-
1
-
-
18144413467
-
PDL reports phase I results of SMART IFNγ Ab
-
387632 Protein Design Labs Inc PRESS RELEASE October 30
-
387632 PDL reports phase I results of SMART IFNγ Ab. Protein Design Labs Inc PRESS RELEASE 2000 October 30
-
(2000)
-
-
-
2
-
-
18144402304
-
Protein Design Labs announces phase I/II trial of SMART anti-γ interferon antibody in Crohn's disease
-
395717 Protein Design Labs Inc PRESS RELEASE January 10
-
395717 Protein Design Labs announces phase I/II trial of SMART anti-γ interferon antibody in Crohn's disease. Protein Design Labs Inc PRESS RELEASE 2001 January 10
-
(2001)
-
-
-
3
-
-
18144363874
-
Humanizer Wire - Winter 2001
-
443330 Protein Design Labs Inc
-
443330 Humanizer Wire - Winter 2001. Protein Design Labs Inc COMPANY NEWSLETTER 2001 1 1
-
(2001)
Company Newsletter
, vol.1
, pp. 1
-
-
-
4
-
-
18144392959
-
Protein Design Labs begins phase II trial of SMART anti-γ interferon antibody in Crohn's disease
-
450688 Protein Design Labs Inc PRESS RELEASE May 08
-
450688 Protein Design Labs begins phase II trial of SMART anti-γ interferon antibody in Crohn's disease. Protein Design Labs Inc PRESS RELEASE 2002 May 08
-
(2002)
-
-
-
5
-
-
0012255203
-
Preliminary results of a phase I/II study of HuZAF, an anti-IFNγ monoclonal antibody, in patients with moderate to severe active Crohn's disease
-
451111 Abs 505
-
451111 Preliminary results of a phase I/II study of HuZAF, an anti-IFNγ monoclonal antibody, in patients with moderate to severe active Crohn's disease. Rutgeerts P, Reinisch W, Colombel JF, Gendre JP, Deventer SV, Oldenburg B, Modigliani R, Layug B, Cheng M, O'Connor J, Levitt D GASTROENTEROLOGY 2002 122 4 Suppl 1 Abs 505
-
(2002)
Gastroenterology
, vol.122
, Issue.4 SUPPL. 1
-
-
Rutgeerts, P.1
Reinisch, W.2
Colombel, J.F.3
Gendre, J.P.4
Deventer, S.V.5
Oldenburg, B.6
Modigliani, R.7
Layug, B.8
Cheng, M.9
O'Connor, J.10
Levitt, D.11
-
6
-
-
18144410477
-
Protein Design Labs presents phase I/II clinical results with SMART anti-γ interferon antibody in Crohn's disease
-
452003 Protein Design Labs Inc PRESS RELEASE May 21
-
452003 Protein Design Labs presents phase I/II clinical results with SMART anti-γ interferon antibody in Crohn's disease. Protein Design Labs Inc PRESS RELEASE 2002 May 21
-
(2002)
-
-
-
7
-
-
18144389334
-
Digestive Disease Week 2002 (Part III) - Overnight Report
-
452048 San Francisco, CA, USA. IDDB MEETING REPORT May 19-22
-
452048 Digestive Disease Week 2002 (Part III) - Overnight Report, San Francisco, CA, USA. Veryard C IDDB MEETING REPORT 2002 May 19-22
-
(2002)
-
-
Veryard, C.1
-
8
-
-
0028519015
-
Inhibition of Th1 responses prevents inflammatory bowel disease in SCID mice reconstituted with CD45RBhi CD4+ T cells
-
459264
-
459264 Inhibition of Th1 responses prevents inflammatory bowel disease in SCID mice reconstituted with CD45RBhi CD4+ T cells. Powrie F, Leach MW, Mauze S, Menon S, Caddie LB, Coffman RL IMMUNITY 1994 1 7 553-562
-
(1994)
Immunity
, vol.1
, Issue.7
, pp. 553-562
-
-
Powrie, F.1
Leach, M.W.2
Mauze, S.3
Menon, S.4
Caddie, L.B.5
Coffman, R.L.6
-
9
-
-
0037043658
-
Inflammatory bowel disease
-
466189
-
466189 Inflammatory bowel disease. Podolsky DK N ENGL J MED 2002 347 6 417-429
-
(2002)
