Differential characteristics of human 15-lipoxygenase isozymes and a novel splice variant of 15s-lipoxygenase

European Journal of Biochemistry

Volumn 266, Issue 1, 1999, Pages 83-93

  Kilty, Lain ^a   Logan, Alison ^a   Vickers, Philip J ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Alternative splicing; Gene regulation; Lipoxygenase

Indexed keywords

ARACHIDONATE 15 LIPOXYGENASE; ARACHIDONIC ACID; CALCIUM; EDETIC ACID; FATTY ACID; LINOLEIC ACID;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME KINETICS; ENZYME REGULATION; ENZYME SPECIFICITY; FATTY ACID METABOLISM; HUMAN; HUMAN CELL; MOLECULAR CLONING; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AMINO ACID SEQUENCE; ARACHIDONATE 15-LIPOXYGENASE; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME ACTIVATION; ENZYME INHIBITORS; FATTY ACIDS; HUMANS; ISOENZYMES; KINETICS; LIPID PEROXIDATION; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; ORGAN SPECIFICITY; PROTEIN CONFORMATION; RECOMBINANT FUSION PROTEINS; RNA SPLICING; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0033571064     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.1999.00818.x     Document Type: Article

References (50)

1. 1. Yamamoto, S. (1992) Mammalian lipoxygenases: molecular structures and functions. Biochim. Biophys. Acta 1128, 117-131.
2. 2. Dixon, R.A., Jones, R.E., Diehl, R.E., Bennet, C.D., Kargman, S. & Rouzer, C.A. (1988) Cloning of the cDNA for human 5-lipoxygenase. Proc. Natl Acad. Sci. USA 85, 416-420.
3. 3. Matsumoto, T., Funk, C.D., Radmark, O., Hoog, J.O., Jornvall, H. & Samuelsson, B. (1988) Molecular cloning and amino acid sequence of human 5-lipoxygenase. Proc. Natl Acad. Sci. USA 85, 26-30.
4. 4. Funk, C.D., Furci, L. & FitzGerald, G.A. (1990) Molecular cloning, primary structure and expression of the human platelet/erythroleukemia cell 12-lipoxygenase. Proc. Natl Acad. Sci. USA 87, 5638-5642.
5. 5. Izumi, T., Hoshiko, S., Radmark, O. & Samuelsson, B. (1990) Cloning of the cDNA for human 12-lipoxygenase. Proc. Natl Acad. Sci. USA 87, 7477-7481.
6. 6. Boeglin, W.E., Kim, R.B. & Brash, A.R. (1998) A (12R)-lipoxygenase in human skin: mechanistic evidence, molecular cloning and expression. Proc. Natl Acad. Sci. USA 95, 6744-6749.
7. 7. Sigal, E., Craik, C.S., Dixon, R.A. & Nadel, J.A. (1989) Cloning and expression of human arachidonate 15-lipoxygenase. Trans. Assoc. Am. Physicians 102, 176-184.
8. 8. Brash, A.R., Boeglin, W.E. & Chang, M.S. (1997) Discovery of a second 15S-lipoxygenase in humans. Proc. Natl Acad. Sci. USA 94, 6148-6152.
9. 9. Kuhn, H., Barnett, J., Grunberger, D., Baeker, P., Chow, J., Nguyen, B., Bursztyn-Pettegrew, H., Chan, H. & Sigal, E. (1993) Overexpression, purification and characterisation of human recombinant 15-lipoxygenase. Biochem. Biophys. Acta 1169, 80-89.
10. 10. Ford-Hutchinson, A.W., Gresser, M. & Young, R.N. (1994) 5-Lipoxygenase. Annu. Rev. Biochem. 63, 383-417.
11. 11. Honn, K.V., Nelson, K.K., Renaud, C., Bazaz, R., Diglio, C.A. & Timar, J. (1992) Fatty acid modulation of tumor cell adhesion to microvessel endothelium and experimental metastasis. Prostaglandins 44, 413-429.
12. 12. Ylä-Herttuala, S., Rosenfeld, M.E., Parthasarathy, S., Sigal, E., Särkioja, T., Witztum, J.L. & Steinberg, D. (1991) Gene expression in macrophage-rich human atherosclerotic lesions. 15-Lipoxygenase and acetyl low density lipoprotein receptor messenger RNA co-localize with oxidation specific lipid-protein adducts. J. Clin. Invest 87, 1146-1152.
