The phosphatidylinositol 3-kinase inhibitor wortmannin blocks mast cell exocytosis but not IL-6 production

Journal of Immunology

Volumn 156, Issue 5, 1996, Pages 1942-1945

  Marquardt, Diana L ^a,b   Alongi, Jeanne L ^a   Walker, Linda L ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE RECEPTOR; ANTIGEN; ARACHIDONIC ACID; CYTOKINE; ENZYME INHIBITOR; GUANINE NUCLEOTIDE BINDING PROTEIN; IMMUNOGLOBULIN E RECEPTOR; INTERLEUKIN 6; LEUKOTRIENE C4; PHOSPHATIDYLINOSITOL 3 KINASE; WORTMANNIN;

ANIMAL CELL; ARACHIDONIC ACID METABOLISM; ARTICLE; BONE MARROW CELL; CALCIUM TRANSPORT; ENZYME INHIBITION; EXOCYTOSIS; HYPERSENSITIVITY; INFLAMMATION; MAST CELL DEGRANULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; ANIMALS; ARACHIDONIC ACID; BONE MARROW CELLS; CELL DEGRANULATION; EXOCYTOSIS; INTERLEUKIN-6; MAST CELLS; MICE; MICE, INBRED BALB C; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR);

EID: 0030051454     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Sullivan, T. J., and C. W. Parker. 1976. Pharmacologic modulation of inflammatory mediator release by rat mast cells. Am. J. Pathol. 85.437.
2. 2 generation after activation of rat and human mast cells with anti-IgE. J. Immunol. 129:1627.
3. 4 from a subclass of mast cells differentiated in vitro from mouse bone marrow. Proc. Natl. Acad. Sci. USA 79:4665.
4. MacGlashan, D W., Jr., R. P. Schleimer, S. P. Peters, E. S. Schulman, G. K. Adams III, H. H. Newball, and L. M. Lichtenstein. 1982. Generation of leukotrienes by purified human lung mast cells. J. Clin. Invest. 70:747.
5. Marquardt, D. L., C. W. Parker, and T. J. Sullivan. 1978. Potentiation of mast cell mediator release by adenosine. J. Immunol. 120:871.
6. Peters, S. P., E. S. Schulman, R. P. Schleimer, D. W. MacGlashan, Jr , H. H. Newball, and L. M. Lichtenstein. 1982. Dispersed human lung mast cells: pharmacologic aspects and comparison with human lung tissue fragments. Am. Rev Respir. Dis. 126:1034.
7. Marquardt, D. L , H. E. Gruber, and S. I. Wasserman. 1986. Aminophylline exposure alters mouse bone marrow-derived mast cell adenosine responsiveness. J. Allergy Clin. Immunol. 78.462.
8. 2 pathway in a rat mast cell line. J. Immunol. 154:5391.
9. Goetzl, E. J., M. J. Phillips, and W. M Gold. 1983. Stimulus specificity of the generation of leukotrienes by dog mastocytoma cells. J. Exp. Med. 158:731.
10. Jullien, D., J. F. Tanti, S. J. Heydrick, N. Gautier, T. Gremeaux, E. Van Obberghen, and Y. Le Marchand-Brustel 1993 Differential effects of okadaic acid on insulin-stimulated glucose and amino acid uptake and phosphatidylinositol 3-kinase activity. J. Biol Chem. 268.15246.
11. Kundra, V , J. A. Escobedo, A. Kazlauskas, H. K. Kim, S. G. Rhee, L. T. Williams, and B R Zetter. 1994. Regulation of chemotaxis by the platelet-derived growth factor receptor-β. Nature 367:474.
12. Cohen, B., Y. Liu, B. Drucker, T. M Roberts, and B. S. Schaffhausen 1990. Characterizanon of pp85, a target of oncogenes and growth factor receptors. Mol. Cell. Biol. 10:2909
13. Ruderman, N B , R. Kapeller, M. F. White, and L. C. Cantley 1990. Activation of phosphatidylinositol 3-kinase by insulin. Proc. Natl. Acad Sci. USA 87:1411.
14. Kitani, S., R Teshima, Y. Morita, K. Ito, Y. Matsuda, and Y. Nonomura. 1992. Inhibition of IgE-mediated histamine release by myosin light chain kinase inhibitors. Biochem. Biophys. Res. Commun. 183:48
15. Yano, H., S. Nakanishi, K. Kimura, N. Hanai, Y. Saitoh, Y. Fukui, Y. Nonomura, and Y. Matsuda. 1993. Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells J Biol Chem 268.25846.
16. Barker, S., M. Martinez, J. Pfeiffer, J. M Oliver, and B S Wilson 1994. Effects of wortmannin on Fc∈RI signalling in RBL-2H3 cells Mol Biol. Cell 5:143a.
17. Thelen, M., M. P. Wymann, and H. Langen. 1994 Wortmannin binds specifically to 1-phosphatidylinositol 3-kinase white inhibiting guanine nucleotide-binding protein-coupled receptor signaling in neutrophil leukocytes. Proc. Natl. Acad Sci USA 91:4960
18. Stephens, L , A Smrcka, F. T Cooke, T. R Jackson, P. C. Sternweis, and P. T. Hawkins. 1994. A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits Cell 77:83
19. Zhang, J , J Zhang, J. L. Benovic, M. Sugai, R. Wetzker, I Gout, and S E. Rittenhouse. 1995. Sequestration of a G-protein βγ subunit or ADP-ribosylation of Rho can inhibit thrombin-induced activation of platelet phosphoinositide 3-kinases. J. Biol Chem 270.6589.
20. Marquardt, D. L , L L Walker, and S Heinemann. 1994. Cloning of two adenosine receptor subtypes from mouse bone marrow-derived mast cells. J. Immunol 152:4508
21. Schwartz, L. B , K. F Austen, and S. I. Wasserman. 1979. Immunologic release of β-hexosaminidase and β-glucuronidase from purified rat serosal mast cells. J Immunol 123:1445.
22. 4, chondroitin sulfate E proteoglycan, β-hexosaminidase, and histamine from cultured bone marrow-derived mouse mast cells. J. Exp. Med. 157:189.
23. Leal-Berumen, I., P. Conlon, and J. S Marshall. 1994. IL-6 production by rat peritoneal mast cells is not necessarily preceded by histamine release and can be induced by bacterial lipopolysaccharide J. Immunol. 152:5468
24. Lawson, D., M. C. Raff, and B. Gomperts 1977. Molecular events in membrane fusion a study of exocytosis in rat peritoneal mast cells. J. Cell Biol. 72:242
25. Barker, S A., K. K. Caldwell, A. Hall, A. M. Martinez, J. R Pfeiffer, J M. Oliver, and B S Wilson. 1995. Wortmannin blocks lipid and protein kinase activities associated with PI 3-kinase and inhibits a subset of responses induced by Fc∈R1 cross-linking Mol. Biol Cell 6 1145
26. Stephens, L. F. T. Cooke, R. Walters, T. Jackson, S. Volinia, I. Gout, M D Waterfield, and P. T Hawkins. 1994 Characterization of a phosphatidylinositol-specific phosphoinositide 3-kinase from mammalian cells. Current Biol 4:203.
27. Leal-Berumen, I , P. O'Byrne, A. Gupta, C. D Richards, and J. S. Marshall 1995 Prostanoid enhancement of interleukin-6 production by rat peritoneal mast cells. J. Immunol. 154 4759.
28. 2b receptors evoke interleukin-8 secretion in human mast cells, an enprophylline-sensitive mechanism with implications for asthma J. Clin Invest. 96:1979.