Isotope sensitive branching and kinetic isotope effects in the reaction of deuterated arachidonic acids with human 12- and 15-lipoxygenases

Biochemistry

Volumn 47, Issue 27, 2008, Pages 7295-7303

  Jacquot, Cyril ^a   Wecksler, Aaron T ^b   McGinley, Chris M ^a   Segraves, Erika N ^b   Holman, Theodore R ^b   Van Der Donk, Wilfred A ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABSTRACTING; ADDITION REACTIONS; CARRIER MOBILITY; DEUTERIUM; ENZYME INHIBITION; HEALTH; HYDROGEN; LIPIDS; MINE FLOODING; OXIDATIVE STRESS; PHOTOACOUSTIC EFFECT; RATE CONSTANTS; REACTION KINETICS; REGIOSELECTIVITY;

(ABIOTIC AND BIOTIC) STRESS; AMERICAN CHEMICAL SOCIETY (ACS); ARACHIDONIC ACID (ARA); HUMAN DISEASES; HYDROGEN ABSTRACTIONS; KINETIC ISOTOPE EFFECTS (KIES); LINOLEIC ACID (LA); LIPID PEROXIDATION (MDA); LIPOXYGENASES (LOX); METHYLENE GROUPS; PRODUCT DISTRIBUTIONS; RATE LIMITING; REACTION PATHWAYS;

ISOTOPES;

ARACHIDONATE 12 LIPOXYGENASE; ARACHIDONATE 15 LIPOXYGENASE; ARACHIDONIC ACID; CARBENE; DEUTERIUM; HYDROGEN; LINOLEIC ACID;

ARTICLE; CHEMICAL REACTION KINETICS; ENZYME KINETICS; EPITHELIUM CELL; HUMAN; INFLAMMATION; LIPID PEROXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; REACTION ANALYSIS; RETICULOCYTE; STEREOCHEMISTRY; THROMBOCYTE;

ARACHIDONATE 12-LIPOXYGENASE; ARACHIDONATE 15-LIPOXYGENASE; ARACHIDONIC ACIDS; CATALYSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; DEUTERIUM; HUMANS; ISOENZYMES; KINETICS; MASS SPECTROMETRY; OXIDATION-REDUCTION;

EID: 46849094690     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi800308q     Document Type: Article

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