Low-dose methotrexate reduces peripheral nerve injury-evoked spinal microglial activation and neuropathic pain behavior in rats

Pain

Volumn 138, Issue 1, 2008, Pages 130-142

  Scholz, Joachim ^a   Abele, Andrea ^b   Marian, Claudiu ^b   Häussler, Annett ^b   Herbert, Teri A ^a   Woolf, Clifford J ^a   Tegeder, Irmgard ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

Dexamethasone; Immunosuppression; Methotrexate; Microglia; Neuropathic pain

Indexed keywords

BIOLOGICAL MARKER; CD11B ANTIGEN; CELL MARKER; DEXAMETHASONE; IONIZED CALCIUM BINDING ADAPTER MOLECULE 1; METHOTREXATE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CELL ACTIVATION; CELL ACTIVITY; CELLULAR IMMUNITY; CHRONIC CONSTRICTION INJURY; CONTINUOUS INFUSION; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; GRAY MATTER; IMMUNE RESPONSE; IMMUNOREACTIVITY; IMMUNOSUPPRESSIVE TREATMENT; INFLAMMATION; LOW DRUG DOSE; LUMBAR SPINAL CORD; MALE; MICROGLIA; NERVE INJURY; NERVE LIGATION; NEUROPATHIC PAIN; NONHUMAN; PERIPHERAL NERVE INJURY; PHAGOCYTE; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RHIZOTOMY; SPARED NERVE INJURY; SPINAL CORD DORSAL HORN; SPINAL CORD NERVE CELL; SPINAL NERVE LIGATION; THORACIC SPINAL CORD;

ANIMALS; BEHAVIOR, ANIMAL; IMMUNOSUPPRESSIVE AGENTS; MALE; METHOTREXATE; MICROGLIA; NEURALGIA; PERIPHERAL NERVES; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; TREATMENT OUTCOME;

EID: 47249092261     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pain.2007.11.019     Document Type: Article

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