N. Engl. J. Med.
, vol.347
, Issue.6
, pp. 417-429
-
-
Podolsky, D.K.1
-
10
-
-
0030183108
-
Interferon-γ in autoimmunity
-
476587
-
476587 Interferon-γ in autoimmunity. Billiau A CYTOKINE GROWTH FACTOR REV 1996 7 125-34
-
(1996)
Cytokine Growth Factor Rev.
, vol.7
, pp. 125-134
-
-
Billiau, A.1
-
11
-
-
18144394216
-
Inflammation in Drug Discovery and Development - SRI's Seventh International Meeting
-
482596 San Diego, CA, USA. IDDB MEETING REPORT February 20-21
-
482596 Inflammation in Drug Discovery and Development - SRI's Seventh International Meeting, San Diego, CA, USA. Braddock M IDDB MEETING REPORT 2003 February 20-21
-
(2003)
-
-
Braddock, M.1
-
12
-
-
18144379088
-
Protein Design Labs - 2002 annual report
-
488784 Protein Design Labs Inc ANNUAL REPORT April 08
-
488784 Protein Design Labs - 2002 annual report. Protein Design Labs Inc ANNUAL REPORT 2003 April 08
-
(2003)
-
-
-
13
-
-
18144366494
-
Protein Design Labs - Corporate presentation
-
488991 Protein Design Labs Inc COMPANY PRESENTATION April 30
-
488991 Protein Design Labs - corporate presentation. Protein Design Labs Inc COMPANY PRESENTATION 2003 April 30
-
(2003)
-
-
-
14
-
-
18144367237
-
Protein Design Labs reports progress with three humanized antibodies in inflammatory bowel disease
-
490211 Protein Design Labs Inc PRESS RELEASE May 19
-
490211 Protein Design Labs reports progress with three humanized antibodies in inflammatory bowel disease. Protein Design Labs Inc PRESS RELEASE 2003 May 19
-
(2003)
-
-
-
15
-
-
18144401189
-
Protein Design Labs announces third quarter 2003 financial results
-
511332 Protein Design Labs Inc PRESS RELEASE November 03
-
511332 Protein Design Labs announces third quarter 2003 financial results. Protein Design Labs Inc PRESS RELEASE 2003 November 03
-
(2003)
-
-
-
16
-
-
0041334132
-
Therapeutic value of α-4 integrin blockade in inflammatory bowel disease: The role of natalizumab
-
511461
-
511461 Therapeutic value of α-4 integrin blockade in inflammatory bowel disease: The role of natalizumab. Ghosh S EXPERT OPIN BIOL THER 2003 3 6 995-1000
-
(2003)
Expert Opin. Biol. Ther.
