Relative biological effectiveness (RBE) values for proton beam therapy

International Journal of Radiation Oncology Biology Physics

Volumn 53, Issue 2, 2002, Pages 407-421

  Paganetti, Harald ^a   Niemierko, Andrzej ^a,b   Ancukiewicz, Marek ^a,b   Gerweck, Leo E ^a,b   Goitein, Michael ^a,b   Loeffler, Jay S ^a,b   Suit, Herman D ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Normal tissues; Protons; RBE; Relative biological effectiveness

Indexed keywords

DATA REDUCTION; ERROR DETECTION; PATIENT TREATMENT; PROBABILITY; PROTON BEAMS; TISSUE;

PROTON BEAM THERAPY;

ONCOLOGY;

COBALT 60; PROTON;

ANALYTICAL ERROR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEAM THERAPY; CANCER RADIOTHERAPY; CELL LINE; CELL SPREADING; CELL SURVIVAL; COBALT THERAPY; COLONY FORMATION; CONTROLLED STUDY; DOSE RESPONSE; DOSIMETRY; GENERAL HOSPITAL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INCIDENCE; LINEAR ENERGY TRANSFER; MAJOR CLINICAL STUDY; MORBIDITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROBABILITY; PROSTATE CANCER; PROTON RADIATION; RADIATION DOSE FRACTIONATION; RADIATION RESPONSE; RADIATION SICKNESS; RADIOBIOLOGY; SKULL CANCER; STATISTICAL SIGNIFICANCE; TISSUE REACTION; TREATMENT OUTCOME; TREATMENT PLANNING;

ANIMALS; BRAIN; BRAIN NEOPLASMS; HUMANS; LINEAR ENERGY TRANSFER; MALE; ORGAN SPECIFICITY; PROSTATIC NEOPLASMS; PROTONS; RADIATION INJURIES; RECTUM; REFERENCE VALUES; RELATIVE BIOLOGICAL EFFECTIVENESS; TUMOR CELLS, CULTURED; TUMOR STEM CELL ASSAY;

EID: 0036603619     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(02)02754-2     Document Type: Article

References (72)

