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Volumn 79, Issue 3, 2008, Pages 143-165

A survey of the syntheses of active pharmaceutical ingredients for antiretroviral drug combinations critical to access in emerging nations

Author keywords

Atazanavir; Drugs; Efavirenz; Emtricitabine; FTC; HIV 1; Kaletra; Lopinavir; Prices; Ritonavir; Second line; Synthesis; TDF; Tenofovir Disoproxil Fumarate

Indexed keywords

ABACAVIR; AMPRENAVIR PHOSPHATE; ANTIRETROVIRUS AGENT; ATAZANAVIR; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; DIDANOSINE; EFAVIRENZ; EFAVIRENZ PLUS EMTRICITABINE PLUS TENOFOVIR DISOPROXIL; EMTRICITABINE; EMTRICITABINE PLUS TENOFOVIR DISOPROXIL; ENFUVIRTIDE; ETRAVIRINE; INDINAVIR; INTEGRASE INHIBITOR; LAMIVUDINE; LAMIVUDINE PLUS NEVIRAPINE PLUS STAVUDINE; LOPINAVIR; LOPINAVIR PLUS RITONAVIR; MARAVIROC; NELFINAVIR; NEVIRAPINE; NUCLEOTIDE; RALTEGRAVIR; RITONAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; SAQUINAVIR; STAVUDINE; TENOFOVIR DISOPROXIL; UNINDEXED DRUG; VIRUS FUSION PROTEIN; ZIDOVUDINE;

EID: 47049098041     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.antiviral.2008.05.001     Document Type: Review
Times cited : (39)

References (161)
  • 1
    • 30944461014 scopus 로고    scopus 로고
    • Stereoselective hydroazidation of amino enones: synthesis of the ritonavir/lopinavir core
    • Adamo I., Benedetti F., Berti F., and Campaner P. Stereoselective hydroazidation of amino enones: synthesis of the ritonavir/lopinavir core. Org. Lett. 8 (2006) 51-54
    • (2006) Org. Lett. , vol.8 , pp. 51-54
    • Adamo, I.1    Benedetti, F.2    Berti, F.3    Campaner, P.4
  • 2
    • 47049100997 scopus 로고    scopus 로고
    • Allen, M.S., 1999. Process for the preparation of 5-hydroxymethylthiazoles. US Patent 5,959,118.
    • Allen, M.S., 1999. Process for the preparation of 5-hydroxymethylthiazoles. US Patent 5,959,118.
  • 3
    • 2942676483 scopus 로고    scopus 로고
    • Emtricitabine/tenofovir disoproxil fumarate
    • Anon. Emtricitabine/tenofovir disoproxil fumarate. Drugs R. D. 5 (2004) 160-161
    • (2004) Drugs R. D. , vol.5 , pp. 160-161
  • 4
    • 4444272887 scopus 로고    scopus 로고
    • Synthesis of l-cyclopentenyl nucleosides using ring-closing metathesis and palladium-mediated allylic alkylation methodologies
    • Agrofoglio L.A., Amblard F., Nolan S.P., Charamon S., Gillaizeau I., Zevaco T.A., and Guenot P. Synthesis of l-cyclopentenyl nucleosides using ring-closing metathesis and palladium-mediated allylic alkylation methodologies. Tetrahedron 60 (2004) 8397-8404
    • (2004) Tetrahedron , vol.60 , pp. 8397-8404
    • Agrofoglio, L.A.1    Amblard, F.2    Nolan, S.P.3    Charamon, S.4    Gillaizeau, I.5    Zevaco, T.A.6    Guenot, P.7
  • 5
    • 0026780035 scopus 로고
    • Palladium catalyzed cross-coupling reactions of arylboronic acids with π-deficient heteroaryl chlorides
    • Ali N.M., McKillop A., Mitchell M.B., Rebelo R.A., and Wallbank P.J. Palladium catalyzed cross-coupling reactions of arylboronic acids with π-deficient heteroaryl chlorides. Tetrahedron 48 (1992) 8117-8126
    • (1992) Tetrahedron , vol.48 , pp. 8117-8126
    • Ali, N.M.1    McKillop, A.2    Mitchell, M.B.3    Rebelo, R.A.4    Wallbank, P.J.5
  • 6
    • 10044234084 scopus 로고    scopus 로고
    • Efficient synthesis of various acycloalkenyl derivatives of pyrimidine using cross-metathesis and Pd(0) methodologies
    • Amblard F., Nolan S.P., Schinazi R.F., and Agrofoglio L.A. Efficient synthesis of various acycloalkenyl derivatives of pyrimidine using cross-metathesis and Pd(0) methodologies. Tetrahedron 61 (2005) 537-544
    • (2005) Tetrahedron , vol.61 , pp. 537-544
    • Amblard, F.1    Nolan, S.P.2    Schinazi, R.F.3    Agrofoglio, L.A.4
  • 7
    • 0030420137 scopus 로고    scopus 로고
    • Inibidores da HIV-1 Protease: Uma Revisão
    • Antunes O.A.C. Inibidores da HIV-1 Protease: Uma Revisão. Rev. Bras. Farm 77 (1996) 164-172
    • (1996) Rev. Bras. Farm , vol.77 , pp. 164-172
    • Antunes, O.A.C.1
  • 8
    • 0030782524 scopus 로고    scopus 로고
    • Synthesis, in vitro biological evaluation and oral bioavailability of prodrugs of the antiretroviral agent 9-[2-(phosphonomethoxy)-propyl]adenine (PMA)
    • Arimilli M.N., Kim C.U., Dougherty J., Mulato A., Oliyai R., Shaw J.P., Cundy K.C., and Bischofberger N. Synthesis, in vitro biological evaluation and oral bioavailability of prodrugs of the antiretroviral agent 9-[2-(phosphonomethoxy)-propyl]adenine (PMA). Antivir. Chem. Chemother. 8 (1997) 557-564
    • (1997) Antivir. Chem. Chemother. , vol.8 , pp. 557-564
    • Arimilli, M.N.1    Kim, C.U.2    Dougherty, J.3    Mulato, A.4    Oliyai, R.5    Shaw, J.P.6    Cundy, K.C.7    Bischofberger, N.8
  • 9
    • 47049090668 scopus 로고    scopus 로고
    • Arimilli, M.N., Cundy, K.C., Dougherty, J.P., Kim, C.U., Oliyai, R., Stella, V.J., 1999. Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability. US Patent 5,922,695.
    • Arimilli, M.N., Cundy, K.C., Dougherty, J.P., Kim, C.U., Oliyai, R., Stella, V.J., 1999. Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability. US Patent 5,922,695.
