Heterochromatin, position effect, and genetic silencing

Russian Journal of Genetics

Volumn 39, Issue 2, 2003, Pages 133-146

  Zhimulev, I F ^a,b   Belyaeva, E S ^a  

^a INSTITUTE OF CYTOLOGY AND GENETICS   (Russian Federation)

^b NOVOSIBIRSK STATE UNIVERSITY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE;

CHROMOSOME; CHROMOSOME REARRANGEMENT; CHROMOSOME STRUCTURE; DNA METHYLATION; DNA MODIFICATION; EMBRYO DEVELOPMENT; EUCHROMATIN; EUKARYOTE; GENE INACTIVATION; GENE SILENCING; GENOME; HETEROCHROMATIN; MAMMAL; MOLECULAR MECHANICS; NONHUMAN; REVIEW; TELOMERE; X CHROMOSOME;

EUKARYOTA; MAMMALIA;

EID: 4644284999     PISSN: 10227954     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1022419506918     Document Type: Review

References (119)

1. Heitz, E., Das Heterochromatin der Moose, Jb. Wiss. Bot., 1928, vol. 69, pp. 762-818.
2. Heitz, E., Der Bau der somalischen Kerne von Drosophila melanogaster, Z. Indukt. Abstammungs-Vererbungslehre, 1930, vol. 54, pp. 248-249.
3. Muller, H., Types of Visible Variations Induced by X-rays in Drosophila melanogaster, J. Genet., 1930, vol. 22, pp. 299-334.
4. Wallrath, L.L., Unfolding the Mysteries of Heterochromatin, Curr. Opin. Genet. Dev., 1998, vol. 8, pp. 147-153.
5. Wakimoto, B.T., Beyond the Nucleosome: Epigenetic Aspects of Position-Effect Variegation in Drosophila, Cell (Cambridge, Mass.), 1998, vol. 93, pp. 321-324.
6. Zhimulev, I.F., Polytene Chromosomes, Heterochromatin and Position Effect Variegation, Adv. Genet., 1998, vol. 37, pp. 1-566.
7. Hennig, W., Heterochromatin, Chromosoma, 1999, vol. 108, pp. 1-9.
8. Redi, C.A., Garagna, S., Zacharias, H., et al., The Other Chromatin, Chromosoma, 2001, vol. 110, pp. 136-147.
9. Dillon, N. and Festenstein, R., Unraveling Heterochromatin: Competition between Positive and Negative Factors Regulates Accessibility, Trends Genet., 2002, vol. 18, pp. 252-258.
10. Richards, E.J. and Elgin, S.C.R., Epigenetic Codes for Heterochromatin Formation and Silencing: Rounding up the Usual Suspects, Cell (Cambridge, Mass.), 2002, vol. 108, pp. 489-500.
11. Gvozdev, V.A., Alatortsev, V.E., Aravin, A.A., et al., Heterochromatin: Molecular Evolution and Position Effect Variegation in Drosophila melanogaster, Mol. Biol. (Moscow), 1999, vol. 33, pp. 14-25.
12. Reuter, G. and Spierer, P., Position Effect Variegation and Chromatin Proteins, BioEssays, 1992, vol. 14, pp. 605-612.
13. Jenuwein, T., Liable, G., Dorn, R., and Reuter, G., SET Domain Proteins Modulate Chromatin Domains in Euand Heterochromatin, Cell. Mol. Life Sci., 1998, vol. 54, pp. 80-93.
14. Pirrotta, V., Chromatin Complexes Regulating Gene Expression in Drosophila, Curr. Opin. Genet. Dev., 1995, vol. 5, pp. 466-472.
15. Pirrotta, V., Polycombing the Genome: PcG, trxG, and Chromatin Silencing, Cell (Cambridge, Mass.), 1998, vol. 93, pp. 333-336.
16. Pirrotta, V., Poux, S., Melfi, R., and Pilyugin, M., Assembly of Polycomb Complexes and Silencing Mechanisms, Genetica (The Hague) (in press).
