. Oncol. Biol. Phys. 48, 1175-1185.
335. Martin, R. L. (1987) 'A proton accelerator for medical applications.' Nucl. Instrum. Meth. Phys. Res. B24/25, 1087-1091.
336. Martinez-Monge, R., Fernandes, P. S., Gupta, N. and Gahbauer, R. (1999) 'Cross-sectional nodal atlas: a tool for the definition of clinical target volumes in three-dimensional radiation therapy planning.' Radiol. 211, 815-828.
337. Maruhashi, A. (1977) 'Characteristics of a miniature dosimeter developed for measurement of electrons.' Nucl. Instrum. Meth. 141, 87-92.
338. Maryanski, M. J., Schulz, R. J., Ibbott, G. S., Gatenby, J. C., Xie, J., Horton, D. and Gore, J. C. (1994) 'Magnetic resonance imaging of radiation dose distributions using a polymer-gel dosimeter.' Phys. Med. Biol. 39, 1437-1455.
339. Matsumura, S., Jikko, A., Ozeki, S., Tang, J. T., Fukushima, S., Yamazaki, H., Inoue, T., Hatanaka, K., Inoue, T. and Fuchihata, H. (1999) 'Differences in the biological effects of in vitro irradiation by 65 MeV protons and 137 cesium gamma-rays.' Anticancer Res. 19, 477-480.
340. McDonald, J. C. (1987) 'Calorimetric measurement of the carbon kerma factor for 14.6 MeV neutrons.' Radiat. Res. 109, 28-35.
341. McDonald, J. C. and Goodman, L. J. (1982) 'Measurements of the thermal defect of A-150 plastic (tissue-equivalent plastic).' Phys. Med. Biol. 27, 229-233.
342. McDonald, J. C. and Domen, S. R. (1986) 'A-150 plastic radiometric calorimeter for charged particles and other radiations.' Nucl. Instrum. Methods. Phys. Res. A252, 35-40.
343. McDonald, J. C., Laughlin, J. S. and Freeman, R. E. (1976) 'Portable tissue equivalent calorimeter.' Med. Phys. 3, 80-86.
344. McEwen, M. R. and Duane, S. (2000) 'A portable calorimeter for measuring absorbed dose in the radiotherapy clinic.' Phys. Med. Biol. 45, 3675-3691.
345. McKenzie, A. L. (2000) 'How should breathing motion be combined with other errors when drawing margins around clinical target volumes?' Br. J. Radiol. 73, 973-977.
346. McShan, D., Lynn, K., Vineberg, K. and Fraass, B. (2002) 'Radiotherapy plan optimization accounting for set-up and motion uncertainty using a multiple instance geometry approximation.' Med. Phys. 29, 1257 (abstract).
347. Medin, J. (1997) Studies of Clinical Proton Dosimetry Using Monte Carlo Simulation and Experimental Techniques, Doctoral Dissertation (Department of Medical Radiation Physics, University of Stockholm).
348. Medin, J. and Andreo, P (1992) 'Stopping powers for the ion-chamber dosimetry of radiotherapeutic heavyparticle beams.' Nucl. Instrum. Methods. Phys. Res. B69, 64-75.
349. Medin, J. and Andreo, P. (1997a) PETRA: A Monte Carlo Code for the Simulation of Proton and Electron Transport in Water, Report MSF 1997-01 (Department of Medical Radiation Physics, University of Stockholm).
350. Medin, J. and Andreo, P. (1997b) 'Monte Carlo calculated stopping-power ratios water/air for clinical proton dosimetry (50-250 MeV).' Phys. Med. Biol. 42, 89-105.
351. K ion chamber calibrations.' Phys. Med. Biol. 40, 1161-1176.
352. Medin, J., Andreo, P. and Vynckier, S. (2000) 'Comparison of dosimetry recommendations for clinical proton beams.' Phys. Med. Biol. 45, 3195-3211.
353. Medin, J., Ross, C. K., Klassen, N. V., Grusell, E. and Grindborg, J.-E. (2005) 'Comparison between water calorimetry and ionization chamber dosimetry in two photon beam qualities and a clinical proton beam.' Biomed. Tech 50 (Suppl. 1), 760-761.
354. Q, for two types of Farmer chamber in a 10 MV photon and a 175 MeV proton beam.' Phys. Med. Biol. 51, 1503-1521.
355. Meer, D., Pedroni, E., Bula, C., Hilbes, C. and Zenklusen, S. (2007) 'Progress on advanced scanning in the Gantry 2 test area,' in PSI Scientific Report 2006, (Paul Scherrer Institute: Villigen, Switzerland) pp. 5-6.
356. Méndez Romero, A., Wunderink, W., Hussain, S. M., De Pooter, J. A., Heijmen, B. J., Nowak, P. C., Nuyttens, J. J., Brandwijk, R. P., Verhoef, C., Ijzermans, J. N. and Levendag, P. C. (2006) 'Stereotactic body radiation therapy for primary and metastatic liver tumors: A single institution phase i-ii study.' Acta Oncol. 45, 831-837.
357. Menzel, H. G., Pihet, P. and Wambersie, A. (1990) 'Microdosimetric specification of radiation quality in neutron radiation therapy.' Int. J. Radiat. Biol. 57, 865-883.
358. Mesoloras, G., Sandison, G. A., Stewart, R. D., Farr, J. B. and Hsi, W. C. (2006) 'Neutron scattered dose equivalent to a fetus from proton radiotherapy of the mother.' Med. Phys. 33, 2479-2490.
359. Mijnheer, B. J. and Williams, J. R. (1985) 'Comments on dry air or humid air values for physical parameters used in the AAPM protocol for photon and electron dosimetry.' Med. Phys. 12, 656-658.
360. Mijnheer, B. J., Battermann, J. J. and Wambersie, A. (1987a) 'What degree of accuracy is required and can be achieved in photon and neutron therapy?' Radiother. Oncol. 8, 237-252.
361. Mijnheer, B. J., Wootton, P., Williams, J. R., Eenmaa, J. and Parnell, C. J. (1987b) 'Uniformity in dosimetry protocols for therapeutic applications of fast neutron beams.' Med. Phys. 14, 1020-1026.
362. Miller, D. W. (1995) 'A review of proton beam radiation therapy.' Med. Phys. 22, 1943-1954.
363. Miller, D., Moyers, M. and Vatnitsky, S. (1999) 'QA and commissioning of treatment planning system for radiotherapy with heavy-charged particles.' Radiother. Oncol. 51 (Suppl. 1), S3 (abstract).
364. Minohara, S., Kanai, T., Endo, M., Noda, K. and Kanazawa, M. (2000) 'Respiratory gated irradiation system for heavy-ion radiotherapy.' Int. J. Radiat. Oncol. Biol. Phys. 47, 1097-1103.
365. Miralbell, R., Lomax, A., Cella, L. and Schneider, U. (2002) 'Potential reduction of the incidence of radiation-induced second cancers by using proton beams in the treatment of pediatric tumors.' Int. J. Radiat. Oncol. Biol. Phys. 54, 824-829.
366. Mobit, P. N., Sandison, G. A. and Bloch, C. (2000) 'Depth ionization curves for an unmodulated proton beam measured with different ionization chambers.' Med. Phys. 27, 2780-2787.
367. Mock, U., Georg, D., Bogner, J., Auberger, T. and Pötter, R. (2004) 'Treatment planning comparison of conventional, 3D conformal, and intensity-modulated photon (IMRT) and proton therapy for paranasal sinus carcinoma.' Int. J. Radiat. Oncol. Biol. Phys. 58, 147-154.
368. Moyers, M. F. (1999) 'Proton therapy,' pp. 823-869 in The Modern Technology of Radiation Oncology, Van Dyk, J. Ed. (Medical Physics Publishing: Madison, WI).
369. Moyers, M. F. and Lesyna, W. (2004) 'Isocenter characteristics of an external ring proton gantry.' Int. J. Radiat. Oncol. Biol. Phys. 60, 1622-1630.
370. Moyers, M. F., Vatnitsky, S. M., Miller, D. W. and Slater, J. M. (2000) 'Determination of the air w-value in proton beams using ionization chambers with gas flow capability.' Med. Phys. 27, 2363-2368.
371. Müller, J. W. (2000a) Weighted Medians, Report BIPM-2000/6 (Bureau International des Poids et Mesures, Sèvres).
372. Müller, J. W. (2000b). 'Possible advantages of a robust evaluation of comparisons.' Res. Natl. Inst. Stand. Technol. 105, 551-555.
