메뉴 건너뛰기




Volumn 372, Issue 9632, 2008, Pages 67-81

Crohn's disease: beyond antagonists of tumour necrosis factor

Author keywords

[No Author keywords available]

Indexed keywords

ABATACEPT; ABT 874; ALICAFORSEN; AMG 714; ATLIZUMAB; C 326; CELL ADHESION MOLECULE; CH 5D12; CNTO 1275; COX 282B; CYTOKINE; DORAMAPIMOD; FONTOLIZUMAB; GAMMA INTERFERON INDUCIBLE PROTEIN 10; HUMAN GROWTH HORMONE; INTERLEUKIN 10; INTERLEUKIN 18 BINDING PROTEIN; IPL 42; J 695; LENALIDOMIDE; MDX 1100; MLN 0002; MLN 02; MONOCLONAL ANTIBODY; NATALIZUMAB; OKT 4; OPEBACAN; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; RECOMBINANT GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; RECOMBINANT INTERLEUKIN 11; SEMAPIMOD; STA 53226; TEDUGLUTIDE; THALIDOMIDE; THYMOSIN BETA4; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR ANTIBODY; UNINDEXED DRUG; VISILIZUMAB; VT 214; VT 346;

EID: 46149125761     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(08)60995-2     Document Type: Review
Times cited : (88)

References (121)
  • 1
    • 33644873228 scopus 로고    scopus 로고
    • New concepts in the pathophysiology of inflammatory bowel disease
    • Bamias G., Nyce M., De La Rue S., and Cominelli F. New concepts in the pathophysiology of inflammatory bowel disease. Ann Intern Med 143 (2005) 895-904
    • (2005) Ann Intern Med , vol.143 , pp. 895-904
    • Bamias, G.1    Nyce, M.2    De La Rue, S.3    Cominelli, F.4
  • 2
    • 34248136828 scopus 로고    scopus 로고
    • Inflammatory bowel disease: cause and immunobiology
    • Baumgart D., and Carding S. Inflammatory bowel disease: cause and immunobiology. Lancet 369 (2007) 1627-1640
    • (2007) Lancet , vol.369 , pp. 1627-1640
    • Baumgart, D.1    Carding, S.2
  • 3
    • 34848850085 scopus 로고    scopus 로고
    • The genetics of inflammatory bowel disease
    • Cho J., and Weaver C. The genetics of inflammatory bowel disease. Gastroenterology 133 (2007) 1327-1339
    • (2007) Gastroenterology , vol.133 , pp. 1327-1339
    • Cho, J.1    Weaver, C.2
  • 4
    • 34547176642 scopus 로고    scopus 로고
    • Unravelling the pathogenesis of inflammatory bowel disease
    • Xavier R., and Podolsky D. Unravelling the pathogenesis of inflammatory bowel disease. Nature 448 (2007) 427-434
    • (2007) Nature , vol.448 , pp. 427-434
    • Xavier, R.1    Podolsky, D.2
  • 6
    • 34249886868 scopus 로고    scopus 로고
    • CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease
    • Barnich N., Carvalho F., Glasser A., et al. CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease. J Clin Invest 117 (2007) 1566-1574
    • (2007) J Clin Invest , vol.117 , pp. 1566-1574
    • Barnich, N.1    Carvalho, F.2    Glasser, A.3
  • 7
    • 34547952781 scopus 로고    scopus 로고
    • Bugging of the intestinal mucosa
    • Abraham C., and Cho J. Bugging of the intestinal mucosa. N Engl J Med 357 (2007) 708-710
    • (2007) N Engl J Med , vol.357 , pp. 708-710
    • Abraham, C.1    Cho, J.2
  • 9
    • 33144473772 scopus 로고    scopus 로고
    • Genetic basis for increased intestinal permeability in families with Crohn's disease: role of CARD15 3020insC mutation?
    • Buhner S., Buning C., Genschel J., et al. Genetic basis for increased intestinal permeability in families with Crohn's disease: role of CARD15 3020insC mutation?. Gut 55 (2006) 342-347
    • (2006) Gut , vol.55 , pp. 342-347
    • Buhner, S.1    Buning, C.2    Genschel, J.3
  • 10
    • 0035978651 scopus 로고    scopus 로고
    • Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
    • Hugot J., Chamaillard M., Zouali H., et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411 (2001) 599-603
    • (2001) Nature , vol.411 , pp. 599-603
    • Hugot, J.1    Chamaillard, M.2    Zouali, H.3
  • 11
    • 0035978533 scopus 로고    scopus 로고
    • A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
    • Ogura Y., Bonen D., Inohara N., et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411 (2001) 603-606
    • (2001) Nature , vol.411 , pp. 603-606
    • Ogura, Y.1    Bonen, D.2    Inohara, N.3
  • 12
    • 29144483937 scopus 로고    scopus 로고
    • Reduced Paneth cell alpha-defensins in ileal Crohn's disease
    • Wehkamp J., Salzman N., Porter E., et al. Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc Natl Acad Sci USA 102 (2005) 18129-18134
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 18129-18134
    • Wehkamp, J.1    Salzman, N.2    Porter, E.3
  • 13
    • 33845340501 scopus 로고    scopus 로고
    • A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
    • Duerr R., Taylor K., Brant S., et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 314 (2006) 1461-1463
    • (2006) Science , vol.314 , pp. 1461-1463
    • Duerr, R.1    Taylor, K.2    Brant, S.3
  • 14
    • 0030954732 scopus 로고    scopus 로고
    • A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. Crohn's Disease cA2 Study Group
    • Targan S., Hanauer S., van Deventer S., et al. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. Crohn's Disease cA2 Study Group. N Engl J Med 337 (1997) 1029-1035
    • (1997) N Engl J Med , vol.337 , pp. 1029-1035
    • Targan, S.1    Hanauer, S.2    van Deventer, S.3
  • 15
    • 0037018761 scopus 로고    scopus 로고
    • Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial
    • Hanauer S., Feagan B., Lichtenstein G., et al. Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial. Lancet 359 (2002) 1541-1549
    • (2002) Lancet , vol.359 , pp. 1541-1549
    • Hanauer, S.1    Feagan, B.2    Lichtenstein, G.3
  • 16
    • 33645958908 scopus 로고    scopus 로고
    • Infliximab plus azathioprine for steroid-dependent Crohn's disease patients: a randomized placebo-controlled trial
    • Lemann M., Mary J., Duclos B., et al. Infliximab plus azathioprine for steroid-dependent Crohn's disease patients: a randomized placebo-controlled trial. Gastroenterology 130 (2006) 1054-1061
    • (2006) Gastroenterology , vol.130 , pp. 1054-1061
    • Lemann, M.1    Mary, J.2    Duclos, B.3
  • 17
    • 0033529049 scopus 로고    scopus 로고
    • Infliximab for the treatment of fistulas in patients with Crohn's disease
    • Present D., Rutgeerts P., Targan S., et al. Infliximab for the treatment of fistulas in patients with Crohn's disease. N Engl J Med 340 (1999) 1398-1405
    • (1999) N Engl J Med , vol.340 , pp. 1398-1405
    • Present, D.1    Rutgeerts, P.2    Targan, S.3
  • 18
    • 10744221312 scopus 로고    scopus 로고
    • Infliximab maintenance therapy for fistulizing Crohn's disease
