Effect of A2B adenosine receptor gene ablation on adenosine-dependent regulation of proinflammatory cytokines

Journal of Pharmacology and Experimental Therapeutics

Volumn 324, Issue 2, 2008, Pages 694-700

  Ryzhov, Sergey ^a   Zaynagetdinov, Rinat ^a   Goldstein, Anna E ^a,b   Novitskiy, Sergey V ^a   Blackburn, Michael R ^c   Biaggioni, Italo ^a,b   Feoktistov, Igor ^a,b  

^a VANDERBILT UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A2B RECEPTOR; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; N (4 CYANOPHENYL) 2 [4 (2,3,6,7 TETRAHYDRO 2,6 DIOXO 1,3 DIPROPYL 1H PURIN 8 YL)PHENOXY]ACETAMIDE; TUMOR NECROSIS FACTOR ALPHA; ADENOSINE; CYTOKINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG EFFECT; DRUG INHIBITION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; COMPARATIVE STUDY; DRUG ANTAGONISM; GENETICS; INFLAMMATION; METABOLISM; MOUSE MUTANT; PERITONEUM MACROPHAGE; PHYSIOLOGY; SECRETION;

ADENOSINE; ANIMALS; CYTOKINES; INFLAMMATION; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTOR, ADENOSINE A2B;

EID: 38749118604     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.107.131540     Document Type: Article

References (41)