373. Munzenrider, J. E. (1999) 'Proton therapy for uveal melanoma and other eye lesions.' Strahlenther. Onkol. 175 (Suppl. II), 68-73.
374. Munzenrider, J. E., Shipley, W. U. and Verhey, L. J. (1981) 'Future prospects of radiation therapy with protons.' Semin. Oncol. 8, 110-124.
375. Mustafa, A. A. M. and Jackson, D. F. (1981) 'Small-angle multiple scattering and spatial resolution in charged particle tomography.' Phys. Med. Biol. 26, 461-472.
376. Myers, I. T. (1968) 'Ionization,' pp. 317-330 in Radiation Dosimetry, Vol. 1, Attix, F. H., Roesch, W. and Tochilin, E. Eds. (Academic Press: New York).
377. Nahum, A. E. and Glimelius, B. (2001) 'Biological models applied to the comparison of proton and photon treatments.' Phys. Med. XV11, 126-130.
378. Nahum, A. E. and Sanchez-Nieto, B. (2001) 'Tumor control probability modelling: Basic principles and applications in treatment planning.' Phys. Med. XV11, 13-23.
379. Nahum, A. E., Dearnaley, D. P. and Steel, G. G. (1994) 'Prospects for proton-beam radiotherapy.' Eur. J. Cancer 30A, 1577-1583.
380. 60Co gamma-rays.' Med. Phys. 8, 85-93.
381. Nauraye, C., Mazal, A., Delacroix, S., Bridier, A., Chavaudra, J. and Rosenwald, J.-C. (1995) 'An experimental approach to the design of a scattering system for a proton therapy beam line dedicated to opthalmological applications.' Int. J. Radiat. Oncol. Biol. Phys. 32, 1177-1183.
382. Nemoto, K., Pickles, T., Minchinton, A. I. and Lam, G. K. (1998) 'The relative biological effectiveness of the modulated proton beam at TRIUMF.' Radiat. Med. 16, 43-46.
383. Newhauser, W. D., Burns, J. and Smith, A. R. (2002a). 'Dosimetry for ocular proton beam therapy at the Harvard Cyclotron Laboratory based on the ICRU Report 59.' Med. Phys. 29, 1953-1961.
384. Newhauser, W. D., Myers, K. D., Rosenthal, S. J. and Smith, A. R. (2002b). 'Proton beam dosimetry for radiosurgery: Implementation of the ICRU Report 59 at the Harvard Cyclotron Laboratory.' Phys. Med. Biol. 47, 1369-1389.
385. Newhauser, W. D., Koch, N., Hummel, S., Ziegler, M. and Titt, U. (2005) 'Monte Carlo simulations of a nozzle for the treatment of ocular tumours with high-energy proton beams.' Phys. Med. Biol. 50, 5229-5249.
386. Niatel, M. T. (1969) 'Étude expérimentale de l'influence de la vapeur d'eau sur l'ionisation produite dans l'air.' C. R. Acad. Sci. Paris B268, 1650-1653.
387. Niatel, M. T., Perroche-Roux, A. M. and Boutillon, M. (1985) 'Two determinations of W for electrons in dry air.' Phys. Med. Biol. 30, 67-75.
388. Nichiporov, D. (2003) 'Verification of absolute ionization chamber dosimetry in a proton beam using carbon activation measurements.' Med. Phys. 30, 972-978.
389. Nichiporov, D., Kostjuchenko, V., Puhl, J. M., Bensen, D. L., Desrosiers, M. F., Dick, C. E., McLaughlin, W. L., Kojima, T., Coursey, B. M. and Zink, S. (1995) 'Investigation of applicability of alanine and radiochromic detectors to dosimetry of proton clinical beams.' Appl. Radiat. Isot. 46, 1355-1362.
390. 22Na sources using 4π-β-γ coincidence system.' Appl. Radiat. Isot. 60, 703-716.
391. Nieder, J. A. and Mead, R. (1965) 'A simplex method for function minimization.' Comp. J. 7, 308-313.
392. Niemierko, A. (1997) 'Reporting and analyzing dose distributions: A concept of equivalent uniform dose.' Med. Phys. 24, 103-110.
393. Niemierko, A. and Goitein, M. (1993) 'Implementation of a model for estimating tumor control probability for an inhomogeneously irradiated tumor.' Radiother. Oncol. 29, 140-147.
394. Niemierko, A. and Goitein, M. (1994) 'Dose-volume distributions: A new approach to dose-volume histograms in three-dimensional treatment planning.' Med. Phys. 21, 3-11.
395. Niroomand-Rad, A., Blackwell, C. R., Coursey, B. M., Gall, K. P., Galvin, J. M., McLaughlin, W. L., Meigooni, A. S., Nath, R., Rodgers, J. E. and Soares, C. G. (1998) 'Radiochromic film dosimetry: Recommendations of AAPM Radiation Therapy Committee Task Group 55.' Med. Phys. 25, 2093-2115.
396. 2O targets by target nuclear fragment reaction using therapeutic MONO and SOBP proton beams.' Med. Phys. 32, 1070-1082.
397. Noel, G., Ferrand, R., Feuvert, L., Boisserie, G., Meyroneinc, S. and Mazeron, J. J. (2003) 'Automatization and robotics of the set-up and treatment of patients irradiated for brain and base of the skull tumors.' Cancer Radiother. 7 (Suppl. 1), 33s-41s.
398. Noel, G., Feuvert, L., Ferrand, R., Boisserie, G., Mazeron, J. J. and Habrand, J. L. (2004) 'Radiotherapeutic factors in the management of cervical-basal chordomas and chondrosarcomas.' Neurosurgery 55 1252-1262.
399. Noel, G., Feuvert, L., Calugaru, V., Dhermain, F., Mammar, H., Haie-Meder, C., Ponvert, D., Hasboun, D., Ferrand, R., Nauraye, C., Boisserie, G., Beaudre, A., Gaboriaud, G., Mazal, A., Habrand, J. L. and Mazeron, J. J. (2005) 'Chordomas of the base of the skull and upper cervical spine. One hundred patients irradiated by a 3D conformal technique combining photon and proton beams.' Acta Oncol. 44, 700-708.
400. Nohtomi, A., Sakae, T., Tsunashima, Y. and Kohno, R. (2001) 'Dosimetry of pulsed clinical proton beams by a small ionization chamber.' Med. Phys. 28, 1431-1435.
401. Oelfke, U. and Bortfeld, T. (2001) 'Inverse planning for photon and proton beams.' Med. Dosim. 26, 113-124.
402. Ohara, K., Okumura, T., Akisada, M., Inada, T., Mori, T., Yokota, H. and Calaguas, M. J. (1989) 'Irradiation synchronized with respiration gating.' Int. J. Radiat. Oncol. Biol. Phys. 17, 853-857.
403. Onori, S., d'Errico, F., De Angelis, C., Egger, E., Fattibene, P. and Janovsky, I. (1997) 'Alanine dosimetry of proton therapy beams.' Med. Phys. 24, 447-453.
404. Onori, S., De Angelis, C., Fattibene, P., Pacilio, M., Petetti, E., Azario, L., Miceli, R., Piermattei, A., Barone Tonghi, L., Cuttone, G. and Lo Nigro, S. (2000) 'Dosimetric characterization of silicon and diamond detectors in low-energy proton beams.' Phys. Med. Biol. 45, 3045-3058.
405. Oozeer, R., Mazal, A., Rosenwald, J. C., Belshi, R., Nauraye, C., Ferrand, R. and Biensan, S. (1997) 'A model for the lateral penumbra in water of a 200-MeV proton beam devoted to clinical applications.' Med. Phys. 24, 1599-1604.
406. Pacilio, M., De Angelis, C., Onori, S., Azario, L., Fidanzio, A., Miceli, R., Piermattei, A. and Kacperek, A. (2002) 'Characteristics of silicon and diamond detectors in a 60 MeV proton beam.' Phys. Med. Biol. 47, N107-N112.
407. Paganetti, H. (1998) 'Monte Carlo method to study the proton fluence for treatment planning.' Med. Phys. 25, 2370-2375.
408. Paganetti, H. (2002) 'Nuclear interactions in proton therapy: Dose and relative biological effect distributions originating from primary and secondary particles.' Phys. Med. Biol. 47, 747-764.
