Hepatic insulin resistance precedes the development of diabetes in a model of intrauterine growth retardation

Diabetes

Volumn 53, Issue 10, 2004, Pages 2617-2622

  Vuguin, Patricia ^a,c   Raab, Elisabeth ^b   Liu, Bing ^a   Barzilai, Nir ^a   Simmons, Rebecca ^b  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c Division of Endocrinology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOKINASE; GLUCOSE 6 PHOSPHATASE; INSULIN; INSULIN RECEPTOR SUBSTRATE 2; MESSENGER RNA; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PROTEIN KINASE B;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FEMALE; GLUCONEOGENESIS; HYPERGLYCEMIA; INSULIN RESISTANCE; INTRAUTERINE GROWTH RETARDATION; LIVER METABOLISM; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; DISEASE MODELS, ANIMAL; FETAL GROWTH RETARDATION; GLUCOKINASE; GLUCOSE CLAMP TECHNIQUE; GLUCOSE-6-PHOSPHATASE; INSULIN; INSULIN RESISTANCE; LIVER; MALE; MODELS, BIOLOGICAL; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER;

EID: 4644311421     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.53.10.2617     Document Type: Article

References (51)

1. Ogata E, Bussey M, Finley S: Altered gas exchange, limited glucose, branched chain amino acids, and hypoinsulinism retard fetal growth in the rat. Metabolism 35:970-977, 1986
2. Simmons R, Gounis A, Bangalore S, Ogata E: Intrauterine growth retardation: fetal glucose transport is diminished in lung but spared in brain. Pediatr Res 31:59-63, 1991
3. Unterman T, Lascon R, Gotway M, Oehler D, Gounis A, Simmons R, Ogata E: Circulating levels of insulin-like growth factor binding protein-1 (IG-FBP-1) and hepatic mRNA are increased in the small for gestational age fetal rat. Endocrinology 127:2035-2037, 1990
4. Simmons R, Templeton L, Gertz SI: Intrauterine growth retardation leads to the development of type 2 diabetes in the rat. Diabetes 50:2279-2286, 2001
5. Peterside IE, Selak MA, Simmons RA: Impaired oxidative phosphorylation in hepatic mitochondria in growth retarded rats. Am J Physiol 285: E1258-E1266, 2003
6. Cherrington AD, Edgerton D, Sindelar DK: The direct and indirect effects of insulin on hepatic glucose production in vivo. Diabetologia 41:987-996, 1998
7. Cherrington C: Control of glucose uptake and release by the liver in vivo. Diabetes 48:1198-1214, 1999
8. Zawadzki JK, Wolfe RR, Mott DM, Lillioja S, Howard BV, Bogardus C: Increased rate of Cori cycle in obese subjects with NIDDM and effect of weight reduction. Diabetes 37:154-159, 1988
9. Consoli A, Nurjhan N, Capani F, Gerich J: Predominant role of gluconeogenesis in increased hepatic glucose production in NIDDM. Diabetes 38:550-557, 1989
10. DeFronzo R, Simonson D, Ferrannini E: Hepatic and peripheral insulin resistance: a common feature of type 2 (non-insulin-dependent) and type 1 (insulin-dependent) diabetes mellitus. Diabetologia 21:313-318, 1982
11. Campbell P, Mandarino L, Gerich J: Quantification of the relative impairment in actions of insulin on hepatic glucose production, and glucose disposal in normal subjects and patients with non-insulin-dependent diabetes. J Clin Invest 82:21-25, 1988
12. Gastaldelli A, Toschi E, Pettiti M, Frascerra S, Quinones-Galvan A, Sironi A, Natali A, Ferrannini E: Effect of physiological hyperinsulinemia on gluconeogenesis in nondiabetic subjects and in type 2 diabetic patients. 50:1807-1812, 2001
13. Roden M, Petersen K, Shulman G: Nuclear magnetic resonance studies of hepatic glucose metabolism in humans. Recent Prog Horm Res 56:219-237, 2001
14. Reaven G: The fourth musketeer: from Alesandre Dumas to Claude Bernard. Diabetologia 38:3-13, 1995