1. 2A adenosine receptors and C/EBPbeta are crucially required for IL-10 production by macrophages exposed to E. coli. Blood 110:2685-2695.
2. Evans BA, Elford C, Pexa A, Francis K, Hughes AC, Deussen A, and Ham J (2006) Human osteoblast precursors produce extracellular adenosine, which modulates their secretion of IL-6 and osteoprotegerin. J Bone Miner Res 21:228-236.
3. 2A receptors evoke interleukin-8 secretion in human mast cells: an enprofylline-sensitive mechanism with implications for asthma. J Clin Invest 96:1979-1986.
4. 2B receptor antagonist 3-isobutyl-8- pyrrolidinoxanthine (IPDX). Biochem Pharmacol 62:1163-1173.
5. 2B receptors in angiogenic factor regulation. Circ Res 90:531-538.
6. 2B receptor stimulation in U373 MG cells depends on p38 mitogen activated kinase and protein kinase C. Neurochem Int 46:501-512.
7. 2B receptors mediate an increase in interleukin (IL)-6 mRNA and IL-6 protein synthesis in human astroglioma cells. J Neurochem 66:1426-1431.
8. Fredholm BB, Ijzerman AP, Jacobson KA, Klotz KN, and Linden J (2001a) International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol Rev 53:527-552.
9. Fredholm BB, Irenius E, Kull B, and Schulte G (2001b) Comparison of the potency of adenosine as an agonist at human adenosine receptors expressed in Chinese hamster ovary cells. Biochem Pharmacol 61:443-448.
10. Gabay C (2006) Interleukin-6 and chronic inflammation. Arthritis Res Ther 8 (Suppl 2):S3.
11. 3 adenosine receptors for the protective effect of inosine in vivo. Blood 102:4472-4478.
12. 2A adenosine receptor is necessary for sustained activation of the ERK/MAP kinase pathway. J Biol Chem 280:31898-31905.
13. Haskó G and Cronstein BN (2004) Adenosine: an endogenous regulator of innate immunity. Trends Immunol 25:33-39.
14. Haskó G, Szabo C, Nemeth ZH, Kvetan V, Pastores SM, and Vizi ES (1996) Adenosine receptor agonists differentially regulate IL-10, TNF-alpha, and nitric oxide production in RAW 264.7 macrophages and in endotoxemic mice. J Immunol 157:4634-4640.
15. 2B adenosine receptor. J Exp Med 204:117-128.
16. Institute of Laboratory Animal Resources (1996) Guide for the Care and Use of Laboratory Animals 7th ed. Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council, Washington DC.
17. 2B adenosine receptors. Biochem Pharmacol 61:657-663.
18. 3 adenosine receptor. J Pharmacol Exp Ther 317:172-180.
19. Linden J (2006) New insights into the regulation of inflammation by adenosine. J Clin Invest 116:1835-1837.
20. Martin CA and Dorf ME (1991) Differential regulation of interleukin-6, macrophage inflammatory protein-1, and JE/MCP-1 cytokine expression in macrophage cell lines. Cell Immunol 135:245-258.
21. Mauël J, Ransijn A, Corradin SB, and Buchmuller-Rouiller Y (1995) Effect of PGE2 and of agents that raise cAMP levels on macrophage activation induced by IFN-gamma and TNF-alpha. J Leukoc Biol 58:217-224.
22. 2A receptor. Mol Pharmacol 69:1083-1094.
23. Pacheco R, Martinez-Navio JM, Lejeune M, Climent N, Oliva H, Gatell JM, Gallart T, Mallol J, Lluis C, and Franco R (2005) CD26, adenosine deaminase, and adenosine receptors mediate costimulatory signals in the immunological synapse. Proc Natl Acad Sci U S A 102:9583-9588.
24. Parmely MJ, Zhou WW, Edwards CK 3rd, Borcherding DR, Silverstein R, and Morrison DC (1993) Adenosine and a related carbocyclic nucleoside analogue selectively inhibit tumor necrosis factor-alpha production and protect mice against endotoxin challenge. J Immunol 151:389-396.
25. 2B adenosine receptors coupled to PKC and p38 MAPK. Br J Pharmacol 140:764-772.
26. Ritchie PK, Spangelo BL, Krzymowski DK, Rossiter TB, Kurth E, and Judd AM (1997) Adenosine increases interleukin 6 release and decreases tumour necrosis factor release from rat adrenal zona glomerulosa cells, ovarian cells, anterior pituitary cells, and peritoneal macrophages. Cytokine 9:187-198.
27. 2B adenosine receptors in human mast cells. Mol Pharmacol 70:727-735.
28. 2B-mediated process involving Th2 cytokines IL-4 and IL-13 with implications for asthma. J Immunol 172:7726-7733.
29. Ryzhov S, McCaleb JL, Goldstein AE, Biaggioni I, and Feoktistov I (2007) Role of adenosine receptors in the regulation of angiogenic factors and neovascularization in hypoxia. J Pharmacol Exp Ther 382:565-572.
30. 3 adenosine receptor gene in mice and its effect on stimulated inflammatory cells. J Biol Chem 275:4429-4434.
31. Schwaninger M, Neher M, Viegas E, Schneider A, and Spranger M (1997) Stimulation of interleukin-6 secretion and gene transcription in primary astrocytes by adenosine. J Neurochem 69:1145-1150.
32. Sitaraman SV, Merlin D, Wang L, Wong M, Gewirtz AT, Si-Tahar M, and Madara JL (2001) Neutrophil-epithelial crosstalk at the intestinal lumenal surface mediated by reciprocal secretion of adenosine and IL-6. J Clin Invest 107:861-869.
33. Sitaraman SV, Wang L, Wong M, Bruewer M, Hobert M, Yun CH, Merlin D, and Madara JL (2002) The adenosine 2b receptor is recruited to the plasma membrane and associates with E3KARP and Ezrin upon agonist stimulation. J Biol Chem 277:33188-33195.
34. 2A adenosine receptor via a novel interacting protein, translin-associated protein X. Mol Pharmacol 70:454-466.
35. 2B adenosine receptor signaling in adenosine-dependent pulmonary inflammation and injury. J Clin Invest 116:2173-2182.
36. Tang Y, Feng Y, and Wang X (1998) Calcitonin gene-related peptide potentiates LPS-induced IL-6 release from mouse peritoneal macrophages. J Neuroimmunol 84:207-212.
37. Weiterová L, Hofer M, Pospíšil M, Znojil V, and Štreitová D (2007) Drugs elevating extracellular adenosine administered in vivo induce serum colony-stimulating activity and interleukin-6 in mice. Physiol Res 56:463-474.
38. 2B adenosine receptor protects against inflammation and excessive vascular adhesion. J Clin Invest 116:1913-1923.
39. 2B adenosine receptors in the U87MG tumor cells. Drug Dev Res 58:405-411.
40. 2B adenosine receptors increase cytokine release by bronchial smooth muscle cells. Am J Resp Cell Mol Biol 30:118-125.
41. 2B adenosine receptors and hypoxia in activating human lung fibroblasts. Am J Resp Cell Mol Biol 32:2-8.