409. Paganetti, H. and Goitein, M. (2000) 'Radiobiological significance of beam line dependent proton energy distributions in a spread-out Bragg peak.' Med. Phys. 27, 1119-1126.
410. Paganetti, H. and Gottschalk, B. (2003) 'Test of GEANT3 and GEANT4 nuclear models for 160 MeV protons stopping in CH2.' Med. Phys. 30, 1926-1931.
411. Paganetti, H., Niemierko, A., Ancukiewicz, M., Gerweck, L. E., Goitein, M., Loeffler, J. S. and Suit, H. D. (2002) 'Relative biological effectiveness (RBE) values for proton therapy.' Int. J. Radiat. Oncol. Biol. Phys. 53, 407-421.
412. Paganetti, H., Jiang, H., Lee, S.-Y. and Kooy, H. M. (2004) 'Accurate Monte Carlo simulations for nozzle design, commissioning and quality assurance for a proton radiation therapy facility.' Med. Phys. 31, 2107-2118.
413. Paganetti, H., Jiang, H. and Trofimov, A. (2005) '4D Monte Carlo simulation of proton beam scanning: Modeling of variations in time and space to study the interplay between scanning pattern and time-dependent patient geometry.' Phys. Med. Biol. 50, 983-990.
414. Palmans, H. (2003) 'Effect of alanine energy response and phantom material on depth dose measurements in ocular proton beams.' Technol. Cancer Res. Treatment 2, 579-586.
415. Palmans, H. and Verhaegen, F. (1997) 'Calculated depth dose distributions for proton beams in some low-Z materials.' Phys. Med. Biol. 42, 1175-1183.
416. Palmans, H. and Verhaegen, F. (1998) 'Monte Carlo study of fluence perturbation effects on cavity dose response in clinical proton beams.' Phys. Med. Biol. 43, 65-89.
417. Palmans, H. and Vynckier, S. (2002) 'Reference dosimetry for clinical proton beams,' pp. 157-194 in Recent Developments in Accurate Radiation Dosimetry, Seuntjens, J. and Mobit, P. N. Eds. (Medical Physics Publishing: Madison, WI).
418. Palmans, H., Seuntjens, J., Verhaegen, F., Denis, J.-M., Vynckier, S. and Thierens, H. (1996) 'Water calorimetry and ionization chamber dosimetry in an 85-MeV clinical proton beam.' Med. Phys. 23, 643-650.
419. Palmans, H., Verhaegen, F., Denis, J.-M., Vynckier, S. and Thierens, H. (1999) 'Experimental study of perturbation correction factors for ionization chambers in a 75 MeV clinical proton beam.' Radiother. Oncol. 51 Suppl. 1, S39 (abstract).
420. cel correction factors for ionization chambers in low-energy clinical proton beams.' Phys. Med. Biol. 46, 1187-1204.
421. Palmans, H., Verhaegen, F., Denis, J.-M. and Vynckier, S. (2002a). 'Dosimetry using plane-parallel ionization chambers in a 75 MeV clinical proton beam.' Phys. Med. Biol. 47, 2895-2905.
422. Palmans, H., Symons, J. E., Denis, J-M., de Kock, E. A., Jones, D. T. L. and Vynckier, S. (2002b) 'Fluence correction factors in plastic phantoms for clinical proton beams.' Phys. Med. Biol. 47, 3055-3071.
423. Palmans, H., Thomas, R., Simon, M., Duane, S., Kacperek, A., DuSautoy, A. and Verhaegen, F. (2004) 'A small-body portable graphite calorimeter for dosimetry in low-energy clinical proton beams.' Phys. Med. Biol. 49, 3737-3749.
424. Palmans, H., Thomas, R. and Kacperek, A. (2006) 'Ion recombination correction in the Clatterbridge Centre of Oncology clinical proton beam.' Med. Phys. 21, 3-11.
425. Pan, T., Lee, T. Y., Rietzel, E. and Chen, G. T. Y. (2004) '4D-CT imaging of a volume influenced by respiratory motion on multi-slice CT.' Med. Phys. 31, 333-340.
426. Parodi, K. and Enghardt, W. (2000) 'Potential application of PET in quality assurance of proton therapy.' Phys. Med. Biol. 45, N151-N156.
427. +-radioactivity induced by proton beams.' Phys. Med. Biol. 47, 21-36.
428. Parodi, K., Ferrari, A., Sommerer, F. and Paganetti, H. (2007a) 'Clinical CT-based calculations and positron emitter distributions in proton therapy using the FLUKA Monte Carlo code.' Phys. Med. Biol. 52, 3369-3387.
429. Parodi, K., Paganetti, H., Cascio, E., Flanz, J., Bonab, A., Alpert, N., Lohmann, K. and Bortfeld, T. (2007b) 'PET/CT imaging for treatment verification after proton therapy - a study with plastic phantoms and metallic implants.' Med. Phys. 34, 419-435.
430. Parodi, K., Paganetti, H., Loeffler, J. S., DeLaney, T. F., Liebsch, N. J., Munzenrider, J., Fischman, A. J., Knopf, A. and Bortfeld, T. (2007c) 'Patient study of in vivo verification of beam delivery and range, using positron emission tomography and computed tomography imaging after proton therapy.' Int. J. Radiat. Oncol. Biol. Phys. 68, 920-934.
431. Pedroni, E., Bacher, R., Blattmann, H., Böhringer, T., Coray, A., Egger, E., Phillips, M. and Sheib, S. (1990) 'The 200 MeV proton therapy project at PSI: A status report,' pp. 1-8 in Proc. Int. Heavy Particle Therapy Workshop (PTCOG/EORTC/ECNEU), Blattmann, H. Ed. PSI-Bericht Nr. 69 (Paul Scherrer Institute: Villigen, Switzerland).
432. Pedroni, E., Bacher, R., Blattman, H., Boehringer, T., Coray, A., Lomax, A., Lin, S., Munkel, G., Scheib, S., Schneider, U. and Tourovsky, A. (1995) 'The 200-MeV proton therapy project at the Paul Scherrer Institute: Conceptual design and practical realization.' Med. Phys. 22, 37-53.
433. Pedroni, E., Bearpark, R., Böhringer, T., Coray, A., Duppich, J., Forss, S., Gearge, D., Grossman, M., Goitein, G., Hilbes, C., Jermann, M., Lin, S., Lomax, A., Negrazus, M., Schippers, M. and Kotle, G. (2004) 'The PSI gantry 2: a second generation proton scanning gantry.' Z. Med. Phys. 14, 25-34.
434. Pedroni, E., Scheib, S., Böhringer, T., Coray, A., Grossmann, M., Lin, S. and Lomax, A. (2005) 'Experimental characterization and physical modelling of the dose distribution of scanned proton pencil beams.' Phys. Med. Biol. 50, 541-561.
435. Petti, P. L. (1992) 'Differential-pencil-beam dose calculations for charged particles.' Med. Phys. 19, 137-149.
436. Petti, P. L. (1996) 'Evaluation of a pencil-beam dose calculation technique for charged particle radiotherapy.' Int. J. Radiat. Oncol. Biol. Phys. 35, 1049-1057.
437. Petti, P. L. (1997) 'New compensator design options for charged-particle radiotherapy.' Phys. Med. Biol., 42, 1289-1300.
438. Petti, P. L. and Lennox, A. J. (1994) 'Hadronic radiotherapy.' Ann. Rev. Nucl. Part. Sci. 44, 155-197.
439. Phillips, M. H., Pedroni, E., Blattmann, H., Boehringer, T., Coray, A. and Scheib, S. (1992) 'Effects of respiratory motion on dose uniformity with a charged particle scanning method.' Phys. Med. Biol. 37, 223-233.
440. Piermattei, A., Miceli, R., Azario, L., Fidanzio, A., delle Canne, S., de Angelis, C., Onori, S., Pacilio, M., Petetti, E., Raffaele, L. and Sabini, M. G. (2000) 'Radiochromic film dosimetry of a low energy proton beam.' Med. Phys. 27, 1655-1660.
441. Podgorsak, M. B. and Schreiner, L. J. (1992) 'Nuclear magnetic relaxation characterization of irradiated Fricke solution.' Med. Phys. 19, 87-95.
442. Polf, J. C. and Newhauser, W. D. (2005) 'Calculations of neutron dose equivalent exposures from range-modulated proton therapy beams.' Phys. Med. Biol. 50, 3859-3873.
