P2Y1 and cysteinyl leukotriene receptors mediate purine and cysteinyl leukotriene co-release in primary cultures of rat microglia

International Journal of Immunopathology and Pharmacology

Volumn 18, Issue 2, 2005, Pages 255-268

  Ballerini, Patrizia ^a   Di Iorio, P ^a   Ciccarelli, R ^a   Caciagli, F ^a   Poli, A ^b   Beraudi, A ^b   Buccella, S ^a   D'Alimonte, I ^a   D'Auro, M ^a   Nargi, E ^a   Patricelli, P ^a   Visini, D ^a   Traversa, U ^c  

^a UNIVERSITY OF CHIETI   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c UNIVERSITY OF TRIESTE   (Italy)

Author keywords

ABC expression; Adenine basedpurines; Calcium; Cysteinyl leukotrienes; Microglia; P2Y1 and CysLT receptor expression; Release

Indexed keywords

2 METHYLTHIOADENOSINE TRIPHOSPHATE; 3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; 6 (4 CARBOXYPHENYLTHIO) 5 HYDROXY 7,9,11,14 ICOSATETRAENOIC ACID; ABC TRANSPORTER; ADENINE; ADENOSINE TRIPHOSPHATE; ARACHIDONATE 5 LIPOXYGENASE ACTIVATING PROTEIN; CALCIMYCIN; CALCIUM CHELATING AGENT; CALCIUM ION; CYSTEINYLLEUKOTRIENE 1 RECEPTOR; CYSTEINYLLEUKOTRIENE 2 RECEPTOR; CYSTEINYLLEUKOTRIENE RECEPTOR; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; GLYCOPROTEIN P; LEUKOTRIENE; LEUKOTRIENE D4; LEUKOTRIENE RECEPTOR; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 4; PEPTIDOLEUKOTRIENE; PROTEIN INHIBITOR; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; PURINE; PURINE P2Y1 RECEPTOR; PURINE P2Y2 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; RECEPTOR SUBTYPE; STAUROSPORINE; SURAMIN; UNCLASSIFIED DRUG; CALCIUM; CYSTEINE; CYSTEINYL-LEUKOTRIENE; LEUKOTRIENE D4 RECEPTOR; MEMBRANE PROTEIN; PURINE DERIVATIVE; PURINE P2 RECEPTOR;

ANIMAL CELL; ARTICLE; AUTOCRINE EFFECT; CONTROLLED STUDY; DEGENERATIVE DISEASE; DISEASE COURSE; ENCEPHALITIS; GENE EXPRESSION; INFLAMMATION; MICROGLIA; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSOR; SIGNAL TRANSDUCTION; ANIMAL; BIOSYNTHESIS; BRAIN; CELL CULTURE; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BRAIN; CALCIUM; CELLS, CULTURED; CYSTEINE; LEUKOTRIENES; MEMBRANE PROTEINS; MICROGLIA; PURINES; RATS; RECEPTOR CROSS-TALK; RECEPTORS, LEUKOTRIENE; RECEPTORS, PURINERGIC P2;

EID: 20444437974     PISSN: 03946320     EISSN: None     Source Type: Journal    
DOI: 10.1177/039463200501800208     Document Type: Article

References (64)

