Wild-type HFE protein normalizes transferrin iron accumulation in macrophages from subjects with hereditary hemochromatosis

Blood

Volumn 96, Issue 3, 2000, Pages 1125-1129

  Montosi, G ^a   Paglia, P ^a   Garuti, C ^a   Guzman, C A ^a   Bastin, J M ^a   Colombo, M P ^a   Pietrangelo, A ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

FERRITIN; IRON; TRANSFERRIN;

ADULT; AMINO ACID SUBSTITUTION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE MUTATION; GENE TARGETING; GENETIC TRANSFECTION; HEMOCHROMATOSIS; HUMAN; HUMAN CELL; IRON METABOLISM; IRON OVERLOAD; IRON STORAGE; MACROPHAGE; MALE; MONOCYTE; PHENOTYPE; PRIORITY JOURNAL; SALMONELLA TYPHIMURIUM;

EID: 0034254794     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v96.3.1125     Document Type: Article

References (27)

1. Haemochromatosis: The genetic disorder of the twenty-first century
2. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis
3. Haemochromatosis and HLA-H
4. Haemochromatosis and HLA-H
5. The haemochromatosis founder mutation in HLA H disrupts beta(2) microglobulin interaction and cell surface expression
6. Hereditary haemochromatosis effects of C282Y and H63D mutations on association with beta(2)-microglobulin intracellular processing and cell surface expression of the HFE protein in COS-7 cells
7. The haemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding
8. Crystal structure of the haemochromatosis protein hfe and characterization of its interaction with transferrin receptor
9. Inappropriately high iron regulatory protein activity in monocytes of patients with genetic hemochromatosis
10. HFE gene knockout produces mouse model of hereditary hemochromatosis
11. Beta2 knockout mice develop parenchymal iron overload: A putative role for class I genes of the major histocompatlbility complex in iron metabolism
12. Salmonellosis: Host immune responses and bacterial virulence determinants
13. Oral somatic transgene vaccination using attenuated S typhimurium
14. Gene transfer in dendritic cells, induced by oral DNA vaccination with Salmonella typhimurium, results in protective immunity against a murine fibrosarooma
15. Hereditary hemochromatosis in adults without pathogenic mutations in the hemochromatosis gene
16. Kupffer cell staining by an HFE-specific monoclonal antibody: Implications for hereditary haemochromatosis
17. Location of MHC-encoded transporters in the endoplasmic reticulum and cis-Golgi
18. Iron metabolism
19. The transferrin receptor
20. Transferrin receptors on circulating monocytes in hereditary haemochromatosis
21. Duodenal ferritin synthesis in genetic hemochromatosis
22. Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum
23. Co-trafficking of HFE, a nonclassical major histocompatibility complex class I protein, with the transferrin receptor implies a role in intracellular iron regulation
24. Transferrin receptor is negatively modulated by the hemochromatosis protein HFE: Implications for cellular iron homeostasis
25. Iron release from human monocytes after erythrophagocytosis in vitro: An investigation in normal subjects and hereditary hemochromatosis patients
26. Positional cloning of zebrafish ferroportin 1 identifies a conserved vertebrate iron exporter
27. The C282Y mutation causing hereditary hemochromatosis does not produce a null allele