17. Paro, R. and Hogness, D.S., The Polycomb Protein Shares a Homologous Domain with a Heterochromatin-Associated Protein of Drosophila, Proc. Natl. Acad. Sci. USA, 1991, vol. 88, pp. 263-267.
18. Ellison, J.R. and Barr, H.J., Quinacrine Fluorescence of Specific Chromosome Regions: Late Replication and High A-T Content in Samoaia leonensis, Chromosoma, 1972, vol. 36, pp. 375-390.
19. Brown, S.W., Heterochromatin, Science, 1966, vol. 151, pp. 417-425.
20. Back, F., The Variable Condition of Euchromatin and Heterochromatin, Int. Rev. Cytol., 1976, vol. 45, pp. 25-64.
21. John, B., The Biology of Heterochromatin, Heterochromatin, Verma, R.S., Ed., Cambridge: Cambridge Univ. Press, 1988, pp. 1-147.
22. Grunstein, M., Yeast Heterochromatin: Regulation of Its Assembly and Inheritance by Histones, Cell (Cambridge, Mass.), 1998, vol. 93, pp. 325-328.
23. Gatti, M. and Pimpinelli, S., Functional Elements in Drosophila melanogaster Heterochromatin, Annu. Rev. Genet., 1992, vol. 26, pp. 239-275.
24. Adams, M.D., Celniker, S.E., Holt, R.A., et al., The Genome Sequence of Drosophila melanogaster, Science, 2000, vol. 287, pp. 2185-2195.
25. Dimitri, P., Corradini, N., Rossi, F., et al., Vital Genes in the Heterochromatin of Chromosomes 2 and 3 of Drosophila melanogaster, Genetica (The Hague), 2003 (in press).
26. Hilliker, A.J., Appels, R., and Shalet, A., The Genetic Analysis of Drosophila melanogaster Heterochromatin, Cell (Cambridge, Mass.), 1980, vol. 21, pp. 607-619.
27. Noma, K., Allis, C.D., and Grewall, S.I., Transitions in Distinct Histone H3 Methylation Patterns at the Heterochromatin Domain Boundaries, Science, 2001, vol. 293, pp. 1150-1155.
28. Pokholkova, G.V., Makunin, I.V., Belyaeva, E.S., and Zhimulev, I.F., Observations on the Induction of Position Effect Variegation of Euchromatic Genes in Drosophila melanogaster, Genetics, 1993, vol. 133, pp. 231-242.
29. var7, Chromosoma, 1986, vol. 94, pp. 492-504.
30. Belyaeva, E.S. and Zhimulev, I.F., Cytogenetic and Molecular Aspects of Position Effect Variegation in Drosophila melanogaster: III. Continuous and Discontinuous Compaction of Chromosomal Material, Chromosoma, 1991, vol. 100, pp. 453-466.
31. Cooper, K.W., Cytogenetic Analysis of Major Heterochromatic Elements (Especially X and Y) in Drosophila melanogaster and Theory of "Heterochromatin," Chromosoma, 1959, vol. 10, pp. 535-588.
32. Vlassova, I.E., Graphodatsky, A.S., Belyaeva, E.S., and Zhimulev, I.F., Constitutive Heterochromatin in Early Embryogenesis of Drosophila melanogaster, Mol. Gen. Genet., 1991, vol. 229, pp. 316-318.
33. James, T.C., Eissenberg, J.C., Craig, C., et al., Distribution of HP1, a Heterochromatin-Associated Nonhistone Chromosomal Protein of Drosophila, Eur. J. Cell Biol., 1989, vol. 50, pp. 170-180.
34. Eissenberg, J.C., Ge, Y.-W., and Hartnett, T., Increased Phosphorylation of HP1, a Heterochromatin-Associated Protein of Drosophila, Is Correlated with Heterochromatin Assembly, J. Biol. Chem., 1994, vol. 269, pp. 21 315-21 321.
