CysLT1 leukotriene receptor antagonists inhibit the effects of nucleotides acting at P2Y receptors

Biochemical Pharmacology

Volumn 71, Issue 1-2, 2005, Pages 115-125

  Mamedova, Liaman ^a   Capra, Valérie ^b   Accomazzo, Maria Rosa ^b   Gao, Zhan Guo ^a   Ferrario, Silvia ^b   Fumagalli, Marta ^b   Abbracchio, Maria P ^b   Rovati, G Enrico ^b   Jacobson, Kenneth A ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

ATP; Montelukast; Nucleotides; Pranlukast; Purine receptors; UDP

Indexed keywords

CALCIUM; CARBACHOL; DIMETHYL SULFOXIDE; LEUKOTRIENE RECEPTOR BLOCKING AGENT; MONTELUKAST; MUSCARINIC M3 RECEPTOR; NUCLEOTIDE; PEPTIDOLEUKOTRIENE; PHOSPHOLIPASE C; PRANLUKAST; PURINE P2Y RECEPTOR; PURINE P2Y11 RECEPTOR; PURINE P2Y2 RECEPTOR; PURINE P2Y4 RECEPTOR; PURINE P2Y6 RECEPTOR; URIDINE DIPHOSPHATE; URIDINE TRIPHOSPHATE; ACETIC ACID DERIVATIVE; CHROMONE DERIVATIVE; LEUKOTRIENE D4 RECEPTOR; LEUKOTRIENE RECEPTOR; MEMBRANE PROTEIN; PRIMER DNA; PURINE P2 RECEPTOR; QUINOLINE DERIVATIVE;

ARTICLE; ASTHMA; ASTROCYTOMA CELL; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CONTROLLED STUDY; DRUG EFFECT; HUMAN; HUMAN CELL; IC 50; INFLAMMATION; MACROPHAGE; MONOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; CELL STRAIN U937; DRUG ANTAGONISM; METABOLISM; NUCLEOTIDE SEQUENCE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ACETATES; BASE SEQUENCE; CALCIUM; CHROMONES; DNA PRIMERS; HUMANS; MEMBRANE PROTEINS; QUINOLINES; RECEPTORS, LEUKOTRIENE; RECEPTORS, PURINERGIC P2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; U937 CELLS; URIDINE TRIPHOSPHATE;

EID: 28244496554     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2005.10.003     Document Type: Article

References (45)

