Nramp1 equips macrophages for efficient iron recycling

Experimental Hematology

Volumn 36, Issue 8, 2008, Pages 929-937

  Soe Lin, Shan ^a,b   Sheftel, Alex D ^c   Wasyluk, Brandi ^a,b   Ponka, Prem ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN; HEME OXYGENASE 1; HEMIN; IRON; IRON 59; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 1;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME INDUCTION; ERYTHROCYTE; ERYTHROPHAGOCYTOSIS; FEMALE; GENE OVEREXPRESSION; IRON CHELATION; IRON METABOLISM; MACROPHAGE; MOUSE; NONHUMAN; OPSONIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RETICULOCYTE; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CATION TRANSPORT PROTEINS; CELLS, CULTURED; ERYTHROCYTES; FEMALE; HEME OXYGENASE-1; HEMIN; IRON; MACROPHAGES; MICE; MICE, INBRED STRAINS; MODELS, BIOLOGICAL; OPSONIN PROTEINS; PHAGOCYTOSIS; UP-REGULATION;

EID: 47149095786     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2008.02.013     Document Type: Article

References (57)

1. Sheftel A.D., Kim S.F., and Ponka P. Non-heme induction of heme oxygenase-1 does not alter cellular iron metabolism. J Biol Chem 282 (2007) 10480-10486
2. Poss K.D., and Tonegawa S. Heme oxygenase 1 is required for mammalian iron reutilization. Proc Natl Acad Sci U S A 94 (1997) 10919-10924
3. Maines M.D. The heme oxygenase system: update 2005. Antioxid Redox Signal 7 (2005) 1761-1766
4. Harris Z.L., Durley A.P., Man T.K., and Gitlin J.D. Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux. Proc Natl Acad Sci U S A 96 (1999) 10812-10817
5. Bothwell Th C.R., Cook J.D., and Finch C.A. Iron Metabolism in Man (1979), Blackwell Scientific Publications, Oxford
6. Moura E., Noordermeer M.A., Verhoeven N., Verheul A.F., and Marx J.J. Iron release from human monocytes after erythrophagocytosis in vitro: an investigation in normal subjects and hereditary hemochromatosis patients. Blood 92 (1998) 2511-2519
7. Montosi G., Paglia P., Garuti C., et al. Wild-type HFE protein normalizes transferrin iron accumulation in macrophages from subjects with hereditary hemochromatosis. Blood 96 (2000) 1125-1129
8. Esparza I., and Brock J.H. Release of iron by resident and stimulated mouse peritoneal macrophages following ingestion and degradation of transferrin-antitransferrin immune complexes. Br J Haematol 49 (1981) 603-614
9. Kampschmidt R.F., Upchurch H.F., and Johnson H.L. Iron transport after injection of endotoxin in rats. Am J Physiol 208 (1965) 68-72
10. Konijn A.M., and Hershko C. Ferritin synthesis in inflammation. I. Pathogenesis of impaired iron release. Br J Haematol 37 (1977) 7-16
11. Harris Z.L., Takahashi Y., Miyajima H., Serizawa M., MacGillivray R.T., and Gitlin J.D. Aceruloplasminemia: molecular characterization of this disorder of iron metabolism. Proc Natl Acad Sci U S A 92 (1995) 2539-2543
12. Yoshida K., Furihata K., Takeda S., et al. A mutation in the ceruloplasmin gene is associated with systemic hemosiderosis in humans. Nat Genet 9 (1995) 267-272
13. Yachie A., Niida Y., Wada T., et al. Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. J Clin Invest 103 (1999) 129-135
14. Donovan A., Brownlie A., Zhou Y., et al. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature 403 (2000) 776-781
15. Abboud S., and Haile D.J. A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J Biol Chem 275 (2000) 19906-19912
16. McKie A.T., Marciani P., Rolfs A., et al. A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol Cell 5 (2000) 299-309
17. Knutson M.D., Vafa M.R., Haile D.J., and Wessling-Resnick M. Iron loading and erythrophagocytosis increase ferroportin 1 (FPN1) expression in J774 macrophages. Blood 102 (2003) 4191-4197
