Regulation of hepcidin in HepG2 and RINm5F cells

Peptides

Volumn 28, Issue 5, 2007, Pages 951-957

  Fein, Evelyn ^a   Merle, Uta ^a   Ehehalt, Robert ^a   Herrmann, Thomas ^a   Kulaksiz, Hasan ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Hepcidin; Iron metabolism; Liver; Pancreas; Pro hepcidin

Indexed keywords

DEFEROXAMINE; ERYTHROPOIETIN; HEPCIDIN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; HORMONE ACTION; HUMAN; HUMAN CELL; INFLAMMATION; IRON METABOLISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; DEFEROXAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROPOIETIN; GENE EXPRESSION REGULATION; HUMANS; IMMUNOBLOTTING; INTERLEUKIN-6; IRON; LIPOPOLYSACCHARIDES; MICROSCOPY, FLUORESCENCE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 34247523321     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2007.01.016     Document Type: Article

References (31)

1. Barbé-Tuana F.M., Klein D., Ichii H., Berman D.M., Coffey L., Kenyon N.S., et al. CD40-CD40 Ligand interaction activates proinflammatory pathways in pancreatic islets. Diabetes 55 (2006) 2437-2445
2. Bhathena S.J., Oie H.K., Gazdar A.F., Voyles N.R., Wilkins S.D., and Recant L. Insulin, glucagon, and somatostatin receptors on cultured cells and clones from rat islet cell tumor. Diabetes 31 (1982) 521-531
3. Borenfreund E., and Shopsis C. Toxicity monitored with a correlated set of cell-culture assays. Xenobiotica 15 (1985) 705-711
4. Farrell F., and Lee A. The erythropoietin receptor and its expression in tumor cells and other tissues. The Oncologist 9 (2004) 18-30
5. Fenjves E.S., Ochoa M.S., Cabera O., Mendez A.J., Kenyon N.S., Inverardi L., et al. Human, nonhuman primate, and rat pancreatic islets express erythropoietin receptors. Transplantation 75 (2003) 1356-1360
6. Fernandez-Real J.M., Lopez-Bermejo A., and Ricart W. Cross-talk between iron metabolism and diabetes. Diabetes 51 (2002) 2348-2354
7. Ganz T. Hepcidin-a regulator of intestinal iron absorption and iron recycling by macrophages. Best Pract Res Clin Haematol 18 (2005) 171-182
8. Gazdar A.F., Chick W.L., Oie H.K., Sims H.L., King D.L., Weir G.C., et al. Continuous, clonal, insulin- and somatostatin-secreting cell lines established from a transplantable rat islet cell tumor. PNAS 77 (1980) 3519-3523
9. Gehrke S.G., Kulaksiz H., Herrmann T., Riedel H.D., Bents K., Veltkamp C., et al. Expression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron. Blood 102 (2003) 371-376
10. Grube B.J., Cochane C.G., Ye R.D., Green C.E., McPhail M.E., Ulevitch R.J., et al. Lipopolysaccharide binding protein expression in primary human hepatocytes and HepG2 hepatoma cells. J Biol Chem 269 (1994) 8477-8482
11. Kaplan J., and O'Halloran T.V. Iron metabolism in eukaryotes: Mars and Venus at it again. Science 271 (1996) 1510-1512
12. Koury M.J., and Ponka P. New insights into erythropoiesis: the roles of folate, vitamin B12, and iron. Ann Rev Nutr 24 (2004) 105-131
13. Krause A., Neitz S., Magert H.J., Schulz A., Forssmann W.G., Schulz-Knappe P., et al. LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. FEBS 480 (2000) 147-150
14. Kulaksiz H., Gehrke S.G., Janetzko A., Rost D., Bruckner T., Kallinowski B., et al. Pro-hepcidin: expression and cell specific localisation in the liver and its regulation in hereditary haemochromatosis, chronic renal insufficiency, and renal anemia. Gut 53 (2004) 735-743
15. Kulaksiz H., Theilig F., Bachmann S., Gehrke S.G., Rost D., Janetzko A., et al. The iron-regulatory peptide hormone hepcidin: expression and cellular localization in the mammalian kidney. J Endocr 184 (2005) 361-370
16. Lee P., Peng H., Gelbart T., and Beutler E. The IL-6- and lipopolysaccharide-induced transcription of hepcidin in HFE-, transferrin receptor 2-, and beta 2-microglobulin-deficient hepatocytes. PNAS 101 (2004) 9263-9265
17. Mertz W. The essential trace elements. Science 213 (1981) 1332-1338
18. Muckenthaler M., Roy C.N., Custodio A.O., Minana B., deGraaf J., Montross L.K., et al. Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis. Nat Genet 34 (2003) 102-107
19. Nemeth E., Rivera S., Gabayan V., Keller C., Taudorf S., Pedersen B.K., et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest 113 (2004) 1271-1276
20. Nemeth E., Tuttle M.S., Powelson J., Vaughn M.B., Donovan A., Ward D.M., et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306 (2004) 2090-2093
21. Nemeth E., Valore E.V., Territo M., Schiller G., Lichtenstein A., and Ganz T. Hepcidin, A putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 101 (2003) 2461-2463
22. Nicolas G., Bennoun M., Devaux I., Beaumont C., Grandchamp B., Kahn A., et al. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. PNAS 98 (2001) 8780-8785
23. Nicolas G., Bennoun M., Porteu A., Mativet S., Beaumont C., Grandchamp B., et al. Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. PNAS 99 (2002) 4596-4601
24. Nicolas G., Chauvet C., Viatte L., Danan J.L., Bigard X., Devaux I., et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest 110 (2002) 1037-1044
25. Nicolas G., Viatte L., Bennoun M., Beaumont C., Kahn A., and Vaulont S. Hepcidin, a new iron regulatory peptide. Bl Cells Mol Des 29 (2002) 327-335
26. Park C.H., Valore E.V., Waring A.J., and Ganz T. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 276 (2001) 7806-7810
27. Pigeon C., Ilyin G., Courselaud B., Leroyer P., Turlin B., Brissot P., et al. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem 276 (2001) 7811-7819
28. Roetto A., Papanikolaou G., Politou M., Alberti F., Girelli D., Christakis J., et al. Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis. Nat Genet 33 1 (2003) 21-22
29. Schagger H., and von Jagow G. Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. Anal Biochem 166 (1987) 368-379
30. Taga T. IL6 signaling through IL6 receptor and receptor-associated signal transducer, gp130. Res Immunol 143 (1992) 737-739
31. Vives-Pi N., Somoza M., Fernandez-Alvarez J., Vargas F., Caro P., Alba A., et al. Evidence of expression of endotoxin receptors CD14, toll-like receptors TLR4 and TLR2 and associated molecule MD-2 and of sensitivity to endotoxin (LPS) in islet beta cells. Clin Exp Immunol 133 (2003) 208-218