X-chromosome inactivation: Closing in on proteins that bind Xist RNA

Trends in Genetics

Volumn 18, Issue 7, 2002, Pages 352-358

  Brockdorff, Neil ^a  

^a MRC CLINICAL SCIENCES CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EMBRYONIC ECTODERM DEVELOPMENT PROTEIN; HISTONE; PROTEIN; PROTEIN ENX1; PROTEIN PHO; RIBONUCLEOPROTEIN; RNA; UNCLASSIFIED DRUG;

GENE CONTROL; GENE EXPRESSION; GENE SILENCING; GENE TARGETING; GENETIC TRANSCRIPTION; GENOME IMPRINTING; HERITABILITY; HUMAN; NONHUMAN; NUCLEOTIDE REPEAT; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; REVIEW; X CHROMOSOME; X CHROMOSOME INACTIVATION;

ANIMALS; DOSAGE COMPENSATION, GENETIC; FEMALE; GENE SILENCING; HISTONES; HUMANS; PROTEINS; REPRESSOR PROTEINS; RNA, UNTRANSLATED; TRANSCRIPTION FACTORS; X CHROMOSOME;

MAMMALIA;

EID: 0036641071     PISSN: 01689525     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-9525(02)02717-8     Document Type: Review

References (61)

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3. Non-random X-chromosome inactivation in mouse X-autosome translocation embryos-location of the inactivation centre
4. A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome
5. The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus
6. The human XIST gene: Analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus
7. Requirement for Xist in X chromosome inactivation
8. A 450 kb transgene displays properties of the X inactivation centre
9. Long-range cis effects of ectopic X inactivation centres on a mouse autosome
10. Xist deficient mice are defective in dosage compensation but not spermatogenesis
11. Xist has properties of the X chromosome inactivation centre
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14. Imprinted X inactivation in eutherians: A model of gametic execution and zygotic relaxation
15. XIST RNA paints the inactive X chromosome at interphase: Evidence for a novel RNA involved in nuclear chromosome structure
16. Stabilization and localization of Xist RNA are controlled by separate mechanisms and are not sufficient for X inactivation
17. Stabilization of Xist RNA mediates initiation of X chromosome inactivation
18. A shift from reversible to irreversible X inactivation is triggered during ES cell differentiation
19. Evolutionary conservation of possible functional domains of the human and murine XIST genes
20. Characterization of the genomic Xist locus in rodents reveals conservation of overall gene structure and tandem repeats but rapid evolution of unique sequence
21. Chromosomal silencing and localization are mediated by different domains of Xist RNA
22. Evidence that heteronuclear proteins interact with the XIST RNA in vitro
23. Developmentally regulated Xist promoter switch mediates initiation of X inactivation
24. Quantitative RT-PCR assays show Xist RNA levels are low in mouse female adult tissue, embryos and embryoid bodies
25. Xist RNA exhibits a banded localization on the inactive X chromosome and is excluded from autosomal material in cis
26. Human XIST yeast artificial chromosome transgenes show partial X inactivation center function in mouse embryonic stem cells
27. Loss of Xist imprinting in diploid parthenogenetic preimplantation embryos
28. X inactivation and histone H4 acetylation in embryonic stem cells
29. Histone macroH2A1.2 relocates to the inactive X chromosome after initiation and propagation of X inactivation
30. Dynamic relocalization of histone MacroH2A1 from centrosomes to inactive X chromosomes during X inactivation
31. Conditional deletion of Xist disrupts histone macroH2A localization but not maintenance of X inactivation
32. Expression of Xist RNA is sufficient to initiate macrochromatin body formation
33. Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin
34. Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomes
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43. Expression of Xist during mouse development suggests a role in the initiation of X chromosome inactivation
44. Imprinting and X chromosome counting mechanisms determine Xist expresssion in early mouse development
45. Disruption of imprinted X inactivation by parent of origin effects at Tsix
46. Differences in the DNA of the inactive X chromosome of fetal and extraembryonic tissues of mice
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48. Cell lineage-specific undermethylation of mouse repetitive DNA
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50. Histone macroH2A1 is concentrated in the inactive X chromosome of female preimplantation mouse embryos
51. Imprinted X inactivation maintained by a mouse Polycomb group gene
52. Chromatin complexes regulating gene expression in Drosophila
53. Transcriptional repression mediated by the human Polycomb-Group protein EED involves histone deacetylation
54. Characterization of interactions between the mammalian polycomb-group proteins Enx1/EZH2 and EED suggests the existence of different mammalian polycomb-group protein complexes
55. The Drosophila polycomb group proteins ESC and E(Z) are present in a complex containing the histone-binding protein p55 and the histone deacetylase RPD3
56. Stabilization of chromatin structure by PCR1, a Polycomb complex
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58. Establishment of Polycomb silencing requires a transient interaction between PC and ESC
59. Positional cloning of a global regulator of anterior posterior patterning in mice
60. Mitotically stable association of Polycomb-group proteins Eed and Enx1 with the inactive X chromosome in trophoblast stem cells
61. Promotion of trophoblast stem cell proliferation by FGF4