1. Aloisi F. 2001. Immune function of microglia. Glia 36:165.
2. 1 receptors. Glia 32 (S):91
3. Ballerini P., P. Di Iorio, R. Ciccarelli, E. Nargi, I. D'Alimente, U. Traversa, M.P. Rathbone and F. Caciagli. 2002. Glial cells express multiple ATP binding cassette proteins which are involved in ATP release. Neuroreport 13:1789.
4. 7) receptors regulate intracellular calcium and purine release. Neuroreport 7:2533.
5. Boucsein C., R. Zacharias, K. Farber, S. Pavlovic, U.K. Hanisch and H. Kettenmann. 2003. Purinergic receptors on microglial cells: functional expression in acute brain slices and modulation of microglial activation in vitro. Eur. J. Neurosci. 17:2267.
6. 2 receptors on rat alveolar macrophages. Br. J. Pharmacol. 140:567.
7. Caciagli F., R. Ciccarelli, P. Di Iorio, P. Ballerini and L. Tacconelli. 1988. Cultures of glial cells release purines under field electrical stimulation: the possible ionic mechanisms. Pharmacol. Res. Commun. 20:935.
8. Capra V., S. Nicosia, D. Ragnini, M. Mezzetti, D. Keppler and G.E. Rovati. 1998. Identification and characterization of two cysteinyl-leukotriene high affinity binding sites with receptor characteristics in human lung parenchyma. Mol. Pharmacol. 53:750.
9. Chen Z.S., S. Aoki, M. Komatsu, K. Ueda, T. Sumizawa, T. Furukawa, H. Okumura, X.Q. Ren, M.G. Belinsky, K. Lee, G.D. Kruh, M. Kobayashi and S. Akiyama. 2001. Reversal of drug resistance mediated by multidrug resistance protein (MRP) 1 by dual effects of agosterol A on MRP1 function. Int. J. Cancer 93:107.
10. Ciccarelli R., P. Ballerini, G. Sabatino, M.P. Rathbone, M. D'Onofrio, F. Caciagli and P. Di Iorio. 2001. Involvement of astrocytes in purine-mediated reparative processes in the brain. Int. J. Dev. Neurosci. 19:395.
11. Ciccarelli R., I. D'Alimonte, C. Santavenere, M. D'Auro, P. Ballerini, E. Nargi, S. Buccella, S. Nicosia, G. Folco, F. Caciagli and P. Di Iorio. 2004. Cysteinyl-leukotrienes are released from astrocytes and increase astrocyte proliferation and glial fibrillary acidic protein via cys-LT1 receptors and mitogen-activated protein kinase pathway. Eur. J. Neurosci. 20:1514.
12. Ciccarelli R., P. Di Iorio, P. Ballerini, G. Ambrosini, P. Giuliani, G.M. Tiboni and F. Caciagli. 1994. Effects of exogenous ATP and related analogues on the proliferation rate of dissociated primary cultures of rat astrocytes. J. Neurosci. Res. 39:556.
13. Ciccarelli R., P. Di Iorio, I. D'Alimonte, P. Giuliani, T. Florio, F. Caciagli, P.J. Middlemiss and M.P. Rathbone. 2000. Cultured astrocyte proliferation induced by extracellular guanosine involves endogenous adenosine and is raised by the co-presence of microglia. Glia 29:202.
14. Ciccarelli R., P. Di Iorio, P. Giuliani, I. D'Alimonte, P. Ballerini, F. Caciagli and M.P. Rathbone. 1999. Rat cultured astrocytes release guanine-based purines in basal conditions and after hypoxia/hypoglycemia. Glia 25:93.
15. Coco S., F. Calegari, E. Pravettoni, D. Pozzi, E. Taverna, P. Rosa, M. Matteoli and C. Verderio. 2003. Storage and release of ATP from astrocytes in culture. J. Biol. Chem. 278:1354.
16. Cudd L., C. Clarke and K. Clinkenbeard. 2003. Mannheimia haemolytica leukotoxin-induced increase in leukotriene B4 production by bovine neutrophils is mediated by a sustained and excessive increase in intracellular calcium concentration. FEMS Microbiol. Lett. 224:85.
17. Cunha R.A., E.S. Vizi, J.A. Ribeiro and A.M. Sebastiao. 1996. Preferential release of ATP and its extracellular catabolism as a source of adenosine upon high- but not low-frequency stimulation of rat hippocampal slices. J. Neurochem. 67:2180.
18. Delgado M. and D. Ganea. 2003. Vasoactive intestinal peptide prevents activated microglia-induced neurodegeneration under inflammatory conditions: potential therapeutic role in brain trauma. FASEB J. 17:1922.
19. Di Iorio P., P. Ballerini, F. Caciagli and R. Ciccarelli. 1998. Purinoceptor-mediated modulation of purine and neurotransmitter release from nervous tissue. Pharmacol. Res. 37:169.