35. Illmensee, K., Developmental Potencies of Nuclei from Cleavage, Preblastoderm and Syncytial Blastoderm Transplanted into Unfertilized Eggs in Drosophila melanogaster, Wilhelm Roux's Arch., 1972, vol. 170, pp. 267-298.
36. Lu, B.Y., Ma, J., and Eissenberg, J.C., Developmental Regulation of Heterochromatin-Mediated Gene Silencing in Drosophila, Development (Cambridge, UK), 1998, vol. 125, pp. 2223-2234.
37. Spofford, J., Position-Effect Variegation in Drosophila, The Genetics and Biology of Drosophila, Ashburner, M. and Novitski E., Eds., London: Academic, 1976, vol. 1, pp. 955-1018.
38. var7 Chromosome in Males, Chromosoma, 1988, vol. 96, pp. 255-261.
39. Prokof'eva-Bel'govskaya, A.A., The Nuclear Cycle in Cell Differentiation, in Voprosy tsitologii i obshchei biologii (Problems of Cytology and General Biology), Moscow: Akad. Nauk SSSR, 1960, pp. 215-233.
40. Miklos, G.L.G. and Nankivell, R.N., Telomeric Satellite DNA Functions in Regulating Recombination, Chromosoma, 1976, vol. 56, pp. 143-167.
41. Pardue, M.-L. and DeBaryshe, P.G., Telomeres and Telomerase: More Than the End of the Line, Chromosoma, 1999, vol. 108, pp. 73-82.
42. Gottschling, D.E., Aparicio, O.M., Billington, B.L., and Zakian, V.A., Position Effects at S. cerevisiae Telomeres: Reversible Repression of PolII Transcription, Cell (Cambridge, Mass.), 1990, vol. 63, pp. 751-762.
43. Lyon, M.L., Gene Action in the X Chromosome of the Mouse, Nature, 1961, vol. 190, pp. 372-373.
44. Russell, L.B. and Montgomery, C.S., The Use of X-Autosome Translocations in Locating the X-Chromosome Inactivation Center, Genetics, 1965, vol. 52, pp. 470-471.
45. Lima-de-Faria, A. and Jaworska, H., Late DNA Synthesis in Heterochromatin, Nature, 1968, vol. 217, pp. 138-142.
46. Heard, E., Clerc, P., and Avner, P., X-Chromosome Inactivation in Mammals, Annu. Rev. Genet., 1997, vol. 31, pp. 571-610.
47. Wintersberger, E., Why Is There Late Replication?, Chromosoma, 2000, vol. 109, pp. 300-307.
48. Brockdorff, N., X-Chromosome Inactivation: Closing in on Proteins That Bind Xist RNA, Trends Genet., 2002, vol. 18, pp. 352-358.
49. Epstein, H., James, T.C., and Singh, P.B., Cloning and Expression of Drosophila HP l Homologs from a Mealy Bug, Planococcus citri, J. Cell Sci., 1992, vol. 101, pp. 463-474.
50. Bongiorni, S., Cintio, O., and Prantera, G., The Relationship between DNA Methylation and Chromosome Imprinting in the Coccid Planococcus citri, Genetics, 1999, vol. 151, pp. 1471-1478.
51. Bongiorni, S., Mazzuoli, M., Masci, S., and Prantera, G., Facultative Heterochromatization in Parahaploid Male Mealybugs: Involvement of a Heterochromatin-Associated Protein, Development (Cambridge, UK), 2001, vol. 128, pp. 3809-3817.
52. Cowell, I.G., Aucott, R., Mahadevaiah, S.K., et al., Heterochromatin, HP1, and Methylation at Lysine 9 of Histone H3 in Animals, Chromosoma, 2002, vol. 111, pp. 22-36.
53. Lima-de-Faria, A., Differential Uptake of Tritiated Thymidine into Hetero- and Euchromatin in Melanoplus and Secale, J. Biophys. Biochem., 1959, vol. 6, pp. 457-466.