443. Polf, J. C., Newhauser, W. D. and Titt, U. (2005) 'Patient neutron dose equivalent exposures outside of the proton therapy treatment field.' Radiat. Prot. Dosim. 115, 154-158.
444. Pommier, P., Liebsch, N. J., Deschler, D. G., Lin, D. T., McIntyre, J. F., Barker, F. G., II, Adams, J. A., Lopes, V. V., Varvares, M., Loeffler, J. S. and Chan, A. W. (2006) 'Proton beam radiation therapy for skull base adenoid cystic carcinoma.' Arch. Otolaryngol. Head Neck Surg. 132, 1242-1249.
445. Rabin, M. S. W. (1987) 'Skin/tumor dose ratio as a function of source to isocenter distance for a 250 MeV proton beam.' Proton Therapy Co-Operative Group Meeting, Boston, MA.
446. Raju, M. R. (1966) 'The use of the miniature silicon diode as a radiation dosimeter.' Phys. Med. Biol. 11, 371-376.
447. Raju, M. R. (1980) Heavy Particle Radiotherapy (Academic Press, Inc.: New York).
448. Raju, M. R. (1994) 'Hadrontherapy in a historical and international perspective,' pp. 67-79 in Hadrontherapy in Oncology, Amaldi, U. and Larsson, B. Eds. (Elsevier Science B. V.: Amsterdam).
449. Raju, M. R. (1995a) 'The history of ion beam therapy,' pp. 3-32 in Ion Beams in Tumor Therapy, Linz, U. Ed (Chapman and Hall, Weinheim, Germany).
450. Raju, M. R. (1995b) 'Proton radiobiology, radiosurgery and radiotherapy.' Int. J. Radiat. Biol. 67, 237-259.
451. Raju, M. R. (1996) 'Particle radiotherapy: historical developments and current status.' Radiat. Res. 145, 391-407.
452. Raju, M. R., Bain, E., Carpenter, S. G., Cox, R. A. and Robertson, J. B. (1978) 'A heavy particle comparative study. Part II: Cell survival versus depth.' Br. J. Radiol. 51, 704-711.
453. Ramm, U., Weber, U., Bock, M., Krämer, M., Bankamp, A., Damrau, M., Thilmann, C., Böttcher, H. D., Schad, L. R. and Kraft, G. (2000) 'Three-dimensional BANG™ gel dosimetry in conformal carbon ion radiotherapy.' Phys. Med. Biol. 45, N95-N102.
454. Regulla, D. F. and Deffner, U. (1982) 'Dosimetry by ESR spectroscopy of alanine.' Int. J. Appl. Radiat. Isot. 33, 1101-1114.
455. Renner, T. R., Chu, W. T., Ludewigt, B., Nyman, M. A. and Stradtner, R. (1989) 'Multisegmented ionization chamber dosimetry system for light ion beams.' Nucl. Instr. Meth. Phys. Res. A281, 640-648.
456. Rexed, B., Mair, W., Sourander, P., Larsson, B. and Leksell, L. (1960) 'Effect of high energy protons on the brain of the rabbit.' Acta Radiol. 53, 289-299.
457. Rikner, G. (1983) Silicon diodes as detectors in relative dosimetry of photon, electron and proton radiation fields, PhD Dissertation (Uppsala University, Sweden).
458. Rikner, G. (1985) 'Characteristics of a p-Si detector in high energy electron fields.' Acta Radiol. Oncol. 24, 71-74.
459. Rikner, G. and Grusell, E. (1987) 'General specifications for silicon semiconductors for use in radiation dosimetry.' Phys. Med. Biol. 32, 1109-1117.
460. Robertson, J. B., Williams, J. R., Schmidt, R. A., Little, J. B., Flynn, D. F. and Suit, H. D. (1975) 'Radiobiological studies of a high-energy modulated proton beam utilizing cultured mammalian cells.' Cancer 35, 1664-1677.
461. Roeske, J. C., Forman, J. D., Mesina, C. F., He, T., Pelizzari, C. A., Fontenla, E., Vijayakumar, S. and Chen, G. T. Y. (1995) 'Evaluation of changes in the size and location of the prostate, seminal vesicles, bladder, and rectum during a course of external beam radiation therapy.' Int. J. Radiat. Oncol. Biol. Phys. 33, 1321-1329.
462. Rogers, D. W. O. (1992) 'The advantages of absorbed-dose calibration factors.' Med. Phys. 19, 1227-1239.
463. Rogers, D. W. O. and Ross, C. K. (1988) 'The role of humidity and other correction factors in the AAPM TG-21 dosimetry protocol.' Med. Phys. 15, 40-48.
464. Rosenberg, A. E., Nielsen, G. P., Keel, S. B., Renard, L. G., Fitzek, M. M., Munzenrider, J. E. and Liebsch, N. J. (1999) 'Chondrosarcoma of the base of the skull: a clinicopathological study of 200 cases with emphasis on its distinction from chordoma.' Am. J. Surg. Pathol. 23, 1370-1378.
465. Ross, C. K. and Klassen, N. V. (1996) 'Water calorimetry for radiation dosimetry.' Phys. Med. Biol. 41, 1-29.
466. Ross, C. K., Klaasen, N. V., Shortt, K. R. and Smith, G. D. (1989) 'A direct comparison of water calorimetry and Fricke dosimetry.' Phys. Med. Biol. 34, 23-42.
467. Rosser, K. E. (1994) 'An ice calorimeter for photon dosimetry.' Phys. Med. Biol. 39, 293-298.
468. Roy, S. C. and Sandison, G. A. (2004) 'Scattered neutron dose equivalent to a fetus from proton therapy of the mother.' Radiat. Phys. Chem. 71, 997-998.
469. Rutz, H-P. and Lomax, A. (2005) 'Donut-shaped highdose configuration for proton beam radiation therapy.' Strahlenther. Onkol., 181, 49-53.
470. Ryneveld, S. (1998) Measurement of Proton Beam Dose Profiles Using a Sensitive Scintillation Screen Observed with a CCD Camera, Master of Science thesis (Department of Physics, The University of British Columbia, Vancouver, Canada).
471. Säbel, M., Schmidt, Th. and Pauly, H. (1973) 'Heat defect of low energy x-rays absorbed in carbon and various plastics.' Health Phys. 25, 519-521.
472. Safai, S., Lin, S. and Pedroni, E. (2004) 'Development of an inorganic scintillating mixture for proton beam verification dosimetry.' Phys. Med. Biol. 49, 4637-4655.
473. Sankar, A., Ayyangar, K., Nehru, R., Gopalakrishna Kurup, P., Murai, E., Enke, C. and Velmurugan, J. (2006) 'Comparison of Kodak EDR2 and GafChromic EBT film for intensity-modulated radiation therapy dose distribution verification.' Med. Dosim. 31, 273-282.
474. Sauli, F. (1977) Principles of Operation of Multiwire Proportional and Drift Chambers, CERN Report 77-09 (CERN, Geneva, Switzerland).
475. Sauli, F. (1992) 'Applications of gaseous detectors in astrophysics, medicine and biology.' Nucl. Instrum. Meth. Phys. Res. A323, 1-11.
476. Schaffner, B. and Pedroni, E. (1998) 'The precision of proton range calculations in proton radiotherapy treatment planning: experimental verification of the relation between CT-HU and proton stopping power.' Phys. Med. Biol. 43, 1579-1592.
477. Scheib, S. and Pedroni, E. (1992) 'Dose calculations and optimization for 3D conformal voxel scanning.' Radiat. Environ. Biophys. 31, 251-256.
478. Schneider, U. and Pedroni, E. (1995) 'Proton radiography as a tool for quality control in proton therapy.' Med. Phys. 22, 353-363.
479. Schneider, U., Pedroni, E. and Lomax, A. (1996) 'The calibration of CT Hounsfield units for radiotherapy treatment planning.' Phys. Med. Biol. 41, 111-124.
480. Schneider, U., Pemler, P., Besserer, J., Dellert, M., Moosburger, M., de Boer, J., Pedroni, E. and Boehringer, T. (2002a) 'The water equivalence of solid materials used for dosimetry with small proton beams.' Med. Phys. 29, 2946-2951.
481. Schneider, U., Agosteo, S., Pedroni, E. and Besserer, J. (2002b) 'Secondary neutron dose during proton therapy using spot scanning.' Int. J. Radiat. Oncol. Biol. Phys. 53, 244-251.