13. 13. Chen, X.S., Brash, A.R. & Funk, C.D. (1993) Purification and characterization of recombinant histidine-tagged human platelet 12-lipoxygenase expressed in a baculovirus/insect cell system. Eur J. Biochem. 214, 845-852.
14. 14. Funk, C.D., Gunne, H., Steiner, H., Izumi, T. & Samuelsson, B. (1989) Native and mutant 5-lipoxygenase expression in a baculovirus/insect cell system. Proc. Natl Acad. Sci. USA 86, 2592-2596.
15. 15. Prigge, S.T., Boyington, J.C., Faig, M., Doctor, K.S., Gaffney, B.J. & Amzel, L.M. (1997) Structure and mechanism of lipoxygenases. Biochimie 79, 629-636.
16. 16. Brinkmann, R., Schnurr, K., Heydeck, D., Rosenbach, T., Kolde, G. & Kuhn, H. (1998) Membrane translocation of 15-lipoxygenase in hematopoietic cells is calcium-dependent and activates oxygenase activity of the enzyme. Blood 91, 64-74.
17. 17. Rouzer, C.A. & Samuelsson, B. (1987) Reversible, calcium-dependent membrane association of human leukocyte 5-lipoxygenase. Proc. Natl Acad. Sci. USA 84, 7393-7397.
18. 18. Abramovitz, M., Wong, E., Cox, M.E., Richardson, C.D., Li, C. & Vickers, P.J. (1993) 5-Lipoxygenase-activating protein stimulates the utilisation of arachidonic acid by 5-lipoxygenase. Eur. J. Biochem. 215, 105-111.
19. 19. Kühn, H. & Brash, A.R. (1990) Occurrence of lipoxygenase products in membranes of rabbit reticulocytes. Evidence for a role of the reticulocyte lipoxygenase in the maturation of red cells. J. Biol. Chem. 265, 1454-1458.
20. 20. Sambrook, J., Fritsch, E.F. & Maniatis, T. (1989) Molecular Cloning: a Laboratory Manual. 2nd edn. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, USA.
21. 21. Gibian, M.J. & Vandenberg, P. (1987) Product yield in oxygenation of linoleate by soybean lipoxygenase: the value of the molar extinction coefficient in the spectrophotometric assay. Anal. Biochem. 163, 343-349.
22. 22. Bligh, E.G. & Dyer, W.J. (1959) A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37, 911-917.
23. 23. Gray, T.E., Guzman, K., Davis, C.W., Abdullah, L.H. & Nettesheim, P. (1996) Mucociliary differentiation of serially passaged normal human tracheobronchial epithelial cells. Am. J. Respir. Cell Mol. Biol. 14, 104-112.
24. 24. Gillmor, S.A., Villasenor, A., Fletterick, R., Sigal, E. & Browner, M.F. (1997) The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity. Nat. Struct. Biol. 4, 1003-1009.
25. 25. Hammarberg, T., Zhang, Y.Y., Lind, B., Radmark, O. & Samuelsson, B. (1995) Mutations at the C-terminal isoleucine and other potential iron ligands of 5-lipoxygenase. Eur. J. Biochem. 230, 401-407.
26. 26. Yoshimoto, T. & Yamamoto, S. (1995) Arachidonate 12-lipoxy genase. J. Lipid Med. Cell Signal. 12, 195-212.
27. 27. Sloane, D.L., Leung, R., Barnett, J., Craik, C.S. & Sigal, E. (1995) Conversion of human 15-lipoxygenase to an efficient 12-lipoxygenase: the side-chain geometry of amino acids 417 and 418 determine positional specificity. Prot. Eng. 8, 275-282.
28. 28. Borngräber, S., Kuban, R.J., Anton, M. & Kühn, H. (1996) Phenylalanine 353 is a primary determinant for the positional specificity of mammalian 15-lipoxygenases. J. Mol. Biol. 264, 1145-1153.
29. 29. Woods, J.W., Evans, J.F., Ethier, D., Scott, S., Vickers, P.J., Hearn, L., Heibein, J.A., Charleson, S. & Singer, I.I. (1993) 5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes. J. Exp. Med. 178, 1935-1946.
30. 2+-dependent translocation to membranes. Prostaglandins 46, 471-477.
31. 31. Bottomley, M.J., Salim, K. & Panayotou, G. (1998) Phospholipid-binding protein domains. Biochim. Biophys. Acta 1436, 165-183.