15. Barthel A, Schmoll D: Novel concepts in insulin regulation of hepatic gluconeogenesis. Am J Physiol Endocrinol Metab 285:E685-E692, 2003
16. Previs SF, Withers DJ, Ren JM, White MF, Shulman GI: Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo. J Biol Chem 275:38990-38994, 2000
17. Lochhead PA, Coghlan M, Rice SQ, Sutherland C: Inhibition of GSK-3 selectively reduces glucose-6-phosphatase and phosphatase and phosphoenolpyruvate carboxykinase gene expression. Diabetes 50:937-946, 2001
18. Cichy SB, Uddin S, Danilkovich A, Guo S, Klippel A, Unterman TG: Protein kinase B/Akt mediates effects of insulin on hepatic insulin-like growth factor binding protein-1 gene expression through a conserved insulin response sequence. J Biol Chem 273:6482-6487, 1998
19. Sun Y, Liu S, Ferguson S, Wang L, Klepcyk P, Yun JS, Friedman JE: Phosphoenolpyruvate carboxykinase overexpression selectively attenuates insulin signaling and hepatic insulin sensitivity in transgenic mice. J Biol Chem 277:23301-23307, 2002
20. Kubota N, Tobe K, Terauchi Y, Eto K, Yamauchi T, Suzuki R, Tsubamoto Y, Komeda K, Nakano R, Miki H, Satoh S, Sekihara H, Sciacchitano S, Lesniak M, Aizawa S, Nagai R, Kimura S, Akanuma Y, Taylor SI, Kadowaki T: Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory β-cell hyperplasia. Diabetes 49:1880-1889, 2000
21. Sutherland C, O'Brien RM, Granner DK: Phosphatidylinositol 3-kinase, but not p70/p85 ribosomal S6 protein kinase, is required for the regulation of phosphoenolpyruvate carboxykinase (PEPCK) gene expression by insulin: dissociation of signaling pathways for insulin and phorbol ester regulation of PEPCK gene expression. J Biol Chem 270:5501-5506, 1995
22. Barzilai N, Hawkins M, Hu M, Rossetti L: Glucosamine-induced inhibition of glucokinase impairs the ability of hyperglycemia to suppress endogenous glucose production. Diabetes 45:1329-1335, 1996
23. Gupta G, Cases J, She L, Ma X, Yang X, Hu M, Wu J, Rossetti L, Barzilai N: Ability of insulin modulate of hepatic glucose production with aging rats is impaired by fat accumulation. Am J Physiol 278:E985-E911, 2000
24. Gupta G, She L, Ma X, Yang X, Hu M, Cases J, Vuguin P, Rossetti L, Barzilai N: Aging does not contribute to the decline in insulin action on storage of muscle glycogen in rats. Am J Physiol 278:R111-R117, 2000
25. Hawkins M, Barzilai N, Liu R, Chen W, Rossetti L: Role of the glucosamine pathway in fat-induced insulin resistance. J Clin Invest 99:2173-2182, 1997
26. Banerjee S, Saenger P, Mitsu H, Chen W, Barzilai N: Fat accretion and the regulation of insulin-mediated glycogen synthesis following puberty in rats. Am J Physiol 273:R1534-R1539, 1997
27. Vuguin P, Max, Yang X, Surana M, Liu B, Barzilai N: Food deprivation limits the insulin secretory capacity in postpubertal rats. Pediatr Res 49:468-473, 2001
28. Bontemps F, Hue L, Hers HG: Phosphorylation of glucose in isolated rat hepatocytes: sigmoidal kinetics explained by the activity of glucokinase alone. Biochem J 174:603-611, 1978
29. Keppler D, Decker K: Glycogen Determination With Amyloglucosidase. New York, London, Academic Press, 1974
30. Barzilai N, Rossetti L: Relationship between changes in body composition and insulin responsiveness in models of the aging rat. Am J Physiol 269:E591-E597, 1995
31. Barzilai N, She L, Liu L, Wang J, Hu M, Vuguin P, Rossetti L: Decreased visceral adiposity accounts for leptin's effect on hepatic but not peripheral insulin action. Am J Physiol 277:E291-E298, 1999
32. Barzilai N, Banerjee S, Hawkins M, Chen W, Rossetti L: Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat. J Clin Invest 101:1353-1361, 1998