482. Schneider, U., Pemler, P., Besserer, J., Pedroni, E., Lomax, A. and Kaser-Hotz, B. (2005) 'Patient specific optimization of the relation between CT-Hounsfield units and proton stopping powers with proton radiography.' Med. Phys. 32, 195-199.
483. Schreuder, A. N. (2002) Proton Therapy Operations and Treatment Procedure Manual. Internal Report (iThemba LABS, Somerset West, South Africa).
484. Schreuder, A. N. (2004) 'The MPRI robotic patient positioner,' in Particles 34, Abstracts of the 40th Proton Therapy Co-Operative Group Meeting, Paris, France.
485. Schreuder, A. N., Jones, D. T. L. and Kiefer, A. (1997) 'A small ionization chamber for dose distribution measurements in a clinical proton beam,' pp. 284-289 in Advances in Hadrontherapy, Amaldi, U., Larsson, B. and Lemoigne, Y. Eds (Elsevier Science B. V: Amsterdam).
486. Schreuder, A. N., Mazal, A., Nauraye, C., Delacroix, S., Bridier, A., Gall, K., Wagner, M. and Beatty, J. (1994) 'Proton dosimetry intercomparisons at CPO, France and HCL, USA,' pp. 95-97 in National Accelerator Centre Annual Report, NAC/AR/94-01 (National Accelerator Centre: Faure, South Africa).
487. Schreuder, A. N., Tourovsky, A., Kiefer, A. and van der Merwe, J. (2001) 'The development of a multi-layer Faraday cup to characterize the NAC proton therapy beam,' in NAC Annual Report, March 2001.http://www4.tlabs.ac.za/ annualreport/developmentofamulti.htm.
488. Schulte, R. W., Fargo, R. A., Meinass, H. J., Slater, J. D. and Slater, J. M. (2000) 'Analysis of head motion prior to and during proton beam therapy.' Int. J. Radiat. Oncol. Biol. Phys. 47, 1105-1110.
489. Schultheiss, T. E., Orton, C. G. and Peck, R. A. (1983) 'Models in radiotherapy: Volume effects.' Med. Phys. 10, 410-415.
490. Schulz, R. J., Almond, P. R., Kutcher, G., Loevinger, R., Nath, R., Rogers, D. W. O., Suntharalingam, N., Wright, K. A. and Kahn, F. M. (1986) 'Clarification of the AAPM Task Group 21 protocol.' Med. Phys. 13, 755-759.
491. Schulz, R. J., Wuu, C. S. and Weinhous, M. S. (1987) 'The direct determination of dose-to-water using a water calorimeter.' Med. Phys. 14, 790-796.
492. Schulz, R. J., Venkataramanan, N. and Huq, M. S. (1990) 'The thermal defect of A-150 plastic and graphite for low-energy protons.' Phys. Med. Biol. 35, 1563-1574.
493. Schulz, R. J., Huq, M. S., Venkataramanan, N. and Motakabbir, K. A. (1991) 'A comparison of ionization-chamber and water-calorimeter dosimetry for high-energy x rays.' Med. Phys. 18, 1229-1233.
494. Schulz, R. J., Verhey, L. J., Huq, M. S. and Venkataramanan, N. (1992) 'Water calorimeter dosimetry for 160 MeV protons.' Phys. Med. Biol. 37, 947-953.
495. Schweikard, A., Shiomi, H. and Adler, J. (2004) 'Respiration tracking in radiosurgery.' Med. Phys. 31, 2738-2741.
496. Seltzer, S. M. (1993) An Assessment of the Role of Charged Secondaries from Nonelastic Nuclear Interactions by Therapy Proton Beams in Water, NISTIR 5221 (National Institute of Standards and Technology, Gaithersburg, MD).
497. Seuntjens, J. and Palmans, H. (1999) 'Correction factors and performance of a 4°C sealed water calorimeter.' Phys. Med. Biol. 44, 627-646.
498. Seuntjens, J. P. and DuSautoy, A. R. (2002) 'Review of calorimeter based absorbed dose to water standards,' pp. 37-66 in Proc. Int. Symp. on Standards and Codes of Practice in Medical Radiation Dosimetry. IAEA-CN-96 (International Atomic Energy Agency: Vienna.
499. Seuntjens, J., Palmans, H., Verhaegen, F., Denis, J.-M., Vynckier, S. and Thierens, H. (1994) 'Water calorimetry for clinical proton beams,' in Proc. NPL Calorimetry Workshop (National Physical Laboratory: Teddington, UK).
500. Shalev, S., Bartel, L., Therrien, P., Hahn, P. and Carey, M. (1988) 'The objective evaluation of alternative treatment plans: I. Images of regret.' Int. J. Radiat. Oncol. Biol. Phys., 15, 763-767
501. Sharp, G. C., Kollipara, S., Madden, T., Jiang, S. B. and Rosenthal, S. (2005) 'Anatomic feature-based registration for patient setup in head and neck cancer radiotherapy.' Phys. Med. Biol. 50, 4667-4679.
502. Sheng, K., Jeraj, R., Shaw, R., Mackie, T. R. and Paliwal, B. R. (2005) Imaging dose management using multi-resolution in CT-guided radiation therapy.'
503. Shipley, W. U., Tepper, J. E., Prout, G. R., Verhey, L. J., Mendiondo, O. A., Goitein, M., Koehler, A. M. and Suit, H. D. (1979) 'Proton radiation as boost therapy for localized prostatic carcinoma.' J. Am. Med. Assoc. 241, 1912-1915.
504. Shipley, W. U., Verhey, L. J., Munzenrider, J. E., Suit, H. D., Urie, M. M., McManus, P. L., Young, R. H., Shipley, J. W., Zietman, A. L., Biggs, P. J., Heney, N. M. and Goitein, M. (1995) 'Advanced prostate cancer: The results of a randomized comparative trial of high dose irradiation boosting with conformal protons compared with conventional dose irradiation using photons alone.' Int. J. Radiat. Oncol. Biol. Phys. 32, 3-12.
505. Siebers, J. V., DeLuca, P. M. Jr., Awschalom, M. and Coutrakon, G. (1988) 'Performance of a prototype range ionization chamber bombarded by 160 MeV protons.' Paper MPWP9.7, World Congress on Medical Physics and Biomedical Engineering, San Antonio, TX.
506. Siebers, J. V., Vatnitsky, S. M., Miller, D. W. and Moyers, M. F. (1995) 'Deduction of the air w value in a therapeutic proton beam.' Phys. Med. Biol. 40, 1339-1356.
507. Sisterson, J. M. (2005) Particles Newsletter, Vol. 37 (Northeast Proton Therapy Center, Boston, MA).
508. Sisterson, J. M., Urie, M. M., Koehler, A. M. and Goitein, M. (1989) 'Distal penetration of proton beams: the effects of air gaps between compensating bolus and patient.' Phys. Med. Biol. 34, 1309-1315.
509. Sisterson, J. M., Cascio, E., Koehler, A. M. and Johnson, K. N. (1991) 'Proton beam therapy: Reliability of the synchrocyclotron at the Harvard Cyclotron Laboratory.' Phys. Med. Biol. 36, 285-290.
510. Skarsgard, L. D. (1998) 'Radiobiology with heavy charged particles: a historical review.' Phys. Med. XIV (Suppl. 1), 1-19.
511. Slabbert, J. P., Jones, D. T. L., Schreuder, A. N., Jones, H. L., Symons, J. and Hough, J. H. (1994) 'Variations in biological effectiveness with depth in a 200 MeV proton beam,' pp. 103-106 in NAC Annual Report, NAC/AR/94-1 (National Accelerator: Faure, South Africa).
512. Slater, J. D., Slater, J. M. and Schulte, R. W. (1995) 'Proton beam therapy at Loma Linda University Medical Center: clinical experience of the first four years,' pp. 673-679 in Proc. 5th Int. Meeting on Progress in Radio-Oncology (ICRO, Ocombining double acute accentGRO 5), Salzburg, Austria (Monduzzi Editore S.p.A.: Bologna, Italy).
513. Slater, J. D., Rossi, C. J., Yonemoto, L. T., Bush, D. A., Jabola, B. R., Levy, R. P., Grove, R. I., Preston, W. and Slater, J. M. (2004) 'Proton therapy for prostate cancer: The initial Loma Linda University experience.' Int. J. Radiat. Oncol. Biol. Phys. 59, 348-352.