  • 10
  • 11
    • 0027534661 scopus 로고
    • Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine
    • Balzarini J., Holý A., Jindrich J., Naesens L., Snoeck R., Schols D., and De Clercq E. Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine. Antimicrob. Agents Chemother. 37 (1993) 332-338
    • (1993) Antimicrob. Agents Chemother. , vol.37 , pp. 332-338
    • Balzarini, J.1    Holý, A.2    Jindrich, J.3    Naesens, L.4    Snoeck, R.5    Schols, D.6    De Clercq, E.7
  • 12
    • 0029989972 scopus 로고    scopus 로고
    • Activity of the (R)-enantiomers of 9-(2-phosphonylmethoxypropyl)-adenine and 9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine against human immunodeficiency virus in different human cell systems
    • Balzarini J., Aquaro S., Perno C.F., Witvrouw M., Holý A., and De Clercq E. Activity of the (R)-enantiomers of 9-(2-phosphonylmethoxypropyl)-adenine and 9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine against human immunodeficiency virus in different human cell systems. Biochem. Biophys. Res. Commun. 219 (1996) 337-341
    • (1996) Biochem. Biophys. Res. Commun. , vol.219 , pp. 337-341
    • Balzarini, J.1    Aquaro, S.2    Perno, C.F.3    Witvrouw, M.4    Holý, A.5    De Clercq, E.6
  • 14
    • 0035924978 scopus 로고    scopus 로고
    • Epoxyalcohol route to hydroxyethylene dipeptide isosteres: a new synthesis of the diaminoalcohol core of HIV-protease inhibitor ABT-538 (Ritonavir)
    • Benedetti F., and Norbedo S. Epoxyalcohol route to hydroxyethylene dipeptide isosteres: a new synthesis of the diaminoalcohol core of HIV-protease inhibitor ABT-538 (Ritonavir). J. Chem. Soc. Chem. Commun. (2001) 203-204
    • (2001) J. Chem. Soc. Chem. Commun. , pp. 203-204
    • Benedetti, F.1    Norbedo, S.2
  • 15
    • 0037195685 scopus 로고    scopus 로고
    • Epoxyalcohol route to hydroxyethylene dipeptide isosteres Stereodivergent synthesis of the diamino alcohol core of ritonavir and its C-2 epimer
    • Benedetti F., Berti F., and Norbedo S. Epoxyalcohol route to hydroxyethylene dipeptide isosteres Stereodivergent synthesis of the diamino alcohol core of ritonavir and its C-2 epimer. J. Org. Chem. 67 (2002) 8635-8643
    • (2002) J. Org. Chem. , vol.67 , pp. 8635-8643
    • Benedetti, F.1    Berti, F.2    Norbedo, S.3
  • 16
    • 0029731207 scopus 로고    scopus 로고
    • Synthesis, in vitro antiviral evaluation, and stability studies of bis(S-acyl-2-thioethyl) ester derivatives of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) as potential PMEA prodrugs with improved oral bioavailability
    • Benzaria S., Pélicano H., Johnson R., Maury G., Imbach J.L., Aubertin A.M., Obert G., and Gosselin G. Synthesis, in vitro antiviral evaluation, and stability studies of bis(S-acyl-2-thioethyl) ester derivatives of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) as potential PMEA prodrugs with improved oral bioavailability. J. Med. Chem. 39 (1996) 4958-4965
    • (1996) J. Med. Chem. , vol.39 , pp. 4958-4965
    • Benzaria, S.1    Pélicano, H.2    Johnson, R.3    Maury, G.4    Imbach, J.L.5    Aubertin, A.M.6    Obert, G.7    Gosselin, G.8
  • 17
    • 0033574618 scopus 로고    scopus 로고
    • Acylnitrene route to vicinal amino alcohols Application to the synthesis of (-)-bestatin and analogues
    • Bergmeier S.C., and Stanchina D.M. Acylnitrene route to vicinal amino alcohols Application to the synthesis of (-)-bestatin and analogues. J. Org. Chem. 64 (1999) 2852-2859
    • (1999) J. Org. Chem. , vol.64 , pp. 2852-2859
    • Bergmeier, S.C.1    Stanchina, D.M.2
  • 18
    • 0029114274 scopus 로고
    • [2 + 3]-Cycloadditions of enantiomerically pure oxazoline-N-oxides 1: a short stereoselective synthesis of (+)-carbovir
    • Berranger T., and Langlois Y. [2 + 3]-Cycloadditions of enantiomerically pure oxazoline-N-oxides 1: a short stereoselective synthesis of (+)-carbovir. Tetrahedron Lett. 36 (1995) 5523-5526
    • (1995) Tetrahedron Lett. , vol.36 , pp. 5523-5526
    • Berranger, T.1    Langlois, Y.2
  • 20
    • 0029670017 scopus 로고    scopus 로고
    • Stereospecific gamma-lactamase activity in a Pseudomonas fluorescens species
    • Brabban D., Littlechild J., and Wisdom R. Stereospecific gamma-lactamase activity in a Pseudomonas fluorescens species. J. Ind. Microbiol. 16 (1996) 8-14
    • (1996) J. Ind. Microbiol. , vol.16 , pp. 8-14
    • Brabban, D.1    Littlechild, J.2    Wisdom, R.3
  • 22
    • 0034708747 scopus 로고    scopus 로고
    • A novel, one-pot ring expansion of cyclobutanones Syntheses of carbovir and aristeromycin
    • Brown B., and Hegedus L.S. A novel, one-pot ring expansion of cyclobutanones Syntheses of carbovir and aristeromycin. J. Org. Chem. 65 (2000) 1865-1872
    • (2000) J. Org. Chem. , vol.65 , pp. 1865-1872
    • Brown, B.1    Hegedus, L.S.2
  • 23
    • 1642432974 scopus 로고    scopus 로고
    • Emtricitabine: a new nucleoside analogue for once-daily antiretroviral therapy
    • Cahn P. Emtricitabine: a new nucleoside analogue for once-daily antiretroviral therapy. Exp. Opin. Investig. Drugs 13 (2004) 55-68
    • (2004) Exp. Opin. Investig. Drugs , vol.13 , pp. 55-68
    • Cahn, P.1
  • 24
    • 0032770639 scopus 로고    scopus 로고
    • A new strategy for the asymmetric synthesis of 1,3-oxathiolane-based nucleoside analogues
    • Caputo R., Guaragna A., Palumbo G., and Pedatella S. A new strategy for the asymmetric synthesis of 1,3-oxathiolane-based nucleoside analogues. Eur. J. Org. Chem. (1999) 1455-1458
    • (1999) Eur. J. Org. Chem. , pp. 1455-1458
    • Caputo, R.1    Guaragna, A.2    Palumbo, G.3    Pedatella, S.4
  • 27
    • 0041657275 scopus 로고    scopus 로고
    • Palladium-catalyzed Suzuki-Miyaura reaction using aminophosphine as ligand
    • Cheng J., Wang F., Xu J.-H., Pan Y., and Zhang Z. Palladium-catalyzed Suzuki-Miyaura reaction using aminophosphine as ligand. Tetrahedron Lett. 44 (2003) 7095-7098
    • (2003) Tetrahedron Lett. , vol.44 , pp. 7095-7098
    • Cheng, J.1    Wang, F.2    Xu, J.-H.3    Pan, Y.4    Zhang, Z.5
  • 28
    • 0141682457 scopus 로고    scopus 로고
    • Water-mediated transition-metal-free Tsuji-Trost-type reaction
    • Chevrin C., Le Bras J., Hénin F., and Muzart J. Water-mediated transition-metal-free Tsuji-Trost-type reaction. Tetrahedron Lett. 44 (2003) 8099-8102
    • (2003) Tetrahedron Lett. , vol.44 , pp. 8099-8102
    • Chevrin, C.1    Le Bras, J.2    Hénin, F.3    Muzart, J.4
  • 29
    • 0038384673 scopus 로고    scopus 로고
    • In situ recycling of chiral ligand and surplus nucleophile for a noncatalytic reaction: amplification of process throughput in the asymmetric addition step of efavirenz (DMP 266)
    • Choudhury A., Moore J.R., Pierce M.E., Fortunak J.M., Valvis I., and Confalone P.N. In situ recycling of chiral ligand and surplus nucleophile for a noncatalytic reaction: amplification of process throughput in the asymmetric addition step of efavirenz (DMP 266). Org. Process Res. Dev. 7 (2003) 324-328
    • (2003) Org. Process Res. Dev. , vol.7 , pp. 324-328
    • Choudhury, A.1    Moore, J.R.2    Pierce, M.E.3    Fortunak, J.M.4    Valvis, I.5    Confalone, P.N.6
  • 30
    • 47049118962 scopus 로고    scopus 로고
    • Coates, J.A., Mutton, I.M., Penn, C.R., Williamson, C., Storer, R., 2001. 1,3-Oxathiolane nucleoside analogues. US Patent 6,180,639.
    • Coates, J.A., Mutton, I.M., Penn, C.R., Williamson, C., Storer, R., 2001. 1,3-Oxathiolane nucleoside analogues. US Patent 6,180,639.
  • 31
    • 47049128309 scopus 로고    scopus 로고
    • Coppola, K., 2003. Process for the preparation of thiazole derivatives. US Patent 6,566,530.
    • Coppola, K., 2003. Process for the preparation of thiazole derivatives. US Patent 6,566,530.
  • 33
    • 0028942305 scopus 로고
    • Enzymic resolution of oxathiolane intermediates-an alternative approach to the anti-viral agent Lamivudine (3TC™)
    • Cousins R.P.C., Mahmoudian M., and Youds P.M. Enzymic resolution of oxathiolane intermediates-an alternative approach to the anti-viral agent Lamivudine (3TC™). Tetrahedron: Asymm. 6 (1995) 393-396
    • (1995) Tetrahedron: Asymm. , vol.6 , pp. 393-396
    • Cousins, R.P.C.1    Mahmoudian, M.2    Youds, P.M.3
  • 34
    • 0032490986 scopus 로고    scopus 로고
    • New developments in the enantioselective synthesis of cyclopentyl carbocyelic nucleosides
    • Crimmins M.T. New developments in the enantioselective synthesis of cyclopentyl carbocyelic nucleosides. Tetrahedron 54 (1998) 9229-9272
    • (1998) Tetrahedron , vol.54 , pp. 9229-9272
    • Crimmins, M.T.1
  • 35
    • 0030018804 scopus 로고    scopus 로고
    • An efficient asymmetric approach to carbocyclic nucleosides: asymmetric synthesis of 1592U89, a potent inhibitor of HIV reverse transcriptase
    • Crimmins M.T., and King B.W. An efficient asymmetric approach to carbocyclic nucleosides: asymmetric synthesis of 1592U89, a potent inhibitor of HIV reverse transcriptase. J. Org. Chem. 61 (1996) 4192-4193
    • (1996) J. Org. Chem. , vol.61 , pp. 4192-4193
    • Crimmins, M.T.1    King, B.W.2
  • 36
    • 0034670585 scopus 로고    scopus 로고
    • An efficient, general asymmetric synthesis of carbocyclic nucleosides: application of an asymmetric aldol/ring-closing metathesis strategy
    • Crimmins M.T., King B.W., Zuercher W.J., and Choy A.L. An efficient, general asymmetric synthesis of carbocyclic nucleosides: application of an asymmetric aldol/ring-closing metathesis strategy. J. Org. Chem. 65 (2000) 8499-8509
    • (2000) J. Org. Chem. , vol.65 , pp. 8499-8509
    • Crimmins, M.T.1    King, B.W.2    Zuercher, W.J.3    Choy, A.L.4
  • 37
    • 47049086350 scopus 로고    scopus 로고
    • Daluge, S.M., 1991a. Therapeutic nucleosides. US Patent 5,034,394.
