Effect of A2B adenosine receptor gene ablation on proinflammatory adenosine signaling in mast cells

Journal of Immunology

Volumn 180, Issue 11, 2008, Pages 7212-7220

  Ryzhov, Sergey ^a   Zaynagetdinov, Rinat ^a   Goldstein, Anna E ^a   Novitskiy, Sergey V ^a   Dikov, Mikhail M ^a   Blackburn, Michael R ^b   Biaggioni, Italo ^a   Feoktistov, Igor ^a  

^a VANDERBILT UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; ADENOSINE A2B RECEPTOR; ADENOSINE A3 RECEPTOR; INTERLEUKIN 13; VASCULOTROPIN; 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE PHOSPHATE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; N (4 ACETYLPHENYL) 2 (4 (2,3,6,7 TETRAHYDRO 2,6 DIOXO 1,3 DIPROPYL 1H PURIN 8 YL)PHENOXY)ACETAMIDE; N-(4-ACETYLPHENYL)-2-(4-(2,3,6,7-TETRAHYDRO-2,6-DIOXO-1,3-DIPROPYL-1H-PURIN-8-YL)PHENOXY)ACETAMIDE; PURINE DERIVATIVE; VASCULOTROPIN A; XANTHINE DERIVATIVE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; INFLAMMATION; KNOCKOUT GENE; MAST CELL; MAST CELL DEGRANULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; SIGNAL TRANSDUCTION; ANIMAL; BIOSYNTHESIS; BONE MARROW CELL; C57BL MOUSE; CELL CULTURE; CELL LINE; DEGRANULATION; DRUG ANTAGONISM; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM;

ADENOSINE; ADENOSINE MONOPHOSPHATE; ANIMALS; BONE MARROW CELLS; CELL DEGRANULATION; CELL LINE; CELLS, CULTURED; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; INTERLEUKIN-13; MAST CELLS; MICE; MICE, INBRED C57BL; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PURINES; RECEPTOR, ADENOSINE A2B; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; XANTHINES;

EID: 47249138181     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.180.11.7212     Document Type: Article

References (61)

