GPR17: Molecular modeling and dynamics studies of the 3-D structure and purinergic ligand binding features in comparison with P2Y receptors

BMC Bioinformatics

Volumn 9, Issue , 2008, Pages

  Parravicini, Chiara ^a   Ranghino, Graziella ^b   Abbracchio, Maria P ^a   Fantucci, Piercarlo ^b,c  

^a UNIVERSITY OF MILAN   (Italy)

^b Delos Srl   (Italy)

^c UNIVERSITY OF MILANO BICOCCA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

EXTRACELLULAR NUCLEOTIDES; G PROTEIN COUPLED RECEPTORS; MOLECULAR DYNAMICS SIMULATIONS; MULTI-STEP MECHANISM; PHOSPHOLIPID BILAYER; RECEPTOR ANTAGONISTS; SYNTHETIC COMPOUNDS; THERAPEUTIC TARGETS;

BINDING ENERGY; MOLECULAR DYNAMICS; MOLECULAR MODELING; NUCLEOTIDES; PHOSPHOLIPIDS;

LIGANDS;

2' DEOXY 6 N METHYLADENOSINE 3',5' BISPHOSPHATE; ARGININE; CANGRELOR; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 17; PURINERGIC P2Y RECEPTOR; URIDINE DIPHOSPHATE; ADENOSINE DIPHOSPHATE; ADENOSINE PHOSPHATE; DRUG DERIVATIVE; GPR17 PROTEIN, HUMAN; N(6) METHYL 2' DEOXYADENOSINE 3',5' DIPHOSPHATE; N(6)-METHYL-2'-DEOXYADENOSINE 3',5'-DIPHOSPHATE; PURINERGIC P2 RECEPTOR;

ARTICLE; BINDING AFFINITY; BINDING KINETICS; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG TARGETING; HYDROGEN BOND; LIGAND BINDING; MOLECULAR DYNAMICS; MOLECULAR MODEL; MOLECULAR RECOGNITION; NUCLEOTIDE BINDING SITE; NUCLEOTIDE SEQUENCE; PHOSPHOLIPID BILAYER; PROTEIN STRUCTURE; RECEPTOR BINDING; ANIMAL; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; DRUG ANTAGONISM; HUMAN; METABOLISM; RAT; STRUCTURAL HOMOLOGY; X RAY CRYSTALLOGRAPHY;

RATTUS;

ADENOSINE DIPHOSPHATE; ADENOSINE MONOPHOSPHATE; ANIMALS; BINDING SITES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; HUMANS; MODELS, MOLECULAR; RATS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, PURINERGIC P2; STRUCTURAL HOMOLOGY, PROTEIN; URIDINE DIPHOSPHATE;

EID: 47149104523     PISSN: None     EISSN: 14712105     Source Type: Journal    
DOI: 10.1186/1471-2105-9-263     Document Type: Article

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