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Volumn 118, Issue 23, 2005, Pages 5625-5636

CysLT1 receptor is a target for extracellular nucleotide-induced heterologous desensitization: A possible feedback mechanism in inflammation

Author keywords

CysLT1 receptor; Extracellular nucleotides; Heterologous desensitization; Inflammation; U937 cells

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM; G PROTEIN COUPLED RECEPTOR KINASE 2; LEUKOTRIENE RECEPTOR; NUCLEOTIDE; PEPTIDOLEUKOTRIENE 1 RECEPTOR; PROTEIN KINASE C; PURINE P2Y RECEPTOR; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE; CYCLOPEPTIDE; LEUKOTRIENE D4; LEUKOTRIENE D4 RECEPTOR; MEMBRANE PROTEIN; PACLITAXEL; PROTEIN KINASE; PURINE P2 RECEPTOR; YM 254890; YM-254890;

EID: 30544447195     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.02668     Document Type: Article
Times cited : (55)

References (52)
  • 1
    • 0027962545 scopus 로고
    • Purinoceptors: Are there families of P2X and P2Y purinoceptors?
    • Abbracchio, M. P. and Burnstock, G. (1994). Purinoceptors: are there families of P2X and P2Y purinoceptors? Pharmacol. Ther. 64, 445-475.
    • (1994) Pharmacol. Ther. , vol.64 , pp. 445-475
    • Abbracchio, M.P.1    Burnstock, G.2
  • 2
    • 0031770379 scopus 로고    scopus 로고
    • Purinergic signalling: Pathophysiological roles
    • Abbracchio, M. P. and Burnstock, G. (1998). Purinergic signalling: pathophysiological roles. Jpn. J. Pharmacol. 78, 113-145.
    • (1998) Jpn. J. Pharmacol. , vol.78 , pp. 113-145
    • Abbracchio, M.P.1    Burnstock, G.2
  • 7
    • 0023897940 scopus 로고
    • Removal of phosphorylation sites from the beta 2-adrenergic receptor delays onset of agonist-promoted desensitization
    • Bouvier, M., Hausdorff, W. P., De Blasi, A., O'Dowd, B. F., Kobilka, B. K., Caron, M. G. and Lefkowitz, R. J. (1988). Removal of phosphorylation sites from the beta 2-adrenergic receptor delays onset of agonist-promoted desensitization. Nature 333, 370-373.
    • (1988) Nature , vol.333 , pp. 370-373
    • Bouvier, M.1    Hausdorff, W.P.2    De Blasi, A.3    O'Dowd, B.F.4    Kobilka, B.K.5    Caron, M.G.6    Lefkowitz, R.J.7
  • 10
    • 1842635533 scopus 로고    scopus 로고
    • Molecular and functional aspects of human cysteinyl leukotriene receptors
    • Capra, V. (2004). Molecular and functional aspects of human cysteinyl leukotriene receptors. Pharmacol. Res. 50, 1-11.
    • (2004) Pharmacol. Res. , vol.50 , pp. 1-11
    • Capra, V.1
  • 11
    • 0031965149 scopus 로고    scopus 로고
    • Pharmacological characterization of the cysteinyl-leukotriene antagonists CGP 45715A (iralukast) and CGP 57698 in human airways in vitro
    • Capra, V., Bolla, M., Belloni, P. A., Mezzetti, M., Folco, G. C., Nicosia, S. and Rovati, G. E. (1998a). Pharmacological characterization of the cysteinyl-leukotriene antagonists CGP 45715A (iralukast) and CGP 57698 in human airways in vitro. Br. J. Pharmacol. 123, 590-598.