    • Daluge, S.M., 1991a. Therapeutic nucleosides. US Patent 5,034,394.
  • 38
    • 47049089437 scopus 로고    scopus 로고
    • Daluge, S.M., 1991b. Therapeutics nucleosides. EP0434450 A2.
    • Daluge, S.M., 1991b. Therapeutics nucleosides. EP0434450 A2.
  • 39
    • 0032437454 scopus 로고    scopus 로고
    • The role of non-nucleoside reverse transcriptase inhibitors (NNRTIs) in the therapy of HIV-1 infection
    • De Clercq E. The role of non-nucleoside reverse transcriptase inhibitors (NNRTIs) in the therapy of HIV-1 infection. Antivir. Res. 38 (1998) 153-179
    • (1998) Antivir. Res. , vol.38 , pp. 153-179
    • De Clercq, E.1
  • 40
    • 0003490784 scopus 로고    scopus 로고
    • De Clercq E. (Ed), American Society for Microbiology, Washington, DC, USA 359 pp.
    • In: De Clercq E. (Ed). Antiretroviral Therapy (2001), American Society for Microbiology, Washington, DC, USA 359 pp.
    • (2001) Antiretroviral Therapy
  • 41
    • 23444445718 scopus 로고    scopus 로고
    • Antiviral drug discovery and development: where chemistry meets with biomedicine
    • De Clercq E. Antiviral drug discovery and development: where chemistry meets with biomedicine. Antivir. Res. 67 (2005) 56-75
    • (2005) Antivir. Res. , vol.67 , pp. 56-75
    • De Clercq, E.1
  • 42
    • 36749037438 scopus 로고    scopus 로고
    • From adefovir to Atripla™ via tenofovir Viread™ and Truvada™
    • De Clercq E. From adefovir to Atripla™ via tenofovir Viread™ and Truvada™. Future Virol. 1 (2006) 709-715
    • (2006) Future Virol. , vol.1 , pp. 709-715
    • De Clercq, E.1
  • 43
    • 36749073433 scopus 로고    scopus 로고
    • The design of drugs for HIV and HCV
    • De Clercq E. The design of drugs for HIV and HCV. Nat. Rev. Drug Discov. 6 (2007) 1001-1018
    • (2007) Nat. Rev. Drug Discov. , vol.6 , pp. 1001-1018
    • De Clercq, E.1
  • 44
    • 27844455955 scopus 로고    scopus 로고
    • Acyclic nucleoside phosphonates: a key class of antiviral drugs
    • De Clercq E., and Holý A. Acyclic nucleoside phosphonates: a key class of antiviral drugs. Nat. Rev. Drug Discov. 4 (2005) 928-940
    • (2005) Nat. Rev. Drug Discov. , vol.4 , pp. 928-940
    • De Clercq, E.1    Holý, A.2
  • 45
    • 47049115906 scopus 로고    scopus 로고
    • Dionne, G., 1996. 1,3-Oxathiolane nucleoside compounds and compositions. US Patent 5,538,975.
    • Dionne, G., 1996. 1,3-Oxathiolane nucleoside compounds and compositions. US Patent 5,538,975.
  • 46
    • 47049101852 scopus 로고    scopus 로고
    • Duschinsky, R., Heidelberger, C., 1960. 5-Fluorocytosine and preparation thereof. US Patent 2,945,038.
    • Duschinsky, R., Heidelberger, C., 1960. 5-Fluorocytosine and preparation thereof. US Patent 2,945,038.
  • 47
    • 0000273282 scopus 로고
    • A stereocontrolled synthesis of hydroxyethylene dipeptide isosteres using novel, chiral aminoalkyl epoxides and gamma-(aminoalky1) gamma-lactones
    • Evans B.E., Rittle K.E., Homnick C.F., Springer J.P., Hirshfield J., and Veber D.F. A stereocontrolled synthesis of hydroxyethylene dipeptide isosteres using novel, chiral aminoalkyl epoxides and gamma-(aminoalky1) gamma-lactones. J. Org. Chem. 50 (1985) 4615-4625
    • (1985) J. Org. Chem. , vol.50 , pp. 4615-4625
    • Evans, B.E.1    Rittle, K.E.2    Homnick, C.F.3    Springer, J.P.4    Hirshfield, J.5    Veber, D.F.6
  • 48
    • 37049077349 scopus 로고
    • Potential use of carbocyclic nucleosides for the treatment of AIDS: chemo-enzymatic syntheses of the enantiomers of carbovir
    • Evans C.T., Roberts S.M., Shoberu K.A., and Sutherland A.G. Potential use of carbocyclic nucleosides for the treatment of AIDS: chemo-enzymatic syntheses of the enantiomers of carbovir. J. Chem. Soc. Perkin Trans. 1 (1992) 589-592
    • (1992) J. Chem. Soc. Perkin Trans. , vol.1 , pp. 589-592
    • Evans, C.T.1    Roberts, S.M.2    Shoberu, K.A.3    Sutherland, A.G.4
  • 49
    • 38949153328 scopus 로고    scopus 로고
    • An efficient and practical synthesis of the HIV protease inhibitor atazanavir via a highly diastereoselective reduction approach
    • Fan X., Song Y.-L., and Long Y.-Q. An efficient and practical synthesis of the HIV protease inhibitor atazanavir via a highly diastereoselective reduction approach. Org. Process Res. Dev. 12 (2008) 69-75
    • (2008) Org. Process Res. Dev. , vol.12 , pp. 69-75
    • Fan, X.1    Song, Y.-L.2    Long, Y.-Q.3
  • 50
    • 47049103153 scopus 로고    scopus 로고
    • Fässler, A., Bold, G., Capraro, H. G., Steiner, H., 1997. Process for preparation of hydrazine derivatives useful as intermediates for the preparation of peptide analogues. WO9746515.
    • Fässler, A., Bold, G., Capraro, H. G., Steiner, H., 1997. Process for preparation of hydrazine derivatives useful as intermediates for the preparation of peptide analogues. WO9746515.
  • 51
    • 0032474715 scopus 로고    scopus 로고
    • A concise synthesis of aza-dipeptide isosteres
    • Fässler A., Bold G., and Steiner H. A concise synthesis of aza-dipeptide isosteres. Tetrahedron Lett. 39 (1998) 4925-4928
    • (1998) Tetrahedron Lett. , vol.39 , pp. 4925-4928
    • Fässler, A.1    Bold, G.2    Steiner, H.3
  • 52
    • 47049100732 scopus 로고    scopus 로고
    • Fässler, A., Bold, G., Capraro, H.G., Steiner, H., 1999. Intermediate for the preparation of peptide analogues. US Patent 5,912,352.
    • Fässler, A., Bold, G., Capraro, H.G., Steiner, H., 1999. Intermediate for the preparation of peptide analogues. US Patent 5,912,352.
  • 53
    • 47049093560 scopus 로고    scopus 로고
    • Fässler, A., Bold, G., Capraro, H.G., Lang, M., 2001. Azahexane derivatives as substrate isosteres of retroviral aspartate proteases. US Patent 6,225,345 B1.
    • Fässler, A., Bold, G., Capraro, H.G., Lang, M., 2001. Azahexane derivatives as substrate isosteres of retroviral aspartate proteases. US Patent 6,225,345 B1.