, vol.3
, Issue.6
, pp. 995-1000
-
-
Ghosh, S.1
-
17
-
-
0346463319
-
The Th1 immune pathway as a therapeutic target in Crohn's disease
-
513707
-
513707 The Th1 immune pathway as a therapeutic target in Crohn's disease. Bamias G, Sugawara K, Pagnini C, Cominelli F CURR OPIN INVEST DRUGS 2003 4 11 1279-1286
-
(2003)
Curr. Opin. Invest. Drugs
, vol.4
, Issue.11
, pp. 1279-1286
-
-
Bamias, G.1
Sugawara, K.2
Pagnini, C.3
Cominelli, F.4
-
18
-
-
18144410110
-
HuZaF, a humanized anti-IFNγ antibody, inhibits chemokine production by activated T cells and intestinal epithelial cells and blocks chemotaxis of activated CXCR3+ lymphocytes
-
518854 Abs M1218
-
518854 HuZaF, a humanized anti-IFNγ antibody, inhibits chemokine production by activated T cells and intestinal epithelial cells and blocks chemotaxis of activated CXCR3+ lymphocytes. Tsao T, Li J, Woo J, Keller S, Klingbeil C, Vexler V DIG DIS WEEK 2003 125 Abs M1218
-
(2003)
Dig. Dis. Week
, vol.125
-
-
Tsao, T.1
Li, J.2
Woo, J.3
Keller, S.4
Klingbeil, C.5
Vexler, V.6
-
19
-
-
18144380948
-
Pharmacology and safety evaluation of humanized monoclonal antibodies in the chimpanzee: Study design and conduct issues and application to clinical trials
-
518865
-
518865 Pharmacology and safety evaluation of humanized monoclonal antibodies in the chimpanzee: Study design and conduct issues and application to clinical trials. Bullock C, Tang MT, Wang H, Klingbeil C INT J TOXICOLOGY 2002 21 6 532-533
-
(2002)
Int. J. Toxicology
, vol.21
, Issue.6
, pp. 532-533
-
-
Bullock, C.1
Tang, M.T.2
Wang, H.3
Klingbeil, C.4
-
20
-
-
0037420518
-
Psoriasis
-
526730
-
526730 Psoriasis. Lebwohl M LANCET 2003 361 9364 1197-1204
-
(2003)
Lancet
, vol.361
, Issue.9364
, pp. 1197-1204
-
-
Lebwohl, M.1
-
21
-
-
18144373715
-
PDL unveils data on bowel disease portfolio
-
528130 Protein Design Labs Inc PRESS RELEASE March 22
-
528130 PDL unveils data on bowel disease portfolio. Protein Design Labs Inc PRESS RELEASE 2004 March 22
-
(2004)
-
-
-
22
-
-
0038215374
-
Tolerance, DCs and tryptophan: Much ado about IDO
-
530750
-
530750 Tolerance, DCs and tryptophan: Much ado about IDO. Grohmann U, Fallarino F, Puccetti P TRENDS IMMUNOL 2003 24 5 242-248
-
(2003)
Trends Immunol.
, vol.24
, Issue.5
, pp. 242-248
-
-
Grohmann, U.1
Fallarino, F.2
Puccetti, P.3
-
23
-
-
3242879898
-
Fontolizumab (HuZAF) pharmacokinetics (PK), pharmacodynamics (PD), immunogenicity and exposure/response relationship in patients (Pts) with moderate and severe Crohn's disease (CD)
-
538242 Abs T1302
-
538242 Fontolizumab (HuZAF) pharmacokinetics (PK), pharmacodynamics (PD), immunogenicity and exposure/response relationship in patients (Pts) with moderate and severe Crohn's disease (CD). Ding H, Maia M, Keller S, Colombell JF, Van Deventer SJ, Gendre JP, Reinisch W, Rutgeerts P, Tang MT GASTROENTEROLOGY 2004 126 4 Suppl 2 Abs T1302
-
(2004)
Gastroenterology
, vol.126
, Issue.4 SUPPL. 2
-
-
Ding, H.1
Maia, M.2
Keller, S.3
Colombell, J.F.4
Van Deventer, S.J.5
Gendre, J.P.6
Reinisch, W.7
Rutgeerts, P.8
Tang, M.T.9
-
24
-
-
18144409358
-
-
566219 United European Gastroenterology Week - 12th Annual Meeting, Prague, Czech Republic. IDDB MEETING REPORT 2004 September 25-29
-
566219 United European Gastroenterology Week - 12th Annual Meeting, Prague, Czech Republic. Beglinger C IDDB MEETING REPORT 2004 September 25-29
-
-
-
Beglinger, C.1
-
25
-
-
8344284998
-
Anti-interleukin-12 antibody for active Crohn's disease
-
578232
-
578232 Anti-interleukin-12 antibody for active Crohn's disease. Mannon PJ, Fuss IJ, Mayer L, Elson CO, Sandborn WJ, Present D, Dolin B, Goodman N, Groden C, Homung RL, Quezado M et al N ENGL J MED 2004 351 20 2069-2079
-
(2004)