    • Sands B., Anderson F., Bernstein C., et al. Infliximab maintenance therapy for fistulizing Crohn's disease. N Engl J Med 350 (2004) 876-885
    • (2004) N Engl J Med , vol.350 , pp. 876-885
    • Sands, B.1    Anderson, F.2    Bernstein, C.3
  • 19
    • 32044451548 scopus 로고    scopus 로고
    • Human anti-tumor necrosis factor monoclonal antibody (adalimumab) in Crohn's disease: the CLASSIC-I trial
    • Hanauer S., Sandborn W., Rutgeerts P., et al. Human anti-tumor necrosis factor monoclonal antibody (adalimumab) in Crohn's disease: the CLASSIC-I trial. Gastroenterology 130 (2006) 323-333
    • (2006) Gastroenterology , vol.130 , pp. 323-333
    • Hanauer, S.1    Sandborn, W.2    Rutgeerts, P.3
  • 20
    • 33846242958 scopus 로고    scopus 로고
    • Adalimumab for maintenance of clinical response and remission in patients with Crohn's disease: the CHARM trial
    • Colombel J., Sandborn W., Rutgeerts P., et al. Adalimumab for maintenance of clinical response and remission in patients with Crohn's disease: the CHARM trial. Gastroenterology 132 (2007) 52-65
    • (2007) Gastroenterology , vol.132 , pp. 52-65
    • Colombel, J.1    Sandborn, W.2    Rutgeerts, P.3
  • 21
    • 34447523749 scopus 로고    scopus 로고
    • Certolizumab pegol for the treatment of Crohn's disease
    • PRECISE 1 Study Investigators
    • Sandborn W., Feagan B., Stoinov S., et al., PRECISE 1 Study Investigators. Certolizumab pegol for the treatment of Crohn's disease. N Engl J Med 357 (2007) 228-238
    • (2007) N Engl J Med , vol.357 , pp. 228-238
    • Sandborn, W.1    Feagan, B.2    Stoinov, S.3
  • 22
    • 34347402306 scopus 로고    scopus 로고
    • Adalimumab induction therapy for Crohn disease previously treated with infliximab: a randomized trial
    • Sandborn W., Rutgeerts P., Enns R., et al. Adalimumab induction therapy for Crohn disease previously treated with infliximab: a randomized trial. Ann Intern Med 146 (2007) 829-838
    • (2007) Ann Intern Med , vol.146 , pp. 829-838
    • Sandborn, W.1    Rutgeerts, P.2    Enns, R.3
  • 23
    • 33644774565 scopus 로고    scopus 로고
    • Evolving knowledge and therapy of inflammatory bowel disease
    • Korzenik J., and Podolsky D. Evolving knowledge and therapy of inflammatory bowel disease. Nat Rev Drug Discov 5 (2006) 197-209
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 197-209
    • Korzenik, J.1    Podolsky, D.2
  • 24
    • 0029798204 scopus 로고    scopus 로고
    • Treatment of severe Crohn's disease with anti-CD4 monoclonal antibody
    • Canva-Delcambre V., Jacquot S., et al. Treatment of severe Crohn's disease with anti-CD4 monoclonal antibody. Aliment Pharmacol Ther 10 (1996) 721-727
    • (1996) Aliment Pharmacol Ther , vol.10 , pp. 721-727
    • Canva-Delcambre, V.1    Jacquot, S.2
  • 25
    • 0030989417 scopus 로고    scopus 로고
    • CD4 antibody treatment in patients with active Crohn's disease: a phase 1 dose finding study
    • Stronkhorst A., Radema S., Yong S., et al. CD4 antibody treatment in patients with active Crohn's disease: a phase 1 dose finding study. Gut 40 (1997) 320-327
    • (1997) Gut , vol.40 , pp. 320-327
    • Stronkhorst, A.1    Radema, S.2    Yong, S.3
  • 26
    • 33751226331 scopus 로고    scopus 로고
    • A phase I study: visilizumab therapy in Crohn's disease (CD) patients refractory to infliximab treatment
    • Hommes D., Targan S., Baumgart D., Dignass A., Mayer L., and Lowder J. A phase I study: visilizumab therapy in Crohn's disease (CD) patients refractory to infliximab treatment. Gastroenterology 130 suppl 2 (2006) A111
    • (2006) Gastroenterology , vol.130 , Issue.SUPPL. 2
    • Hommes, D.1    Targan, S.2    Baumgart, D.3    Dignass, A.4    Mayer, L.5    Lowder, J.6
  • 27
    • 34047167732 scopus 로고    scopus 로고
    • A phase I study: visilizumab therapy in Crohn's disease (CD) patients with perianal fistula
    • Lowder J., Baumgart D., Hommes D., et al. A phase I study: visilizumab therapy in Crohn's disease (CD) patients with perianal fistula. Gut 55 suppl (2006) A127
    • (2006) Gut , vol.55 , Issue.SUPPL
    • Lowder, J.1    Baumgart, D.2    Hommes, D.3
  • 28
    • 11144358366 scopus 로고    scopus 로고
    • A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease
    • discussion 947.
    • Ito H., Takazoe M., Fukuda Y., et al. A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease. Gastroenterology 126 (2004) 989-996 discussion 947.
    • (2004) Gastroenterology , vol.126 , pp. 989-996
    • Ito, H.1    Takazoe, M.2    Fukuda, Y.3
  • 29
    • 33746176176 scopus 로고    scopus 로고
    • Fontolizumab, a humanised anti-interferon gamma antibody, demonstrates safety and clinical activity in patients with moderate to severe Crohn's disease
    • Hommes D., Mikhajlova T., Stoinov S., et al. Fontolizumab, a humanised anti-interferon gamma antibody, demonstrates safety and clinical activity in patients with moderate to severe Crohn's disease. Gut 55 (2006) 1131-1137
    • (2006) Gut , vol.55 , pp. 1131-1137
    • Hommes, D.1    Mikhajlova, T.2    Stoinov, S.3
  • 30
    • 33746132472 scopus 로고    scopus 로고
    • A dose escalating, placebo controlled, double blind, single dose and multidose, safety and tolerability study of fontolizumab, a humanised anti-interferon gamma antibody, in patients with moderate to severe Crohn's disease
    • Reinisch W., Hommes D., Van Assche G., et al. A dose escalating, placebo controlled, double blind, single dose and multidose, safety and tolerability study of fontolizumab, a humanised anti-interferon gamma antibody, in patients with moderate to severe Crohn's disease. Gut 55 (2006) 1138-1144
    • (2006) Gut , vol.55 , pp. 1138-1144
    • Reinisch, W.1    Hommes, D.2    Van Assche, G.3
  • 31
    • 18144371659 scopus 로고    scopus 로고
    • Fontolizumab protein design labs
    • Dumont F. Fontolizumab protein design labs. Curr Opin Investig Drugs 6 (2005) 537-544
    • (2005) Curr Opin Investig Drugs , vol.6 , pp. 537-544
    • Dumont, F.1
  • 32
    • 8344284998 scopus 로고    scopus 로고
    • Anti-interleukin-12 antibody for active Crohn's disease
    • Mannon P., Fuss I., Mayer L., et al. Anti-interleukin-12 antibody for active Crohn's disease. N Engl J Med 351 (2004) 2069-2079
    • (2004) N Engl J Med , vol.351 , pp. 2069-2079
    • Mannon, P.1    Fuss, I.2    Mayer, L.3
  • 33
    • 34848915789 scopus 로고    scopus 로고
    • A multicenter, randomized, phase 2a study of human monoclonal antibody to IL-12/23p40 (CNTO 1275) in patients with moderately to severely active Crohn's disease
