Identification of MHC class II-restricted peptide ligands, including a glutamic acid decarboxylase 65 sequence, that stimulate diabetogenic T cells from transgenic BDC2.5 nonobese diabetic mice

Journal of Immunology

Volumn 166, Issue 2, 2001, Pages 908-917

  Judkowski, V ^a   Pinilla, C ^a   Schroder, K ^a   Tucker, L ^a   Sarvetnick, N ^a   Wilson, D B ^a  

^a TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; GLUTAMATE DECARBOXYLASE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PEPTIDE LIBRARY; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; FEMALE; IMMUNOPATHOGENESIS; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCID MOUSE; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE RECEPTOR GENE; TRANSGENIC MOUSE;

EID: 0035863724     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.2.908     Document Type: Article

References (48)

1. Type-1 diabetes: A chronic autoimmune disease of human, mouse and rat
2. Breeding of a non-obese, diabetic strain of mice
3. Absence of insulitis and overt diabetes in athymic nude mice with NOD genetic background
4. The inhibitory effect of neonatal thymectomy on the incidence of insulitis in non-obese diabetes (NOD) mice
5. Acceleration of the onset of diabetes in NOD mice by thymectomy at weaning
6. Suppression of overt diabetes in NOD mice by anti-thymocyte serum or anti-Thy1.2 antibody
7. Preventive effects of cyclosporin on diabetes in NOD mice
8. Preventive effect of monoclonal anti-L3T4 antibody on development of diabetes in NOD mice
9. Immunotherapy of the nonobese diabetic mouse: Treatment with an antibody to T-helper lymphocytes
10. Neonatal injection of CD3 antibody into nonobese diabetic mice reduces the incidence of insulitis and diabetes
11. Anti-αβ T cell receptor monoclonal antibody provides an efficient therapy for autoimmune diabetes in nonobese diabetic NOD mice
12. Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates
13. + T cell subsets are required for the transfer of diabetes in nonobese diabetic mice
14. Pancreatic islet-specific T-cell clones from nonobese diabetic mice
15. An explanation for the protective effect of the MHC class II-E molecule in murine diabetes
16. + islet-specific T-cell clone
17. T cell receptor V gene usage of islet β cell-reactive T cells is not restricted in non-obese diabetic mice
18. Islet-infiltrating T cell clones from non-obese diabetic mice that promote or prevent accelerated onset diabetes
19. + T cells in autoimmune diabetes of NOD mice using transfer to NOD athymic nude mice
20. + islet-specific T-cell clone
21. Initiation of autoimmune diabetes in NOD/Lt mice is MHC class I-dependent
22. CD8 T cell clones from young non-obese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells
23. Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library
24. Islet-specific T-cell clones from the NOD mouse respond to β granule antigen
25. Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23)
26. + Th1 cells induce diabetes in NOD/SCID mice
27. Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein
28. Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes
29. Immune response to glutamic acid decarboxylase correlates with insulitis in nonobese diabetic mice
30. Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes
31. Retardation or acceleration of diabetes in NOD/Lt mice mediated by intrathymic administration of candidate β-cell antigens
32. Control of autoimmune diabetes in NOD mice by GAD expression or suppression in β cells
33. Following a diabetogenic T cell from genesis through pathogenesis
34. Mechanism underlying counterregulation of autoimmune diabetes
35. Investigation of antigen-antibody interactions using a soluble nonsupport-bound synthetic decapeptide library composed of four trillion sequences
36. General method for the rapid solid-phase synthesis of large numbers of peptides: Specificity of antigen-antibody interaction at the level of individual amino acids
37. Cloning and sequence analysis of a murine cDNA encoding glutamate decarboxylase (GAD65)
38. Identification of high potency microbial and self ligands for a human autoreactive class II-restricted T cell clone
39. The use of soluble synthetic peptide combinatorial libraries to determine antigen recognition of T cells
40. Probing degeneracy in T-cell recognition using peptide combinatorial libraries
41. Specificity and degeneracy of minor histocompatibility antigen-specific MHC-restricted CTL
42. Self-MHC-restricted peptides recognized by an alloreactive T lymphocyte clone
43. + T cells and induce T cell responses to native peptide ligands
44. Identification of candidate T-cell epitopes and molecular mimics in chronic Lyme disease
45. A basis for alloreactivity: MHC helical residues broaden peptide recognition by the TCR
46. Definition of agonists and design of antagonists for alloreactive T cell clones using synthetic peptide libraries
47. g7
48. g7 and autoimmune diabetes