N. Engl. J. Med.
, vol.351
, Issue.20
, pp. 2069-2079
-
-
Mannon, P.J.1
Fuss, I.J.2
Mayer, L.3
Elson, C.O.4
Sandborn, W.J.5
Present, D.6
Dolin, B.7
Goodman, N.8
Groden, C.9
Homung, R.L.10
Quezado, M.11
-
26
-
-
18144371082
-
PDL updates status of clinical development programs & partnering objectives
-
579638 Protein Design Labs Inc PRESS RELEASE January 12
-
579638 PDL updates status of clinical development programs & partnering objectives. Protein Design Labs Inc PRESS RELEASE 2005 January 12
-
(2005)
-
-
-
27
-
-
13744255984
-
Safety and efficacy of adalimumab (D2E7) in Crohn's disease patients with an attenuated response to infliximab
-
582555
-
582555 Safety and efficacy of adalimumab (D2E7) in Crohn's disease patients with an attenuated response to infliximab. Papadakis KA, Shaye OA, Vasiliauskas EA, Ippoliti A, Dubinsky MC, Birt J, Paavola J, Lee SK, Price J, Targan SR, Abreu MT AM J GASTROENTEROL 2005 100 1 75-79
-
(2005)
Am. J. Gastroenterol.
, vol.100
, Issue.1
, pp. 75-79
-
-
Papadakis, K.A.1
Shaye, O.A.2
Vasiliauskas, E.A.3
Ippoliti, A.4
Dubinsky, M.C.5
Birt, J.6
Paavola, J.7
Lee, S.K.8
Price, J.9
Targan, S.R.10
Abreu, M.T.11
-
28
-
-
0036888372
-
Cytokines: Promoters and dampeners of autoimmunity
-
587647
-
587647 Cytokines: Promoters and dampeners of autoimmunity. Hill N, Sarvetnick N CURR OPIN IMMUNOL 2002 14 6 791-797
-
(2002)
Curr. Opin. Immunol.
, vol.14
, Issue.6
, pp. 791-797
-
-
Hill, N.1
Sarvetnick, N.2
-
29
-
-
0842266786
-
Interferon-γ: An overview of signals, mechanisms and functions
-
587648
-
587648 Interferon-γ: An overview of signals, mechanisms and functions. Schroder K, Hertzog PJ, Ravasi T, Hume DA J LEUKOCYTE BIOL 2004 75 2 163-189
-
(2004)
J. Leukocyte Biol.
, vol.75
, Issue.2
, pp. 163-189
-
-
Schroder, K.1
Hertzog, P.J.2
Ravasi, T.3
Hume, D.A.4
-
30
-
-
0029928417
-
The expanding universe of T-cell subsets: Th1, Th2 and more
-
587651
-
587651 The expanding universe of T-cell subsets: Th1, Th2 and more. Mosmann TR, Sad S IMMUNOL TODAY 1996 17 3 138-146
-
(1996)
Immunol. Today
, vol.17
, Issue.3
, pp. 138-146
-
-
Mosmann, T.R.1
Sad, S.2
-
31
-
-
0036125389
-
Modulation of Th1 and Th2 responses for immunotherapy
-
587654
-
587654 Modulation of Th1 and Th2 responses for immunotherapy. Dumont FJ EXPERT OPIN THER PAT 2002 12 3 341-367
-
(2002)
Expert Opin. Ther. Pat.
, vol.12
, Issue.3
, pp. 341-367
-
-
Dumont, F.J.1
-
32
-
-
10344220475
-
Th1/Th2 cells in inflammatory disease states: Therapeutic implications
-
587655
-
587655 Th1/Th2 cells in inflammatory disease states: Therapeutic implications. Moss RB, Moll T, EI-Kalay M, Kohne C, Soo Hoo W, Encinas J, Carlo DJ EXPERT OPIN BIOL THER 2004 4 12 1887-1896
-
(2004)
Expert Opin. Biol. Ther.