    • Sandborn W., Feagan B., Fedorak R., et al. A multicenter, randomized, phase 2a study of human monoclonal antibody to IL-12/23p40 (CNTO 1275) in patients with moderately to severely active Crohn's disease. Gastroenterology 132 suppl 2 (2007) A51
    • (2007) Gastroenterology , vol.132 , Issue.SUPPL. 2
    • Sandborn, W.1    Feagan, B.2    Fedorak, R.3
  • 34
    • 33745553245 scopus 로고    scopus 로고
    • A phase 1/2A trial of STA 5326, an oral interleukin-12/23 inhibitor, in patients with active moderate to severe Crohn's disease
    • Burakoff R., Barish C., Riff D., et al. A phase 1/2A trial of STA 5326, an oral interleukin-12/23 inhibitor, in patients with active moderate to severe Crohn's disease. Inflamm Bowel Dis 12 (2006) 558-565
    • (2006) Inflamm Bowel Dis , vol.12 , pp. 558-565
    • Burakoff, R.1    Barish, C.2    Riff, D.3
  • 35
    • 22844449094 scopus 로고    scopus 로고
    • Safety and tolerability of antagonist anti-human CD40 Mab ch5D12 in patients with moderate to severe Crohn's disease
    • Kasran A., Boon L., Wortel C., et al. Safety and tolerability of antagonist anti-human CD40 Mab ch5D12 in patients with moderate to severe Crohn's disease. Aliment Pharmacol Ther 22 (2005) 111-122
    • (2005) Aliment Pharmacol Ther , vol.22 , pp. 111-122
    • Kasran, A.1    Boon, L.2    Wortel, C.3
  • 36
    • 15744405106 scopus 로고    scopus 로고
    • Autologous hematopoietic stem cell transplantation in patients with refractory Crohn's disease
    • Oyama Y., Craig R., Traynor A., et al. Autologous hematopoietic stem cell transplantation in patients with refractory Crohn's disease. Gastroenterology 128 (2005) 552-563
    • (2005) Gastroenterology , vol.128 , pp. 552-563
    • Oyama, Y.1    Craig, R.2    Traynor, A.3
  • 37
    • 34548165122 scopus 로고    scopus 로고
    • A randomized, double blind, placebocontrolled phase II study with long-term open-label extension of semapimod (CNI-1493) for treatment of moderate to severe Crohn's disease
    • Dotan I., Van der Woude J., Schreiber S., Plasse T., and Powers B. A randomized, double blind, placebocontrolled phase II study with long-term open-label extension of semapimod (CNI-1493) for treatment of moderate to severe Crohn's disease. Gut 55 suppl (2006) A22
    • (2006) Gut , vol.55 , Issue.SUPPL
    • Dotan, I.1    Van der Woude, J.2    Schreiber, S.3    Plasse, T.4    Powers, B.5
  • 38
    • 0036142395 scopus 로고    scopus 로고
    • Inhibition of stress-activated MAP kinases induces clinical improvement in moderate to severe Crohn's disease
    • Hommes D., van den Blink B., Plasse T., et al. Inhibition of stress-activated MAP kinases induces clinical improvement in moderate to severe Crohn's disease. Gastroenterology 122 (2002) 7-14
    • (2002) Gastroenterology , vol.122 , pp. 7-14
    • Hommes, D.1    van den Blink, B.2    Plasse, T.3
  • 39
    • 33644756429 scopus 로고    scopus 로고
    • Oral p38 mitogen-activated protein kinase inhibition with BIRB 796 for active Crohn's disease: a randomized, double-blind, placebo-controlled trial
    • Schreiber S., Feagan B., D'Haens G., et al. Oral p38 mitogen-activated protein kinase inhibition with BIRB 796 for active Crohn's disease: a randomized, double-blind, placebo-controlled trial. Clin Gastroenterol Hepatol 4 (2006) 325-334
    • (2006) Clin Gastroenterol Hepatol , vol.4 , pp. 325-334
    • Schreiber, S.1    Feagan, B.2    D'Haens, G.3
  • 40
    • 33846990852 scopus 로고    scopus 로고
    • Thalidomide in luminal and fistulizing Crohn's disease resistant to standard therapies
    • Plamondon S., Ng S., and Kamm M. Thalidomide in luminal and fistulizing Crohn's disease resistant to standard therapies. Aliment Pharmacol Ther 25 (2007) 557-567
    • (2007) Aliment Pharmacol Ther , vol.25 , pp. 557-567
    • Plamondon, S.1    Ng, S.2    Kamm, M.3
  • 41
    • 0034463305 scopus 로고    scopus 로고
    • Recombinant human interleukin 10 in the treatment of patients with mild to moderately active Crohn's disease. The Interleukin 10 Inflammatory Bowel Disease Cooperative Study Group
    • Fedorak R., Gangl A., Elson C., et al. Recombinant human interleukin 10 in the treatment of patients with mild to moderately active Crohn's disease. The Interleukin 10 Inflammatory Bowel Disease Cooperative Study Group. Gastroenterology 119 (2000) 1473-1482
    • (2000) Gastroenterology , vol.119 , pp. 1473-1482
    • Fedorak, R.1    Gangl, A.2    Elson, C.3
  • 42
    • 0034464148 scopus 로고    scopus 로고
    • Safety and efficacy of recombinant human interleukin 10 in chronic active Crohn's disease. Crohn's Disease IL-10 Cooperative Study Group
    • Schreiber S., Fedorak R., Nielsen O., et al. Safety and efficacy of recombinant human interleukin 10 in chronic active Crohn's disease. Crohn's Disease IL-10 Cooperative Study Group. Gastroenterology 119 (2000) 1461-1472
    • (2000) Gastroenterology , vol.119 , pp. 1461-1472
    • Schreiber, S.1    Fedorak, R.2    Nielsen, O.3
  • 43
    • 0034956334 scopus 로고    scopus 로고
    • Interleukin 10 (Tenovil) in the prevention of postoperative recurrence of Crohn's disease
    • Colombel J., Rutgeerts P., Malchow H., et al. Interleukin 10 (Tenovil) in the prevention of postoperative recurrence of Crohn's disease. Gut 49 (2001) 42-46
    • (2001) Gut , vol.49 , pp. 42-46
    • Colombel, J.1    Rutgeerts, P.2    Malchow, H.3
  • 44
    • 0032989443 scopus 로고    scopus 로고
    • Preliminary evaluation of safety and activity of recombinant human interleukin 11 in patients with active Crohn's disease
    • Sands B., Bank S., Sninsky C., et al. Preliminary evaluation of safety and activity of recombinant human interleukin 11 in patients with active Crohn's disease. Gastroenterology 117 (1999) 58-64
    • (1999) Gastroenterology , vol.117 , pp. 58-64
    • Sands, B.1    Bank, S.2    Sninsky, C.3
  • 45
    • 0036186051 scopus 로고    scopus 로고
    • Randomized, controlled trial of recombinant human interleukin-11 in patients with active Crohn's disease
    • Sands B., Winston B., Salzberg B., et al. Randomized, controlled trial of recombinant human interleukin-11 in patients with active Crohn's disease. Aliment Pharmacol Ther 16 (2002) 399-406
    • (2002) Aliment Pharmacol Ther , vol.16 , pp. 399-406
    • Sands, B.1    Winston, B.2    Salzberg, B.3
  • 46
    • 33645455612 scopus 로고    scopus 로고
    • Randomized, double blind controlled trial of subcutaneous recombinant human interleukin-11 versus prednisolone in active Crohn's disease
