Iron release from human monocytes after erythrophagocytosis in vitro: An investigation in normal subjects and hereditary hemochromatosis patients

Blood

Volumn 92, Issue 7, 1998, Pages 2511-2519

  Moura, Eunice ^b   Noordermeer, Minke A ^b   Verhoeven, Nanda ^b   Verheul, Andreas P M ^b   Marx, Joannes J M ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CELL LEVEL; CLINICAL ARTICLE; ERYTHROPHAGOCYTOSIS; HEMOCHROMATOSIS; HUMAN; HUMAN CELL; IRON BLOOD LEVEL; IRON KINETICS; IRON METABOLISM; IRON OVERLOAD; PATHOGENESIS; PRIORITY JOURNAL;

EID: 0032189835     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v92.7.2511     Document Type: Article

References (40)

1. Gutteridge JMC, Rowley DA, Griffiths E, Halliwell B: Lowmolecular-weight iron complexes and oxygen radical reactions in idiopathic hemochromatosis. Clin Sci 68:463, 1985
2. Custer G, Balcerzak S, Rinehart J: Human macrophages hemoglobin-iron metabolism in vitro. Am J Hematol 13:23, 1982
3. Saito K, Nishisato T, Grasso JA, Aisen P: Interaction of transferrin with iron-loaded peritoneal macrophages. Br J Haematol 62:275, 1986
4. Kondo H, Saito K, Grasso JP, Aisen P: Iron metabolism in the erythrophagocytosing Kupffer cell. Hepatology 8:32, 1988
5. Sibille JC, Kondo H, Aisen P: Interactions between isolated hepatocytes and Kupffer cells in iron metabolism: A possible role for ferritin as an iron carrier protein. Hepatology 8:296, 1988
6. Moura E, Verheul AFM, Marx JJM; A functional defect in hereditary haemochromatosis monocytes and monocyte-derived macrophages. Eur J Clin Invest 28:164, 1998
7. Santos M, Clevers HC, Marx JJM: Mutations of the hereditary haemochromatosis candidate gene HLA-H in porphyria cutanea tarda. N Engl J Med 336:1327, 1997
8. Shen L, Guyre PM, Ball ED, Fanger MW: Glucocorticoid enhances gamma interferon effects on human monocyte antigen expression and ADCC. Clin Exp Immunol 65:387, 1986
9. Moura E, Verheul AFM, Marx JJM: Fe-labelling of rabbit erythrocytes as a continuous source for iron metabolism studies. Lab Anim 32:284, 1998
10. Simon RH, Scoggin CH, Patterson D: Hydrogen peroxide causes the fatal injury to human fibroblasts exposed to oxygen radicals. J Biol Chem 256:7181, 1981
11. Weaver J, Pollack S, Zhan H: Low molecular weight iron from guinea pig reticulocytes isolated by Sephadex G-25 chromatography. Eur J Haematol 43:321, 1989
12. Mansour AN, Thompson C, Theil EC, Chasteen ND, Sayers DE: Fe(III)-ATP complexes. Models for ferritin and other polynuclear iron complexes with phosphate. J Biol Chem 260:7975, 1985
13. International Committee for Standardization in Haematology: Recommendation for measurement of serum iron in human blood. Br J Haematol 38:291, 1987
14. International Committee for Standardization in Haematology: The measurement of total and unsaturated iron-binding capacity in serum. Br J Haematol 38:281, 1987
15. Dacie Sir JV, Lewis SM: Practical Haematology. New York, NY, Churchill Livingstone, 1985
16. Shibahara S, Yoshida T, Kikuchi G: Induction of heme oxygenase by haemin in cultured pig alveolar macrophages. Arch Biochem Biophys 188:243, 1978
17. Tenhunen R, Ross ME, Marver HS, Schmid R: Reduced nicotinamide-adenine dinucleotide phosphate dependent biliverdin reductase: Partial purification and characterization. Biochemistry 9:298, 1970
18. Sörensen K, Brodbeck U: A sensitive protein assay using microtiter plates. Experientia42:161, 1986
19. Tenhunen R, Marver HS, Schmid R: The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase. Proc Natl Acad Sci USA 61:748, 1986
