Discovery of aminoquinolines as a new class of potent inhibitors of heat shock protein 90 (Hsp90): Synthesis, biology, and molecular modeling

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 14, 2008, Pages 6903-6910

  Ganesh, Thota ^a   Min, Jaeki ^a   Thepchatri, Pahk ^a   Du, Yuhong ^a,b   Li, Lian ^a   Lewis, Iestyn ^a   Wilson, Larry ^a   Fu, Haian ^a,b   Chiosis, Gabriela ^c   Dingledine, Raymond ^a,b   Liotta, Dennis ^a   Snyder, James P ^a   Sun, Aiming ^a  

^a EMORY UNIVERSITY   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Program in Molecular Pharmacology   (United States)

Author keywords

Aminoquinoline; Heat shock protein 90 (Hsp90); High throughput screening (HTS)

Indexed keywords

2 (DIISOBUTYLAMINO) ETHYL IODIDE; 4 (6 METHOXYQUINOLIN 8 YLAMINO)BUTANENITRILE; 8 (5 (DIETHYLAMINO)PENTYLAMINO)QUINOLIN 6 OL DIHYDROBROMIDE; 8 (5 (ISOPROPYLAMINO)PENTYLAMINO)QUINOLIN 6 OL; AMINOQUINOLINE DERIVATIVE; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; N 1 ,N 1 DIBUTYL N 2 (6 METHOXYQUINOLON 8 YL)ETHANE 1,2 DIAMINE; N 1, N 1 DIETHYL N 4 (6 METHOXYQUINOLIN 8 YL)BUTANE 1,4 DIAMINE; N 1, N 1 DIISOBUTYL N 3 (6 METHOXYQUINOLIN 8 YL)PROPANE 1,3 DIAMINE; N 1,N 1 DIETHYL N 2 (6 METHOXYQUINOLIN 8 YL)ETHANE 1,2 DIAMINE; N 1,N 1 DIISOBUTYL N 2 (6 METHOXYQUINOLIN 8 YL)ETHANE 1,2 DIAMINE; N 1,N 1 DIISOPROPYL N 2 (6 METHOXYQUINOLIN 8 YL)ETHANE 1,2 DIAMINE; QUINOCIDE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CHEMICAL REACTION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; MOLECULAR MODEL; POLARIZATION; PROTEIN BINDING; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; WESTERN BLOTTING;

AMINOQUINOLINES; ANTINEOPLASTIC AGENTS; BLOTTING, WESTERN; DRUG EVALUATION, PRECLINICAL; FLUORESCENCE POLARIZATION IMMUNOASSAY; HSP90 HEAT-SHOCK PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 47349092634     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.05.047     Document Type: Article

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