  • 54
    • 0034500277 scopus 로고    scopus 로고
    • Biocatalytic selective modifications of conventional nucleosides, carbocyclic nucleosides, and C-nucleosides
    • Ferrero M., and Gotor V. Biocatalytic selective modifications of conventional nucleosides, carbocyclic nucleosides, and C-nucleosides. Chem. Rev. 100 (2000) 4319-4347
    • (2000) Chem. Rev. , vol.100 , pp. 4319-4347
    • Ferrero, M.1    Gotor, V.2
  • 55
    • 0032580479 scopus 로고    scopus 로고
    • HIV-protease inhibitors
    • Flexner C. HIV-protease inhibitors. N. Engl. J. Med. 338 (1998) 1281-1292
    • (1998) N. Engl. J. Med. , vol.338 , pp. 1281-1292
    • Flexner, C.1
  • 56
    • 0041407526 scopus 로고    scopus 로고
    • Facile enantioselective synthesis of propargylic alcohols by direct addition of terminal alkynes to aldehydes
    • Frantz D.E., Fässler R., and Carreira E.M. Facile enantioselective synthesis of propargylic alcohols by direct addition of terminal alkynes to aldehydes. J. Am. Chem. Soc. 122 (2000) 1806-1807
    • (2000) J. Am. Chem. Soc. , vol.122 , pp. 1806-1807
    • Frantz, D.E.1    Fässler, R.2    Carreira, E.M.3
  • 57
    • 0038252959 scopus 로고    scopus 로고
    • The discovery of novel reactivity in the development of C-C bond-forming reactions: in situ generation of zinc acetylides with Zn-(II)/R(3)N
    • Frantz D.E., Fässler R., Tomooka C.S., and Carreira E.M. The discovery of novel reactivity in the development of C-C bond-forming reactions: in situ generation of zinc acetylides with Zn-(II)/R(3)N. Acc. Chem. Res. 33 (2000) 373-381
    • (2000) Acc. Chem. Res. , vol.33 , pp. 373-381
    • Frantz, D.E.1    Fässler, R.2    Tomooka, C.S.3    Carreira, E.M.4
  • 58
    • 0022975915 scopus 로고
    • A short, stereoselective synthesis of the lactone precursor to 2R,4S,5S hydroxyethylene dipeptide isosteres
    • Fray A.H., Kaye R.L., and Kleinman E.F. A short, stereoselective synthesis of the lactone precursor to 2R,4S,5S hydroxyethylene dipeptide isosteres. J. Org. Chem. 51 (1986) 4828-4833
    • (1986) J. Org. Chem. , vol.51 , pp. 4828-4833
    • Fray, A.H.1    Kaye, R.L.2    Kleinman, E.F.3
  • 59
    • 0027496517 scopus 로고
    • Pharmacokinetics, oral bioavailability, and metabolic disposition in rats of (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl] cytosine, a nucleoside analog active against human immunodeficiency virus and hepatitis B virus
    • Frick L.W., John L.S., Taylor L.C., Painter G.R., Furman P.A., Liotta D.C., Furfine E.S., and Nelson D.J. Pharmacokinetics, oral bioavailability, and metabolic disposition in rats of (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl] cytosine, a nucleoside analog active against human immunodeficiency virus and hepatitis B virus. Antimicrob. Agents Chemother. 37 (1993) 2285-22292
    • (1993) Antimicrob. Agents Chemother. , vol.37 , pp. 2285-22292
    • Frick, L.W.1    John, L.S.2    Taylor, L.C.3    Painter, G.R.4    Furman, P.A.5    Liotta, D.C.6    Furfine, E.S.7    Nelson, D.J.8
  • 60
    • 0037989563 scopus 로고    scopus 로고
    • Recent developments of palladium(0) catalyzed reactions in aqueous medium
    • Genet J.P., and Savignac M. Recent developments of palladium(0) catalyzed reactions in aqueous medium. J. Organom. Chem. 576 (1999) 305-317
    • (1999) J. Organom. Chem. , vol.576 , pp. 305-317
    • Genet, J.P.1    Savignac, M.2
  • 61
    • 0032483577 scopus 로고    scopus 로고
    • Transition-state mimetics for HIV protease inhibitors: stereocontrolled synthesis of hydroxyethylene and hydroxyethylamine isosteres by ester-derived titanium enolate syn and anti-aldol reactions
    • Ghosh A.K., and Fidanze S. Transition-state mimetics for HIV protease inhibitors: stereocontrolled synthesis of hydroxyethylene and hydroxyethylamine isosteres by ester-derived titanium enolate syn and anti-aldol reactions. J. Org. Chem. 63 (1998) 6146-6152
    • (1998) J. Org. Chem. , vol.63 , pp. 6146-6152
    • Ghosh, A.K.1    Fidanze, S.2
  • 62
    • 0026331003 scopus 로고
    • An efficient synthesis of hydroxyethylene dipeptide isosteres: the core unit of potent HIV-1 protease inhibitors
    • Ghosh A.K., McKee S.P., and Thompson W.J. An efficient synthesis of hydroxyethylene dipeptide isosteres: the core unit of potent HIV-1 protease inhibitors. J. Org. Chem. 56 (1991) 6500-6503
    • (1991) J. Org. Chem. , vol.56 , pp. 6500-6503
    • Ghosh, A.K.1    McKee, S.P.2    Thompson, W.J.3
  • 63
    • 0027516887 scopus 로고
    • Potent HIV-1 protease inhibitors: stereoselective synthesis of a dipeptide mimic
    • Ghosh A.K., McKee S.P., Thompson W.J., Darke P.L., and Zugay J.C. Potent HIV-1 protease inhibitors: stereoselective synthesis of a dipeptide mimic. J. Org. Chem. 58 (1993) 1025-1029
    • (1993) J. Org. Chem. , vol.58 , pp. 1025-1029
    • Ghosh, A.K.1    McKee, S.P.2    Thompson, W.J.3    Darke, P.L.4    Zugay, J.C.5
  • 64
    • 0033532612 scopus 로고    scopus 로고
    • Asymmetric dihydroxylation route to a dipeptide isostere of a protease inhibitor: enantioselective synthesis of the core unit of ritonavir
    • Ghosh A.K., Shin D., and Mathivanan P. Asymmetric dihydroxylation route to a dipeptide isostere of a protease inhibitor: enantioselective synthesis of the core unit of ritonavir. Chem. Commun. (1999) 1025-1026
    • (1999) Chem. Commun. , pp. 1025-1026
    • Ghosh, A.K.1    Shin, D.2    Mathivanan, P.3
  • 65
    • 47049125888 scopus 로고    scopus 로고
    • Giordano, C., Pozzoli, C., Benedetti, F., 2001. Process for the preparation of aryl-pyridinyl compounds. WO0127083 A1.
    • Giordano, C., Pozzoli, C., Benedetti, F., 2001. Process for the preparation of aryl-pyridinyl compounds. WO0127083 A1.
  • 67
    • 47049106930 scopus 로고    scopus 로고
    • Goodyear, M.D., Dwyer, P.O., Hill, M.L., Whitehead, A.J., Hornby, R., Hallet, P., 1995. Process for the diastereoselective synthesis of nucleoside analogues. WO9529174.
    • Goodyear, M.D., Dwyer, P.O., Hill, M.L., Whitehead, A.J., Hornby, R., Hallet, P., 1995. Process for the diastereoselective synthesis of nucleoside analogues. WO9529174.
  • 68
    • 47049127543 scopus 로고    scopus 로고
    • Goodyear, M.D., Dwyer, P.O., Hill, M.L., Whitehead, A.J., Hornby, R., Hallet, P., 2000. Process for the diastereoselective synthesis of nucleoside analogues. US Patent 6,051,709.
    • Goodyear, M.D., Dwyer, P.O., Hill, M.L., Whitehead, A.J., Hornby, R., Hallet, P., 2000. Process for the diastereoselective synthesis of nucleoside analogues. US Patent 6,051,709.
  • 69
    • 47049100198 scopus 로고    scopus 로고
    • Griffiths, G., Previdoli, F., 1993. Process for the production of 2-azabicyclo[2.2.1]hep-5-ene-3-one. US Patent 5,200,527.
    • Griffiths, G., Previdoli, F., 1993. Process for the production of 2-azabicyclo[2.2.1]hep-5-ene-3-one. US Patent 5,200,527.
  • 70
    • 0038751836 scopus 로고    scopus 로고
    • Tenofovir disoproxil fumarate
    • Grim S.A., and Romanelli F. Tenofovir disoproxil fumarate. Ann. Pharmacother. 37 (2003) 849-859
    • (2003) Ann. Pharmacother. , vol.37 , pp. 849-859
    • Grim, S.A.1    Romanelli, F.2
  • 72
    • 0031006749 scopus 로고    scopus 로고
    • A convenient synthesis of enaminones using tandem acetonitrile condensation, grignard addition
    • Haight A.R., Stuk T.L., Menzia J.A., and Robbins T.A. A convenient synthesis of enaminones using tandem acetonitrile condensation, grignard addition. Tetrahedron Lett. 38 (1997) 4191-4194
    • (1997) Tetrahedron Lett. , vol.38 , pp. 4191-4194
    • Haight, A.R.1    Stuk, T.L.2    Menzia, J.A.3    Robbins, T.A.4
  • 74
    • 0033599540 scopus 로고    scopus 로고
    • A new bifunctional asymmetric catalysis: an efficient catalytic asymmetric cyanosilylation of aldehydes
    • Hamashima Y., Sawada D., Kanai M., and Shibasaki M. A new bifunctional asymmetric catalysis: an efficient catalytic asymmetric cyanosilylation of aldehydes. J. Am. Chem. Soc. 121 (1999) 2641-2642
    • (1999) J. Am. Chem. Soc. , vol.121 , pp. 2641-2642
    • Hamashima, Y.1    Sawada, D.2    Kanai, M.3    Shibasaki, M.4
  • 75
    • 0035961108 scopus 로고    scopus 로고
    • Highly enantioselective cyanosilylation of aldehydes catalyzed by a Lewis acid-Lewis base bifunctional catalyst
    • Hamashima Y., Sawada D., Nogami H., Kanai M., and Shibasaki M. Highly enantioselective cyanosilylation of aldehydes catalyzed by a Lewis acid-Lewis base bifunctional catalyst. Tetrahedron 57 (2001) 805-814
    • (2001) Tetrahedron , vol.57 , pp. 805-814
    • Hamashima, Y.1    Sawada, D.2    Nogami, H.3    Kanai, M.4    Shibasaki, M.5
  • 76
    • 47049096150 scopus 로고    scopus 로고
    • Heidelberger, C., Duschinsky, R., 1957. 5-Fluorouracil. US Patent 2,802,005.