18. Delaby C., Pilard N., Goncalves A.S., Beaumont C., and Canonne-Hergaux F. Presence of the iron exporter ferroportin at the plasma membrane of macrophages is enhanced by iron loading and down-regulated by hepcidin. Blood 106 (2005) 3979-3984
19. Knutson M.D., Oukka M., Koss L.M., Aydemir F., and Wessling-Resnick M. Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidin. Proc Natl Acad Sci U S A 102 (2005) 1324-1328
20. Pietrangelo A. The ferroportin disease. Blood Cells Mol Dis 32 (2004) 131-138
21. Touret N., Furuya W., Forbes J., Gros P., and Grinstein S. Dynamic traffic through the recycling compartment couples the metal transporter Nramp2 (DMT1) with the transferrin receptor. J Biol Chem 278 (2003) 25548-25557
22. Canonne-Hergaux F., Gruenheid S., Ponka P., and Gros P. Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron. Blood 93 (1999) 4406-4417
23. Canonne-Hergaux F., Fleming M.D., Levy J.E., et al. The Nramp2/DMT1 iron transporter is induced in the duodenum of microcytic anemia mk mice but is not properly targeted to the intestinal brush border. Blood 96 (2000) 3964-3970
24. Canonne-Hergaux F., Zhang A.S., Ponka P., and Gros P. Characterization of the iron transporter DMT1 (NRAMP2/DCT1) in red blood cells of normal and anemic mk/mk mice. Blood 98 (2001) 3823-3830
25. Mims M.P., Guan Y., Pospisilova D., et al. Identification of a human mutation of DMT1 in a patient with microcytic anemia and iron overload. Blood 105 (2005) 1337-1342
26. Vidal S.M., Malo D., Vogan K., Skamene E., and Gros P. Natural resistance to infection with intracellular parasites: isolation of a candidate for. Bcg. Cell 73 (1993) 469-485
27. Fritsche G., Dlaska M., Barton H., Theurl I., Garimorth K., and Weiss G. Nramp1 functionality increases inducible nitric oxide synthase transcription via stimulation of IFN regulatory factor 1 expression. J Immunol 171 (2003) 1994-1998
28. Vidal S., Tremblay M.L., Govoni G., et al. The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene. J Exp Med 182 (1995) 655-666
29. Govoni G., Gauthier S., Billia F., Iscove N.N., and Gros P. Cell-specific and inducible Nramp1 gene expression in mouse macrophages in vitro and in vivo. J Leukoc Biol 62 (1997) 277-286
30. Canonne-Hergaux F., Calafat J., Richer E., et al. Expression and subcellular localization of NRAMP1 in human neutrophil granules. Blood 100 (2002) 268-275
31. Jabado N., Jankowski A., Dougaparsad S., Picard V., Grinstein S., and Gros P. Natural resistance to intracellular infections: natural resistance-associated macrophage protein 1 (Nramp1) functions as a pH-dependent manganese transporter at the phagosomal membrane. J Exp Med 192 (2000) 1237-1248
32. Fleming M.D., Romano M.A., Su M.A., Garrick L.M., Garrick M.D., and Andrews N.C. Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. Proc Natl Acad Sci U S A 95 (1998) 1148-1153
33. Fleming M.D., Trenor III C.C., Su M.A., et al. Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nat Genet 16 (1997) 383-386
34. Mulero V., Searle S., Blackwell J.M., and Brock J.H. Solute carrier 11a1 (Slc11a1; formerly Nramp1) regulates metabolism and release of iron acquired by phagocytic, but not transferrin-receptor-mediated, iron uptake. Biochem J 363 (2002) 89-94
35. Ponka P., Borova J., Neuwirt J., Fuchs O., and Necas E. A study of intracellular iron metabolism using pyridoxal isonicotinoyl hydrazone and other synthetic chelating agents. Biochim Biophys Acta 586 (1979) 278-297
36. Edward Jt G.M., Chubb F.L., and Ponka P. Synthesis of new acylhydrazones as iron chelating compounds. J Chem Eng Data 33 (1988) 538-540