    • (1998) Br. J. Pharmacol. , vol.123 , pp. 590-598
    • Capra, V.1    Bolla, M.2    Belloni, P.A.3    Mezzetti, M.4    Folco, G.C.5    Nicosia, S.6    Rovati, G.E.7
  • 12
    • 0031969376 scopus 로고    scopus 로고
    • Identification and characterization of two cysteinyl-leukotriene high affinity binding sites with receptor characteristics in human lung parenchyma
    • Capra, V., Nicosia, S., Ragnini, D., Mezzetti, M., Keppler, D. and Rovati, G. E. (1998b). Identification and characterization of two cysteinyl-leukotriene high affinity binding sites with receptor characteristics in human lung parenchyma. Mol. Pharmacol. 53, 750-758.
    • (1998) Mol. Pharmacol. , vol.53 , pp. 750-758
    • Capra, V.1    Nicosia, S.2    Ragnini, D.3    Mezzetti, M.4    Keppler, D.5    Rovati, G.E.6
  • 14
    • 1642414063 scopus 로고    scopus 로고
    • CysLT1 signal transduction in differentiated U937 cells involves the activation of the small GTP-binding protein Ras
    • Capra, V., Ravasi, S., Accomazzo, M. R., Parenti, M. and Rovati, G. E. (2004a). CysLT1 signal transduction in differentiated U937 cells involves the activation of the small GTP-binding protein Ras. Biochem. Pharmacol. 67, 1569-1577.
    • (2004) Biochem. Pharmacol. , vol.67 , pp. 1569-1577
    • Capra, V.1    Ravasi, S.2    Accomazzo, M.R.3    Parenti, M.4    Rovati, G.E.5
  • 15
    • 4844225371 scopus 로고    scopus 로고
    • Mutational analysis of the highly conserved ERY motif of the thromboxane A2 receptor: Alternative role in G protein-coupled receptor signaling
    • Capra, V., Veltri, A., Foglia, C., Crimaldi, L., Habib, A., Parenti, M. and Rovati, G. E. (2004b). Mutational analysis of the highly conserved ERY motif of the thromboxane A2 receptor: alternative role in G protein-coupled receptor signaling. Mol. Pharmacol. 66, 880-889.
    • (2004) Mol. Pharmacol. , vol.66 , pp. 880-889
    • Capra, V.1    Veltri, A.2    Foglia, C.3    Crimaldi, L.4    Habib, A.5    Parenti, M.6    Rovati, G.E.7
  • 16
    • 0030296744 scopus 로고    scopus 로고
    • G protein-coupled receptors: Heterologous regulation of homologous desensitization and its implications
    • Chuang, T. T., Iacovelli, L., Sallese, M. and De Blasi, A. (1996). G protein-coupled receptors: heterologous regulation of homologous desensitization and its implications. Trends Pharmacol. Sci. 17, 416-421.
    • (1996) Trends Pharmacol. Sci. , vol.17 , pp. 416-421
    • Chuang, T.T.1    Iacovelli, L.2    Sallese, M.3    De Blasi, A.4
  • 17
    • 0034866203 scopus 로고    scopus 로고
    • Production of leukotrienes in a model of focal cerebral ischaemia in the rat
    • Ciceri, P., Rabuffetti, M., Monopoli, A. and Nicosia, S. (2001). Production of leukotrienes in a model of focal cerebral ischaemia in the rat. Br. J. Pharmacol. 133, 1323-1329.
    • (2001) Br. J. Pharmacol. , vol.133 , pp. 1323-1329
    • Ciceri, P.1    Rabuffetti, M.2    Monopoli, A.3    Nicosia, S.4
  • 18
    • 16444384786 scopus 로고    scopus 로고
    • Thromboxane prostanoid receptor signals through Gi protein to rapidly activate ERK in human airways
    • Citro, S., Ravasi, S., Rovati, G. E. and Capra, V. (2005). Thromboxane prostanoid receptor signals through Gi protein to rapidly activate ERK in human airways. Am. J. Respir. Cell Mol. Biol. 32, 326-333.