1. Fredholm, B. B., A. P. Ijzerman, K. A. Jacobson, K. N. Klotz, and J. Linden. 2001. International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol. Rev. 53: 527-552.
2. Fredholm, B. B., E. Irenius, B. Kull, and G. Schulte. 2001. Comparison of the potency of adenosine as an agonist at human adenosine receptors expressed in Chinese hamster ovary cells. Biochem: Pharmacol. 61: 443-448.
3. Driver, A. G., C. A. Kukoly, S. Ali, and S. J. Mustafa. 1993. Adenosine in bronchoalveolar lavage fluid in asthma. Am. Rev. Respir. Dis. 148: 91-97.
4. Huszar, E, G. Vass, E. Vizi, Z. Csoma, E. Barat, V. G. Molnar, I. Herjavecz, and I. Horvath. 2002. Adenosine in exhaled breath condensate in healthy volunteers and in patients with asthma. Eur. Respir. J. 20: 1393-1398.
5. Blackburn, M. R., J. B. Volmer, J. L. Thrasher, H. Zhong, J. R. Crosby, J. J. Lee, and R. E. Kellems. 2000. Metabolic consequences of adenosine deaminase deficiency in mice are associated with defects in alveogenesis, pulmonary inflammation, and airway obstruction. J. Exp. Med. 192: 159-170.
6. Blackburn, M. R. 2003. Too much of a good thing: adenosine overload in aden-osine-deaminase-deficient mice. Trends Pharmacol. Sci. 24: 66-70.
7. Blackburn, M. R., C. G. Lee, H. W. Young, Z. Zhu, J, L. Chunn, M. J. Kang, S. K. Banerjee, and J. A. Elias. 2003. Adenosine mediates IL-13-induced inflammation and remodeling in the lung and interacts in an IL-13-adenosine amplification pathway. J. Clin. Invest. 112: 332-344.
8. 2B adenosine receptor signaling in adenosine-dependent pulmonary inflammation and injury. J. Clin. Invest. 116: 2173-2182.
9. Bradding, P., A. F. Walls, and S. T. Holgate. 2006. The role of the mast cell in the pathophysiology of asthma. J. Allergy Clin. Immunol. 117: 1277-1284.
10. Rorke, S., and S. T. Holgate. 2002. Targeting adenosine receptors: novel therapeutic targets in asthma and chronic obstructive pulmonary disease. Am. J. Respir. Med. 1: 99-105.
11. 2B-mediated process involving Th2 cytokines IL-4 and IL-13 with implications for asthma. J. Immunol. 172: 7726-7733.
12. 2B adenosine receptors in human mast cells. Mol. Pharmacol. 70: 727-735.
13. 2B receptors evoke interleu-kin-8 secretion in human mast cells: an enprofylline-sensitive mechanism with implications for asthma. J. Clin. Invest. 96: 1979-1986.
14. 3 adenosine receptors. Circ. Res. 92: 485-492.
15. 2b adenosine receptor. J. Exp. Med. 204: 117-128.
16. 2A adenosine receptors and C/EBPβ are crucially required for IL-10 production by mac-rophages exposed to E. coli. Blood 110: 2685-2695.
17. Ryzhov, S., J. L. McCaleb, A. E. Goldstein, I. Biaggioni, and I. Feoktistov. 2007. Role of adenosine receptors in the regulation of angiogenic factors and neovas-cularization in hypoxia. J. Pharmacol. Exp. Ther. 382: 565-572.
18. 2B receptors in angiogenic factor regulation. Circ. Res. 90: 531-538.
19. Schwartz, L. B., K. F. Austen, and S. I. Wasserman. 1979. Immunologic release of β-hexosaminidase and β-glucoronidase from peritoneal rat scrosal mast cells. J. Immunol. 330: 393-411.
20. Forsythe, J. A., B. H. Jiang, N. V. Iyer, F. Agani, S. W. Leung, R. D. Koos, and G. L. Semenza. 1996. Activation of vascular endothelial growth factor gene transcription by hypoxia-induciblc factor 1. Mol. Cell. Biol. 16: 4604-4613.
21. Chung, H. K., H. A. Young, P. K. Goon, G. Heidecker, G. L. Princler, O. Shimozato, G. P. Taylor, C. R. Bangham, and D. Derse. 2003. Activation of interleukin-13 expression in T cells from HTLV-1-infected individuals and in chronically infected cell lines. Blood 102: 4130-4136.
22. Marquardt, D. L., L. L. Walker, and S. I. Wasserman. 1984. Adenosinc receptors on mouse bone marrow-derived mast cells: functional significance and regulation by aminophylline. J. Immunol. 133: 932-937.
23. 3 adenosine receptor gene in mice and its effect on stimulated inflammatory cells. J. Biol. Chem 275: 4429-4434.
24. Marquardt, D. L., J. L. Alongi, and L. L. Walker. 1996. The phosphatidylinositol 3-kinase inhibitor wortmannin blocks mast cell exocytosis but not IL-6 production. J. Immunol. 156: 1942-1945.
25. Burd, P. R., W. C. Thompson, E. E. Max, and F. C. Mills. 1995. Activated mast cells produce interleukin 13. J. Exp. Med. 181: 1373-1380.
26. Boesiger, J., M. Tsai, M. Maurer, M. Yamaguchi, L. F. Brown, K. P. Claffey, H. F. Dvorak, and S. J. Galli. 1998. Mast cells can secrete vascular permeability factor/vascular endothelial cell growth factor and exhibit enhanced release after immunoglobulin E-dependent upregulation of Feε receptor I expression. J. Exp. Med. 188: 1135-1145.