37. Raschke W.C., Baird S., Ralph P., and Nakoinz I. Functional macrophage cell lines transformed by Abelson leukemia virus. Cell 15 (1978) 261-267
38. Govoni G., Canonne-Hergaux F., Pfeifer C.G., et al. Functional expression of Nramp1 in vitro in the murine macrophage line RAW264.7. Infect Immun 67 (1999) 2225-2232
39. Morita T., and Perkins E.H. A simple quantitative method to assess the in vitro engulfing and degradative potentials of mouse peritoneal phagocytic cells. J Reticuloendothel Soc 2 (1965) 406-419
40. Motterlini R., Foresti R., Vandegriff K., Intaglietta M., and Winslow R.M. Oxidative-stress response in vascular endothelial cells exposed to acellular hemoglobin solutions. Am J Physiol 269 (1995) H648-H655
41. Cabantchik Z.I., Glickstein H., Milgram P., and Breuer W. A fluorescence assay for assessing chelation of intracellular iron in a membrane model system and in mammalian cells. Anal Biochem 233 (1996) 221-227
42. Breuer W., Epsztejn S., and Cabantchik Z.I. Iron acquired from transferrin by K562 cells is delivered into a cytoplasmic pool of chelatable iron(II). J Biol Chem 270 (1995) 24209-24215
43. Atkinson P.G., and Barton C.H. High level expression of Nramp1G169 in RAW264.7 cell transfectants: analysis of intracellular iron transport. Immunology 96 (1999) 656-662
44. Maines M.D. The heme oxygenase system: a regulator of second messenger gases. Annu Rev Pharmacol Toxicol 37 (1997) 517-554
45. Knutson M., and Wessling-Resnick M. Iron metabolism in the reticuloendothelial system. Crit Rev Biochem Mol Biol 38 (2003) 61-88
46. Fillet G., Beguin Y., and Baldelli L. Model of reticuloendothelial iron metabolism in humans: abnormal behavior in idiopathic hemochromatosis and in inflammation. Blood 74 (1989) 844-851
47. Fillet G., Cook J.D., and Finch C.A. Storage iron kinetics. VII. A biologic model for reticuloendothelial iron transport. J Clin Invest 53 (1974) 1527-1533
48. Kondo H., Saito K., Grasso J.P., and Aisen P. Iron metabolism in the erythrophagocytosing Kupffer cell. Hepatology 8 (1988) 32-38
49. Tanno T., Bhanu N.V., Oneal P.A., et al. High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat Med 13 (2007) 1096-1101
50. Rhodes M.M., Kopsombut P., Bondurant M.C., Price J.O., and Koury M.J. Adherence to macrophages in erythroblastic islands enhances erythroblast proliferation and increases erythrocyte production by a different mechanism than erythropoietin. Blood 111 (2008) 1700-1708
51. Joyeux-Faure M. Cellular protection by erythropoietin: new therapeutic implications?. J Pharmacol Exp Ther 323 (2007) 759-762
52. Pak M., Lopez M.A., Gabayan V., Ganz T., and Rivera S. Suppression of hepcidin during anemia requires erythropoietic activity. Blood 108 (2006) 3730-3735
53. Vokurka M., Krijt J., Sulc K., and Necas E. Hepcidin mRNA levels in mouse liver respond to inhibition of erythropoiesis. Physiol Res 55 (2006) 667-674
54. Blackwell J.M., and Searle S. Genetic regulation of macrophage activation: understanding the function of Nramp1 (=Ity/Lsh/Bcg). Immunol Lett 65 (1999) 73-80
55. Mackenzie B., and Hediger M.A. SLC11 family of H+-coupled metal-ion transporters NRAMP1 and DMT1. Pflugers Arch 447 (2004) 571-579
56. Forbes J.R., and Gros P. Divalent-metal transport by NRAMP proteins at the interface of host-pathogen interactions. Trends Microbiol 9 (2001) 397-403
57. Lam-Yuk-Tseung S., Mathieu M., and Gros P. Functional characterization of the E399D DMT1/NRAMP2/SLC11A2 protein produced by an exon 12 mutation in a patient with microcytic anemia and iron overload. Blood Cells Mol Dis 35 (2005) 212-216