    • Herrlinger K., Witthoeft T., Raedler A., et al. Randomized, double blind controlled trial of subcutaneous recombinant human interleukin-11 versus prednisolone in active Crohn's disease. Am J Gastroenterol 101 (2006) 793-797
    • (2006) Am J Gastroenterol , vol.101 , pp. 793-797
    • Herrlinger, K.1    Witthoeft, T.2    Raedler, A.3
  • 47
    • 33744933432 scopus 로고    scopus 로고
    • A phase I trial with transgenic bacteria expressing interleukin-10 in Crohn's disease
    • Braat H., Rottiers P., Hommes D., et al. A phase I trial with transgenic bacteria expressing interleukin-10 in Crohn's disease. Clin Gastroenterol Hepatol 4 (2006) 754-759
    • (2006) Clin Gastroenterol Hepatol , vol.4 , pp. 754-759
    • Braat, H.1    Rottiers, P.2    Hommes, D.3
  • 48
    • 0034903450 scopus 로고    scopus 로고
    • A randomized placebo-controlled trial of a humanized monoclonal antibody to alpha4 integrin in active Crohn's disease
    • Gordon F., Lai C., Hamilton M., et al. A randomized placebo-controlled trial of a humanized monoclonal antibody to alpha4 integrin in active Crohn's disease. Gastroenterology 121 (2001) 268-274
    • (2001) Gastroenterology , vol.121 , pp. 268-274
    • Gordon, F.1    Lai, C.2    Hamilton, M.3
  • 49
    • 0037413468 scopus 로고    scopus 로고
    • Natalizumab for active Crohn's disease
    • Ghosh S., Goldin E., Gordon F., et al. Natalizumab for active Crohn's disease. N Engl J Med 348 (2003) 24-32
    • (2003) N Engl J Med , vol.348 , pp. 24-32
    • Ghosh, S.1    Goldin, E.2    Gordon, F.3
  • 50
    • 33846184129 scopus 로고    scopus 로고
    • Safety and tolerability of concurrent natalizumab treatment for patients with Crohn's disease not in remission while receiving infliximab
    • Sands B., Kozarek R., Spainhour J., et al. Safety and tolerability of concurrent natalizumab treatment for patients with Crohn's disease not in remission while receiving infliximab. Inflamm Bowel Dis 13 (2007) 2-11
    • (2007) Inflamm Bowel Dis , vol.13 , pp. 2-11
    • Sands, B.1    Kozarek, R.2    Spainhour, J.3
  • 51
    • 27644441529 scopus 로고    scopus 로고
    • Natalizumab induction and maintenance therapy for Crohn's disease
    • Sandborn W., Colombel J., Enns R., et al. Natalizumab induction and maintenance therapy for Crohn's disease. N Engl J Med 353 (2005) 1912-1925
    • (2005) N Engl J Med , vol.353 , pp. 1912-1925
    • Sandborn, W.1    Colombel, J.2    Enns, R.3
  • 52
    • 34247884424 scopus 로고    scopus 로고
    • Natalizumab for the treatment of active Crohn's disease: results of the ENCORE trial
    • Targan S., Feagan B., Fedorak R., et al. Natalizumab for the treatment of active Crohn's disease: results of the ENCORE trial. Gastroenterology 132 (2007) 1672-1683
    • (2007) Gastroenterology , vol.132 , pp. 1672-1683
    • Targan, S.1    Feagan, B.2    Fedorak, R.3
  • 53
    • 22844445587 scopus 로고    scopus 로고
    • Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn's disease
    • Van Assche G., Van Ranst M., Sciot R., et al. Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn's disease. N Engl J Med 353 (2005) 362-368
    • (2005) N Engl J Med , vol.353 , pp. 362-368
    • Van Assche, G.1    Van Ranst, M.2    Sciot, R.3
  • 54
    • 22844439662 scopus 로고    scopus 로고
    • Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon beta-1a for multiple sclerosis
    • Kleinschmidt-DeMasters B., and Tyler K. Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon beta-1a for multiple sclerosis. N Engl J Med 353 (2005) 369-374
    • (2005) N Engl J Med , vol.353 , pp. 369-374
    • Kleinschmidt-DeMasters, B.1    Tyler, K.2
  • 55
    • 22844445230 scopus 로고    scopus 로고
    • Progressive multifocal leukoencephalopathy in a patient treated with natalizumab
    • Langer-Gould A., Atlas S., Green A., Bollen A., and Pelletier D. Progressive multifocal leukoencephalopathy in a patient treated with natalizumab. N Engl J Med 353 (2005) 375-381
    • (2005) N Engl J Med , vol.353 , pp. 375-381
    • Langer-Gould, A.1    Atlas, S.2    Green, A.3    Bollen, A.4    Pelletier, D.5
  • 56
    • 33644605483 scopus 로고    scopus 로고
    • Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy
    • Yousry T., Major E., Ryschkewitsch C., et al. Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy. N Engl J Med 354 (2006) 924-933
    • (2006) N Engl J Med , vol.354 , pp. 924-933
    • Yousry, T.1    Major, E.2    Ryschkewitsch, C.3
  • 57
    • 0031782392 scopus 로고    scopus 로고
    • A placebo-controlled trial of ICAM-1 antisense oligonucleotide in the treatment of Crohn's disease
    • Yacyshyn B., Bowen-Yacyshyn M., Jewell L., et al. A placebo-controlled trial of ICAM-1 antisense oligonucleotide in the treatment of Crohn's disease. Gastroenterology 114 (1998) 1133-1142
    • (1998) Gastroenterology , vol.114 , pp. 1133-1142
    • Yacyshyn, B.1    Bowen-Yacyshyn, M.2    Jewell, L.3
  • 58
    • 0035045185 scopus 로고    scopus 로고
    • Absence of efficacy of subcutaneous antisense ICAM-1 treatment of chronic active Crohn's disease
    • Schreiber S., Nikolaus S., Malchow H., et al. Absence of efficacy of subcutaneous antisense ICAM-1 treatment of chronic active Crohn's disease. Gastroenterology 120 (2001) 1339-1346
    • (2001) Gastroenterology , vol.120 , pp. 1339-1346
    • Schreiber, S.1    Nikolaus, S.2    Malchow, H.3
  • 59
    • 0036288638 scopus 로고    scopus 로고
    • Double blind, placebo controlled trial of the remission inducing and steroid sparing properties of an ICAM-1 antisense oligodeoxynucleotide, alicaforsen (ISIS 2302), in active steroid dependent Crohn's disease
    • Yacyshyn B., Chey W., Goff J., et al. Double blind, placebo controlled trial of the remission inducing and steroid sparing properties of an ICAM-1 antisense oligodeoxynucleotide, alicaforsen (ISIS 2302), in active steroid dependent Crohn's disease. Gut 51 (2002) 30-36
    • (2002) Gut , vol.51 , pp. 30-36
    • Yacyshyn, B.1    Chey, W.2    Goff, J.3
  • 60
    • 0036790088 scopus 로고    scopus 로고
    • Dose ranging pharmacokinetic trial of high-dose alicaforsen (intercellular adhesion molecule-1 antisense oligodeoxynucleotide) (ISIS 2302) in active Crohn's disease
    • Yacyshyn B., Barish C., Goff J., et al. Dose ranging pharmacokinetic trial of high-dose alicaforsen (intercellular adhesion molecule-1 antisense oligodeoxynucleotide) (ISIS 2302) in active Crohn's disease. Aliment Pharmacol Ther 16 (2002) 1761-1770
    • (2002) Aliment Pharmacol Ther , vol.16 , pp. 1761-1770
