메뉴 건너뛰기




Volumn 118, Issue 7, 2008, Pages 2629-2639

TGF-β-dependent suppressive function of Tregs requires wild-type levels of CD18 in a mouse model of psoriasis

Author keywords

[No Author keywords available]

Indexed keywords

BETA2 INTEGRIN; CD18 ANTIGEN; CD4 ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 7 RECEPTOR; TRANSFORMING GROWTH FACTOR BETA;

EID: 46749143803     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI34916     Document Type: Article
Times cited : (59)

References (63)
  • 2
    • 0036866646 scopus 로고    scopus 로고
    • Recombinantly engineered human proteins: Transforming the treatment of psoriasis
    • Gottlieb, A.B., and Bos, J.D. 2002. Recombinantly engineered human proteins: transforming the treatment of psoriasis. Clin Immunol 105:105-116.
    • (2002) Clin Immunol , vol.105 , pp. 105-116
    • Gottlieb, A.B.1    Bos, J.D.2
  • 3
    • 0031047296 scopus 로고    scopus 로고
    • Murine psoriasis-like disorder induced by naive CD4+ T cells
    • Schon, M.P., Detmar, M., and Parker, CM. 1997. Murine psoriasis-like disorder induced by naive CD4+ T cells. Nat. Med. 3:183-188.
    • (1997) Nat. Med , vol.3 , pp. 183-188
    • Schon, M.P.1    Detmar, M.2    Parker, C.M.3
  • 4
    • 13444269249 scopus 로고    scopus 로고
    • Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model
    • Sano, S., et al. 2005. Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model. Nat. Med. 11:43-49.
    • (2005) Nat. Med , vol.11 , pp. 43-49
    • Sano, S.1
  • 5
    • 34447124969 scopus 로고    scopus 로고
    • Alpha1beta1 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis
    • Conrad, C, et al. 2007. Alpha1beta1 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis. Nat. Med. 13:836-842.
    • (2007) Nat. Med , vol.13 , pp. 836-842
    • Conrad, C.1
  • 6
    • 0028990380 scopus 로고
    • Response of psoriasis to a lymphocyte-selective toxin (DAB389IL-2) suggests a primary immune, but not keratinocyte, pathogenic basis
    • Gottlieb, S.L., et al. 1995. Response of psoriasis to a lymphocyte-selective toxin (DAB389IL-2) suggests a primary immune, but not keratinocyte, pathogenic basis. Nat. Med. 1:442-447.
    • (1995) Nat. Med , vol.1 , pp. 442-447
    • Gottlieb, S.L.1
  • 7
    • 0034074077 scopus 로고    scopus 로고
    • Successful treatment of severe psoriasis with basiliximab, an interleukin-2 receptor monoclonal antibody
    • Owen, CM., and Harrison, P.V. 2000. Successful treatment of severe psoriasis with basiliximab, an interleukin-2 receptor monoclonal antibody. Clin. Exp. Dermatol. 25:195-197.
    • (2000) Clin. Exp. Dermatol , vol.25 , pp. 195-197
    • Owen, C.M.1    Harrison, P.V.2
  • 8
    • 0026746595 scopus 로고
    • Anti-CD4 monoclonal antibody therapy in severe psoriasis
    • Morel, P., et al. 1992. Anti-CD4 monoclonal antibody therapy in severe psoriasis. J. Autoimmun. 5:465-477.
    • (1992) J. Autoimmun , vol.5 , pp. 465-477
    • Morel, P.1
  • 9
    • 10844222790 scopus 로고    scopus 로고
    • Dysfunctional blood and target tissue CD4+CD25high regulatory T cells in psoriasis: Mechanism underlying unrestrained pathogenic effector T cell proliferation
    • Sugiyama, H., et al. 2005. Dysfunctional blood and target tissue CD4+CD25high regulatory T cells in psoriasis: mechanism underlying unrestrained pathogenic effector T cell proliferation. J. Immunol. 174:164-173.