27. 2B receptor. J. Pharmacol. Exp. Ther. 320: 637-645.
28. Butterfield, J. H., D. Weiler, G. Dewald, and G. J. Gleich. 1988. Establishment of an immature mast cell line from a patient with mast cell leukemia. Leukemia Res. 12: 345-355.
29. 2B adenosine receptor subtypes. Biochem. Pharmacol. 55: 627-633.
30. 2B receptor-mediated interleukin-8 production in human mast cells. Mol. Pharmacol. 55: 726-735.
31. 2b receptors mediate an increase in interleukin (IL)-6 mRNA and IL-6 protein synthesis in human astroglioma cells. J. Neurochem. 66: 1426-1431.
32. Schwaninger, M., M. Neher, E. Viegas, A. Schneider, and M. Spranger. 1997. Stimulation of interleukin-6 secretion and gene transcription in primary astro-cytes by adenosine. J. Neurochem. 69: 1145-1150.
33. 2B adenosine receptors in the U87MG tumor cells. Drug Dev. Res. 58: 405-411.
34. 2b adenosine receptors coupled to PKC and p38 MAPK. Br. J. Pharmacol 140: 764-772.
35. 2B adenosine receptors increase cytokine release by bronchial smooth muscle cells. Am. J. Resp. Cell Mol. Biol. 30: 118-125.
36. 2b receptor stimulation in U373 MG cells depends on p38 mitogen activated kinase and protein kinase C. Neurochem. Int. 46: 501-512.
37. 2B adenosine receptors and hypoxia in activating human lung fibroblasts. Am. J. Resp. Cell Mol. Biol. 32: 2-8.
38. Evans, B. A., C. Elford, A. Pexa, K. Francis, A. C. Hughes, A. Dcussen, and J. Ham. 2006. Human osteoblast precursors produce extracellular adenosine, which modulates their secretion of IL-6 and osteoprotegerin. J. Bone Miner. Res. 21: 228-236.
39. Fan, M., W. Qin, and S. J. Mustafa. 2003. Characterization of adenosine receptor(s) involved in adenosine-induced bronchoconstriction in an allergic mouse model. Am. J. Physiol. 284: L1012-L1019.
40. 2B adenosine receptor antagonist on adenosine agonist AMP and allergen-induced airway responsiveness and cellular influx in a mouse model of asthma. J. Pharmacol. Exp. Ther. 320: 1246-1251.
41. 3 adenosine receptor is the unique adenosine receptor which facilitates release of allergic mediators in mast cells. J. Biol. Chem. 268: 16887-16890.
42. 3 receptors promote degranulation of rat mast cells both in vitro and in vivo. Inflamm. Res. 46: 180-184.
43. 3 receptor. J. Immunol. 171: 338-345.
44. 3 receptor expression and function in eosino-phils. Am. J. Resp. Cell Mol. Biol. 16: 531-537.
45. 2B receptor. Mol. Pharmacol. 52: 846-860.
46. Metcalfe, D. D., D. Baram, and Y. A. Mekori. 1997. Mast cells. Physiol. Rev. 77: 1033-1079.
47. 2 release. J. Allergy Clin. Immunol 87: 88-93.
48. 2 induces degran-ulation-independent production of vascular endothelial growth factor by human mast cells. J. Immunol. 172: 1227-1236.
49. 2 promotes degranulation-independent release of MCP-1 from mast cells. J. Leukocyte Biol. 79: 95-104.
50. Qiao, H., M. V. Andrade, F. A. Lisboa, K. Morgan, and M. A. Beaven. 2006. FCεR1 and Toll-like receptors mediate synergistic signals to markedly augment production of inflammatory cytokines in murine mast cells. Blood 107:610-618.
51. 2B adenosine receptor protects against inflammation and excessive vascular adhesion. J. Clin. Invest. 116: 1913-1923.
52. 2B adenosine receptor gene ablation on adenosine-dependent regulation of pro-inflammatory cytokines. J. Pharmacol. Exp. Ther. 324: 694-700.
53. s-coupled receptors. FEBS Lett. 419: 171-174.
54. Costa, T., and S. Cotecchia. 2005. Historical review: negative efficacy and the constitutive activity of G-protein-coupled receptors. Trends Pharmacol. Sci. 26: 618-624.
55. 2B adenosine receptors. J. Med. Chem. 43: 1165-1172.
56. 3 adenosine receptor. J. Pharmacol. Exp. Ther. 317: 172-180.
57. 2A adenosine receptor is necessary for sustained activation of the ERK/MAP kinase pathway. J. Biol. Chem. 280: 31898-31905.
58. 2A receptor. Mol. Pharmacol. 69: 1083-1094.
59. 2A adenosine receptor via a novel interacting protein, translin-associated protein X. Mol. Pharmacol. 70: 454-466.
60. Sitaraman, S. V., L. Wang, M. Wong, M. Bruewer, M. Hobert, C. H. Yun, D. Merlin, and J. L. Madara. 2002. The adenosine 2b receptor is recruited to the plasma membrane and associates with E3KARP and Ezrin upon agonist stimulation. J. Biol. Chem. 277: 33188-33195.
61. Pacheco, R;, J. M. Martinez-Navio, M. Lejeune, N. Climent, H. Oliva, J. M. Gatell, T. Gallart, J. Mallol, C. Lluis, and R. Franco. 2005. CD26, adenosine deaminase, and adenosine receptors mediate costimulalory signals in the immu-nological synapse. Proc. Natl. Acad. Sci. USA 102: 9583-9588.