    • Yacyshyn, B.1    Barish, C.2    Goff, J.3
  • 61
    • 21344472110 scopus 로고    scopus 로고
    • Gene polymorphisms and serological markers of patients with active Crohn's disease in a clinical trial of antisense to ICAM-1
    • Yacyshyn B., Schievella A., Sewell K., and Tami J. Gene polymorphisms and serological markers of patients with active Crohn's disease in a clinical trial of antisense to ICAM-1. Clin Exp Immunol 141 (2005) 141-147
    • (2005) Clin Exp Immunol , vol.141 , pp. 141-147
    • Yacyshyn, B.1    Schievella, A.2    Sewell, K.3    Tami, J.4
  • 62
    • 33846804162 scopus 로고    scopus 로고
    • A randomized, double-masked, placebo-controlled study of alicaforsen, an antisense inhibitor of intercellular adhesion molecule 1, for the treatment of subjects with active Crohn's disease
    • Yacyshyn B., Chey W., Wedel M., Yu R., Paul D., and Chuang E. A randomized, double-masked, placebo-controlled study of alicaforsen, an antisense inhibitor of intercellular adhesion molecule 1, for the treatment of subjects with active Crohn's disease. Clin Gastroenterol Hepatol 5 (2007) 215-220
    • (2007) Clin Gastroenterol Hepatol , vol.5 , pp. 215-220
    • Yacyshyn, B.1    Chey, W.2    Wedel, M.3    Yu, R.4    Paul, D.5    Chuang, E.6
  • 63
    • 34848886760 scopus 로고    scopus 로고
    • CCX282-B, an orally active inhibitor of chemokine receptor CCR9, shows anti-inflammatory and clinical activity in the treatment of Crohn's disease
    • Keshav S., Ungashe S., Zheng W., Bekker P., Wright K., and Schall T. CCX282-B, an orally active inhibitor of chemokine receptor CCR9, shows anti-inflammatory and clinical activity in the treatment of Crohn's disease. Gastroenterology 132 suppl 2 (2007) A157
    • (2007) Gastroenterology , vol.132 , Issue.SUPPL. 2
    • Keshav, S.1    Ungashe, S.2    Zheng, W.3    Bekker, P.4    Wright, K.5    Schall, T.6
  • 64
    • 46149117709 scopus 로고    scopus 로고
    • PROTECT-1, prospective randomized oral therapy evaluationof CCX282-B (TRAFICET-EN) in Crohn's disease
    • Bekker P., Schreiber S., Keshav S., et al. PROTECT-1, prospective randomized oral therapy evaluationof CCX282-B (TRAFICET-EN) in Crohn's disease. Gut 56 suppl (2007) A23
    • (2007) Gut , vol.56 , Issue.SUPPL
    • Bekker, P.1    Schreiber, S.2    Keshav, S.3
  • 65
    • 0142157983 scopus 로고    scopus 로고
    • Efficacy and safety of a humanized a4ß7 antibody in active Crohn's disease (CD)
    • Feagan B., Greenberg G., Wild G., et al. Efficacy and safety of a humanized a4ß7 antibody in active Crohn's disease (CD). Gastroenterology 124 (2003) A25-A26
    • (2003) Gastroenterology , vol.124
    • Feagan, B.1    Greenberg, G.2    Wild, G.3
  • 66
    • 33846646939 scopus 로고    scopus 로고
    • Effect of teduglutide on patients with moderate-severe Crohn's disease after 8 weeks of therapy: a prospective, double-blind, placebo-controlled trial
    • Buchman A., Katz S., Shnaidman M., and Jacobs D. Effect of teduglutide on patients with moderate-severe Crohn's disease after 8 weeks of therapy: a prospective, double-blind, placebo-controlled trial. Gastroenterology 131 (2006) 949-951
    • (2006) Gastroenterology , vol.131 , pp. 949-951
    • Buchman, A.1    Katz, S.2    Shnaidman, M.3    Jacobs, D.4
  • 68
    • 0037048904 scopus 로고    scopus 로고
    • Treatment of active Crohn's disease with recombinant human granulocyte-macrophage colony-stimulating factor
    • Dieckgraefe B., and Korzenik J. Treatment of active Crohn's disease with recombinant human granulocyte-macrophage colony-stimulating factor. Lancet 360 (2002) 1478-1480
    • (2002) Lancet , vol.360 , pp. 1478-1480
    • Dieckgraefe, B.1    Korzenik, J.2
  • 70
    • 34848819109 scopus 로고    scopus 로고
    • Sargramostim induces steroid-free remission in corticosteroid-dependent Crohn's Disease: results of n.o.v.e.l. 2, a phase II multicenter study
    • Valentine J., Fedorak R., Fredlund P., and Feagan B. Sargramostim induces steroid-free remission in corticosteroid-dependent Crohn's Disease: results of n.o.v.e.l. 2, a phase II multicenter study. Gastroenterology 132 Suppl 2 (2007) A502
    • (2007) Gastroenterology , vol.132 , Issue.SUPPL. 2
    • Valentine, J.1    Fedorak, R.2    Fredlund, P.3    Feagan, B.4
  • 71
    • 34848858527 scopus 로고    scopus 로고
    • Efficacy and safety of sargramostim in moderate to severe Crohn's disease: results of n.o.v.e.l. 4, a Phase III multicenter study
    • Feagan B., Anderson F., Radford-Smith G., Solovyov O., and Zurdel-Dillinger S. Efficacy and safety of sargramostim in moderate to severe Crohn's disease: results of n.o.v.e.l. 4, a Phase III multicenter study. Gastroenterology 132 suppl 2 (2007) A103
    • (2007) Gastroenterology , vol.132 , Issue.SUPPL. 2
    • Feagan, B.1    Anderson, F.2    Radford-Smith, G.3    Solovyov, O.4    Zurdel-Dillinger, S.5
  • 72
    • 14644404938 scopus 로고    scopus 로고
    • An open-labelled study of granulocyte colony-stimulating factor in the treatment of active Crohn's disease
    • Korzenik J., and Dieckgraefe B. An open-labelled study of granulocyte colony-stimulating factor in the treatment of active Crohn's disease. Aliment Pharmacol Ther 21 (2005) 391-400
    • (2005) Aliment Pharmacol Ther , vol.21 , pp. 391-400
    • Korzenik, J.1    Dieckgraefe, B.2
  • 73
    • 33644747714 scopus 로고    scopus 로고
    • A double-blind clinical trial for treatment of Crohn's disease by oral administration of Alequel, a mixture of autologous colon-extracted proteins: a patient-tailored approach
    • Margalit M., Israeli E., Shibolet O., et al. A double-blind clinical trial for treatment of Crohn's disease by oral administration of Alequel, a mixture of autologous colon-extracted proteins: a patient-tailored approach. Am J Gastroenterol 101 (2006) 561-568
    • (2006) Am J Gastroenterol , vol.101 , pp. 561-568
    • Margalit, M.1    Israeli, E.2    Shibolet, O.3
  • 74
    • 34047178588 scopus 로고    scopus 로고
    • Cytokine therapy for Crohn's disease: advances in translational research
    • Pizarro T., and Cominelli F. Cytokine therapy for Crohn's disease: advances in translational research. Annu Rev Med 58 (2007) 433-444
    • (2007) Annu Rev Med , vol.58 , pp. 433-444
    • Pizarro, T.1    Cominelli, F.2
  • 75
    • 0037089222 scopus 로고    scopus 로고
    • A humanized non-FcR-binding anti-CD3 antibody, visilizumab, for treatment of steroid-refractory acute graft-versus-host disease
