Process research and development for an efficient synthesis of the HIV protease inhibitor BMS-232632

Organic Process Research and Development

Volumn 6, Issue 3, 2002, Pages 323-328

  Xu, Zhongmin ^a   Singh, Janak ^a   Schwinden, Mark D ^a   Zheng, Bin ^a   Kissick, Thomas P ^a   Patel, Bharat ^a   Humora, Michael J ^a   Quiroz, Fernando ^a   Dong, Lin ^a   Hsieh, Dau Ming ^a   Heikes, James E ^a   Pudipeddi, Madhusudhan ^b   Lindrud, Mark D ^a   Srivastava, Sushil K ^a   Kronenthal, David R ^a   Mueller, Richard H ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b Biopharmaceutics Research and Development   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 BROMOPYRIDINE; ALCOHOL DERIVATIVE; BORONIC ACID DERIVATIVE; HYDRAZINE CARBAMATE; HYDRAZINE DERIVATIVE; HYDRAZONE DERIVATIVE; N (TERT BUTYLOXYCARBONYL)AMINO 1 PHENYL 3,4 EPOXYBUTANE; N 1 (TERT BUTYLOXYCARBONYL) N 2 [4 (PYRIDIN 2 YL)BENZYLIDENE]HYDRAZONE; N METHYOXYCARBONYL TERT LEUCINE; N' [2 HYDROXY 3 (N METHOXYCARBONYL TERT LEUCYLAMINO) 4 PHENYLBUTYL] NALPHA METHOXYCARBONYL N' [4 (2 PYRIDYL)BENZYL] TERT LEUCYLHYDRAZIDE; PALLADIUM; PROTEINASE INHIBITOR; PYRIDINE DERIVATIVE; SULFATE; UNCLASSIFIED DRUG;

ARTICLE; CHIRALITY; DRUG BIOAVAILABILITY; DRUG PURITY; DRUG SOLUBILITY; DRUG SYNTHESIS; PROCESS DEVELOPMENT; REDUCTION; STEREOCHEMISTRY;

EID: 0036308128     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op025504r     Document Type: Article

References (33)