    • (2005) J. Immunol , vol.174 , pp. 164-173
    • Sugiyama, H.1
  • 10
    • 33847373481 scopus 로고    scopus 로고
    • No alterations in the frequency of FOXP3+ regulatory T-cells in type 1 diabetes
    • Brusko, T., et al. 2007. No alterations in the frequency of FOXP3+ regulatory T-cells in type 1 diabetes. Diabetes. 56:604-612.
    • (2007) Diabetes , vol.56 , pp. 604-612
    • Brusko, T.1
  • 11
    • 1842607712 scopus 로고    scopus 로고
    • Circulating CD4+CD25+ T regulatory cells are not altered in multiple sclerosis and unaffected by disease-modulating drugs
    • Putheti, P., Pettersson, A., Soderstrom, M., Link, H., and Huang, Y. 2004. Circulating CD4+CD25+ T regulatory cells are not altered in multiple sclerosis and unaffected by disease-modulating drugs. J. Clin. Immunol. 24:155-161.
    • (2004) J. Clin. Immunol , vol.24 , pp. 155-161
    • Putheti, P.1    Pettersson, A.2    Soderstrom, M.3    Link, H.4    Huang, Y.5
  • 12
    • 3543140687 scopus 로고    scopus 로고
    • Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy
    • Ehrenstein, M.R., et al. 2004. Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy. J. Exp. Med. 200:277-285.
    • (2004) J. Exp. Med , vol.200 , pp. 277-285
    • Ehrenstein, M.R.1
  • 13
    • 0035413350 scopus 로고    scopus 로고
    • CD4+CD25high regulatory cells in human peripheral blood
    • Baecher-Allan, C, Brown, J.A., Freeman, G.J., and Hafler, D.A. 2001. CD4+CD25high regulatory cells in human peripheral blood. J. Immunol. 167:1245-1253.
    • (2001) J. Immunol , vol.167 , pp. 1245-1253
    • Baecher-Allan, C.1    Brown, J.A.2    Freeman, G.J.3    Hafler, D.A.4
  • 14
    • 0035180065 scopus 로고    scopus 로고
    • Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: Their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance
    • Sakaguchi, S., et al. 2001. Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol. Rev. 182:18-32.
    • (2001) Immunol. Rev , vol.182 , pp. 18-32
    • Sakaguchi, S.1
  • 15
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    • Fontenot, J.D., Gavin, M.A., and Rudensky, A.Y. 2003. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat. Immunol. 4:330-336.
    • (2003) Nat. Immunol , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 16
    • 33645510596 scopus 로고    scopus 로고
    • Persistence of naive CD45RA+ regulatory T cells in adult life
    • Seddiki, N., et al. 2006. Persistence of naive CD45RA+ regulatory T cells in adult life. Blood. 107:2830-2838.
    • (2006) Blood , vol.107 , pp. 2830-2838
    • Seddiki, N.1
  • 17
    • 33745813929 scopus 로고    scopus 로고
    • Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells
    • Seddiki, N., et al. 2006. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J. Exp. Med. 203:1693-1700.
    • (2006) J. Exp. Med , vol.203 , pp. 1693-1700
    • Seddiki, N.1
  • 18
    • 33745817085 scopus 로고    scopus 로고
    • CD 127 expression inversely correlates with FoxP3 and suppressive function of human CD4+Treg cells
    • Liu, W., et al. 2006. CD 127 expression inversely correlates with FoxP3 and suppressive function of human CD4+Treg cells. J. Exp. Med. 203:1701-1711.
    • (2006) J. Exp. Med , vol.203 , pp. 1701-1711
    • Liu, W.1
  • 19
    • 33846283803 scopus 로고    scopus 로고
    • Human CD4+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells
    • Hartigan-O'Connor, D.J., Poon, C, Sinclair, E., and McCune, J.M. 2007. Human CD4+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells. J. Immunol. Methods. 319:41-52.