54. Holmquist, G.R., Role of Replication Time in the Control of Tissue-Specific Gene Expression, Am. J. Hum. Genet., 1987, vol. 40, pp. 151-173.
55. 2 by string, Cell (Cambridge, Mass.), 1990, vol. 60, pp. 469-480.
56. Foe, V.E., Odell, G.M., and Edgar, B.A., Mitosis and Morphogenesis in the Drosophila Embryo: Point and Counterpoint, The Development of Drosophila melanogaster, Bate, M. and Arias, A.M., Eds., Cold Spring Harbor, New York: Cold Spring Harbor Lab., 1993, pp. 149-300.
57. Zhimulev, I.E., Belyaeva, E.S., Bolshakov, V.N., and Mal'ceva, N.I., Position Effect Variegation and Intercalary Heterochromatin: A Comparative Study, Chromosoma, 1989, vol. 98, pp. 378-387.
58. Baer, D., Asynchronous Replication of DNA in a Heterochromatic Set of Chromosomes in Pseudococcus obscurus, Genetics, 1965, vol. 52, pp. 275-285.
59. Belyaeva, E.S., Zhimulev, I.E., Volkova, E.I., et al., Su(UR)ES, a Gene Suppressing DNA Underreplication in Intercalary and Pericentric Heterochromatin of Drosophila melanogaster Polytene Chromosomes, Proc. Natl. Acad. Sci. USA, 1998, vol. 95, pp. 7532-7537.
60. Zhimulev, I.F., Belyaeva, E.S., Makunin, I.V., et al., Influence of the SuUR Gene on Intercalary Heterochromatin in Drosophila melanogaster Polytene Chromosomes, Chromosoma, 2003 (in press).
61. Beerman, S., The Diminution of Heterochromatic Chromosomal Segments in Cyclops (Crustacea, Copepoda), Chromosoma, 1977, vol. 60, pp. 297-344.
62. Akifjev, A.P., Grishanin, A.K., and Degtyarev, S.V., Some Evolutionary Inference from the Phenomenon of Chromatin Diminution, BioEssays, 2003 (in press).
63. Ammermann, D., Chromatin Diminution and Chromosome Elimination: Mechanisms and Adaptive Significance, The Evolution of Genome Size, Cavalier-Smith, T., Ed., Singapore: Wiley, 1985, pp. 427-442.
64. Goday, C., Ciofi-Luzzatto, A., and Pimpinelli, S., Centromere Ultrastructure in Germ-Line Chromosome of Parascaris, Chromosoma, 1985, vol. 91, pp. 121-125.
65. Mathog, D., Hochstrasser, M., Gruenbaum, Y., et al., Characteristic Folding Pattern of Polytene Chromosomes in Drosophila Salivary-Gland Nuclei, Nature, 1984, vol. 308, pp. 414-421.
66. Hochstrasser, M., Mathog, D., Gruenbaum, Y., et al., Spatial Organization of Chromosomes in the Salivary-Gland Nuclei of Drosophila melanogaster, J. Cell Biol., 1986, vol. 102, pp. 112-123.
67. Marshall, W.F., Fung, J.C., and Sedat, J.W., Deconstructing the Nucleus: Global Architecture from Local Interactions, Curr. Opin. Genet. Dev., 1997, vol. 7, pp. 259-263.
68. Ye, Q. and Worman, H.J., Interaction between an Integral Protein of the Nuclear Envelope Inner Membrane and Human Chromodomain Proteins Homologous to Drosophila HP1, J. Biol. Chem., 1996, vol. 271, no. 25, pp. 14 653-14 656.
69. Ye, Q., Callebaut, I., Pezhman, A., et al., Domain-Specific Interactions of Human HP1-Type Chromodomain Proteins and Inner Nuclear Membrane Protein LBR, J. Biol. Chem., 1997, vol. 272, pp. 14 983-14 989.
70. 69a. Hediger, F. and Gasser, S.M., Nuclear Organization and Silencing: Putting Things in Their Place, Nat. Cell. Biol., 2002, vol. 4, pp. E53-E55.