    • (2005) Am. J. Respir. Cell Mol. Biol. , vol.32 , pp. 326-333
    • Citro, S.1    Ravasi, S.2    Rovati, G.E.3    Capra, V.4
  • 19
    • 0034125277 scopus 로고    scopus 로고
    • Advances in signalling by extracellular nucleotides. the role and transduction mechanisms of P2Y receptors
    • Communi, D., Janssens, R., Suarez-Huerta, N., Robaye, B. and Boeynaems, J. M. (2000). Advances in signalling by extracellular nucleotides. the role and transduction mechanisms of P2Y receptors. Cell Signal. 12, 351-360.
    • (2000) Cell Signal. , vol.12 , pp. 351-360
    • Communi, D.1    Janssens, R.2    Suarez-Huerta, N.3    Robaye, B.4    Boeynaems, J.M.5
  • 20
    • 0025923083 scopus 로고
    • Chronic treatment with P2-purinergic receptor agonists induces phenotypic modulation of the HL-60 and U937 human myelogenous leukemia cell lines
    • Cowen, D. S., Berger, M., Nuttle, L. and Dubyak, G. R. (1991). Chronic treatment with P2-purinergic receptor agonists induces phenotypic modulation of the HL-60 and U937 human myelogenous leukemia cell lines. J. Leukoc. Biol. 50, 109-122.
    • (1991) J. Leukoc. Biol. , vol.50 , pp. 109-122
    • Cowen, D.S.1    Berger, M.2    Nuttle, L.3    Dubyak, G.R.4
  • 21
    • 0037868080 scopus 로고    scopus 로고
    • Leukotrienes in asthma
    • Drazen, J. M. (2003). Leukotrienes in asthma. Adv. Exp. Med. Biol. 525, 1-5.
    • (2003) Adv. Exp. Med. Biol. , vol.525 , pp. 1-5
    • Drazen, J.M.1
  • 22
    • 0035101820 scopus 로고    scopus 로고
    • Evolving concepts in G protein-coupled receptor endocytosis: The role in receptor desensitization and signaling
    • Ferguson, S. S. (2001). Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. Pharmacol. Rev. 53, 1-24.
    • (2001) Pharmacol. Rev. , vol.53 , pp. 1-24
    • Ferguson, S.S.1
  • 23
    • 0036892374 scopus 로고    scopus 로고
    • Reduction of G protein-coupled receptor kinase 2 expression in U-937 cells attenuates H2 histamine receptor desensitization and induces cell maturation
    • Fernandez, N., Monczor, F., Lemos, B., Notcovich, C., Baldi, A., Davio, C. and Shayo, C. (2002). Reduction of G protein-coupled receptor kinase 2 expression in U-937 cells attenuates H2 histamine receptor desensitization and induces cell maturation. Mol. Pharmacol. 62, 1506-1514.
    • (2002) Mol. Pharmacol. , vol.62 , pp. 1506-1514
    • Fernandez, N.1    Monczor, F.2    Lemos, B.3    Notcovich, C.4    Baldi, A.5    Davio, C.6    Shayo, C.7
  • 26
    • 0038024615 scopus 로고    scopus 로고
    • The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints
    • Fredriksson, R., Lagerstrom, M. C., Lundin, L. G. and Schioth, H. B. (2003). The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints. Mol. Pharmacol. 63, 1256-1272.
    • (2003) Mol. Pharmacol. , vol.63 , pp. 1256-1272
    • Fredriksson, R.1    Lagerstrom, M.C.2    Lundin, L.G.3    Schioth, H.B.4
  • 27
    • 0027916849 scopus 로고
    • Characterization of the leukotriene D4 receptor in dimethylsulphoxide-differentiated U937 cells: Comparison with the leukotriene D4 receptor in human lung and guinea-pig lung
    • Frey, E. A., Nicholson, D. W. and Metters, K. M. (1993). Characterization of the leukotriene D4 receptor in dimethylsulphoxide-differentiated U937 cells: comparison with the leukotriene D4 receptor in human lung and guinea-pig lung. Eur. J. Pharmacol. 244, 239-250.