    • Carpenter P., Appelbaum F., Corey L., et al. A humanized non-FcR-binding anti-CD3 antibody, visilizumab, for treatment of steroid-refractory acute graft-versus-host disease. Blood 99 (2002) 2712-2719
    • (2002) Blood , vol.99 , pp. 2712-2719
    • Carpenter, P.1    Appelbaum, F.2    Corey, L.3
  • 77
    • 0028796711 scopus 로고
    • Soluble interleukin-6 receptors in inflammatory bowel disease: relation to circulating interleukin-6
    • Mitsuyama K., Toyonaga A., Sasaki E., et al. Soluble interleukin-6 receptors in inflammatory bowel disease: relation to circulating interleukin-6. Gut 36 (1995) 45-49
    • (1995) Gut , vol.36 , pp. 45-49
    • Mitsuyama, K.1    Toyonaga, A.2    Sasaki, E.3
  • 78
    • 33846889522 scopus 로고    scopus 로고
    • A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis
    • Krueger G., Langley R., Leonardi C., et al. A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis. N Engl J Med 356 (2007) 580-592
    • (2007) N Engl J Med , vol.356 , pp. 580-592
    • Krueger, G.1    Langley, R.2    Leonardi, C.3
  • 79
    • 34047186008 scopus 로고    scopus 로고
    • T cell costimulation: a rational target in the therapeutic armamentarium for autoimmune diseases and transplantation
    • Vincenti F., and Luggen M. T cell costimulation: a rational target in the therapeutic armamentarium for autoimmune diseases and transplantation. Ann Rev Med 58 (2007) 347-358
    • (2007) Ann Rev Med , vol.58 , pp. 347-358
    • Vincenti, F.1    Luggen, M.2
  • 80
    • 0031889085 scopus 로고    scopus 로고
    • Course of Crohn's disease after allogeneic marrow transplantation
    • Lopez-Cubero S., Sullivan K., and McDonald G. Course of Crohn's disease after allogeneic marrow transplantation. Gastroenterology 114 (1998) 433-440
    • (1998) Gastroenterology , vol.114 , pp. 433-440
    • Lopez-Cubero, S.1    Sullivan, K.2    McDonald, G.3
  • 81
    • 12144286975 scopus 로고    scopus 로고
    • Autologous hemopoietic stem cell transplantation in severe rheumatoid arthritis: a report from the EBMT and ABMTR
    • Snowden J., Passweg J., Moore J., et al. Autologous hemopoietic stem cell transplantation in severe rheumatoid arthritis: a report from the EBMT and ABMTR. J Rheumatol 31 (2004) 482-488
    • (2004) J Rheumatol , vol.31 , pp. 482-488
    • Snowden, J.1    Passweg, J.2    Moore, J.3
  • 82
    • 24644495105 scopus 로고    scopus 로고
    • RDP58 is a novel and potentially effective oral therapy for ulcerative colitis
    • Travis S., Yap L., Hawkey C., et al. RDP58 is a novel and potentially effective oral therapy for ulcerative colitis. Inflamm Bowel Dis 11 (2005) 713-719
    • (2005) Inflamm Bowel Dis , vol.11 , pp. 713-719
    • Travis, S.1    Yap, L.2    Hawkey, C.3
  • 83
    • 0026770377 scopus 로고
    • Integrins: versatility, modulation, and signaling in cell adhesion
    • Hynes R. Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69 (1992) 11-25
    • (1992) Cell , vol.69 , pp. 11-25
    • Hynes, R.1
  • 84
    • 0027407109 scopus 로고
    • Endothelial-leukocyte adhesion molecules
    • Bevilacqua M. Endothelial-leukocyte adhesion molecules. Ann Rev Immunol 11 (1993) 767-804
    • (1993) Ann Rev Immunol , vol.11 , pp. 767-804
    • Bevilacqua, M.1
  • 85
    • 34250011713 scopus 로고    scopus 로고
    • Reduced chemokine receptor 9 on intraepithelial lymphocytes in celiac disease suggests persistent epithelial activation
    • Olaussen R., Karlsson M., Lundin K., Jahnsen J., Brandtzaeg P., and Farstad I. Reduced chemokine receptor 9 on intraepithelial lymphocytes in celiac disease suggests persistent epithelial activation. Gastroenterology 132 (2007) 2371-2382
    • (2007) Gastroenterology , vol.132 , pp. 2371-2382
    • Olaussen, R.1    Karlsson, M.2    Lundin, K.3    Jahnsen, J.4    Brandtzaeg, P.5    Farstad, I.6
  • 86
    • 2942741259 scopus 로고    scopus 로고
    • Selective granulocyte and monocyte adsorptive apheresis as a first-line treatment for steroid naive patients with active ulcerative colitis: a prospective uncontrolled study
    • Suzuki Y., Yoshimura N., Saniabadi A., and Saito Y. Selective granulocyte and monocyte adsorptive apheresis as a first-line treatment for steroid naive patients with active ulcerative colitis: a prospective uncontrolled study. Dig Dis Sci 49 (2004) 565-571
    • (2004) Dig Dis Sci , vol.49 , pp. 565-571
    • Suzuki, Y.1    Yoshimura, N.2    Saniabadi, A.3    Saito, Y.4
  • 87
    • 33846581916 scopus 로고    scopus 로고
    • Review article: glucagon-like peptide 2-current applications and future directions
    • Wallis K., Walters J., and Forbes A. Review article: glucagon-like peptide 2-current applications and future directions. Aliment Pharmacol Ther 25 (2007) 365-372
    • (2007) Aliment Pharmacol Ther , vol.25 , pp. 365-372
    • Wallis, K.1    Walters, J.2    Forbes, A.3
  • 88
    • 0034927011 scopus 로고    scopus 로고
    • Beneficial effects of growth hormone on bacterial translocation during the course of acute necrotizing pancreatitis in rats
    • Wang X., Wang B., Wu J., and Wang G. Beneficial effects of growth hormone on bacterial translocation during the course of acute necrotizing pancreatitis in rats. Pancreas 23 (2001) 148-156
    • (2001) Pancreas , vol.23 , pp. 148-156
    • Wang, X.1    Wang, B.2    Wu, J.3    Wang, G.4
  • 89
    • 0036898069 scopus 로고    scopus 로고
    • Effects of recombinant human growth hormone on rat septic shock with intraabdominal infection by E. coli
    • Huang Y., Wang S., Yi C., Ying M., Lin Y., and Zhi M. Effects of recombinant human growth hormone on rat septic shock with intraabdominal infection by E. coli. World J Gastroenterol 8 (2002) 1134-1137
    • (2002) World J Gastroenterol , vol.8 , pp. 1134-1137
    • Huang, Y.1    Wang, S.2    Yi, C.3    Ying, M.4    Lin, Y.5    Zhi, M.6
  • 90
    • 0034094204 scopus 로고    scopus 로고
    • Gastrointestinal effects of growth hormone
    • Shulman D. Gastrointestinal effects of growth hormone. Endocrine 12 (2000) 147-152
    • (2000) Endocrine , vol.12 , pp. 147-152
    • Shulman, D.1
  • 91
    • 19944364186 scopus 로고    scopus 로고
    • Perioperative treatment with human growth hormone down-regulates apoptosis and increases superoxide production in PMN from patients undergoing infrarenal abdominal aortic aneurysm repair
    • Decker D., Springer W., Tolba R., Lauschke H., Hirner A., and von Ruecker A. Perioperative treatment with human growth hormone down-regulates apoptosis and increases superoxide production in PMN from patients undergoing infrarenal abdominal aortic aneurysm repair. Growth Horm IGF Res 15 (2005) 193-199