    • Heidelberger, C., Duschinsky, R., 1957. 5-Fluorouracil. US Patent 2,802,005.
  • 77
    • 0348048805 scopus 로고    scopus 로고
    • The preparation of a stable 2-pyridylboronate and its reactivity in the Suzuki-Miyaura cross-coupling reaction
    • Hodgson P.B., and Salingue F.H. The preparation of a stable 2-pyridylboronate and its reactivity in the Suzuki-Miyaura cross-coupling reaction. Tetrahedron Lett. 45 (2004) 685-687
    • (2004) Tetrahedron Lett. , vol.45 , pp. 685-687
    • Hodgson, P.B.1    Salingue, F.H.2
  • 78
    • 37049089998 scopus 로고
    • Concise racemic and highly enantioselective approaches to key intermediates for the syntheses of carbocyclic nucleosides and pseudo-ribofuranoses: formal syntheses of carbovir
    • Hodgson D.M., Witherington J., and Moloney B.A. Concise racemic and highly enantioselective approaches to key intermediates for the syntheses of carbocyclic nucleosides and pseudo-ribofuranoses: formal syntheses of carbovir. J. Chem. Soc. Perkin Trans. 1 (1994) 3373-3378
    • (1994) J. Chem. Soc. Perkin Trans. , vol.1 , pp. 3373-3378
    • Hodgson, D.M.1    Witherington, J.2    Moloney, B.A.3
  • 79
    • 0001003363 scopus 로고
    • Preparation of 5′-O-phosphonylmethyl analogues of nucleoside-5′-phosphates 5′-diphosphates and 5'-triphosphates
    • Holý A., and Rosenberg I. Preparation of 5′-O-phosphonylmethyl analogues of nucleoside-5′-phosphates 5′-diphosphates and 5'-triphosphates. Collect. Czech. Chem. Commun. 47 (1982) 3447-3463
    • (1982) Collect. Czech. Chem. Commun. , vol.47 , pp. 3447-3463
    • Holý, A.1    Rosenberg, I.2
  • 80
    • 21844495129 scopus 로고
    • Synthesis of enantiomeric N-(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases I. The stepwise approach
    • Holý A., and Masojidkova M. Synthesis of enantiomeric N-(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases I. The stepwise approach. Collect. Czech. Chem. Commun. 60 (1995) 1196-1212
    • (1995) Collect. Czech. Chem. Commun. , vol.60 , pp. 1196-1212
    • Holý, A.1    Masojidkova, M.2
  • 81
    • 21844502307 scopus 로고
    • Synthesis of Enantiomeric N-(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases II. The synthon approach
    • Holý A., Dvorakova H., and Masojidkova M. Synthesis of Enantiomeric N-(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases II. The synthon approach. Collect. Czech. Chem. Commun. 60 (1995) 1390-1409
    • (1995) Collect. Czech. Chem. Commun. , vol.60 , pp. 1390-1409
    • Holý, A.1    Dvorakova, H.2    Masojidkova, M.3
  • 82
    • 0037565117 scopus 로고    scopus 로고
    • A convenient preparation of dityrosine via Miyaura borylation-Suzuki coupling of iodotyrosine derivatives
    • Hutton C.A., and Skaff O. A convenient preparation of dityrosine via Miyaura borylation-Suzuki coupling of iodotyrosine derivatives. Tetrahedron Lett. 44 (2003) 4895-4898
    • (2003) Tetrahedron Lett. , vol.44 , pp. 4895-4898
    • Hutton, C.A.1    Skaff, O.2
  • 83
    • 33746893025 scopus 로고    scopus 로고
    • Industrial syntheses of the central core molecules of HIV protease inhibitors
    • Izawa K., and Onishi T. Industrial syntheses of the central core molecules of HIV protease inhibitors. Chem. Rev. 106 (2006) 2811-2827
    • (2006) Chem. Rev. , vol.106 , pp. 2811-2827
    • Izawa, K.1    Onishi, T.2
  • 84
    • 0034647731 scopus 로고    scopus 로고
    • Synthesis of acyclic nucleoside and nucleotide analogues from amino acids: a convenient approach to a PMEA-PMPA hybrid
    • Jeffery A.L., Kim J.-H., and Wiemer D.F. Synthesis of acyclic nucleoside and nucleotide analogues from amino acids: a convenient approach to a PMEA-PMPA hybrid. Tetrahedron 56 (2000) 5077-5083
    • (2000) Tetrahedron , vol.56 , pp. 5077-5083
    • Jeffery, A.L.1    Kim, J.-H.2    Wiemer, D.F.3
  • 85
    • 47049119211 scopus 로고    scopus 로고
    • Jin, L., Shi, X., Liu, B., 2004. Process for preparing alcohol by heterocyclic carboxylic ester reduction. Chinese Patent 1,554,648.
    • Jin, L., Shi, X., Liu, B., 2004. Process for preparing alcohol by heterocyclic carboxylic ester reduction. Chinese Patent 1,554,648.
  • 87
    • 0141537064 scopus 로고    scopus 로고
    • Synthesis of a dicyclobutylideneethane derivative via sequential palladium-catalyzed Miyaura borylation and Suzuki coupling
    • Kabalka G.W., and Yao M.-L. Synthesis of a dicyclobutylideneethane derivative via sequential palladium-catalyzed Miyaura borylation and Suzuki coupling. Tetrahedron Lett. 44 (2003) 7885-7887
    • (2003) Tetrahedron Lett. , vol.44 , pp. 7885-7887
    • Kabalka, G.W.1    Yao, M.-L.2
  • 88
    • 0028884333 scopus 로고
    • Versatile synthetic routes to threo-beta-amino hydroxy carboxylic acids, statine and its analogues
    • Kang S.H., and Ryu D.H. Versatile synthetic routes to threo-beta-amino hydroxy carboxylic acids, statine and its analogues. Bioorg. Med. Chem. Lett. 54 (1995) 2959-2962
    • (1995) Bioorg. Med. Chem. Lett. , vol.54 , pp. 2959-2962
    • Kang, S.H.1    Ryu, D.H.2
  • 89
    • 0030894463 scopus 로고    scopus 로고
    • Efficient synthesis of carbovir and its congener via π-allylpalladium complex formation by ring strain-assisted C-N bond cleavage
    • Katagiri N., Takebayashi M., Kokufuda H., Kaneko C., Kanehira K., and Torihara M. Efficient synthesis of carbovir and its congener via π-allylpalladium complex formation by ring strain-assisted C-N bond cleavage. J. Org. Chem. 62 (1997) 1580-1581
    • (1997) J. Org. Chem. , vol.62 , pp. 1580-1581
    • Katagiri, N.1    Takebayashi, M.2    Kokufuda, H.3    Kaneko, C.4    Kanehira, K.5    Torihara, M.6
  • 92
    • 47049120807 scopus 로고    scopus 로고
    • Kempf, D.J., Norbeck, D.W., Sham, H.L., Zhao, C., 1996. Retroviral protease inhibiting compounds. US Patent 5,541,206.
    • Kempf, D.J., Norbeck, D.W., Sham, H.L., Zhao, C., 1996. Retroviral protease inhibiting compounds. US Patent 5,541,206.
  • 96
    • 3142757947 scopus 로고    scopus 로고
    • Diastereoselective zinc-catalyzed conjugate addition of alkynes
    • Knöpfel T.F., Boyall D., and Carreira E.M. Diastereoselective zinc-catalyzed conjugate addition of alkynes. Org. Lett. 6 (2004) 2281-2283
    • (2004) Org. Lett. , vol.6 , pp. 2281-2283
    • Knöpfel, T.F.1    Boyall, D.2    Carreira, E.M.3
  • 97
    • 0037175592 scopus 로고    scopus 로고
    • Recent applications of the Suzuki-Miyaura cross-coupling reaction in organic synthesis
    • Kotha S., Lahiri K., and Kashinath D. Recent applications of the Suzuki-Miyaura cross-coupling reaction in organic synthesis. Tetrahedron 58 (2002) 9633-9695
    • (2002) Tetrahedron , vol.58 , pp. 9633-9695
    • Kotha, S.1    Lahiri, K.2    Kashinath, D.3
  • 98
    • 47049109706 scopus 로고    scopus 로고
    • Kraus, H., Fiege, H., 1998. Process for the preparation of 5-hydroxymethylthiazole. US Patent 5,780,638.