    • (1993) Eur. J. Pharmacol. , vol.244 , pp. 239-250
    • Frey, E.A.1    Nicholson, D.W.2    Metters, K.M.3
  • 28
    • 0030796728 scopus 로고    scopus 로고
    • Internalization and down-regulation of the prostacyclin receptor in human platelets
    • Giovanazzi, S., Accomazzo, M. R., Letari, O., Oliva, D. and Nicosia, S. (1997). Internalization and down-regulation of the prostacyclin receptor in human platelets. Biochem. J. 325, 71-77.
    • (1997) Biochem. J. , vol.325 , pp. 71-77
    • Giovanazzi, S.1    Accomazzo, M.R.2    Letari, O.3    Oliva, D.4    Nicosia, S.5
  • 29
    • 0031587949 scopus 로고    scopus 로고
    • Lack of nucleotide-promoted second messenger signaling responses in 1321N1 cells expressing the proposed P2Y receptor, p2y7
    • Herold, C. L., Li, Q., Schachter, J. B., Harden, T. K. and Nicholas, R. A. (1997). Lack of nucleotide-promoted second messenger signaling responses in 1321N1 cells expressing the proposed P2Y receptor, p2y7. Biochem. Biophys. Res. Commun. 235, 717-721.
    • (1997) Biochem. Biophys. Res. Commun. , vol.235 , pp. 717-721
    • Herold, C.L.1    Li, Q.2    Schachter, J.B.3    Harden, T.K.4    Nicholas, R.A.5
  • 30
    • 0037161582 scopus 로고    scopus 로고
    • Rational design and evaluation of new lead compound structures for selective betaARK1 inhibitors
    • Iino, M., Furugori, T., Mori, T., Moriyama, S., Fukuzawa, A. and Shibano, T. (2002). Rational design and evaluation of new lead compound structures for selective betaARK1 inhibitors. J. Med. Chem. 45, 2150-2159.
    • (2002) J. Med. Chem. , vol.45 , pp. 2150-2159
    • Iino, M.1    Furugori, T.2    Mori, T.3    Moriyama, S.4    Fukuzawa, A.5    Shibano, T.6
  • 31
    • 0031907232 scopus 로고    scopus 로고
    • Distribution of P2Y receptor subtypes on haematopoietic cells
    • Jin, J., Dasari, V. R., Sistare, F. D. and Kunapuli, S. P. (1998). Distribution of P2Y receptor subtypes on haematopoietic cells. Br. J. Pharmacol. 123, 789-794.
    • (1998) Br. J. Pharmacol. , vol.123 , pp. 789-794
    • Jin, J.1    Dasari, V.R.2    Sistare, F.D.3    Kunapuli, S.P.4
  • 32
    • 3242807236 scopus 로고    scopus 로고
    • Cysteinyl leukotrienes and their receptors: Cellular distribution and function in immune and inflammatory responses
    • Kanaoka, Y. and Boyce, J. A. (2004). Cysteinyl leukotrienes and their receptors: cellular distribution and function in immune and inflammatory responses. J. Immunol. 173, 1503-1510.
    • (2004) J. Immunol. , vol.173 , pp. 1503-1510
    • Kanaoka, Y.1    Boyce, J.A.2
  • 33
    • 0032535761 scopus 로고    scopus 로고
    • P2 receptor subtypes in the cardiovascular system
    • Kunapuli, S. P. and Daniel, J. L. (1998). P2 receptor subtypes in the cardiovascular system. Biochem. J. 336, 513-523.