    • (2007) J. Immunol. Methods , vol.319 , pp. 41-52
    • Hartigan-O'Connor, D.J.1    Poon, C.2    Sinclair, E.3    McCune, J.M.4
  • 20
    • 0027257221 scopus 로고
    • Gene targeting yields a CD18-mutant mouse for study of inflammation
    • Wilson, R.W., et al. 1993. Gene targeting yields a CD18-mutant mouse for study of inflammation. J. Immunol. 151:1571-1578.
    • (1993) J. Immunol , vol.151 , pp. 1571-1578
    • Wilson, R.W.1
  • 21
    • 0029875796 scopus 로고    scopus 로고
    • A polygenic mouse model of psoriasiform skin disease in CD18-deficient mice
    • Bullard, D.C, et al. 1996. A polygenic mouse model of psoriasiform skin disease in CD18-deficient mice. Proc. Natl. Acad. Sci. U. S. A. 93:2116-2121.
    • (1996) Proc. Natl. Acad. Sci. U. S. A , vol.93 , pp. 2116-2121
    • Bullard, D.C.1
  • 22
    • 10744227499 scopus 로고    scopus 로고
    • CD4+ T cell-associated pathophysiology critically depends on CD18 gene dose effects in a murine model of psoriasis
    • Kess, D., et al. 2003. CD4+ T cell-associated pathophysiology critically depends on CD18 gene dose effects in a murine model of psoriasis. J. Immunol. 171:5697-5706.
    • (2003) J. Immunol , vol.171 , pp. 5697-5706
    • Kess, D.1
  • 23
    • 33746766314 scopus 로고    scopus 로고
    • Activated macrophages are essential in a murine model for T cell-mediated chronic psoriasiform skin inflammation
    • Wang, H., et al. 2006. Activated macrophages are essential in a murine model for T cell-mediated chronic psoriasiform skin inflammation. J. Clin. Invest. 116:2105-2114.
    • (2006) J. Clin. Invest , vol.116 , pp. 2105-2114
    • Wang, H.1
  • 24
    • 0023666065 scopus 로고
    • Integrins: A family of cell surface receptors
    • Hynes, R.O. 1987. Integrins: a family of cell surface receptors. Cell. 48:549-554.
    • (1987) Cell , vol.48 , pp. 549-554
    • Hynes, R.O.1
  • 25
    • 0029619851 scopus 로고
    • The ICAM-3/LFA-1 interaction is critical for epidermal Langerhans cell alloantigen presentation to CD4+ T cells
    • Griffiths, C.E., Railan, D., Gallatin, W.M., and Cooper, K.D. 1995. The ICAM-3/LFA-1 interaction is critical for epidermal Langerhans cell alloantigen presentation to CD4+ T cells. Br. J. Dermatol. 133:823-829.
    • (1995) Br. J. Dermatol , vol.133 , pp. 823-829
    • Griffiths, C.E.1    Railan, D.2    Gallatin, W.M.3    Cooper, K.D.4
  • 26
    • 0033971781 scopus 로고    scopus 로고
    • The association of CD18 alleles with anti-myeloperoxidase subtypes of ANCA-associated systemic vasculitides
    • Gencik, M., et al. 2000. The association of CD18 alleles with anti-myeloperoxidase subtypes of ANCA-associated systemic vasculitides. Clin. Immunol. 94:9-12.
    • (2000) Clin. Immunol , vol.94 , pp. 9-12
    • Gencik, M.1
  • 27
    • 0035433970 scopus 로고    scopus 로고
    • Novel SNPs in the CD 18 gene validate the association with MPO-ANCA+ vasculitis
    • Meller, S., et al. 2001. Novel SNPs in the CD 18 gene validate the association with MPO-ANCA+ vasculitis. Genes Immun. 2:269-272.
    • (2001) Genes Immun , vol.2 , pp. 269-272
    • Meller, S.1
  • 28
    • 0024998254 scopus 로고
    • Skin manifestations in congenital deficiency of leucocyte-adherence glycoproteins (CDLG)
    • van de Kerkhof, P.C, and Weemaes, CM. 1990. Skin manifestations in congenital deficiency of leucocyte-adherence glycoproteins (CDLG). Br. J. Dermatol. 123:395-401.