    • Kraus, H., Fiege, H., 1998. Process for the preparation of 5-hydroxymethylthiazole. US Patent 5,780,638.
  • 99
    • 17444370974 scopus 로고    scopus 로고
    • Cost estimates for new molecules
    • Laird T. Cost estimates for new molecules. Org. Process Res. Dev. 9 (2005) 125-126
    • (2005) Org. Process Res. Dev. , vol.9 , pp. 125-126
    • Laird, T.1
  • 100
    • 47049120551 scopus 로고    scopus 로고
    • Langridge, D.C., 1998. Process for the preparation of disubstituted carbonates. US Patent 5,773,625.
    • Langridge, D.C., 1998. Process for the preparation of disubstituted carbonates. US Patent 5,773,625.
  • 101
    • 47049121317 scopus 로고    scopus 로고
    • Leanna, M.R., 1996. Process for preparation of 5-hydroxymethylthiazole. World Patent WO9616050A1.
    • Leanna, M.R., 1996. Process for preparation of 5-hydroxymethylthiazole. World Patent WO9616050A1.
  • 102
    • 47049117449 scopus 로고    scopus 로고
    • Leanna, M.R., Morton, H.E., Allen, M.S., 1998. Process for preparation of 5-hydroxymethylthiazole. US Patent 5,712,400.
    • Leanna, M.R., Morton, H.E., Allen, M.S., 1998. Process for preparation of 5-hydroxymethylthiazole. US Patent 5,712,400.
  • 103
    • 1642487286 scopus 로고    scopus 로고
    • BINOL-salen-catalyzed highly enantioselective alkyne additions to aromatic aldehydes
    • Li Z.-B., and Pu L. BINOL-salen-catalyzed highly enantioselective alkyne additions to aromatic aldehydes. Org. Lett. 6 (2004) 1065-1068
    • (2004) Org. Lett. , vol.6 , pp. 1065-1068
    • Li, Z.-B.1    Pu, L.2
  • 106
    • 0028458505 scopus 로고
    • Enzyme-catalysed kinetic resolution of 4-endo-hydroxy-2-oxabicyclo[3,3.0]oct-7-en-3-one and employment of the pure enantiomers for the synthesis of anti-viral and hypocholestemic agents
    • MacKeith R.A., McCague R., Olivo H.F., Roberts S.M., Taylor S.J.C., and Xiong H. Enzyme-catalysed kinetic resolution of 4-endo-hydroxy-2-oxabicyclo[3,3.0]oct-7-en-3-one and employment of the pure enantiomers for the synthesis of anti-viral and hypocholestemic agents. Bioorg. Med. Chem. 2 (1994) 387-394
    • (1994) Bioorg. Med. Chem. , vol.2 , pp. 387-394
    • MacKeith, R.A.1    McCague, R.2    Olivo, H.F.3    Roberts, S.M.4    Taylor, S.J.C.5    Xiong, H.6
  • 107
    • 33846630858 scopus 로고    scopus 로고
    • Directed reductive amination of β-hydroxyketones: convergent assembly of the ritonavir/lopinavir core
    • Menche D., Arikan F., Li J., and Rudolph S. Directed reductive amination of β-hydroxyketones: convergent assembly of the ritonavir/lopinavir core. Org. Lett. 9 (2007) 267-270
    • (2007) Org. Lett. , vol.9 , pp. 267-270
    • Menche, D.1    Arikan, F.2    Li, J.3    Rudolph, S.4
  • 108
    • 0029088240 scopus 로고
    • Enantioselective enzymatic synthesis of the anti-viral agent lamivudine (3TC™)
    • Milton J., Brand S., Jones M.F., and Rayner C.M. Enantioselective enzymatic synthesis of the anti-viral agent lamivudine (3TC™). Tetrahedron Lett. 36 (1995) 6961-6964
    • (1995) Tetrahedron Lett. , vol.36 , pp. 6961-6964
    • Milton, J.1    Brand, S.2    Jones, M.F.3    Rayner, C.M.4
  • 109
    • 47049121065 scopus 로고    scopus 로고
    • Murth, K.S.K., Horne, S.E., Reddy, G.V., Senanayake, C.B.W., Radatus, B.K., 2002. 1,3-Oxathiolan-5-ones useful in the production of antiviral nucleoside analogues. US Patent 6,380,388 B1.
    • Murth, K.S.K., Horne, S.E., Reddy, G.V., Senanayake, C.B.W., Radatus, B.K., 2002. 1,3-Oxathiolan-5-ones useful in the production of antiviral nucleoside analogues. US Patent 6,380,388 B1.
  • 111
    • 4143060245 scopus 로고    scopus 로고
    • Alkoxy group facilitated ring closing metathesis (RCM) of acyclic 1,6-dienes. Convenient synthesis of non-racemic highly substituted cyclopentenols
    • Nayek A., Banerjee S., Sinha S., and Ghosh S. Alkoxy group facilitated ring closing metathesis (RCM) of acyclic 1,6-dienes. Convenient synthesis of non-racemic highly substituted cyclopentenols. Tetrahedron Lett. 45 (2004) 6457-6460
    • (2004) Tetrahedron Lett. , vol.45 , pp. 6457-6460
    • Nayek, A.1    Banerjee, S.2    Sinha, S.3    Ghosh, S.4
  • 112
    • 37049085863 scopus 로고
    • Catalytic asymmetric synthesis of optically active alkynyl alcohols by enantioselective alkynylation of aldehydes and by enantioselective alkylation of alkynyl aldehydes
    • Niwa S., and Soai K. Catalytic asymmetric synthesis of optically active alkynyl alcohols by enantioselective alkynylation of aldehydes and by enantioselective alkylation of alkynyl aldehydes. Chem. Soc. Perkin I (1990) 937-943
    • (1990) Chem. Soc. Perkin I , pp. 937-943
    • Niwa, S.1    Soai, K.2
  • 113
    • 0035825054 scopus 로고    scopus 로고
    • Enantioselecitive strecker-type reaction promoted by polymer-supported bifunctional catalyst
    • Nogami H., Matsunaga S., Kanai M., and Shibasaki M. Enantioselecitive strecker-type reaction promoted by polymer-supported bifunctional catalyst. Tetrahedron Lett. 42 (2001) 279-283
    • (2001) Tetrahedron Lett. , vol.42 , pp. 279-283
    • Nogami, H.1    Matsunaga, S.2    Kanai, M.3    Shibasaki, M.4
  • 116
    • 33748636953 scopus 로고    scopus 로고
    • Practical enantiodivergent syntheses of both enantiomers of carbovir 1592U89 and six-membered ring analogues
    • Olivo H.F., and Yu J. Practical enantiodivergent syntheses of both enantiomers of carbovir 1592U89 and six-membered ring analogues. Chem. Soc. Perkin Trans. 1 (1998) 391-392
    • (1998) Chem. Soc. Perkin Trans. , vol.1 , pp. 391-392
    • Olivo, H.F.1    Yu, J.2
  • 117
    • 3042801756 scopus 로고    scopus 로고
    • Biochemical and mechanistic basis for the activity of nucleoside analogue inhibitors of HIV reverse transcriptase
    • Painter G.R., Almond M.R., Mao S., and Liotta D.C. Biochemical and mechanistic basis for the activity of nucleoside analogue inhibitors of HIV reverse transcriptase. Curr. Top. Med. Chem. 4 (2004) 1035-1044
    • (2004) Curr. Top. Med. Chem. , vol.4 , pp. 1035-1044
    • Painter, G.R.1    Almond, M.R.2    Mao, S.3    Liotta, D.C.4
  • 118
    • 0034631778 scopus 로고    scopus 로고
    • Fluorinated nucleosides
    • Pankiewicz K.W. Fluorinated nucleosides. Carbohydr. Res. 327 (2000) 87-105
    • (2000) Carbohydr. Res. , vol.327 , pp. 87-105
    • Pankiewicz, K.W.1
  • 122
    • 4544229079 scopus 로고    scopus 로고
    • Estratégias Farmacológicas para a Terapia Anti-AIDS
    • Peçanha E.P., Tanuri A., and Antunes O.A.C. Estratégias Farmacológicas para a Terapia Anti-AIDS. Química Nova 25 (2002) 1108-1116
    • (2002) Química Nova , vol.25 , pp. 1108-1116
    • Peçanha, E.P.1    Tanuri, A.2    Antunes, O.A.C.3
  • 124
    • 0842283394 scopus 로고    scopus 로고
    • Synthesis of C1-alkyl- and acylglycals from glycals using a B-alkyl Suzuki-Miyaura cross coupling approach
    • Potuzak J.S., and Tan D.S. Synthesis of C1-alkyl- and acylglycals from glycals using a B-alkyl Suzuki-Miyaura cross coupling approach. Tetrahedron Lett. 45 (2004) 1797-1801
    • (2004) Tetrahedron Lett. , vol.45 , pp. 1797-1801
    • Potuzak, J.S.1    Tan, D.S.2
  • 125
    • 0031466876 scopus 로고    scopus 로고
    • Synthesis of HIV-1 reverse transcriptase inhibitor DMP 266