71. Reuter, G. and Wolf, I., Isolation of Dominant Suppressor Mutations for Position-Effect Variegation, Mol. Gen. Genet., 1981, vol. 182, pp. 516-519.
72. Reuter, G., Werner, W., and Hoffman, H.J., Mutants Affecting Position-Effect Heterochromatinization in Drosophila melanogaster, Chromosoma, 1982, vol. 85, pp. 539-551.
73. Sinclair, D.A.R., Mottus, R.C., and Grigliatti, T.A., Genes Which Suppress Position Effect Variegation in Drosophila melanogaster Are Clustered, Mol. Gen. Genet., 1983, vol. 191, pp. 326-333.
74. Locke, J., Kotarski, M.A., and Tartof, K.D., Dosage-Dependent Modifiers of Position Effect Variegation in Drosophila and a Mass Action Model That Explains Their Effect, Genetics, 1988, vol. 120, pp. 181-198.
75. Sun, F.-L., Cuayacong, M.H., and Elgin, S.C.R., Long-Range Nucleosome Ordering Is Associated with Gene Silencing in Drosophila melanogaster Pericentric Heterochromatin, Mol. Cell. Biol., 2001, vol. 21, pp. 2867-2879.
76. Grewal, S.I.S. and Elgin, S.C.R., Heterochromatin: New Possibilities for the Inheritance of Structure, Curr. Opin. Cell. Genet. Dev., 2002, vol. 12, pp. 178-187.
77. Wallrath, L.L. and Elgin, S.C.R., Position Effect Variegation Is Related with an Altered Chromatin Structure, Genes Dev., 1995, vol. 9, pp. 1263-1277.
78. Eissenberg, J.C., Decisive Factors: A Transcription Activator Can Overcome Heterochromatin Silencing, BioEssays, 2001, vol. 23, pp. 767-771.
79. Khan, A.U. and Hampsey, M., Connecting the DOTs: Covalent Histone Modifications and the Formation of Silent Chromatin, Trends Genet, 2002, vol. 18, pp. 387-389.
80. Strahl, B.D. and Allis, C.D., The Language of Covalent Histone Modifications, Nature, 2000, vol. 403, pp. 41-45.
81. Turner, B.M., Histone Acetylation and an Epigenetic Code, BioEssays, 2000, vol. 22, pp. 836-845.
82. Jenuwein, T. and Allis, C.D., Translating the Histone Code, Science, 2001, vol. 293, pp. 1074-1080.
83. Rice, J.C. and Allis, C.D., Histone Methylation versus Histone Acetylation: New Insights into Epigenetic Regulation, Curr. Opin. Cell. Biol., 2001, vol. 13, pp. 263-273.
84. Jason, L.J.M., Moore, S.C., Lewis, J.D., et al., Histone Ubiquitination: A Tagging Tail Unfolds?, BioEssays, 2002, vol. 24, pp. 1666-1674.
85. Li, E., Chromatin Modification and Epigenetic Reprogramming in Mammalian Development, Nat. Rev. Genet., 2002, vol. 3, pp. 662-673.
86. Li, G., Hall, T.C., and Holmes-Davis, R., Plant Chromatin: Development and Gene Control, BioEssays, 2002, vol. 24, pp. 234-243.
87. Nishioka, K., Rice, J.C., Sarma, K., et al., PR-Set7 Is a Nucleosome-Specific Methyltransferase That Modifies Lysine 20 of Histone H4 and Is Associated with Silent Chromatin, Mol. Cell, 2002, vol. 9, pp. 1201-1213.
88. Bannister, A.J., Zegerman, P., Partridge, J.F., et al., Selective Recognition of Methylated Lysine 9 on Histone H3 by the HP1 Chromo Domain, Nature, 2001, vol. 410, pp. 120-124.
89. Jacobs, S.A., Taverna, S.D., Zhang, Y., et al., Specificity of the HP1 Chromo Domain for the Methylated N-Terminus of Histone H3, EMBO J., 2001, vol. 20, pp. 5232-5241.