    • (1990) Br. J. Dermatol , vol.123 , pp. 395-401
    • van de Kerkhof, P.C.1    Weemaes, C.M.2
  • 29
    • 0028366154 scopus 로고
    • Gene for familial psoriasis susceptibility mapped to the distal end of human chromosome 17q
    • Tomfohrde, J., et al. 1994. Gene for familial psoriasis susceptibility mapped to the distal end of human chromosome 17q. Science. 264:1141-1145.
    • (1994) Science , vol.264 , pp. 1141-1145
    • Tomfohrde, J.1
  • 30
    • 0025314483 scopus 로고
    • The LFA-1 ligand ICAM-1 provides an important costimulatory signal for T cell receptor-mediated activation of resting T cells
    • Van Seventer, G.A., Shimizu, Y., Horgan, K.J., and Shaw, S. 1990. The LFA-1 ligand ICAM-1 provides an important costimulatory signal for T cell receptor-mediated activation of resting T cells. J. Immunol. 144:4579-4586.
    • (1990) J. Immunol , vol.144 , pp. 4579-4586
    • Van Seventer, G.A.1    Shimizu, Y.2    Horgan, K.J.3    Shaw, S.4
  • 31
    • 0030589228 scopus 로고    scopus 로고
    • Impaired immune responses toward alloantigens and tumor cells but normal thymic selection in mice deficient in the beta2 integrin leukocyte function-associated antigen-1
    • Shier, P., et al. 1996. Impaired immune responses toward alloantigens and tumor cells but normal thymic selection in mice deficient in the beta2 integrin leukocyte function-associated antigen-1. J. Immunol. 157:5375-5386.
    • (1996) J. Immunol , vol.157 , pp. 5375-5386
    • Shier, P.1
  • 32
    • 0026571222 scopus 로고
    • Intercellular adhesion molecule-2, a second counter-receptor for CD11a/CD18 (leukocyte function-associated antigen-1), provides acostimulatory signal for T-cell receptor-initiated activation of human T cells
    • Damle, N.K., Klussman, K., and Aruffo, A. 1992. Intercellular adhesion molecule-2, a second counter-receptor for CD11a/CD18 (leukocyte function-associated antigen-1), provides acostimulatory signal for T-cell receptor-initiated activation of human T cells. J. Immunol. 148:665-671.
    • (1992) J. Immunol , vol.148 , pp. 665-671
    • Damle, N.K.1    Klussman, K.2    Aruffo, A.3
  • 34
    • 0031647622 scopus 로고    scopus 로고
    • Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: Induction of autoimmune disease by breaking their anergic/suppressive state
    • Takahashi, T., et al. 1998. Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int. Immunol. 10:1969-1980.
    • (1998) Int. Immunol , vol.10 , pp. 1969-1980
    • Takahashi, T.1
  • 35
    • 32644461186 scopus 로고    scopus 로고
    • Effective expansion of alloantigen-specific Foxp3+ CD25+ CD4+ regulatory T cells by dendritic cells during the mixed leukocyte reaction
    • Yamazaki, S., et al. 2006. Effective expansion of alloantigen-specific Foxp3+ CD25+ CD4+ regulatory T cells by dendritic cells during the mixed leukocyte reaction. Proc. Natl. Acad. Sci. U. S. A. 103:2758-2763.
    • (2006) Proc. Natl. Acad. Sci. U. S. A , vol.103 , pp. 2758-2763
    • Yamazaki, S.1
  • 36
    • 0042512461 scopus 로고    scopus 로고
    • Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells
    • Yamazaki, S., et al. 2003. Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells. J. Exp. Med. 198:235-247.