    • Radesca L.A., Lo Y.S., Moore J.R., and Pierce M.E. Synthesis of HIV-1 reverse transcriptase inhibitor DMP 266. Synth. Commun. 27 (1997) 4373-4384
    • (1997) Synth. Commun. , vol.27 , pp. 4373-4384
    • Radesca, L.A.1    Lo, Y.S.2    Moore, J.R.3    Pierce, M.E.4
  • 126
    • 33746921221 scopus 로고    scopus 로고
    • α-Aminoalkyl-α′-halomethylketones: preparation and application to pharmaceutically interesting compounds
    • Reeder M.R., and Anderson R.M. α-Aminoalkyl-α′-halomethylketones: preparation and application to pharmaceutically interesting compounds. Chem. Rev. 106 (2006) 2828-2842
    • (2006) Chem. Rev. , vol.106 , pp. 2828-2842
    • Reeder, M.R.1    Anderson, R.M.2
  • 127
    • 0031916651 scopus 로고    scopus 로고
    • Anti-human immunodeficiency virus activity and cellular metabolism of a potential prodrug of the acyclic nucleoside phosphonate 9-R-(2-phosphonomethoxypropyl)adenine (PMPA), bis(isopropyloxymethylcarbonyl)PMPA
    • Robbins B.L., Srinivas R.V., Kim C., Bischofberger N., and Fridland A. Anti-human immunodeficiency virus activity and cellular metabolism of a potential prodrug of the acyclic nucleoside phosphonate 9-R-(2-phosphonomethoxypropyl)adenine (PMPA), bis(isopropyloxymethylcarbonyl)PMPA. Antimicrob. Agents Chemother. 42 (1998) 612-617
    • (1998) Antimicrob. Agents Chemother. , vol.42 , pp. 612-617
    • Robbins, B.L.1    Srinivas, R.V.2    Kim, C.3    Bischofberger, N.4    Fridland, A.5
  • 128
    • 0017303926 scopus 로고
    • Nucleic acid related compounds. 21. Direct fluorination of uracil and cytosine bases and nucleosides using trifluoromethyl hypofluorite. Mechanism, stereochemistry, and synthetic applications
    • Robins M.J., MacCoss M., Naik S.R., and Ramani G. Nucleic acid related compounds. 21. Direct fluorination of uracil and cytosine bases and nucleosides using trifluoromethyl hypofluorite. Mechanism, stereochemistry, and synthetic applications. J. Am. Chem. Soc. 98 (1976) 7381-7389
    • (1976) J. Am. Chem. Soc. , vol.98 , pp. 7381-7389
    • Robins, M.J.1    MacCoss, M.2    Naik, S.R.3    Ramani, G.4
  • 130
    • 2942534993 scopus 로고    scopus 로고
    • HIV protease inhibition: limited recent progress and advances in understanding current pitfalls
    • Rodriguez-Barrios F., and Gago F. HIV protease inhibition: limited recent progress and advances in understanding current pitfalls. Curr. Top. Med. Chem. 4 (2004) 991-1007
    • (2004) Curr. Top. Med. Chem. , vol.4 , pp. 991-1007
    • Rodriguez-Barrios, F.1    Gago, F.2
  • 131
    • 47049098452 scopus 로고    scopus 로고
    • Simplifying syntheses is always a key goal
    • Rouhi A.M. Simplifying syntheses is always a key goal. Chem. Eng. News 81 (2003) 41-43
    • (2003) Chem. Eng. News , vol.81 , pp. 41-43
    • Rouhi, A.M.1
  • 132
    • 0038666434 scopus 로고    scopus 로고
    • Enantioselective synthesis of the carbocyclic moiety of (-)-carbovir
    • Roulland E., Monneret C., and Florent J.-C. Enantioselective synthesis of the carbocyclic moiety of (-)-carbovir. Tetrahedron Lett. 44 (2003) 4125-4128
    • (2003) Tetrahedron Lett. , vol.44 , pp. 4125-4128
    • Roulland, E.1    Monneret, C.2    Florent, J.-C.3
  • 133
    • 0029878151 scopus 로고    scopus 로고
    • A synthesis of biaryls via Nickel(0)-catalyzed cross-coupling reaction of chloroarenes with phenylboronic acids
    • Saito S., Sakai M., and Miyaura N. A synthesis of biaryls via Nickel(0)-catalyzed cross-coupling reaction of chloroarenes with phenylboronic acids. Tetrahedron Lett. 37 (1996) 2993-2996
    • (1996) Tetrahedron Lett. , vol.37 , pp. 2993-2996
    • Saito, S.1    Sakai, M.2    Miyaura, N.3
  • 134
    • 0000728442 scopus 로고    scopus 로고
    • Synthesis of biaryls via a Nickel(0)-catalyzed cross-coupling reaction of chloroarenes with arylboronic acids
    • Saito S., Oh-tani S., and Miyaura N. Synthesis of biaryls via a Nickel(0)-catalyzed cross-coupling reaction of chloroarenes with arylboronic acids. J. Org. Chem. 62 (1997) 8024-8030
    • (1997) J. Org. Chem. , vol.62 , pp. 8024-8030
    • Saito, S.1    Oh-tani, S.2    Miyaura, N.3
  • 135
    • 0035052373 scopus 로고    scopus 로고
    • Facile asymmetric addition of acetylene to aldehydes: in situ generation of reactive zinc acetylide
    • Sasaki H., Boyall D., and Carreira E.M. Facile asymmetric addition of acetylene to aldehydes: in situ generation of reactive zinc acetylide. Helv. Chim. Acta 84 (2001) 964-971
    • (2001) Helv. Chim. Acta , vol.84 , pp. 964-971
    • Sasaki, H.1    Boyall, D.2    Carreira, E.M.3
  • 138
    • 47049114858 scopus 로고    scopus 로고
    • Sham, H.L., Norbeck, D.W., Chen, X., Betebenner, D.A., 1999. Retroviral protease inhibiting compounds. US Patent 5,914,332.
    • Sham, H.L., Norbeck, D.W., Chen, X., Betebenner, D.A., 1999. Retroviral protease inhibiting compounds. US Patent 5,914,332.
  • 140
    • 0012397313 scopus 로고
    • Directed ortho metalation Tertiary amide and O-carbamate directors in synthetic strategies for polysubstituted aromatics
    • Snieckus V. Directed ortho metalation Tertiary amide and O-carbamate directors in synthetic strategies for polysubstituted aromatics. Chem. Rev. 90 (1990) 879-933
    • (1990) Chem. Rev. , vol.90 , pp. 879-933
    • Snieckus, V.1
  • 141
    • 0038673708 scopus 로고    scopus 로고
    • Allylic alcohols via catalytic asymmetric epoxide rearrangement
    • Södergren M.J., Bertilsson S.K., and Anderson P.G. Allylic alcohols via catalytic asymmetric epoxide rearrangement. J. Am. Chem. Soc. 122 (2000) 6610-6618
    • (2000) J. Am. Chem. Soc. , vol.122 , pp. 6610-6618
    • Södergren, M.J.1    Bertilsson, S.K.2    Anderson, P.G.3
  • 142
    • 0028306517 scopus 로고
    • Synthesis, oral bioavailability determination, and in vitro evaluation of prodrugs of the antiviral agent 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA)
    • Starrett Jr. J.E., Tortolani D.R., Russell J., Hitchcock M.J.M., Whiterock V., Martin J.C., and Mansuri M.M. Synthesis, oral bioavailability determination, and in vitro evaluation of prodrugs of the antiviral agent 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA). J. Med. Chem. 37 (1994) 1857-1864
    • (1994) J. Med. Chem. , vol.37 , pp. 1857-1864
    • Starrett Jr., J.E.1    Tortolani, D.R.2    Russell, J.3    Hitchcock, M.J.M.4    Whiterock, V.5    Martin, J.C.6    Mansuri, M.M.7
  • 143
    • 3542991447 scopus 로고    scopus 로고
    • Increasing number of anti-HIV drugs but no definite cure-review of anti-HIV drugs
    • Stolk L.M.L., and Lüers J.F.J. Increasing number of anti-HIV drugs but no definite cure-review of anti-HIV drugs. Pharm. World Sci. 26 (2004) 133-136
    • (2004) Pharm. World Sci. , vol.26 , pp. 133-136
    • Stolk, L.M.L.1    Lüers, J.F.J.2
  • 144
    • 0033417984 scopus 로고    scopus 로고
    • Synthesis of ABT-378, an HIV protease inhibitor candidate: avoiding the use of carbodiimides in a difficult peptide coupling
    • Stoner E.J., Stengel P.J., and Cooper A.J. Synthesis of ABT-378, an HIV protease inhibitor candidate: avoiding the use of carbodiimides in a difficult peptide coupling. Org. Process Res. Dev. 3 (1999) 145-148