20. Di Iorio P., G. Battaglia, R. Ciccarelli, P. Ballerini, P. Giuliani, A. Poli, F. Nicoletti and F. Caciagli. 1996. Interaction between Al adenosine and class II metabotropic glutamate receptors in the regulation of purine and glutamate release from rat hippocampal slices. J. Neurochem. 67:302.
21. Di Iorio P., F. Caciagli, P. Giuliani, P. Ballerini, R. Ciccarelli, O. Sperling, E. Zoref-Shani, L. Benowitz, U. Traversa, T. Florio, I. D'Alimonte, C.M. Andrei, C.E. Crocker, E.S. Werstiuk, P.J. Middlemiss and M.P. Rathbone 2001. Purine nucleosides protect injured neurons and stimulate neuronal regeneration by intracellular and memebrane receptor-mediated mechanisms. Drug Dev. Res. 52:303.
22. Di Iorio P., S. Kleywegt, R. Ciccarelli, U. Traversa, C.M. Andrew, C.E. Crocker, E.S. Werstiuk and M.P. Rathbone. 2002. Mechanisms of apoptosis induced by purine nucleosides in astrocytes. Glia 38:179.
23. Ferrari D., P. Chiozzi, S. Falzoni, S. Hanau and F. Di Virgilio. 1997. Purinergic modulation of interleukin-1 beta release from microglial cells stimulated with bacterial endotoxin. J. Exp. Med. 185:579.
24. Ferrari D., M. Villalba, P. Chiozzi, S. Falzoni, P. Ricciardi-Castagnoli and F. Di Virgilio. 1996. Mouse microglial cells express a plasma membrane pore gated by extracellular ATP. J. Immunol. 156:1531.
25. Ferreira Z.S., C.R. Garcia, D.C. Spray and R.P. Markus. 2003. P2Y(1) receptor activation enhances the rate of rat pinealocyte-induced extracellular acidification via a calcium-dependent mechanism. Pharmacol. 69:33.
26. 2 receptors. J. Neurosci. 23:6728.
27. 7 nucleotide receptor activation enhances IFN gamma-induced type II nitric oxide synthase activity in BV-2 microglial cells. J. Neurochem. 87:344.
28. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260:3440.
29. Hanish U.K. 2001. Microglia as a source and target of cytokine activities in the brain. In Microglia in the degenerating and regenerating CNS, ed. W.J. Streit Spring Verlag New York, p. 79.
30. Hide I., M. Tanaka, A. Inoue, K. Nakajima, S. Kohsaka, K. Inoue and Y. Nakata. 2000. Extracellular ATP triggers tumor necrosis factor-alpha release from rat microglia. J. Neurochem. 75:965.
31. Hui Y. and C.D. Funk. 2002. Cysteinyl leukotriene receptors. Biochem. Pharmacol. 64:1549.
32. 2+-dependent plasminogen release from cultured microglia. Br. J. Pharmacol. 123:1304.
33. Inoue K. 2002. Microglial activation by purines and pyrimidines. Glia 40:156
34. Kannan S. 2003. Neutrophil chemotaxis: potential role of chemokine receptors in extracellular nucleotide induced Mac-1 expression. Med. Hypotheses 61:577.
35. Klegeris A. and P.L. McGeer. 2003. Toxicity of human monocytic THP-1 cells and microglia toward SH-SY5Y neuroblastoma cells is reduced by inhibitors of 5-lipoxygenase and its activating protein FLAP. J. Leukoc. Biol. 73:369.
36. 2+ signaling mediated by P2Y receptors in cultured rat hippocampal astrocytes. Life Sci. 72:431.
37. Kreutzberg G.W. 1996. Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 19:312.
38. Lazarowski E.R., R.C. Boucher and T.K. Harden. 2000. Constitutive release of ATP and evidence for major contribution of ecto-nucleotide pyrophosphatase and nucleoside diphosphokinase to extracellular nucleotide concentrations. J. Biol. Chem. 275:31061.
39. Liminga G., P. Nygren and R. Larsson. 1994. Microfluorometric evaluation of calcein acetoxymethyl ester as a probe for P-glycoprotein-mediated resistance: effects of cyclosporin A and its nonimmunosuppressive analogue SDZ PSC 833. Exp. Cell Res. 212:291.
40. Ma L., N. Krishnamachary and M.S. Center. 1995. Phosphorylation of the multidrug resistance associated protein gene encoded protein P190. Biochemistry 34:3338.
41. Manev H., T. Uz, K. Sugaya and T. Qu. 2000. Putative role of neuronal 5-lipoxygenase in an aging brain. FASEB J. 14:1464.
42. Mansour M. and A. Agha. 1999. Inhibition of calcium ionophore-stimulated leukotriene generation from intact human neutrophils by captopril. Res. Commun. Mol. Pathol. Pharmacol. 104:345.
43. Meghji P., J.B. Tuttle and R. Rubio. 1989. Adenosine formation and release by embryonic chick neurons and glia in cell culture. J. Neurochem. 53:1852.
