Solute carrier 11a1 (Slc11a1; formerly Nramp1) regulates metabolism and release of iron acquired by phagocytic, but not transferrin-receptor-mediated, iron uptake

Biochemical Journal

Volumn 363, Issue 1, 2002, Pages 89-94

  Mulero, Victoriano ^a   Searle, Susan ^a   Blackwell, Jenefer M ^a   Brock, Jeremy H ^a  

^a ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

Macrophage; Nitric oxide; Phagocytosis

Indexed keywords

DEGRADATION; IRON; MICROSCOPIC EXAMINATION; POLYSACCHARIDES; PROTEINS;

PATHOGENS;

BIOCHEMISTRY;

ANTIPORTER; CARRIER PROTEIN; DIVALENT CATION; FERRITIN; GAMMA INTERFERON; IRON; LIPOPOLYSACCHARIDE; MEMBRANE PROTEIN; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN; NITRIC OXIDE; PROTON; TRANSFERRIN RECEPTOR;

ANIMAL CELL; ANTIGEN ANTIBODY COMPLEX; ARTICLE; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; DEGRADATION; ENDOSOME; GENETIC TRANSFECTION; IRON KINETICS; IRON TRANSPORT; LYSOSOME; MOUSE; NONHUMAN; NULL ALLELE; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SOLUTE; WESTERN BLOTTING;

ALLELES; ANIMALS; APOPTOSIS; CATION TRANSPORT PROTEINS; CATIONS; CELL LINE; CYTOPLASM; ENDOSOMES; HUMANS; IRON; LYSOSOMES; MACROPHAGES; MICE; MICROSCOPY, CONFOCAL; MUTATION; NITRIC OXIDE; NITRITES; PHAGOCYTOSIS; TIME FACTORS; TRANSFECTION; TRANSFERRIN; UP-REGULATION;

ANIMALIA;

EID: 0036534742     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3630089     Document Type: Article

References (32)

1. The red cell cycle
2. Role of transferrin, transferrin receptors, and iron in macrophage listericidal activity
3. Central role of transcription factor NF-IL6 for cytokine and iron-mediated regulation of murine inducible nitric oxide synthase expression
4. The iron transport protein NRAMP2 is an integral membrane glycoprotein that colocalizes with transferrin in recycling endosomes
5. Natural resistance to infections with intracellular pathogens: The Nramp1 protein is recruited to the membrane of the phagosome
6. Localisation of Nramp1 in macrophages: Modulation with activation and infection
7. +/bivalent cation antiporter
8. Uptake and handling of iron from transferrin, lactoferrin and immune complexes by a macrophage cell line
9. Release of iron by resident and stimulated mouse peritoneal macrophages following ingestion and degradation of transferrin-antitransferrin immune complexes
10. Nramp transfection transfers Ity/Lsh/Bcg-related pleiotropic effects on macrophage activation: Influence on oxidative burst and nitric oxide pathways
11. Regulation of iron metabolism in murine J774 macrophages: Role of nitric oxide-dependent and -independent pathways following activation with gamma interferon and lipopolysaccharide
12. Host resistance to intracellular infection: Mutation of natural resistance-associated macrophage protein 1 (Nramp1) impairs phagosomal acidification
13. SLC11A1 (formerly NRAMP1) and disease resistance
14. Quantitative photometrical assessment of iron deposits in synovial membranes in different joint diseases
15. The roles of inflammation and iron deficiency as causes of anemia
16. Pathogenesis and treatment of the anemia of chronic disease
17. Positional cloning of a zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
18. A novel mammalian iron-regulated protein involved in intracellular iron metabolism
19. Natural resistance to intracellular infections: Natural resistance-associated macrophage protein 1 (Nramp1) functions as a pH-dependent managenese transporter at the phagosomal membrane
20. Differential iron transport into phagosomes isolated from the RAW264.7 macrophage cell lines transfected with Nramp1 Gly169 or Nramp1 Asp169
21. Iron transport into mycobacterium avium-containing phagosomes from an Nramp1(Gly169)-transfected RAW264.7 macrophage cell line
22. Gly169
23. Iron metabolism in the erythrophagocytosing Kupffer cell
24. Expression of the natural resistance gene Lsh in resident liver macrophages
25. Heme oxygenase-1 and NADPH cytochrome P450 reductase expression in experimental allergic encephalomyelitis: An expanded view of the stress response
26. Differential regulation and expression of stress proteins and ferritin in human monocytes
27. Regulated secretion from hematopoietic cells
28. Potentiation and inhibition of fMLP-activated exocytosis in neutrophils by exogenous nitric oxide
29. Evidence that nitric oxide synthase is involved in progesterone-induced acrosomal exocytosis in mouse spermatozoa
30. Autophagic degradation of protein generales a pool of ferric iron required for the killing of cultured hepatocytes by an oxidative stress
31. G169 in RAW264.7 cell transfectants: Analysis of intracellular iron transport
32. A negative autoregulatory link between Nramp1 function and expression