514. Smith, A. R. (2006) 'Proton therapy.' Phys. Med. Biol. 51, R491-R504.
515. Smith, A. R., Rosen, I. I. and Hogstrom, K. R. (1977) 'The silicon diode as an in vivo dosimeter for fast neutrons.' Int. J. Radiat. Oncol. Biol. Phys. 2, 111-116.
516. Soares, C. G. (2006) 'New developments in radiochromic film dosimetry.' Radiat. Prot. Dosim. 120, 100-106.
517. Spielberger, B., Scholz, M., Krämer, M. and Kraft, G. (2001) 'Experimental investigations of the response of films to heavy-ion irradiation.' Phys. Med. Biol. 46, 2889-2897.
518. Spielberger, B., Scholz, M., Krämer, M. and Kraft, G. (2002) 'Calculation of the x-ray film response to heavy charged particle irradiation.' Phys. Med. Biol. 47, 4107-4120.
519. Stavrev, P., Niemierko, A., Stavreva, N. and Goitein, M. (2001) 'The application of biological models to clinical data.' Phys. Med. XV11, 71-82.
520. Stroom, J. C., de Boer, H. C. J., Huizenga, H. and Visser, A. G. (1999) 'Inclusion of geometrical uncertainties in radiotherapy treatment planning by means of coverage probability.' Int. J. Radiat. Oncol. Biol. Phys. 43, 905-919.
521. Suit, H. (2002) 'The Gray Lecture 2001: Coming technical advances in radiation oncology.' Int. J. Radiat. Oncol. Biol. Phys. 53, 798-809.
522. Suit, H. D. and Goitein, M. (1974) 'Dose-limiting tissues in relation to type and location of tumors: implications for efforts to improve radiation dose distributions.' Eur. J. Cancer 10, 217-224.
523. Suit, H. and Urie, M. (1992) 'Proton beams in radiation therapy.' J. Natl. Cancer Inst. 84, 155-164.
524. Suit, H. D. and Krengli, M. (1997) 'Basis for interest in proton beam radiation therapy,' pp. 29-37 in Advances in Hadrontherapy, Amaldi, U., Larsson, B. and Lemoigne, Y. Eds (Elsevier Science B. V: Amsterdam).
525. Suit, H. D., Goitein, M., Tepper, J., Koehler, A. M., Schmidt, R. A. and Schneider, R. (1975) 'Exploratory study of proton radiation therapy using large field techniques and fractionated dose schedules.' Cancer 35, 1646-1657.
526. Suit, H., Goitein, M., Munzenrider, J., Verhey, L., Blitzer, P., Gragoudas, E., Koehler, A. M., Urie, M., Gentry, R., Shipley, W., Urano, M., Duttenhaver, J. and Wagner, M. (1982) 'Evaluation of the clinical applicability of proton beams in definitive fractionated radiation therapy.' Int. J. Radiat. Oncol. Biol. Phys. 8, 2199-2205.
527. Suit, H., Urie, M. and Efird, J. T. (1992) 'Proton beams in clinical radiation therapy.' Principles Practice Oncol. 6, 1-15.
528. Suit, H., Goldberg, S., Niermierko, A., Trofimov, A., Adams, J., Paganetti, H., Chen, G. T. Y., Bortfeld, T., Rosenthal, S., Loeffler, J. and Delaney, T. (2003) 'Proton beams to replace photon beams in radical dose treatments.' Acta. Oncol. 42, 800-808.
529. Sunaga, H., Agematsu, T., Tanaka, R., Yosida, K. and Kohno, I. (1988) 'Dosimetry by cellulose triacetate film dosimetry in proton-beam irradiation.' Radioisotopes 37, 84-87 (in Japanese).
530. Szymanowski, H. and Oelfke, U. (2003) 'CT calibration for two-dimensional scaling of proton pencil beams.' Phys. Med. Biol. 48, 861-874.
531. Tang, J. T., Inoue, T., Yamazaki, H., Fukushima, S., Fournier-Bidoz, N., Koizumi, M., Ozeki, S. and Hatanaka, K. (1997) 'Comparison of radiobiological effective depths in 65 MeV modulated proton beams.' Br. J. Cancer 76, 220-225.
532. Tatsuzaki, H. and Urie, M. (1991) 'Importance of precise positioning for proton beam therapy in the base of skull and cervical spine.' Int. J. Radiat. Oncol. Biol. Phys. 21, 757-765.
533. Tatsuzaki, H., Inada, T., Arimoto, T., Shimizu, T., Sato, S., Yaguchi, M. and Akisada, M. (1991) 'Early and late effects of fractionated 250 MeV proton beam irradiation on murine legs.' J. Jpn. Soc. Ther. Radiol. Oncol. 3, 171-179.
534. Tautfest, G. W. and Fechter, H. R. (1955) 'A nonsaturable high-energy beam monitor.' Rev. Sci. Instrum. 26, 229-231.
535. Terahara, A., Niemierko, A., Goitein, M., Finkelstein, D., Hug, E., Liebsch, N., O'Farrell, D., Lyons, S. and Munzenrider, J. (1999) 'Analysis of the relationship between tumor dose inhomogeneity and local control in patients with skull base chordoma.' Int. J. Radiat. Oncol. Biol. Phys. 45, 351-358.
536. Terunuma, T., Sakae, T., Nohtomi, A. and Tsunashima, Y. (2003) 'The direct measurement using an imaging plate for coincidence of radiation centre and laser position in external radiation therapy.' Phys. Med. Biol. 48, N59-N63.
537. Thomas, L. H. (1938) 'The paths of ions in the cyclotron. I. Orbits in the magnetic field.' Phys. Rev. 54, 580-588.
538. Tobias, C. A., Anger, H. O. and Lawrence, J. H. (1952) 'Radiological use of high energy deuterons and alpha particles.' Am. J. Roentgenol. Rad. Ther. Nucl. Med. 67, 1-27.
539. Tobias, C. A., Van Dyke, D. C., Simpson, M. E., Anger, H. O., Huff, R. L. and Koneff, A. A. (1954) 'Irradiation of the pituitary of the rat with high energy deuterons.' Am. J. Roentgenol. Rad. Ther. Nucl. Med. 72, 1-21.
540. Tobias, C. A., Roberts, J. E., Lawrence, J. H., Low-Beer, B. V. A., Anger, H. O., Born, J. L., McCombs, R. and Huggins, C. (1955) 'Irradiation hypophysectomy and related studies using 340-MeV protons and 190-MeV deuterons,' pp. 95-105 in Proc. Int. Conf. on Peaceful Uses of Atomic Energy, Geneva, Switzerland.
541. Tobias, C. A., Lawrence, J. H., Born, J. L., McCombs, R. K., Roberts, J. E., Anger, H. O., Low-Beer, B. V. A. and Huggins, C. B. (1958) 'Pituitary irradiation with highenergy proton beams: A preliminary report.' Cancer Res. 18, 121-139.
542. Tourovsky, A., Lomax, A. J., Schneider, U. and Pedroni, E. (2005) 'Monte Carlo dose calculations for spot scanned proton therapy.' Phys. Med. Biol. 50, 971-981.
543. Trump, M. A. and Pinkerton, A. P. (1967) 'Application of PN junction diodes to the measurement of dose distribution of high energy radiation.' Phys. Med. Biol. 12, 573-576.
544. Tsai, Y.-S. (1974) 'Pair production and bremsstrahlung of charged leptons.' Rev. Mod. Phys. 46, 815-851.
545. Tsunashima, Y., Sakae, T., Shioyama, Y., Kagei, K., Terunuma, T., Nohtomi, A. and Akine, Y. (2004) 'Correlation between the respiratory waveform measured using a respiratory sensor and 3D tumor motion in gated radiotherapy.' Int. J. Radiat. Oncol. Biol. Phys. 60, 951-958.
546. UICC (1997) International Union against Cancer. TNM Classification of Malignant Tumors, 5th edn, Sobin, L. H. and Wittekind, C. Eds (Wiley-Liss and Sons, Inc.: New York).
547. Ulmer, W. and Kaissl, W. (2003) 'The inverse problem of a Gaussian convolution and its application to the finite size of the measurement chambers/detectors in photon and proton dosimetry.' Phys. Med. Biol. 48, 707-727.
548. Urie, M. M. and Goitein, M. (1989) 'Variable versus fixed modulation of proton beams for treatments in the cranium.' Med. Phys. 16, 593-601.
549. Urie, M., Goitein, M. and Wagner, M. (1984) 'Compensating for heterogeneities in proton radiation therapy.' Phys. Med. Biol. 29, 553-566.