44. Mellor E.A., A. Maekawa, K.F. Austen and J.A. Boyce. 2001. Cysteinyl leukotriene receptor 1 is also a pyrimidinergic receptor and is expressed by human mast cells. Proc. Natl. Acad. Sci. USA 98:7964.
45. Nabe T., M. Miura, T. Kamiki and S. Kohno. 2000. Arachidonate 5-lipoxygenase and cyclooxygenase metabolites from guinea pig eosinophils and macrophages. Jpn. J. Pharmacol. 83:261.
46. Nakajima K. and S. Kohsaka. 1993. Functional roles of microglia in the brain. Neurosci. Res. 17:187.
47. Nakamura Y. 2002. Regulating factors for microglia activation. Biol. Pharm. Bull 25:945.
48. Nieber K., D. Eschke and A. Brand. 1999. Brain hypoxia: effects of ATP and adenosine. Prog. Brain Res. 120:287.
49. Olson D.P., B.J. Taylor and S.P. Ivy. 2001. Detection of MRP functional activity: calcein AM but not BCECF AM as a Multidrug Resistance-related Protein (MRP1) substrate. Cytometry 46:105.
50. Rathbone M.P., P.J. Middlemiss, J.W. Gysbers, C. Andrew, M.A. Herman, J.K. Reed, R. Ciccarelli, P. Di Iorio and F. Caciagli 1999. Trophic effects of purines in neurons and glial cells. Prog. Neurobiol. 59:663.
51. Rosnowska M., W. Cendrowski and W. Sobczyk. 1997. Leukotrienes B4 and C4 in cerebrospinal of patients with multiple sclerosis. Pol. Merkuriusz. Lek. 2:254.
52. Sedlak J., L. Hunakova, M. Sulikova and B. Chorvath. 1997. Protein kinase inhibitor-induced alterations of drug uptake, cell cycle and surface antigen expression in human multidrug-resistant (Pgp and MRP) promyelocytic leukemia HL-60 cells. Leuk. Res. 21:449.
53. Shigemoto-Mogami Y., S. Koizumi, M. Tsuda, K. Ohsawa, S. Kohsaka and K. Inoue. 2001. Mechanisms underlying extracellular ATP-evoked interleukin-6 release in mouse microglial cell line, MG-5. J. Neurochem. 78:1339.
54. Simmet T., W. Luck, M. Winking, W.K. Delank and B.A. Peskar. 1990. Identification and characterization of cysteinyl-leukotriene formation in tissue slices from human intracranial tumors: evidence for their biosynthesis under in vivo conditions. J. Neurochem. 54:2091.
55. Sperlagh B., M. Baranyi, G. Hasko and E.S. Vizi. 2004. Potent effect of interleukin-1 beta to evoke ATP and adenosine release from rat hippocampal slices. J. Neuroimmunol. 151:33.
56. Sperlagh B., G. Szabo, F. Erdelyi, M. Baranyi and E.S. Vizi. 2003. Homo- and heteroexchange of adenine nucleotides and nucleosides in rat hippocampal slices by the nucleoside transport system. Br. J. Pharmacol. 139:623.
57. Sugaya K., T. Uz, V. Kumar H. and Manev. 2000. New anti-inflammatory treatment strategy in Alzheimer's disease. Jpn. J. Pharmacol. 82:85.
58. Z. Wang, P.G. Haydon and E.S. Yeung. 2000. Direct observation of calcium-independent intercellular ATP signaling in astrocytes. Anal. Chem. 72:2001.
59. Westcott J.Y., S.E. Wenzel and S.C. Dreskin. 1996. Arachidonate-induced eicosanoid synthesis in RBL-2H3 cells: stimulation with antigen or A23187 induces prolonged activation of 5-lipoxygenase. Biochim. Biophys. Acta 1303:74.
60. Winking M., W. Deinsberger, A. Joedicke and D.K. Boeker. 1998. Cysteinyl-leukotriene levels in intracerebral hemorrhage: an edema-promoting factor? Cerebrovasc. Dis. 8:318.
61. Yamakuni H., N. Kawaguchi, Y. Ohtani, J. Nakamura, T. Katayama, T. Nakagawa, M. Minami and M. Satoh. 2002. ATP induces leukemia inhibitory factor mRNA in cultured rat astrocytes. J. Neuroimmunol. 129:43.
62. Zhou H.F., D.B. Niu, B. Xue, F.Q. Li, X.Y. Liu, Q.H. He, X.H. Wang and X.M. Wang. 2003. Triptolide inhibits TNF-alpha, IL-1 beta and NO production in primary microglial cultures. Neuroreport 14:1091.
63. Kempuraj D., S. Frydas, E. Karagouni, M. Hatzistilianou, P. Boscolo, F. Ferro, M. Di Giannantonio, C.M.V. Conti, D. Merlitti R. Doyle, C. Petrarca, M.L. Castellani and T.C. Theoharides. Cytokines and the brain. 2004. Int. J. Immunopathol. Pharmacol. 17:229.
64. Prosperi C., C. Scali, M. Barba, A. Bellucci, M.G. Giovannini, G. Pepeu and F. Casamenti. 2004. Comparison between flurbiprofen and its nitric oxide-releasing derivatives HCT-1026 and NCX-2216 on a (1-42)-induced brain inflammation and neuronal damage in the rat. Int. J. Immunopathol. Pharmacol. 17:317.