    • (2005) Growth Horm IGF Res , vol.15 , pp. 193-199
    • Decker, D.1    Springer, W.2    Tolba, R.3    Lauschke, H.4    Hirner, A.5    von Ruecker, A.6
  • 92
    • 33644773940 scopus 로고    scopus 로고
    • Oral tolerance therapy in inflammatory bowel disease
    • Hyun J., and Barrett T. Oral tolerance therapy in inflammatory bowel disease. Am J Gastroenterol 101 (2006) 569-571
    • (2006) Am J Gastroenterol , vol.101 , pp. 569-571
    • Hyun, J.1    Barrett, T.2
  • 93
    • 0029866466 scopus 로고    scopus 로고
    • Mucosal antibodies in inflammatory bowel disease are directed against intestinal bacteria
    • Macpherson A., Khoo U., Forgacs I., Philpott-Howard J., and Bjarnason I. Mucosal antibodies in inflammatory bowel disease are directed against intestinal bacteria. Gut 38 (1996) 365-375
    • (1996) Gut , vol.38 , pp. 365-375
    • Macpherson, A.1    Khoo, U.2    Forgacs, I.3    Philpott-Howard, J.4    Bjarnason, I.5
  • 94
    • 0029995799 scopus 로고    scopus 로고
    • Experimental granulomatous colitis in mice is abrogated by induction of TGF-beta-mediated oral tolerance
    • Neurath M., Fuss I., Kelsall B., Presky D., Waegell W., and Strober W. Experimental granulomatous colitis in mice is abrogated by induction of TGF-beta-mediated oral tolerance. J Exp Med 183 (1996) 2605-2616
    • (1996) J Exp Med , vol.183 , pp. 2605-2616
    • Neurath, M.1    Fuss, I.2    Kelsall, B.3    Presky, D.4    Waegell, W.5    Strober, W.6
  • 95
    • 35648941736 scopus 로고    scopus 로고
    • A phase I study of visilizumab, a humanized anti-CD3 monoclonal antibody, in severe steroid-refractory ulcerative colitis
    • Plevy S., Salzberg B., Van Assche G., et al. A phase I study of visilizumab, a humanized anti-CD3 monoclonal antibody, in severe steroid-refractory ulcerative colitis. Gastroenterology 133 (2007) 1414-1422
    • (2007) Gastroenterology , vol.133 , pp. 1414-1422
    • Plevy, S.1    Salzberg, B.2    Van Assche, G.3
  • 97
    • 0037285975 scopus 로고    scopus 로고
    • A pilot study on the use of the humanized anti-interleukin-2 receptor antibody daclizumab in active ulcerative colitis
    • Van Assche G., Dalle I., Noman M., et al. A pilot study on the use of the humanized anti-interleukin-2 receptor antibody daclizumab in active ulcerative colitis. Am J Gastroenterol 98 (2003) 369-376
    • (2003) Am J Gastroenterol , vol.98 , pp. 369-376
    • Van Assche, G.1    Dalle, I.2    Noman, M.3
  • 98
    • 33750343050 scopus 로고    scopus 로고
    • Daclizumab, a humanised monoclonal antibody to the interleukin 2 receptor (CD25), for the treatment of moderately to severely active ulcerative colitis: a randomised, double blind, placebo controlled, dose ranging trial
    • Van Assche G., Sandborn W., Feagan B., et al. Daclizumab, a humanised monoclonal antibody to the interleukin 2 receptor (CD25), for the treatment of moderately to severely active ulcerative colitis: a randomised, double blind, placebo controlled, dose ranging trial. Gut 55 (2006) 1568-1574
    • (2006) Gut , vol.55 , pp. 1568-1574
    • Van Assche, G.1    Sandborn, W.2    Feagan, B.3
  • 99
    • 10744232542 scopus 로고    scopus 로고
    • Basiliximab (anti-CD25) in combination with steroids may be an effective new treatment for steroid-resistant ulcerative colitis
    • Creed T., Norman M., Probert C., et al. Basiliximab (anti-CD25) in combination with steroids may be an effective new treatment for steroid-resistant ulcerative colitis. Aliment Pharmacol Ther 18 (2003) 65-75
    • (2003) Aliment Pharmacol Ther , vol.18 , pp. 65-75
    • Creed, T.1    Norman, M.2    Probert, C.3
  • 100
    • 33646232018 scopus 로고    scopus 로고
    • Basiliximab for the treatment of steroid-resistant ulcerative colitis: further experience in moderate and severe disease
    • Creed T., Probert C., Norman M., et al. Basiliximab for the treatment of steroid-resistant ulcerative colitis: further experience in moderate and severe disease. Aliment Pharmacol Ther 23 (2006) 1435-1442
    • (2006) Aliment Pharmacol Ther , vol.23 , pp. 1435-1442
    • Creed, T.1    Probert, C.2    Norman, M.3
  • 101
    • 33745291091 scopus 로고    scopus 로고
    • Effects of abatacept in patients with methotrexate-resistant active rheumatoid arthritis: a randomized trial
    • Kremer J., Genant H., Moreland L., et al. Effects of abatacept in patients with methotrexate-resistant active rheumatoid arthritis: a randomized trial. Ann Intern Med 144 (2006) 865-876
    • (2006) Ann Intern Med , vol.144 , pp. 865-876
    • Kremer, J.1    Genant, H.2    Moreland, L.3
  • 102
    • 24944498854 scopus 로고    scopus 로고
    • Abatacept for rheumatoid arthritis refractory to tumor necrosis factor alpha inhibition
    • Genovese M., Becker J., Schiff M., et al. Abatacept for rheumatoid arthritis refractory to tumor necrosis factor alpha inhibition. N Engl J Med 353 (2005) 1114-1123
    • (2005) N Engl J Med , vol.353 , pp. 1114-1123
    • Genovese, M.1    Becker, J.2    Schiff, M.3
  • 103
    • 35648988128 scopus 로고    scopus 로고
    • New therapies for treatment of rheumatoid arthritis
    • Smolen J., Aletaha D., Koeller M., Weisman M., and Emery P. New therapies for treatment of rheumatoid arthritis. Lancet 370 (2007) 1861-1874
    • (2007) Lancet , vol.370 , pp. 1861-1874
    • Smolen, J.1    Aletaha, D.2    Koeller, M.3    Weisman, M.4    Emery, P.5
  • 104
    • 33749363027 scopus 로고    scopus 로고
    • Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate
    • Maini R., Taylor P., Szechinski J., et al. Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate. Arthritis Rheum 54 (2006) 2817-2829
    • (2006) Arthritis Rheum , vol.54 , pp. 2817-2829
    • Maini, R.1    Taylor, P.2    Szechinski, J.3
  • 105
    • 33748265673 scopus 로고    scopus 로고
    • Pilot feasibility studies of leukocytapheresis with the Adacolumn Apheresis System in patients with active ulcerative colitis or Crohn disease
    • Sands B., Sandborn W., Wolf D., et al. Pilot feasibility studies of leukocytapheresis with the Adacolumn Apheresis System in patients with active ulcerative colitis or Crohn disease. J Clin Gastroenterol 40 (2006) 482-489
    • (2006) J Clin Gastroenterol , vol.40 , pp. 482-489
    • Sands, B.1    Sandborn, W.2    Wolf, D.3
  • 106
    • 46149097124 scopus 로고    scopus 로고
    • Sands BE, Sandborn WJ, Feagan B, et al. A randomized, double-blind, sham-controlled study of granulocyte/monocyte apheresis for active ulcerative colitis. Gastroenterology (in press).