    • (1998) Biochem. J. , vol.336 , pp. 513-523
    • Kunapuli, S.P.1    Daniel, J.L.2
  • 34
    • 0346822886 scopus 로고    scopus 로고
    • Differential leukotriene receptor expression and calcium responses in endothelial cells and macrophages indicate 5-lipoxygenase-dependent circuits of inflammation and atherogenesis
    • Lotzer, K., Spanbroek, R., Hildner, M., Urbach, A., Heller, R., Bretschneider, E., Galczenski, H., Evans, J. F. and Habenicht, A. J. (2003). Differential leukotriene receptor expression and calcium responses in endothelial cells and macrophages indicate 5-lipoxygenase-dependent circuits of inflammation and atherogenesis. Arterioscler. Thromb. Vasc. Biol. 23, E32-E36.
    • (2003) Arterioscler. Thromb. Vasc. Biol. , vol.23
    • Lotzer, K.1    Spanbroek, R.2    Hildner, M.3    Urbach, A.4    Heller, R.5    Bretschneider, E.6    Galczenski, H.7    Evans, J.F.8    Habenicht, A.J.9
  • 35
    • 0036473397 scopus 로고    scopus 로고
    • The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals
    • Luttrell, L. M. and Lefkowitz, R. J. (2002). The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals. J. Cell Sci. 115, 455-465.
    • (2002) J. Cell Sci. , vol.115 , pp. 455-465
    • Luttrell, L.M.1    Lefkowitz, R.J.2
  • 37
    • 0034933024 scopus 로고    scopus 로고
    • Cysteinyl leukotriene receptor 1 is also a pyrimidinergic receptor and is expressed by human mast cells
    • Mellor, E. A., Maekawa, A., Austen, K. F. and Boyce, J. A. (2001). Cysteinyl leukotriene receptor 1 is also a pyrimidinergic receptor and is expressed by human mast cells. Proc. Natl. Acad. Sci. USA 98, 7964-7969.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 7964-7969
    • Mellor, E.A.1    Maekawa, A.2    Austen, K.F.3    Boyce, J.A.4
  • 38
    • 0036240711 scopus 로고    scopus 로고
    • Importance of MEK-1/-2 signaling in monocytic and granulocytic differentiation of myeloid cell lines
    • Miranda, M. B., McGuire, T. F. and Johnson, D. E. (2002). Importance of MEK-1/-2 signaling in monocytic and granulocytic differentiation of myeloid cell lines. Leukemia 16, 683-692.
    • (2002) Leukemia , vol.16 , pp. 683-692
    • Miranda, M.B.1    McGuire, T.F.2    Johnson, D.E.3
  • 39
    • 0019061918 scopus 로고
    • LIGAND: A versatile computerized approach for characterization of ligand-binding systems
    • Munson, P. J. and Rodbard, D. (1980). LIGAND: a versatile computerized approach for characterization of ligand-binding systems. Anal. Biochem. 107, 220-239.
    • (1980) Anal. Biochem. , vol.107 , pp. 220-239
    • Munson, P.J.1    Rodbard, D.2
  • 43
    • 0034043072 scopus 로고    scopus 로고
    • A kinetic binding study to evaluate the pharmacological profile of a specific leukotriene C(4) binding site not coupled to contraction in human lung parenchyma
    • Ravasi, S., Capra, V., Mezzetti, M., Nicosia, S. and Rovati, G. E. (2000). A kinetic binding study to evaluate the pharmacological profile of a specific leukotriene C(4) binding site not coupled to contraction in human lung parenchyma. Mol. Pharmacol. 57, 1182-1189.
    • (2000) Mol. Pharmacol. , vol.57 , pp. 1182-1189
    • Ravasi, S.1    Capra, V.2    Mezzetti, M.3    Nicosia, S.4    Rovati, G.E.5
  • 44
    • 0037091051 scopus 로고    scopus 로고
    • Pharmacological differences among CysLT(1) receptor antagonists with respect to LTC(4) and LTD(4) in human lung parenchyma
    • Ravasi, S., Capra, V., Panigalli, T., Rovati, G. E. and Nicosia, S. (2002). Pharmacological differences among CysLT(1) receptor antagonists with respect to LTC(4) and LTD(4) in human lung parenchyma. Biochem. Pharmacol. 63, 1537-1546.