90. Lachner, M., O'Carroll, D., Rea, S., et al., Methylation of Histone H3 Lysine 9 Creates a Binding Site for HP1 Proteins, Nature, 2001, vol. 410, pp. 116-120.
91. Nielsen, P.R., Nietlispach, D., Mott, H.R., et al., Structure of the HP1 Chromodomain Bound to Histone H3 Methylated at Lysine 9, Nature, 2002, vol. 416, pp. 103-107.
92. Cleard, F., Delattre, M., and Spierer, P., SU(VAR)3-7, a Drosophila Heterochromatin-Associated Protein and Comparison of HP1 in the Genomic Silencing and Position-Effect Variegation, EMBO J., 1997, vol. 16, pp. 5280-5288.
93. Aagaard, L., Laible, G., Selenko, P., et al., Functional Mammalian Homologues of the Drosophila PEV-Modifier Su(var)3-9 Encode Centromere- Associated Proteins Which Complex with the Heterochromatin Component M31, EMBO J., 1999, vol. 18, pp. 1923-1938.
94. Eissenberg, J.C. and Elgin, S.C., HP1 Protein Family: Getting a Grip on Chromatin, Curr. Opin. Genet. Dev., 2000, vol. 10, pp. 204-210.
95. Makunin, I.V., Volkova, E.I., Belyaeva, E.S., et al., The Drosophila Suppressor of Underreplication Protein Binds to Late-Replicating Regions of Polytene Chromosomes, Genetics, 2002, vol. 160, no. 3, pp. 1023-1034.
96. Schotta, G. and Reuter, G., Controlled Expression of Tagged Proteins in Drosophila Using a New Modular P-Element Vector System, Mol. Gen. Genet., 2000, vol. 262, pp. 916-920.
97. Ivanova, A.V., Bonaduce, M.J., Ivanov, S.V., and Klar, A.J.S., The Chromo and SET Domains of the Clr4 Protein Are Essential for Silencing in Fission Yeast, Nat. Genet., 1998, vol. 19, pp. 192-195.
98. Nakayama, J., Rice, J.C., Strahl, B.D., et al., Role of Histone H3 Lysine 9 Methylation in Epigenetic Control of Heterochromatin Assembly, Science, 2001, vol. 292, pp. 110-113.
99. Rea, S., Eisenhaber, F., O'Carroll, D., et al., Regulation of Chromatin Structure by Site-Specific Histone H3 Methyltransferases, Nature, 2000, vol. 406, pp. 593-599.
100. Tschiersch, B., Hoffmann, A., Krauss, V., et al., The Protein Encoded by the Drosophila Position-Effect Variegation Suppressor Gene Su(var)3-9 Combined Domains of Antagonistic Regulators of Homeotic Gene Complexes, EMBO J., 1994, vol. 13, pp. 3822-3831.
101. Czermin, B., Schotta, G., Hulsmann, B.B., et al., Physical and Functional Association of SU(VAR)3-9 and HDAC1 in Drosophila, EMBO Rep., 2001, vol. 2, no. 10, pp. 915-919.
102. Baumbusch, L.O., Thorstensen, T., Krauss, V., et al, The Arabidopsis thaliana Genome Contains at Least 29 Active Genes Encoding SET Domain Protein That Can Be Assigned to Four Evolutionary Conserved Classes, Nucleic Acids Res., 2001, vol. 29, no. 21, pp. 4319-4333.
103. Belyaeva, E.S., Demakova, O.V., Umbetova, G.H., and Zhimulev, I.F., Cytogenetic and Molecular Aspects of Position Effect Variegation in Drosophila melanogaster. V. Heterochromatin-Associated Protein HP1 Appears in Euchromatic Chromosome Regions Inactivated as a Result of Position Effect Variegation, Chromosoma, 1993, vol. 102, pp. 583-590.