    • (2003) J. Exp. Med , vol.198 , pp. 235-247
    • Yamazaki, S.1
  • 37
    • 0344585521 scopus 로고    scopus 로고
    • Cutting edge: Self-peptides drive the peripheral expansion of CD4+CD25+ regulatory T cells
    • Cozzo, C., Larkin,J., 3rd and Caton, A.J. 2003. Cutting edge: self-peptides drive the peripheral expansion of CD4+CD25+ regulatory T cells. J. Immunol. 171:5678-5682.
    • (2003) J. Immunol , vol.171 , pp. 5678-5682
    • Cozzo, C.1    Larkin 3rd, J.2    Caton, A.J.3
  • 38
    • 29244435493 scopus 로고    scopus 로고
    • Inducing and expanding regulatory T cell populations by foreign antigen
    • Kretschmer, K., et al. 2005. Inducing and expanding regulatory T cell populations by foreign antigen. Nat. Immunol. 6:1219-1227.
    • (2005) Nat. Immunol , vol.6 , pp. 1219-1227
    • Kretschmer, K.1
  • 39
    • 29244482759 scopus 로고    scopus 로고
    • Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice
    • Tang, Q., et al. 2006. Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nat. Immunol. 7:83-92.
    • (2006) Nat. Immunol , vol.7 , pp. 83-92
    • Tang, Q.1
  • 40
    • 0022617584 scopus 로고
    • Contributions of the Mac-1 glycoprotein family to adherence-dependent granulocyte functions: Structure-function assessments employing subunit-specific monoclonal antibodies
    • Anderson, D.C, Miller, L.J., Schmalstieg, F.C, Rothlein, R., and Springer, T.A. 1986. Contributions of the Mac-1 glycoprotein family to adherence-dependent granulocyte functions: structure-function assessments employing subunit-specific monoclonal antibodies. J. Immunol. 137:15-27.
    • (1986) J. Immunol , vol.137 , pp. 15-27
    • Anderson, D.C.1    Miller, L.J.2    Schmalstieg, F.C.3    Rothlein, R.4    Springer, T.A.5
  • 41
    • 0037099613 scopus 로고    scopus 로고
    • CD4+CD25+ Regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness
    • Piccirillo, C.A., et al. 2002. CD4+CD25+ Regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness. J. Exp. Med. 196:237-246.
    • (2002) J. Exp. Med , vol.196 , pp. 237-246
    • Piccirillo, C.A.1
  • 42
    • 1642577126 scopus 로고    scopus 로고
    • TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice
    • Nakamura, K., et al. 2004. TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice. J. Immunol. 172:834-842.
    • (2004) J. Immunol , vol.172 , pp. 834-842
    • Nakamura, K.1
  • 43
    • 29144533904 scopus 로고    scopus 로고
    • CD18 is required for optimal development and function of CD4+CD25+ T regulatory cells
    • Marski, M., Kandula, S., Turner, J.R, and Abraham, C 2005. CD18 is required for optimal development and function of CD4+CD25+ T regulatory cells. J. Immunol. 175:7889-7897
    • (2005) J. Immunol , vol.175 , pp. 7889-7897
    • Marski, M.1    Kandula, S.2    Turner, J.R.3    Abraham, C.4
  • 44
    • 2942692039 scopus 로고    scopus 로고
    • CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes
    • Tarbell, K.V., Yamazaki, S., Olson, K., Toy, P., and Steinman, R.M. 2004. CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes. J. Exp. Med. 199:1467-1477.
    • (2004) J. Exp. Med , vol.199 , pp. 1467-1477
    • Tarbell, K.V.1    Yamazaki, S.2    Olson, K.3    Toy, P.4    Steinman, R.M.5
  • 45
    • 0033682056 scopus 로고    scopus 로고
    • B7/CD28costimulationis essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes
    • Salomon, B., et al. 2000. B7/CD28costimulationis essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity. 12:431-440.