33. Barzilai N, She L, Liu B-Q, Vuguin P, Wang J, Cohen P, Rossetti L: Surgical removal of visceral fat in rats reverses hepatic insulin resistance. Diabetes 48:94-98, 1999
34. Valera A, Pujol A, Pelegrin M, Bosch F: Transgenic mice overexpressing phosphoenolpyruvate carboxykinase develop non-insulin-dependent diabetes mellitus. Proc Natl Acad Sci U S A 91:9151-9154, 1994
35. Burns SP, Desai M, Cohen RD, Hales CN, Iles RA, Germain JP, Going TC, Bailey RA: Gluconeogenesis, glucose handling, and structural changes in livers of the adult offspring of rats partially deprived of protein during pregnancy and lactation. J Clin Invest 100:1768-1774, 1997
36. Burns SP, Regan G, Murphy HC, Kinchesh P: Fetal programming of hepatic lobular architecture in the rat demonstrated ex vivo with magnetic resonance imaging. NMR Biomed 13:82-91, 2000
37. Desai M, Byrne CD, Zhang J, Petry CJ, Lucas A, Hales CN: Programming of hepatic insulin-sensitive enzymes in offspring of rat dams fed a protein-restricted diet. Am J Physiol 272:G1083-G1090, 1997
38. Desai M, Byrne CD, Meeran K, Martenz ND, Bloom SR, Hales CN: Regulation of hepatic enzymes and insulin levels in offspring of rat dams fed a reduced-protein diet. Am J Physiol 273:G899-G904, 1997
39. Ozanne SE, Smith GD, Tikerpae J, Hales CN: Altered regulation of hepatic glucose output in the male offspring of protein-malnourished rat dams. Am J Physiol 270:E559-E564, 1996
40. Nyirenda MJ, Lindsay RS, Kenyon CJ, Burchell A, Seckl JR: Glucocorticoid exposure in late gestation permanently programs rat hepatic phosphoenol-pyruvate carboxykinase and glucocorticoid receptor expression and causes glucose intolerance in adult offspring. J Clin Invest 101:2174-2181, 1998
41. Ozanne SE, Wang CL, Coleman N, Smith GD: Altered muscle insulin sensitivity in the male offspring of protein-malnourished rats. Am J Physiol 271:E1128-E1134, 1996
42. Lane RH, MacLennan NK, Hsu JL, Janke SM, Pham TD: Increased hepatic peroxisome proliferator-activated receptor-gamma coactivator-1 gene expression in a rat model of intrauterine growth retardation and subsequent insulin resistance. Endocrinology 143:2486-2490, 2002
43. Stingl H, Krssak M, Krebs M, Bischof MG, Nowotny P, Furnsinn C, Shulman GI, Waldhausl W, Roden M: Lipid-dependent control of hepatic glycogen stores in healthy humans. Diabetologia 44:48-54, 2001
44. Roden M, Stingl H, Chandramouli V, Schumann WC, Hofer A, Landau BR, Nowotny P, Waldhausl W, Shulman GI: Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in humans. Diabetes 49:701-707, 2000
45. Boden G, Chen X, Capulong E, Mozzoli M: Effects of free fatty acids on gluconeogenesis and autoregulation of glucose production in type 2 diabetes. Diabetes 50:810-816, 2001
46. Chen X, Iqbal N, Boden G: The effects of free fatty acids on gluconeogenesis and glycogenolysis in normal subjects. J Clin Invest 103:365-372, 1999
47. Rebrin K, Steil GM, Mittelman SD, Bergman RN: Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs. J Clin Invest 98:741-749, 1996
48. Mittelman SI), You-Yin F, Steil G, Bergman RN: Indirect effect of insulin to suppress endogenous glucose production is dominant, even with hyperglucagonemia. J Clin Invest 12:3121-3130, 1997
49. Murata H, Ihara Y, Nakamura H, Yodoi J, Sumikawa K, Kondo T: Glutaredoxin exerts an antiapoptotic effect by regulating the redox state of Akt. J Biol Chem 278:50226-50233, 2003
50. 2 induce caspase-3-independent degradation of Akt/protein kinase B. J Biol Chem 277:42943-42952, 2002
51. Cho H, Mu J, Kim JK, Thorvaldsen JL, Chu Q, Crenshaw EB, Kaestner KH, Bartolomei MS, Shulman GI, Birnbaum MJ: Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase akt2 (PKBβ). Science 292:1728-1731, 2001