    • (2002) Biochem. Pharmacol. , vol.63 , pp. 1537-1546
    • Ravasi, S.1    Capra, V.2    Panigalli, T.3    Rovati, G.E.4    Nicosia, S.5
  • 45
    • 0344972943 scopus 로고    scopus 로고
    • Ligand-binding studies: Old beliefs and new strategies
    • Rovati, G. E. (1998). Ligand-binding studies: old beliefs and new strategies. Trends Pharmacol. Sci. 19, 365-369.
    • (1998) Trends Pharmacol. Sci. , vol.19 , pp. 365-369
    • Rovati, G.E.1
  • 46
    • 0038320652 scopus 로고    scopus 로고
    • Involvement of P2Y receptors in the differentiation of haematopoietic cells
    • Sak, K., Boeynaems, J. M. and Everaus, H. (2003). Involvement of P2Y receptors in the differentiation of haematopoietic cells. J. Leukoc. Biol. 73, 442-447.
    • (2003) J. Leukoc. Biol. , vol.73 , pp. 442-447
    • Sak, K.1    Boeynaems, J.M.2    Everaus, H.3
  • 47
    • 0020597565 scopus 로고
    • Leukotrienes: Mediators of immediate hypersensitivity reactions and inflammation
    • Samuelsson, B. (1983). Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. Science 220, 568-575.
    • (1983) Science , vol.220 , pp. 568-575
    • Samuelsson, B.1
  • 48
    • 0032033682 scopus 로고    scopus 로고
    • G protein-coupled-receptor cross-talk: The fine-tuning of multiple receptor-signalling pathways
    • Selbie, L. A. and Hill, S. J. (1998). G protein-coupled-receptor cross-talk: the fine-tuning of multiple receptor-signalling pathways. Trends Pharmacol. Sci. 19, 87-93.
    • (1998) Trends Pharmacol. Sci. , vol.19 , pp. 87-93
    • Selbie, L.A.1    Hill, S.J.2
  • 50
    • 0023949864 scopus 로고
    • Staurosporine inhibits protein kinase C and prevents phorbol ester-mediated leukotriene D4 receptor desensitization in RBL-1 cells
    • Vegesna, R. V., Wu, H. L., Mong, S. and Crooke, S. T. (1988). Staurosporine inhibits protein kinase C and prevents phorbol ester-mediated leukotriene D4 receptor desensitization in RBL-1 cells. Mol. Pharmacol. 33, 537-542.
    • (1988) Mol. Pharmacol. , vol.33 , pp. 537-542
    • Vegesna, R.V.1    Wu, H.L.2    Mong, S.3    Crooke, S.T.4
  • 51
    • 0023821243 scopus 로고
    • Leukotriene D4-induced homologous desensitization in basal and differentiated U-937 cells: Characterization with the partial agonist leukotriene E4 and assessment of receptor reserve
    • Winkler, J. D., Saran, H. M., Foley, J. J. and Crooke, S. T. (1988). Leukotriene D4-induced homologous desensitization in basal and differentiated U-937 cells: characterization with the partial agonist leukotriene E4 and assessment of receptor reserve. J. Pharmacol. Exp. Ther. 247, 54-62.
    • (1988) J. Pharmacol. Exp. Ther. , vol.247 , pp. 54-62
    • Winkler, J.D.1    Saran, H.M.2    Foley, J.J.3    Crooke, S.T.4
  • 52
    • 0037163048 scopus 로고    scopus 로고
    • Protein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system
    • Zamah, A. M., Delahunty, M., Luttrell, L. M. and Lefkowitz, R. J. (2002). Protein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system. J Biol. Chem. 277, 31249-31256.
    • (2002) J Biol. Chem. , vol.277 , pp. 31249-31256
    • Zamah, A.M.1    Delahunty, M.2    Luttrell, L.M.3    Lefkowitz, R.J.4


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