32. 32. Kuhn, H. & Thiele, B. (1995) Arachidonate 15-lipoxygenase. J. Lipid Med. Cell Signal. 12, 157-170.
33. 33. Schewe, T., Halangk, W., Hiebsch, C. & Rapaport, S.M. (1975) A lipoxygenase in rabbit reticulocytes which attacks phospholipids and intact mitochondria. FEBS Lett. 60, 149-152.
34. 34. Sigal, E., Dicharry, S., Highland, E. & Finkbeiner, W.E. (1992) Cloning of human airway 15-lipoxygenase: identity to the reticulocyte enzyme and expression in the epithelium. Am. J. Physiol. 262, 392-398.
35. 35. Gan, Q.F., Browner, M.F., Sloane, D.L. & Sigal, E. (1996) Defining the arachidonic acid binding site of human 15-lipoxygenase. J. Biol. Chem. 271, 25412-25418.
36. 36. Buchanan, M.R., Horsewood, P. & Brister, S.J. (1998) Regulation of endothelial cell and platelet receptor-ligand binding by the 12-and 15-lipoxygenase monohydroxides, 12,15-HETE and 13-HODE. Prostaglandins 58, 339-346.
37. 37. Horrobin, D.F. & Ziboh, V.A. (1997) The importance of linoleic acid metabolites in cancer metastasis and in the synthesis and actions of 13-HODE. Adv. Exp. Med. Biol. 433, 291-294.
38. 38. Cho, Y. & Ziboh, V.A. (1994) 13-Hydroxyoctadecadienoic acid reverses epidermal hyperproliferation via selective inhibition of protein kinase C-beta activity. Biochem. Biophys. Res. Commun. 201, 257-265.
39. 39. Corey, E.J. & Nagata, R. (1987) Evidence in favour of an organoiron-mediated pathway for lipoxygenation of fatty acids by soybean lipoxygenase. J. Am. Chem. Soc. 109, 8107-8108.
40. 40. Nelson, M.J., Seitz, S.P. & Cowling, R.A. (1990) Enzyme-bound pentadienyl and peroxyl radicals in purple lipoxygenase. Biochemistry 29, 6897-6903.
41. 41. Schilstra, M.J., Veldink, G.A. & Vliegenthart, J.F.G. (1993) Kinetic analysis of the induction period in lipoxygenase catalysis. Biochemistry 32, 7686-7691.
42. 42. Kuhn, H. (1996) Biosynthesis, metabolization and biological importance of the primary 15-lipoxygenase metabolites 15-hydro (pero) (XY-5Z,8Z,11Z,13E)-eicosatetraenoic acid and 13-hydro (pero) (XY-9Z,11E)-octadecadienoic acid. Prog. Lipid Res. 35, 203-226.
43. 43. Watson, A. & Doherty, F.J. (1994) Calcium promotes membrane association of reticulocyte 15-lipoxygenase. Biochem. J. 298, 377-383.
44. 44. Conrad, D.J., Kuhn, H., Mulkins, M., Highland, E. & Sigal, E. (1992) Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase. Proc. Natl Acad. Sci. USA 89, 217-221.
45. 45. Damonte, G., Guida, L., Sdraffa, A., Benatti, U., Melloni, E., Forteleoni, G., Meloni, T., Carafoli, E. & De Flora, A. (1992). Mechanisms of perturbation of erythrocyte calcium homeostasis in favism. Cell Calcium 13, 649-658.
46. 46. Palek, J., Thomae, M. & Ozog, D. (1977) Red cell calcium content and transmembrane calcium movements in sickle cell anemia. J. Lab. Clin. Med. 89, 1365-1374.
47. 47. Dixon, R.A., Diehl, R.E., Opas, E., Rands, E., Vickers, P.J., Evans, J.F., Gillard, J.W. & Miller, D.K. (1990) Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis. Nature 343, 282-284.
48. 48. Van Leyden, K., Duvoisin, R.M., Engelhardt, H. & Wiedmann, M. (1998). A function for lipoxygenase in programmed organelle degradation. Nature 395, 392-395.
49. 49. Kritzik, M.R., Ziober, A.F., Dicharry, S., Conrad, D.J. & Sigal, E. (1997) Characterization and sequence of an additional 15-lipoxygenase transcript and of the human gene. Biochim. Biophys. Acta 1352, 267-281.
50. 50. Tatulian, S.A., Steczko, J. & Minor, W. (1998) Uncovering a calcium-regulated membrane-binding mechanism for soybean lipoxygenase-1. Biochemistry 37, 15481-15490.