550. Urie, M., Goitein, M., Holley, W. R. and Chen, G. T. Y. (1986a) 'Degradation of the Bragg peak due to inhomogeneities.' Phys Med Biol. 31, 1-15.
551. Urie, M. M., Sisterson, J. M., Koehler, A. M., Goitein, M. and Zoesman, J. (1986b) 'Proton beam penumbra: Effects of separation between patient and beam modifying devices.' Med. Phys. 13, 734-741.
552. Urie, M., Goitein, M., Doppke, K., Kutcher, J. G., LoSasso, T., Mohan, R., Munzenrider, J. E., Sontag, M. and Wong, J. W. (1991) 'The role of uncertainty analysis in treatment planning.' Int. J. Radiat. Oncol. Biol. Phys. 21, 91-107.
553. Uusi-Simola, J., Savolainen, S., Kangasmäki, A., Heikkinen, S., Perkiö, J., Abo Ramadan, U., Seppälä, T., Karila, J., Serén, T., Kotiluoto, P., Sorvari, P. and Auterinen, I. (2003) 'Study of the relative dose-response of BANG-3® polymer gel dosimeters in epithermal neutron irradiation.' Phys. Med. Biol. 48, 2895-2906.
554. van Herk, M. (2004) 'Errors and margins in radiotherapy.' Semin. Radiat. Oncol. 14, 52-64.
555. van Herk, M., Remeijer, P., Rasch, C. and Lebesque, J. V. (2000) 'The probability of correct target dosage: dose population histograms for deriving treatment margins in radiotherapy.' Int. J. Radiat. Oncol. Biol. Phys. 47, 1121-1135.
556. van Luijk, P., van't Veld, A. A., Zelle, H. D. and Schippers, J. M. (2001) 'Collimator scatter and 2D dosimetry in small proton beams.' Phys. Med. Biol. 46, 653-670.
557. van Luijk, P., Delvigne, T. C., Schilstra, C. and Schippers, J. M. (2003) 'Estimation of parameters of dose-volume models and their confidence limits.' Phys. Med. Biol. 48, 1863-1884.
558. van't Riet, A., Mak, A. C., Moerland, M. A., Elders, L. H. and van der Zee, W. (1997) 'A conformation number to quantify the degree of conformality in brachytherapy and external beam irradiation: Application to the prostate.' Int. J. Radiat. Oncol. Biol. Phys. 37, 731-736.
559. Vatnitsky, S. M. (1997) 'Radiochromic film dosimetry for clinical proton beams.' Appl. Radiat. Isot. 48, 643-651.
560. Vatnitsky, S. and Järvinen, H. (1993) 'Application of a natural diamond detector for the measurement of relative dose distributions in radiotherapy.' Phys. Med. Biol. 38, 173-184.
561. Vatnitsky, S. M. and Andreo, P. (2002) 'Codes of practice and protocols for the dosimetry in reference conditions of proton and ion beams,' pp. 279-294 in Proc. Int. Symp. on Standards and Codes of Practice in Medical Radiation Dosimetry. IAEA-CN-96 (International Atomic Energy Agency, Vienna).
562. Vatnitsky, S. M., Khrunov, V. S., Fominych, V. I. and Schuele, E. (1993) 'Diamond detector dosimetry for medical applications.' Radiat. Prot. Dosim. 47, 515-518.
563. Vatnitsky, S. M., Miller, D. W., Siebers, J. and Moyers, M. (1995) 'Application of solid state detectors for dosimetry of therapeutic proton beams.' Med. Phys. 22, 469-473.
564. Q factors for ionization chamber dosimetry in clinical proton beams.' Med. Phys. 23, 25-31.
565. Vatnitsky, S., Siebers, J., Miller, D., Moyers, M., Schaefer, M., Jones, D., Vynckier, S., Hayakawa, Y., Delacroix, S., Isacsson, U., Medin, J., Kacperek, A., Lomax, A., Coray, A., Kluge, H., Heese, J., Verhey, L., Daftari, I., Gall, K., Lam, G., Beck, T. and Hartmann, G. (1996b) 'Proton dosimetry intercomparison.' Radiother. Oncol. 41, 169-177.
566. Vatnitsky, S. M., Schulte, R. W. M., Galindo, R., Meinass, H. J. and Miller, D. W. (1997) 'Radiochromic film dosimetry for verification of dose distributions delivered with proton-beam radiosurgery.' Phys. Med. Biol. 42, 1887-1898.
567. Vatnitsky, S. M., Miller, D. W., Moyers, M. F., Levy, R. P., Schulte, R. W., Slater, J. D. and Slater, J. M. (1999a) Dosimetry techniques for narrow proton beam radiosurgery. Phys. Med. Biol. 44, 2789-2801.
568. Vatnitsky, S., Moyers, M., Miller, D., Abell, G., Slater, J. M., Pedroni, E., Coray, A., Mazal, A., Newhauser, W., Jaekel, O., Heese, J., Fukumura, A., Futami, Y., Verhey, L., Daftari, I., Grusell, E., Molokanov, A. and Bloch, C. (1999b) 'Proton dosimetry intercomparison based on the ICRU Report 59 protocol.' Radiother. Oncol. 51, 273-379.
569. Vatnitsky, S. M., Moyers, M. F. and Vatnitsky, A. S. (2002) 'Parallel-plate and thimble ionization chamber calibrations in proton beams using the TRS 398 and ICRU 59 recommendations,' pp. 327-336 in Proc. Int. Symp. on Standards and Codes of Practice in Medical Radiation Dosimetry. IAEA-CN-96 (International Atomic Energy Agency, Vienna).
570. Verhaegen, F. and Palmans, H. (2001) 'A systematic Monte Carlo study of secondary electron fluence perturbation in clinical proton beams (70-250 MeV) for cylindrical and spherical ion chambers.' Med. Phys. 28, 2088-2095.
571. Verhey, L. J. and Munzenrider, J. E. (1982) 'Proton beam therapy.' Ann. Rev. Biophys. Bioeng. 11, 331-357.
572. Verhey, L. J. and Lyman, J. T. (1992) 'Some considerations regarding w values for heavy charged-particle radiotherapy.' Med. Phys. 19, 151-153.
573. Verhey, L. and Bentel, G. (1999) 'Patient immobilization,' pp. 53-94 in The Modern Technology of Radiation Oncology, Van Dyk, J. Ed. (Medical Physics Publishing: Madison, WI).
574. Verhey, L. J., Koehler, A. M., McDonald, J. C., Goitein, M., Ma, I-C., Schneider, R. J. and Wagner, M. (1979) 'The determination of absorbed dose in a proton beam for purposes of charged-particle radiation therapy.' Radiat. Res. 79, 34-54.
575. Verhey, L. J., Goitein, M., McNulty, P., Munzenrider, J. E. and Suit, H. D. (1982) 'Precise positioning of patients for radiation therapy.' Int. J. Radiat. Oncol. Biol. Phys. 8, 289-294.
576. von Essen, C. F., Blattmann, H., Crawford, J. F., Fessenden, P., Pedroni, E., Perret, C., Salzmann, M., Shortt, K. and Walder, E. (1982) 'The PIOTRON, initial performance, preparation and experience with pion therapy.' Int. J. Radiat. Oncol. Biol. Phys. 8, 1499-1509.
577. Vynckier, S. (1995) 'Dosimetry techniques for ion beams,' in Ion Beams in Tumor Therapy, Linz, U. Ed. (Chapman and Hall: Weinheim, Germany) pp. 246-255.
578. Vynckier, S. (2004) 'Dosimetry of clinical neutron and proton beams: an overview of recommendations.' Radiat. Prot. Dosim. 110, 565-572.
579. Vynckier, S., Meulders, J.-P., Robert, P. and Wambersie, A. (1984) 'The protontherapy program at the cyclotron 'Cyclone' of Louvain-la-Neuve (first dosimetric results).' J. Eur. Radiother. 3, 245-247.
580. Vynckier, S., Bonnett, D. E. and Jones, D. T. L. (1991) 'Code of practice for clinical proton dosimetry.' Radiother. Oncol. 20, 53-63.
581. Vynckier, S., Derreumaux, S., Richard, F., Bol, A., Michel, C. and Wambersie, A. (1993) 'Is it possible to verify directly a proton-treatment plan using positron emission tomography?' Radiother. Oncol. 26, 275-277.