1. B. Samuelsson Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation Science 220 1983 568 575
2. S.E. Dahlen, P. Hedqvist, S. Hammarstrom, and B. Samuelsson Leukotrienes are potent constrictors of human bronchi Nature 288 1980 484 486
3. S. Nicosia, V. Capra, and G.E. Rovati Leukotrienes as mediators of asthma Pulm Pharmacol Ther 14 2001 3 19
4. E. Porreca, C. Di Febbo, A. Di Sciullo, D. Angelucci, M. Nasuti, and P. Vitullo Cysteinyl leukotriene D4 induced vascular smooth muscle cell proliferation: a possible role in myointimal hyperplasia Thromb Haemost 76 1996 99 104
5. K. Lotzer, R. Spanbroek, M. Hildner, A. Urbach, R. Heller, and E. Bretschneider Differential leukotriene receptor expression and calcium responses in endothelial cells and macrophages indicate 5-lipoxygenase-dependent circuits of inflammation and atherogenesis Arterioscl Throm Vas Biol 23 2003 E32 E36
6. P. Ciceri, M. Rabuffetti, A. Monopoli, and S. Nicosia Production of leukotrienes in a model of focal cerebral ischaemia in the rat Br J Pharmacol 133 2001 1323 1329
7. G. Folco, G. Rossoni, C. Buccellati, F. Berti, J. Maclouf, and A. Sala Leukotrienes in cardiovascular diseases Am J Respir Crit Care Med 161 2000 S112 S116
8. C. Brink, S.E. Dahlen, J. Drazen, J.F. Evans, D.W. Hay, and S. Nicosia International Union of Pharmacology XXXVII. Nomenclature for Leukotriene and Lipoxin Receptors Pharmacol Rev 55 2003 195 227
9. V. Capra Molecular and functional aspects of human cysteinyl leukotriene receptors Pharm Res 50 2004 1 11
10. E.A. Frey, D.W. Nicholson, and K.M. Metters Characterization of the leukotriene D4 receptor in dimethylsulphoxide-differentiated U937 cells: comparison with the leukotriene D4 receptor in human lung and guinea-pig lung Eur J Pharmacol 244 1993 239 250
11. H.M. Sarau, R.S. Ames, J. Chambers, C. Ellis, N. Elshourbagy, and J.J. Foley Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor Mol Pharmacol 56 1999 657 663
12. V. Capra, S. Ravasi, M.R. Accomazzo, M. Parenti, and G.E. Rovati CysLT1 signal transduction in differentiated U937 cells involves the activation of the small GTP-binding protein Ras Biochem Pharmacol 67 2004 1569 1577
13. H.-P. Nothacker, Z. Wang, Y. Zhu, R.K. Reinscheid, S.H.S. Lin, and O. Civelli Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist Mol Pharmacol 58 2000 1601 1608
14. Capra V, Ravasi S, Citro S, Accomazzo MR, Grimoldi M, Abbracchio MP, et al. CysLT1 Receptor is a target for extracellular nucleotides-induced heterologous desensitization: a possible feed-back mechanism in inflammation. J Cell Sci, in press.
15. S. Costanzi, L. Mamedova, Z.G. Gao, and K.A. Jacobson Architecture of P2Y nucleotide receptors: Structural comparison based on sequence analysis, mutagenesis, and homology modeling J Med Chem 47 2004 5393 5404
16. R. Fredriksson, M.C. Lagerstrom, L.G. Lundin, and H.B. Schioth The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints Mol Pharmacol 63 2003 1256 1272
17. W.K. Kroeze, D.J. Sheffler, and B.L. Roth G protein-coupled receptors at a glance J Cell Sci 116 2003 4867 4869
18. T.R. Jones, R. Zamboni, M. Belley, E. Champion, L. Charette, and A.W. Ford-Hutchinson Pharmacology of L-660,711 (MK-571): a novel potent and selective leukotriene D4 receptor antagonist Can J Physiol Pharmacol 67 1989 17 28
19. B. Jarvis, and A. Markham Montelukast: a review of its therapeutic potential in persistent asthma Drugs 59 2000 891 928
20. T. Obata, N. Katsube, T. Miyamoto, M. Toda, T. Okegawa, and H. Nakai New antagonists of leukotrienes: ONO-RS-411 and ONO-RS-347 Adv Prostaglandin Thromboxane Leukot Res 15 1985 229 231
21. S.J. Keam, K.A. Lyseng-Williamson, and K.L. Goa Pranlukast: a review of its use in the management of asthma Drugs 63 2003 991 1019
22. S.E. Dahlen Lipid mediator pathways in the lung: leukotrienes as a new target for the treatment of asthma Clin Exp Aller 28 Suppl 5 1998 141 146 [discussion 171-3]
23. J.M. Drazen, E. Israel, and P.M. O'Byrne Treatment of asthma with drugs modifying the leukotriene pathway N Engl J Med 340 1999 197 206
24. S.S. Salvi, M.T. Krishna, A.P. Sampson, and S.T. Holgate The anti-inflammatory effects of leukotriene-modifying drugs and their use in asthma Chest 119 2001 1533 1546
25. 14 receptor) adds diversity to the P2Y receptor family Trends Pharmacol Sci 24 2003 52 55
26. Abbracchio MP, Burnstock G, Boeynaems JM, Barnard EA, Boyer JL, Kennedy C, et al. International Union of Pharmacology. Update and subclassification of the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy. Pharmacol Rev, 2005, under revision.
27. C.L. Herold, Q. Li, J.B. Schachter, T.K. Harden, and R.A. Nicholas Lack of nucleotide-promoted second messenger signaling responses in 1321N1 cells expressing the proposed P2Y receptor, p2y7 Biochem Biophys Res Commun 235 1997 717 721
28. K.L. Gearing, A. Barnes, J. Barnett, A. Brown, D. Cousens, and S. Dowell Complex chimeras to map ligand binding sites of GPCRs Protein Eng 16 2003 365 372
29. 1 and cysteinyl leukotriene receptors mediate purine and cysteinyl leukotriene co-release in primary cultures of rat microglia Int J Immunopathol Pharmacol 18 2005 255 268
30. J. Jin, V.R. Dasari, F.D. Sistare, and S.P. Kunapuli Distribution of P2Y receptor subtypes on haematopoietic cells Br J Pharmacol 123 1998 789 794
31. i J Biol Chem 276 2001 41479 41485
32. 13 receptor Biochem Pharmacol 68 2004 113 124
33. M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72 1976 248 254
34. M. Fumagali, R. Brambilla, N. D'Ambrosi, C. Volonté, M. Matteoli, and C. Verderio Nucleotide-mediated calcium signaling in rat cortical astrocytes: Role of P2X and P2Y receptors Glia 43 2003 218 230
35. 1 receptor signaling without affecting nucleotide binding Biochem Pharmacol 68 2004 231 237
36. V. Capra, M.R. Accomazzo, S. Ravasi, M. Parenti, M. Macchia, and S. Nicosia Involvement of prenylated proteins in calcium signaling induced by LTD4 in differentiated U937 cells Prostaglandins Other Lipid Mediat 71 2003 235 251
37. 1 receptor with a high affinity radiolabeled antagonist Mol Pharmacol 62 2002 1249 1257
38. 2 receptors Br J Pharmacol 140 2003 1169 1176
39. R.Y. Tsien, T. Pozzan, and T.J. Rink Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator J Cell Biol 94 1982 325 334
40. 2+ Biochem J 269 1990 513 519
41. R.R. Neubig, M. Spedding, T. Kenakin, and A. Christopoulos International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on terms and symbols in quantitative pharmacology Pharmacol Rev 55 2003 597 606
42. E.A. Mellor, K.F. Austen, and J.A. Boyce Cysteinyl leukotrienes and uridine diphosphate induce cytokine generation by human mast cells through an interleukin 4-regulated pathway that is inhibited by leukotriene receptor antagonists J Exp Med 195 2002 583 592
43. E.A. Mellor, A. Maekawa, K.F. Austen, and J.A. Boyce Cysteinyl leukotriene receptor 1 is also a pyrimidinergic receptor and is expressed by human mast cells Proc Natl Acad Sci USA 98 2001 7964 7969
44. E. Migoya, G.L. Kearns, A. Hartford, J. Zhao, J. Adelsberg, and A. Carol Pharmacokinetics of montelukast in asthmatic patients 6-24 months old J Clin Pharmacol 44 2004 487 494
45. 1 receptors and mitogen-activated protein kinase pathway Eur J Neurosci 20 2004 1514 1524