1. RBE, reference RBE, and clinical RBE: Applications of these concepts in hadron therapy
2. The relative biological effectiveness of 22-MVp X-rays, cobalt-60 gamma-rays, and 200 kVp X-rays. VII: Summary of studies for five criteria of effect
3. Radiobiological studies of a high-energy modulated proton beam utilizing cultured mammalian cells
4. Estimation of optimum dose per fraction for high LET radiations: Implications for proton radiotherapy
5. Relative biological effectiveness and microdosimetry of a mixed energy field of protons up to 200 MeV
6. Radiobiological significance of beam line dependent proton energy distributions in a spread-out Bragg peak
7. Radiobiology with heavy charged particles: A historical review
8. A report on the change in the proton absorbed dose measurement protocol for the clinical trials conducted at the Harvard Cyclotron Laboratory (abstract)
9. The relative biological effectiveness of 60Co gamma-rays, 55 kVp X-rays, 250 kVp X-rays, and 11 MeV electrons at low doses
10. The relative biological efficiency of X rays generated at 220 kVp and gamma radiation from a Cobalt 60 therapy unit
11. An investigation of changes in relative biological effectiveness (RBE) with depth for X ray beams generated between 100 and 250 kVp using the mouse foot as biological test system
12. Relative biological effectiveness of intermediate energy protons: Comparisons with 60Co gamma-radiation using two cell lines
13. The relative biological effectiveness of 160 MeV protons. II. Biological data and their interpretation in terms of microdosimetry
14. RBE measurement on the 70 MeV proton beam at TRIUMF using V79 cells and the high precision cell sorter assay
15. Inactivation of C3H10T1/2 cells by low energy protons and deuterons
16. Inactivation of human normal and tumour cells irradiated with low energy protons
17. Microdosimetry spectra of the Loma Linda proton beam and relative biological effectiveness comparisons
18. Variations in biological effectiveness with depth in a 200 MeV proton beam
19. Relative biological effectiveness of the 235 MeV proton beams at the National Cancer Center Hospital East
20. Radiobiological studies on the 65 MeV therapeutic proton beam at Nice using human tumour cells
21. Comparison of radiobiological effective depths in 65-MeV modulated proton beams
22. Measurements of radiobiological effectiveness in the 85 MeV proton beam produced at the cyclotron CYCLONE of Louvain-la-Neuve, BEL
23. Relative biological effectiveness of proton medical beam at Moscow synchrotron determined by the Chinese hamster cells assay
24. Low-dose hypersensitivity in Chinese hamster V79 cells targeted with counted protons using a charged-particle microbeam
25. Chromosome aberration frequencies produced by a 70-MeV proton beam
26. Biological effectiveness of light ions for cell inactivation and mutation induction on V79 cells
27. Response of thyroid follicular cells to gamma irradiation compared to proton irradiation. I. Initial characterization of DNA damage, micronucleus formation, apoptosis, cell survival, and cell cycle phase redistribution
28. Micronuclei, CREST-positive micronuclei, and cell inactivation induced in Chinese hamster cells by radiation with different quality
29. Age dependence of T-lymphocyte apoptosis induced by high-energy proton exposure
30. In vivo determinations of RBE in a high energy modulated proton beam using normal tissue reactions and fractionated dose schedules
31. RBE variation as a function of depth in the 200-MeV proton beam produced at the National Accelerator Centre in Faure (South Africa)
32. Proton RBE for early intestinal tolerance in mice after fractionated irradiation
33. The relative biological effectiveness of the modulated proton beam at TRIUMF
34. An RBE study of a proton beam at University of Tsukuba (vs. Co-60)
35. Proton relative biological effectiveness (RBE) for survival in mice after thoracic irradiation with fractional doses
36. Relative biological effectiveness of modulated proton beams in various murine tissues
37. Relative biological effectiveness of a high energy modulated proton beam using a spontaneous murine tumor in vivo
38. Relative biological effectiveness of the therapeutic proton beams at NIRS and Tsukuba University (in Japanese)
39. Acute effects of whole-body proton irradiation on the immune system of the mouse
40. Relative biological effectiveness for protons of energies up to 31 MeV
41. Biological effectiveness of low energy protons. I. Survival of Chinese hamster cells
42. Inactivation of V79 cells by low-energy protons, deuterons and helium-3 ions
43. Inactivation and mutation induction in V79 cells by low energy protons: Re-evaluation of the results at the LNL facility
44. Biological effectiveness of protons on mammalian cells
45. The irradiation of V79 mammalian cells by protons with energies below 2 MeV. Part I: Experimental arrangement and measurement of cell survival
46. The depth-dependent radiation response of human melanoma cells exposed to 65 MeV protons
47. Brainstem tolerance to conformal radiotherapy of skull base tumors
48. Radiation response of the central nervous system
49. Tolerance of normal tissue to therapeutic irradiation
50. The incidence of myelitis after irradiation of the cervical spinal cord
51. Late rectal bleeding following combined X-ray and proton high dose irradiation for patients with stages T3-T4 prostate carcinoma
52. Late rectal toxicity after conformal radiotherapy of prostate cancer (I): Multivariate analysis and dose-response
53. Dosimetric precision requirements in radiation therapy
54. Radiation effects in living cells
55. Calculation of the spatial variation of relative biological effectiveness in a therapeutic proton field for eye treatment
56. Calculation of RBE for proton beams using biological weighting functions
57. Biophysical modeling of proton radiation effects based on amorphous track models
58. The influence of the beam modulation method on dose and RBE in proton radiation therapy
59. Nuclear interactions in proton therapy: Dose and relative biological effect distributions originating from primary and secondary particles
60. Biological effectiveness of high-energy protons: Target fragmentation
61. Relative biological effectiveness of proton beams in clinical therapy
62. The general relation between tissue response to x-radiation (α/β-values) and the relative biological effectiveness (RBE) of protons: Prediction by the Katz track-structure model
63. The relative cellular radiosensitivity of 30 human in vitro cell lines of different histological type to high LET 62.5 MeV (p → Be+) fast neutrons and 4 MeV photons
64. Response of mouse intestine to neutrons and gamma rays in relation to dose fractionation and division cycle
65. RBE for lung and cord
66. The RBE of accelerated protons in different parts of the Bragg curve
67. Studies on relative biological effectiveness and therapeutic gain factor of high energy protons modulated for radiotherapy (in Japanese)
68. Inactivation of cultured human tumor cells irradiated by cyclotron neutrons and protons
69. Early skin reaction following 250 MeV proton peak irradiation
70. Early and late effects of fractionated 250 MeV proton beam irradiation on murine legs