582. Vynckier, S., Bonnett, D. E. and Jones, D. T. L. (1994) 'Supplement to the code of practice for clinical proton dosimetry.' Radiother. Oncol. 32, 174-179.
583. Wagner, M. S. (1982) 'Automated range compensation for proton therapy.' Med. Phys. 9, 749-752.
584. Wagner, W. and Pruss, A. (2002) 'The IAPWS formulation 1995 for the thermodynamic properties of ordinary water substance for general and scientific use.' J. Phys. Chem. Ref. Data 31, 387-535.
585. Waligórski, M. P. R., Danialy, G., Loh, K. S. and Katz, R. (1989) 'The response of the alanine detector after charged-particle and neutron irradiations.' Appl. Radiat. Isot. 40, 923-933.
586. Wambersie, A. and Battermann, J. J. (1995) 'Socioeconomic aspects of ion beam therapy,' pp. 24-32 in Ion Beams in Tumor Therapy, Linz, U. Ed (Chapman and Hall: Weinheim, Germany).
587. Wambersie, A., Auberger, T., Gahbauer, R. A., Jones, D. T. L. and Pötter, R. (1999) 'A challenge for high-precision radiation therapy: the case for hadrons.' Strahlenther. Onkol. 175 (Suppl. II), 122-128.
588. Wambersie, A., Menzel, H., Gahbauer, R., DeLuca, P. and Whitmore, G. (2002) 'RBE and harmonization in prescribing, recording and reporting hadron therapy,' pp. 361-371 in Progress in Radiation Oncology VII, Kogelnik, H. D., Lukas, P. and Sedlmayer, F. Eds (Monduzzi Editore S.p.A.: Bologna, Italy).
589. Wambersie, A., Gahbauer, R. A. and Menzel, H. G. (2004a) 'RBE and weighting of absorbed dose in ion-beam therapy.' Radiother. Oncol. 73 (Suppl. 2), S176-S182.
590. Wambersie, A., Gueulette, J., Jones, D. T. L. and Gahbauer, R. (2004b) 'Ion-beam therapy: rationale, achievements, and expectations,' pp. 743-784 in Charged Particle and Photon Interactions with Matter, Mozumder, A. and Hatano, Y. Eds (Marcel Dekker, Inc.: New York).
591. Wambersie, A., Hendry, J. H., Andreo, P., DeLuca, P. M., Gahbauer, R., Menzel, H. and Whitmore, G. (2006) 'The RBE issues in ion-beam therapy: conclusions of a joint IAEA/ICRU working group regarding quantities and units.' Radiat. Prot. Dosim. 122, 463-470.
592. Webb, S. (1994) 'Optimum parameters in a model for tumour control probability including inter-patient heterogeneity.' Phys. Med. Biol. 39, 1895-1914.
593. Weber, D. C., Trofimov, A. V., Delaney, T. F. and Bortfeld, T. (2004) 'A treatment planning comparison of intensity modulated photon and proton therapy for paraspinal sarcomas.' Int. J. Radiat. Oncol. Biol. Phys. 58, 1596-1606.
594. ion, the correction factor for recombination losses in an ionization chamber.' Med. Phys. 11, 846-849.
595. Welsh, J. S., Patel, R. R., Ritter, M. A., Harari, P. M., Mackie, T. R. and Mehta, M. P. (2002) 'Helical tomotherapy: an innovative technology and approach to radiation therapy.' Technol. Cancer Res. Treat. 1, 311-316.
596. Weyrather, W. K., Ritter, S., Scholz, M. and Kraft, G. (1999) 'RBE for carbon track-segment irradiation in cell lines of differing repair capacity.' Int. J. Radiat. Biol. 75, 1357-1364.
597. Wieser, A., Lettau, C., Fill, U. and Regulla, D. F. (1993) 'The influence of non-radiation induced ESR background signal from paraffin-alanine probes for dosimetry in the radiotherapy dose range.' Appl. Radiat. Isot. 44, 59-65.
598. Wilkins, D., Li, X. A., Cygler, J. and Gerig, L. (1997) 'The effect of dose rate dependence of p-type silicon detectors on linac relative dosimetry.' Med. Phys. 24, 879-891.
599. Wilson, R. R. (1946) 'Radiological use of fast protons.' Radiol. 47, 487-491.
600. Withers, H. R., Taylor, J. M. and Maciejewski, B. (1988) 'Treatment volume and tissue tolerance.' Int.J. Radiat. Oncol. Biol. Phys. 14, 751-759.
601. Wong, J. W., Sharpe, M. B., Jaffray, D. A., Kini, V. R., Robertson, J. M., Stromberg, J. S. and Martinez, A. A. (1999) 'The use of active breathing control (ABC) to reduce margin for breathing motion.' Int. J. Radiat. Oncol. Biol. Phys. 44, 911-919.
602. Wouters, B. G., Lam, G. K. Y., Oelfke, U., Gardey, K., Durand, R. E. and Skarsgard, L. D. (1996) 'Measurements of relative biological effectiveness of the 70 MeV proton beam at TRIUMF using Chinese hamster V79 cells and the high-precision cell sorter assay.' Radiat. Res. 146, 159-170.
603. Wroe, A. J., Cornelius, I. M. and Rosenfeld, A. B. (2005) 'The role of nonelastic reactions in absorbed dose distributions from therapeutic proton beams in different medium.' Med. Phys. 32, 37-41.
604. Wroe, A., Rosenfeld, A. and Schulte, R. (2007) 'Out-of-field dose equivalents delivered by proton therapy of prostate cancer.' Med. Phys. 34, 3449-3456.
605. Wulf, J., Guckenberger, M., Haedinger, U., Oppitz, U., Mueller, G., Baier, K. and Flentje, M. (2006) 'Stereotactic radiotherapy of primary liver cancer and hepatic metastases.' Acta Oncol. 45, 838-847.
606. Yamada, Y., Lovelock, D. M., Yenice, K. M., Bilsky, M. H., Hunt, M. A., Zatcky, J. and Leibel, S. A. (2005) 'Multifractionated image-guided and stereotactic intensity-modulated radiotherapy of paraspinal tumors: A preliminary report.' Int. J. Radiat. Oncol. Biol. Phys. 62, 53-61.
607. Yan, X., Titt, U., Koehler, A. M. and Newhauser, W. D. (2002) 'Measurements of neutron dose equivalent to proton therapy patients outside of the proton radiation field.' Nucl. Instrum. Methods Phys. Res. A476, 429-434.
608. York, E. D. (2003) 'Biological indices for evaluation and optimization of IMRT,' in Intensity Modulated Radiation Therapy: The State of the Art, Palta, J. R. and Mackie, T. R. Eds (Medical Physics Publishing, Madison, WI).
609. Zankowski, C., Vatnitsky, S., Siebers, J. and Podgorsak, E. B. (1998) 'Proton beam output measurement with an extrapolation chamber.' Med. Dosim. 23, 288-291.
610. Zeidan, O. A., Stephenson, S. A. L., Meeks, S. L., Wagner, T. H., Willoughby, T. R., Kupelian, P A. and Langen, K. M. (2006) 'Characterization and use of EBT radiochromic film for IMRT dose verification.' Med. Phys. 33, 4064-4072.
611. Zelefsky, M. J., Chan, H., Hunt, M., Yamada, Y., Shippy, A. M. and Amols, H. (2006) 'Long-term outcome of high dose intensity modulated radiation therapy for patients with clinically localized prostate cancer.' J. Urol. 176, 1415-1419.
612. Ziegler, J. F., Saunders, P. A. and Zabel, T. H. (1996) 'Portable Faraday cup for non vacuum proton beams.' IBM J. Res. Develop. 40, 73-76.
613. Zietman, A. L., DeSilvio, M. L., Slater, J. D., Rossi, C. J. Jr., Miller, D. W., Adams, J. A. and Shipley, W. U. (2005) 'Comparison of conventional-dose vs. high-dose conformal radiation therapy in clinically localized adenocarcinoma of the prostate: a randomized controlled trial.' J. Am. Med. Assoc. 294, 1233-1239.
614. Zurlo, A., Lomax, A., Hoess, A., Bortfeld, T., Russo, M., Goitein, G., Valentini, V., Marucci, L., Capparella, R. and Loasses, A. (2000) 'The role of proton therapy in the treatment of large irradiation volumes: A comparative planning study of pancreatic and biliary tumors.' Int. J. Radiat. Oncol. Biol. Phys. 48, 277-288.