    • (2000) Immunity , vol.12 , pp. 431-440
    • Salomon, B.1
  • 46
    • 0141920662 scopus 로고    scopus 로고
    • Cutting edge: CD28 controls peripheral homeostasis of CD4+CD25+ regulatory T cells
    • Tang, Q., et al. 2003. Cutting edge: CD28 controls peripheral homeostasis of CD4+CD25+ regulatory T cells. J. Immunol. 171:3348-3352.
    • (2003) J. Immunol , vol.171 , pp. 3348-3352
    • Tang, Q.1
  • 47
    • 0035863724 scopus 로고    scopus 로고
    • Identification of MHC class II-restricted peptide ligands, including a glutamic acid decarboxylase 65 sequence, that stimulate diabetogenic T cells from transgenic BDC2.5 nonobese diabetic mice
    • Judkowski, V., et al. 2001. Identification of MHC class II-restricted peptide ligands, including a glutamic acid decarboxylase 65 sequence, that stimulate diabetogenic T cells from transgenic BDC2.5 nonobese diabetic mice. J. Immunol. 166:908-917.
    • (2001) J. Immunol , vol.166 , pp. 908-917
    • Judkowski, V.1
  • 48
    • 1842487380 scopus 로고    scopus 로고
    • Generalized pustular psoriasis following withdrawal of efalizumab
    • Gaylor, M.L., and Duvic, M. 2004. Generalized pustular psoriasis following withdrawal of efalizumab. J. Drugs Dermatol. 3:77-79.
    • (2004) J. Drugs Dermatol , vol.3 , pp. 77-79
    • Gaylor, M.L.1    Duvic, M.2
  • 49
    • 0345414139 scopus 로고    scopus 로고
    • Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
    • Sakaguchi, N., et al. 2003. Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice. Nature. 426:454-460.
    • (2003) Nature , vol.426 , pp. 454-460
    • Sakaguchi, N.1
  • 50
    • 0344394960 scopus 로고    scopus 로고
    • A RUNX trio with a taste for autoimmunity
    • Alarcon-Riquelme, M.E. 2003. A RUNX trio with a taste for autoimmunity. Nat. Genet. 35:299-300.
    • (2003) Nat. Genet , vol.35 , pp. 299-300
    • Alarcon-Riquelme, M.E.1
  • 51
    • 0037234390 scopus 로고    scopus 로고
    • Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease
    • Ghoreschi, K., et al. 2003. Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease. Nat. Med. 9:40-46.
    • (2003) Nat. Med , vol.9 , pp. 40-46
    • Ghoreschi, K.1
  • 52
    • 0032519956 scopus 로고    scopus 로고
    • IL-10 is a key cytokine in psoriasis. Proof of principle by IL-10 therapy: A new therapeutic approach
    • Asadullah, K., et al. 1998. IL-10 is a key cytokine in psoriasis. Proof of principle by IL-10 therapy: a new therapeutic approach. J. Clin. Invest. 101:783-794.
    • (1998) J. Clin. Invest , vol.101 , pp. 783-794
    • Asadullah, K.1
  • 53
    • 0034679567 scopus 로고    scopus 로고
    • Read, S., Malmstrom, V.,andPowrie, F. 2000. Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25+CD4+ regulatory cells that control intestinal inflammation. J. Exp. Med. 192:295-302.
    • Read, S., Malmstrom, V.,andPowrie, F. 2000. Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25+CD4+ regulatory cells that control intestinal inflammation. J. Exp. Med. 192:295-302.
  • 54
    • 0141796312 scopus 로고    scopus 로고
    • TGF-[beta]-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes
    • Belghith, M., et al. 2003. TGF-[beta]-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes. Nat. Med. 9:1202-1208.
    • (2003) Nat. Med , vol.9 , pp. 1202-1208
    • Belghith, M.1
  • 55
    • 33744990181 scopus 로고    scopus 로고
    • + T cells
    • + T cells. Nat. Med. 12:627-635.