    • (1999) Org. Process Res. Dev. , vol.3 , pp. 145-148
    • Stoner, E.J.1    Stengel, P.J.2    Cooper, A.J.3
  • 146
    • 0033105506 scopus 로고    scopus 로고
    • A novel, highly enantioselective ketone alkynylation reaction mediated by chiral zinc aminoalkoxides
    • Tan L., Chen C., Tillyer R.D., Grabowski E.J.J., and Reider P.J. A novel, highly enantioselective ketone alkynylation reaction mediated by chiral zinc aminoalkoxides. Angew. Chem. Int. Ed. 38 (1999) 711-713
    • (1999) Angew. Chem. Int. Ed. , vol.38 , pp. 711-713
    • Tan, L.1    Chen, C.2    Tillyer, R.D.3    Grabowski, E.J.J.4    Reider, P.J.5
  • 147
    • 0029803413 scopus 로고    scopus 로고
    • Chemoenzymatic synthesis of antiviral carbocyclic nucleosides: asymmetric hydrolysis of meso-3,5-bis(acetoxymethyl)cyclopentenes using Rhizopus delemar lipase
    • Tanaka M., Norimine Y., Fujita T., Suemune H., and Sakai K. Chemoenzymatic synthesis of antiviral carbocyclic nucleosides: asymmetric hydrolysis of meso-3,5-bis(acetoxymethyl)cyclopentenes using Rhizopus delemar lipase. J. Org. Chem. 61 (1996) 6952-6957
    • (1996) J. Org. Chem. , vol.61 , pp. 6952-6957
    • Tanaka, M.1    Norimine, Y.2    Fujita, T.3    Suemune, H.4    Sakai, K.5
  • 148
    • 0028788312 scopus 로고
    • Use of an ephedrine alkoxide to mediate enantioselective addition of an acetylide to a prochiral ketone: asymmetric synthesis of the reverse transcriptase inhibitor L-743, 726
    • Thompson A.S., Corley E.G., Huntington M.F., and Grabowski E.J.J. Use of an ephedrine alkoxide to mediate enantioselective addition of an acetylide to a prochiral ketone: asymmetric synthesis of the reverse transcriptase inhibitor L-743, 726. Tetrahedron Lett. 36 (1995) 8937-8940
    • (1995) Tetrahedron Lett. , vol.36 , pp. 8937-8940
    • Thompson, A.S.1    Corley, E.G.2    Huntington, M.F.3    Grabowski, E.J.J.4
  • 149
    • 0032507282 scopus 로고    scopus 로고
    • Lithium ephedrate-mediated addition of a lithium acetylide to a ketone: solution structures and relative reactivities of mixed aggregates underlying the high enantioselectivities
    • Thompson A., Corley E.G., Huntington M.F., Grabowski E.J.J., Remenar J.F., and Collum D.B. Lithium ephedrate-mediated addition of a lithium acetylide to a ketone: solution structures and relative reactivities of mixed aggregates underlying the high enantioselectivities. J. Am. Chem. Soc. 120 (1998) 2028-2038
    • (1998) J. Am. Chem. Soc. , vol.120 , pp. 2028-2038
    • Thompson, A.1    Corley, E.G.2    Huntington, M.F.3    Grabowski, E.J.J.4    Remenar, J.F.5    Collum, D.B.6
  • 150
    • 8644236493 scopus 로고    scopus 로고
    • A stereoselective synthesis of silylated epoxycyclopentanols bearing four contiguous stereogenic centers
    • Thorimbert S., Taillier C., Bareyt S., Humilière D., and Malacria M. A stereoselective synthesis of silylated epoxycyclopentanols bearing four contiguous stereogenic centers. Tetrahedron Lett. 45 (2004) 9123-9126
    • (2004) Tetrahedron Lett. , vol.45 , pp. 9123-9126
    • Thorimbert, S.1    Taillier, C.2    Bareyt, S.3    Humilière, D.4    Malacria, M.5
  • 151
    • 4143058445 scopus 로고    scopus 로고
    • Substrate-selective aqueous organometallic catalysis. How size and chemical modification of cyclodextrin influence the substrate selectivity
    • Torque C., Bricout H., Hapiot F., and Monflier E. Substrate-selective aqueous organometallic catalysis. How size and chemical modification of cyclodextrin influence the substrate selectivity. Tetrahedron 60 (2004) 6487-6493
    • (2004) Tetrahedron , vol.60 , pp. 6487-6493
    • Torque, C.1    Bricout, H.2    Hapiot, F.3    Monflier, E.4
  • 152
    • 0036371962 scopus 로고    scopus 로고
    • Pd asymmetric alkylation (AAA) A powerful synthetic tool
    • Trost B.M. Pd asymmetric alkylation (AAA) A powerful synthetic tool. Chem. Pharm. Bull. 50 (2002) 1-14
    • (2002) Chem. Pharm. Bull. , vol.50 , pp. 1-14
    • Trost, B.M.1
  • 153
    • 0026469179 scopus 로고
    • A novel palladium-catalyzed cycloalkylation to isoxazoline 2-oxides. Application for the asymmetric synthesis of carbanucleosides
    • Trost B.M., Li L., and Guile S.D. A novel palladium-catalyzed cycloalkylation to isoxazoline 2-oxides. Application for the asymmetric synthesis of carbanucleosides. J. Am. Chem. Soc. 114 (1992) 8147-8745
    • (1992) J. Am. Chem. Soc. , vol.114 , pp. 8147-8745
    • Trost, B.M.1    Li, L.2    Guile, S.D.3
  • 155
    • 0025175018 scopus 로고
    • Synthesis and anti-HIV activity of carbocyclic 2′,3′-didehydro-2′,3′-dideoxy 2,6-disubstituted purine nucleosides
    • Vince R., and Hua M. Synthesis and anti-HIV activity of carbocyclic 2′,3′-didehydro-2′,3′-dideoxy 2,6-disubstituted purine nucleosides. J. Med. Chem. 33 (1990) 17-21
    • (1990) J. Med. Chem. , vol.33 , pp. 17-21
    • Vince, R.1    Hua, M.2
  • 156
    • 0032403491 scopus 로고    scopus 로고
    • Recent advances in l-nucleosides: chemistry and biology
    • Wang P., Hong J.H., Cooperwood J.S., and Chu C.K. Recent advances in l-nucleosides: chemistry and biology. Antivir. Res. 40 (1998) 19-44
    • (1998) Antivir. Res. , vol.40 , pp. 19-44
    • Wang, P.1    Hong, J.H.2    Cooperwood, J.S.3    Chu, C.K.4
  • 157
    • 0031804609 scopus 로고    scopus 로고
    • Inhibitors of HIV-1 protease: a major success of structure-assisted drug design
    • Wlodawer A., and Vondrasek J. Inhibitors of HIV-1 protease: a major success of structure-assisted drug design. Annu. Rev. Biophys. Biomol. Struct. 27 (1998) 249-284
    • (1998) Annu. Rev. Biophys. Biomol. Struct. , vol.27 , pp. 249-284
    • Wlodawer, A.1    Vondrasek, J.2
  • 158
    • 0041470235 scopus 로고    scopus 로고
    • Separation of FTC-ester enantiomers using a simulated moving bed
    • Xie Y., Hritzko B., Chin C.Y., and Wang N.-H.L. Separation of FTC-ester enantiomers using a simulated moving bed. Ind. Eng. Chem. Res. 42 (2003) 4055-4067
    • (2003) Ind. Eng. Chem. Res. , vol.42 , pp. 4055-4067
    • Xie, Y.1    Hritzko, B.2    Chin, C.Y.3    Wang, N.-H.L.4
  • 160
    • 47049109451 scopus 로고    scopus 로고
    • Young, S.D., Britcher, S.F., Payne, L.S., Tran, L.O., Lumma Jr., W.C., 1996. Benzoxazinones as inhibitors of HIV reverse transcriptase. US Patent 5,519,021.
    • Young, S.D., Britcher, S.F., Payne, L.S., Tran, L.O., Lumma Jr., W.C., 1996. Benzoxazinones as inhibitors of HIV reverse transcriptase. US Patent 5,519,021.
  • 161
    • 15444380370 scopus 로고    scopus 로고
    • Process optimization in the synthesis of 9-[2-(diethylphosphonomethoxy)ethyl]adenine: replacement of sodium hydride with sodium tert-butoxide as the base for oxygen alkylation
    • Yu R.H., Schultze L.M., Rohloff J.C., Dudzinski P.W., and Kelly D.E. Process optimization in the synthesis of 9-[2-(diethylphosphonomethoxy)ethyl]adenine: replacement of sodium hydride with sodium tert-butoxide as the base for oxygen alkylation. Org. Process Res. Dev. 3 (1999) 53-55
    • (1999) Org. Process Res. Dev. , vol.3 , pp. 53-55
    • Yu, R.H.1    Schultze, L.M.2    Rohloff, J.C.3    Dudzinski, P.W.4    Kelly, D.E.5


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