20. Doumas BT, Kwok-Cheung PP, Perry BW, Jendrzejczak B, McComb RB, Schaffer R, Hause LL: Candidate reference method for determination of total bilirubin in serum: Development and validation. Clin Chem 31:1779, 1985
21. Kreyszig E: Introductionary Mathematical Statistics. Principles and Methods. New York, NY, Wiley, 1970
22. Van Asbeck BS, Marx JJM, Sruyvenberg A, Verhoef J: Functional defects in phagocytic cells from patients with iron overload. J Infect 8:232, 1984
23. Kay MMB: Recognition and removal of senescent cells, in de Sousa M, Brock JH (eds): Iron in Immunity, Cancer and Inflammation. New York, NY, Wiley, 1989, p 17
24. Gemsa D, Woo CH, Fudenberg H, Schmid R: Erythrocyte catabolism by macrophages in vitro. The effect of hydrocortisone on erythrophagocytosis and on the induction of haem oxygenase. J Clin Invest 52:812, 1973
25. Fillet G, Beguin Y, Baldelli L: Model of reticuloendothelial iron metabolism in humans. Blood 74:844, 1989
26. Willis D, Moore AR, Frederick R, Willoughby DA: Heme oxygenase: A novel target for the modulation of the inflammatory response. Nat Med 2:87, 1996
27. Kino K, Tsunoo H, Riga Y, Takami M, Hamaguchi H, Nakajima H: Haemoglobin-haptoglobin receptor in rat liver plasma membrane. J BiolChem 255:9616, 1980
28. Hershko C, Cook JD, Finch CA: Storage iron kinetics. VI. The effect of inflammation on iron exchange in the rat. Br J Haematol 28:67, 1974
29. Williams R, Manenti F, Williams HS, Pitcher CS: Iron absorption in idiopathic haemochromatosis before, during, and after venesection therapy. BMJ 2:78, 1966
30. Walters GO, Jacobs A, Worwood M, Trevett D, Thomson W: Iron retention in normal subjects and patients with idiopathic haemochromatosis: Relationship with serum ferritin concentration. Gut 16:188, 1975
31. Powell LW, Summers KW, Board PG, Axelson E, Webb S, Halliday JW: Expression of haemochromatosis in homozygous subjects: Implications for early diagnosis and prevention. Gastroenterology 98:1625, 1990
32. Marx JJM: Mucosal uptake, mucosal transfer and retention of iron, measured by whole-body counting. Scand J Haematol 23:293, 1979
33. Powell LW, Jazwinska E, Halliday JW: Primary iron overload, in Brock JH, Halliday JW, Pippard MJ, Powell LW (eds): Iron Metabolism in Health and Disease. Philadelphia, PA, Saunders, 1994, p 227
34. Grootveld M, Bell JD, Halliwell B, Aruoma OI. Bomford A, Sadler PJ: Non-transferrin-bound iron in plasma or serum from patients with idiopathic haemochromatosis. Characterization by high performance liquid chromatography and nuclear magnetic resonance spectroscopy. J Biol Chem 264:4417, 1989
35. Wright TC, Brissot P, Wai-Lan M, Weissiger RA: Characterization of non-transferrin-bound iron clearance by rat liver. J Biol Chem 261:10909, 1986
36. Cairo G, Recalcati S, Montosi G, Castrusini E, Conte D, Pietrangelo A: Inappropriately high iron regulatory protein activity in monocytes of patients with genetic hemochromatosis. Blood 89:2549, 1997
37. Feder JN, Penny DM, Irrinki A, Lee VK, Lebrón JA, Watson N, Tsuchihashj Z, Sigal E, BjorkmanJ, Schatzman RC: The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding. Proc Natl Acad Sci USA 95:1472, 1998
38. Hamilton TA, Weiel JE, Adams DO: Expression of the transferrin receptor in murine peritoneal macrophages is modulated in the different stages of activation. J Immunol 132:2285,1984
39. Moura E, Verheul AFM, Marx JJM: Evaluation of the role of Fcγ and complement receptors in the decreased phagocytosis of hereditary haemochromatosis patients. Scand J Immunol 46:399, 1997
40. Gordeuk VR, Ballou S, Lozanski G, Brittenham GH: Decreased concentration of tumor necrosis factor-α in supematants of monocytes from homozygotes for herediatry hemochromatosis. Blood 79:1855, 1992