    • (2006) Nat. Med , vol.12 , pp. 627-635
    • Ochi, H.1
  • 56
    • 0035801335 scopus 로고    scopus 로고
    • Cell contact-dependent immunosuppression by CD4+CD25+ regulatory T Cells is mediated by cell surface-bound transforming growth factor beta
    • Nakamura, K., Kitani, A., and Strober, W. 2001. Cell contact-dependent immunosuppression by CD4+CD25+ regulatory T Cells is mediated by cell surface-bound transforming growth factor beta. J. Exp. Med. 194:629-644.
    • (2001) J. Exp. Med , vol.194 , pp. 629-644
    • Nakamura, K.1    Kitani, A.2    Strober, W.3
  • 57
    • 1842480959 scopus 로고    scopus 로고
    • TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes
    • Peng, Y., Laouar, Y., Li, M.O., Green, E.A., and Flavell, R.A. 2004. TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes. Proc. Natl. Acad. Sci. U. S. A. 101:4572-4577.
    • (2004) Proc. Natl. Acad. Sci. U. S. A , vol.101 , pp. 4572-4577
    • Peng, Y.1    Laouar, Y.2    Li, M.O.3    Green, E.A.4    Flavell, R.A.5
  • 58
    • 0026799402 scopus 로고
    • Targeted disruption of the mouse transforming growth factor-[beta] 1 gene results in multifocal inflammatory disease
    • Shull, M.M., et al. 1992. Targeted disruption of the mouse transforming growth factor-[beta] 1 gene results in multifocal inflammatory disease. Nature. 359:693-699.
    • (1992) Nature , vol.359 , pp. 693-699
    • Shull, M.M.1
  • 59
    • 0027531528 scopus 로고
    • Transforming growth factor beta1 null mutation in mice causes excessive inflammatory response and early death
    • Kulkarni, A.B., et al. 1993. Transforming growth factor beta1 null mutation in mice causes excessive inflammatory response and early death. Proc. Natl. Acad. Sci. U. S. A. 90:770-774.
    • (1993) Proc. Natl. Acad. Sci. U. S. A , vol.90 , pp. 770-774
    • Kulkarni, A.B.1
  • 60
    • 25844504654 scopus 로고    scopus 로고
    • Tumor cells convert immature myeloid dendritic cells into TGF-beta-secreting cells inducing CD4+CD25+ regulatory T cell proliferation
    • Ghiringhelli, F., et al. 2005. Tumor cells convert immature myeloid dendritic cells into TGF-beta-secreting cells inducing CD4+CD25+ regulatory T cell proliferation. J. Exp. Med. 202:919-929.
    • (2005) J. Exp. Med , vol.202 , pp. 919-929
    • Ghiringhelli, F.1
  • 61
    • 34547563816 scopus 로고    scopus 로고
    • Inhibition of autoimmune diabetes by oral administration of anti-CD3 monoclonal antibody
    • Ishikawa, H.,et al. 2007. Inhibition of autoimmune diabetes by oral administration of anti-CD3 monoclonal antibody. Diabetes. 56:2103-2109.
    • (2007) Diabetes , vol.56 , pp. 2103-2109
    • Ishikawa, H.1
  • 62
    • 0035545623 scopus 로고    scopus 로고
    • Intracellular cytokine staining forTGF-[beta]
    • Garba, M.L., and Frelinger, J.A. 2001. Intracellular cytokine staining forTGF-[beta]. J. Immunol. Methods. 258:193-198.
    • (2001) J. Immunol. Methods , vol.258 , pp. 193-198
    • Garba, M.L.1    Frelinger, J.A.2
  • 63
    • 34147092225 scopus 로고    scopus 로고
    • A CFSE based assay for measuring CD4+CD25+ regulatory T cell mediated suppression of auto-antigen specific and polyclonal T cell responses
    • Venken, K., et al. 2007. A CFSE based assay for measuring CD4+CD25+ regulatory T cell mediated suppression of auto-antigen specific and polyclonal T cell responses. J. Immunol. Methods. 322:1-11.
    • (2007) J. Immunol. Methods , vol.322 , pp. 1-11
    • Venken, K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.