    • Sands BE, Sandborn WJ, Feagan B, et al. A randomized, double-blind, sham-controlled study of granulocyte/monocyte apheresis for active ulcerative colitis. Gastroenterology (in press).
  • 107
    • 46149122941 scopus 로고    scopus 로고
    • Verbeeck J, Van Assche G, Ryding J, et al. JC viral loads in Crohn's disease patients treated with immunosuppression: can we screen for elevated risk of PML? Gut (in press).
    • Verbeeck J, Van Assche G, Ryding J, et al. JC viral loads in Crohn's disease patients treated with immunosuppression: can we screen for elevated risk of PML? Gut (in press).
  • 108
    • 3242728399 scopus 로고    scopus 로고
    • Glucagon-like peptide 2 (GLP-2) accelerates the growth of colonic neoplasms in mice
    • Thulesen J., Hartmann B., Hare K., et al. Glucagon-like peptide 2 (GLP-2) accelerates the growth of colonic neoplasms in mice. Gut 53 (2004) 1145-1150
    • (2004) Gut , vol.53 , pp. 1145-1150
    • Thulesen, J.1    Hartmann, B.2    Hare, K.3
  • 109
    • 33748209166 scopus 로고    scopus 로고
    • Developmental regulation of the adhesive and enzymatic activity of vascular adhesion protein-1 (VAP-1) in humans
    • Salmi M., and Jalkanen S. Developmental regulation of the adhesive and enzymatic activity of vascular adhesion protein-1 (VAP-1) in humans. Blood 108 (2006) 1555-1561
    • (2006) Blood , vol.108 , pp. 1555-1561
    • Salmi, M.1    Jalkanen, S.2
  • 110
    • 28644436100 scopus 로고    scopus 로고
    • Multivalent avimer proteins evolved by exon shuffling of a family of human receptor domains
    • Silverman J., Liu Q., Bakker A., et al. Multivalent avimer proteins evolved by exon shuffling of a family of human receptor domains. Nat Biotechnol 23 (2005) 1556-1561
    • (2005) Nat Biotechnol , vol.23 , pp. 1556-1561
    • Silverman, J.1    Liu, Q.2    Bakker, A.3
  • 112
    • 33749165439 scopus 로고    scopus 로고
    • Endocannabinoid overactivity and intestinal inflammation
    • Di Marzo V., and Izzo A. Endocannabinoid overactivity and intestinal inflammation. Gut 55 (2006) 1373-1376
    • (2006) Gut , vol.55 , pp. 1373-1376
    • Di Marzo, V.1    Izzo, A.2
  • 113
    • 21644462655 scopus 로고    scopus 로고
    • A phase I clinical trial of the treatment of Crohn's fistula by adipose mesenchymal stem cell transplantation
    • Garcia-Olmo D., Garcia-Arranz M., Herreros D., Pascual I., Peiro C., and Rodriguez-Montes J. A phase I clinical trial of the treatment of Crohn's fistula by adipose mesenchymal stem cell transplantation. Dis Colon Rectum 48 (2005) 1416-1423
    • (2005) Dis Colon Rectum , vol.48 , pp. 1416-1423
    • Garcia-Olmo, D.1    Garcia-Arranz, M.2    Herreros, D.3    Pascual, I.4    Peiro, C.5    Rodriguez-Montes, J.6
  • 114
    • 34249341111 scopus 로고    scopus 로고
    • Multicenter randomized-controlled clinical trial of probiotics (Lactobacillus johnsonii, LA1) on early endoscopic recurrence of Crohn's disease after lleo-caecal resection
    • Van Gossum A., Dewit O., Louis E., et al. Multicenter randomized-controlled clinical trial of probiotics (Lactobacillus johnsonii, LA1) on early endoscopic recurrence of Crohn's disease after lleo-caecal resection. Inflamm Bowel Dis 13 (2007) 135-142
    • (2007) Inflamm Bowel Dis , vol.13 , pp. 135-142
    • Van Gossum, A.1    Dewit, O.2    Louis, E.3
  • 116
    • 10744233159 scopus 로고    scopus 로고
    • Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis
    • Rachmilewitz D., Katakura K., Karmeli F., et al. Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis. Gastroenterology 126 (2004) 520-528
    • (2004) Gastroenterology , vol.126 , pp. 520-528
    • Rachmilewitz, D.1    Katakura, K.2    Karmeli, F.3
  • 117
    • 39449085441 scopus 로고    scopus 로고
    • Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn's disease: an open randomised trial
    • D'Haens G., Baert F., van Assche G., et al. Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn's disease: an open randomised trial. Lancet 371 (2008) 660-667
    • (2008) Lancet , vol.371 , pp. 660-667
    • D'Haens, G.1    Baert, F.2    van Assche, G.3
  • 118
    • 34147209958 scopus 로고    scopus 로고
    • Mucosal healing in inflammatory bowel disease: impossible ideal or therapeutic target?
    • Rutgeerts P., Vermeire S., and Van Assche G. Mucosal healing in inflammatory bowel disease: impossible ideal or therapeutic target?. Gut 56 (2007) 453-455
    • (2007) Gut , vol.56 , pp. 453-455
    • Rutgeerts, P.1    Vermeire, S.2    Van Assche, G.3
  • 119
    • 33846603748 scopus 로고    scopus 로고
    • Infliximab use and hepatosplenic T cell lymphoma: questions to be asked and lessons learned
    • Rosh J., and Oliva-Hemker M. Infliximab use and hepatosplenic T cell lymphoma: questions to be asked and lessons learned. J Pediatr Gastroenterol Nutr 44 (2007) 165-167
    • (2007) J Pediatr Gastroenterol Nutr , vol.44 , pp. 165-167
    • Rosh, J.1    Oliva-Hemker, M.2
  • 120
    • 33746945553 scopus 로고    scopus 로고
    • Safety first: messages from Digestive Disease Week 2006
    • Hanauer S. Safety first: messages from Digestive Disease Week 2006. Nat Clin Pract Gastroenterol Hepatol 3 (2006) 415
    • (2006) Nat Clin Pract Gastroenterol Hepatol , vol.3 , pp. 415
    • Hanauer, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.