104. Fanti, L., Dorer, D.R., Berloco, M., et al., Heterochromatin Protein 1 Binds to Transgene Arrays, Chromosoma, 1998, vol. 107, pp. 286-292.
105. Hwang, K.K., Eissenberg, J.C., and Worman, H.J., Transcriptional Repression of Euchromatin Genes by Drosophila Heterochromatin Protein 1 and Histone Modifiers, Proc. Natl. Acad. Sci. USA, 2001, vol. 98, pp. 11 423-11 427.
106. Schotta, G., Ebert, A., Krauss, V., et al., Central Role of Drosophila SU(VAR)3-9 in Histone H3 K9 Methylation and Heterochromatic Gene Silencing, EMBO J., 2002, vol. 21, pp. 1121-1131.
107. Kuhfittig, S., Szabad, J., Schotta, G., et al., A Novel Gain-Function Enhancer of Position-Effect Variegation Affects Chromatin Regulation during Oogenesis and Early Embryogenesis in Drosophila, Genetics, 2001, vol. 157, pp. 1227-1244.
108. Delattre, M., Spierer, A., Tonka, C.-H., and Spierer, P., The Genomic Silencing of Position-Effect Variegation in Drosophila melanogaster: Interaction between the Heterochromatin-Associated Proteins Su(var)3-7 and HP1, J. Cell Sci., 2000, vol. 113, pp. 4253-4261.
109. Perrin, L., Demakova, O., Fanti, L., et al., Dynamics of the Sub-Nuclear Distribution of Modulo and the Regulation of Position-Effect Variegation by Nucleolus in Drosophila, J. Cell Sci, 1998, vol. 111, pp. 2753-2761.
110. Jeppesen, P. and Turner, B.M., The Inactive X Chromosome in Female Mammals Is Distinguished by a Lack of Histone H4 Acetylation, a Cytogenetic Marker for Gene Expression, Cell (Cambridge, Mass.), 1993, vol. 74, pp. 281-289.
111. Heard, E., Rougeulle, C., Arnaud, D., et al., Methylation of Histone H3 at Lys-9 Is an Early Mark on the X Chromosome during X Inactivation, Cell (Cambridge, Mass.), 2001, vol. 107, pp. 727-738.
112. Boggs, B.A., Cheung, P., Heard, E., et al., Differentially Methylated Forms of Histone H3 Show Unique Association Patterns with Inactive Human X Chromosomes, Nat. Genet., 2002, vol. 30, pp. 73-76.
113. Peters, A.H.F.M., Mermoud, J.E., O'Carroll, D., et al., Histone H3 Lysine 9 Methylation Is an Epigenetic Imprint of Facultative Heterochromatin, Nat. Genet., 2002, vol. 30, pp. 77-80.
114. Wang, J., Mager, J., Chen, Y., et al., Imprinted X Inactivation Maintained by a Mouse Polycomb Group Gene, Nat. Genet., 2001, vol. 28, pp. 371-375.
115. Van der Vlag, J. and Otte, A.P., Transcriptional Repression Mediated by the Human Polycomb-Group Protein EED Involves Histone Deacetylation, Nature Genet., 1999, vol. 23, pp. 474-478.
116. Keohane, A.M., O'Neill, L.P., Belyaev, N.D., et al., X-Inactivation and Histone H4 Acetylation in Embryonic Stem Cells, Dev. Biol., 1996, vol. 180, pp. 618-630.
117. Burgers, W.A., Fuks, F., and Kouzarides, T., DNA Methyltransferases Get Connected to Chromatin, Trends Genet., 2002, vol. 18, pp. 275-277.
118. + Disrupt the Localization of the Chromo Domain Protein Swi6 and Impair Centromere Function, J. Cell. Sci., 1996, vol. 109, pp. 2637-2648.
119. Prokofyeva-Belgovskaya, A.A., Cytological Properties of Inert Regions and Their Bearing on the Mechanics of Mosaicism and Chromosome Rearrangements, Dros. Inf. Serv., 1941, vol. 15, pp. 34-35.