, vol.4
, Issue.12
, pp. 1887-1896
-
-
Moss, R.B.1
Moll, T.2
EI-Kalay, M.3
Kohne, C.4
Soo Hoo, W.5
Encinas, J.6
Carlo, D.J.7
-
33
-
-
0242416575
-
Cytokines and transcription factors that regulate T helper cell differentiation: New players and new insights
-
587661
-
587661 Cytokines and transcription factors that regulate T helper cell differentiation: New players and new insights. Agnello D, Lankford CS, Bream J, Morinobu A, Gadina M, O'Shea JJ, Frucht DM J CLIN IMMUNOL 2003 23 3 147-161
-
(2003)
J. Clin. Immunol.
, vol.23
, Issue.3
, pp. 147-161
-
-
Agnello, D.1
Lankford, C.S.2
Bream, J.3
Morinobu, A.4
Gadina, M.5
O'Shea, J.J.6
Frucht, D.M.7
-
35
-
-
13444262764
-
Induced recruitment of NK cells to lymph nodes provides IFNγ for Th1 priming
-
587663
-
587663 Induced recruitment of NK cells to lymph nodes provides IFNγ for Th1 priming. Martin-Fontecha A, Thomsen LL, Brett S, Gerard C, Lipp M, Lanzavecchia A, Sallusto F NAT IMMUNOL 2004 5 12 1260-1265
-
(2004)
Nat. Immunol.
, vol.5
, Issue.12
, pp. 1260-1265
-
-
Martin-Fontecha, A.1
Thomsen, L.L.2
Brett, S.3
Gerard, C.4
Lipp, M.5
Lanzavecchia, A.6
Sallusto, F.7
-
36
-
-
0037300753
-
Anti-interferon-γ antibodies in the treatment of autoimmune diseases
-
587788
-
587788 Anti-interferon-γ antibodies in the treatment of autoimmune diseases. Skurkovich B, Skurkovich S CURR OPIN MOL THER 2003 5 1 52-57
-
(2003)
Curr. Opin. Mol. Ther.
, vol.5
, Issue.1
, pp. 52-57
-
-
Skurkovich, B.1
Skurkovich, S.2
-
37
-
-
0037565297
-
Using single-gene deletions to identify checkpoints in the progression of systemic autoimmunity
-
587791
-
587791 Using single-gene deletions to identify checkpoints in the progression of systemic autoimmunity. Pollard KM, Hultman P, Kono DH ANN NY ACAD SCI 2003 987 236-239
-
(2003)
Ann. NY Acad. Sci.
, vol.987
, pp. 236-239
-
-
Pollard, K.M.1
Hultman, P.2
Kono, D.H.3
-
38
-
-
0035253598
-
The integrity of the ball-and-socket joint between V and C domains is essential for complete activity of a humanized antibody
-
587792
-
587792 The integrity of the ball-and-socket joint between V and C domains is essential for complete activity of a humanized antibody. Landolfi NF, Thakur AB, Fu H, Vasquez M, Queen C, Tsurushita N J IMMUNOL 2001 166 3 1748-1754
-
(2001)
J. Immunol.
, vol.166
, Issue.3
, pp. 1748-1754
-
-
Landolfi, N.F.1
Thakur, A.B.2
Fu, H.3
Vasquez, M.4
Queen, C.5
Tsurushita, N.6
-
39
-
-
0242693481
-
Simultaneous measurement of multiple Th1 and Th2 serum cytokines in psoriasis and correlation with disease severity
-
587797
-
587797 Simultaneous measurement of multiple Th1 and Th2 serum cytokines in psoriasis and correlation with disease severity. Jacob SE, Nassiri M, Kerdel FA, Vincek V MEDIATORS INFLAMM 2003 12 5 309-313
-
(2003)
Mediators Inflamm.
, vol.12
, Issue.5
, pp. 309-313
-
-
Jacob, S.E.1
Nassiri, M.2
Kerdel, F.A.3
Vincek, V.4
-
40
-
-
2342485676
-
Psoriasis vulgaris: Cutaneous lymphoid tissue supports T-cell activation and 'Type 1' inflammatory gone expression
-
587799
-
587799 Psoriasis vulgaris: Cutaneous lymphoid tissue supports T-cell activation and 'Type 1' inflammatory gone expression. Lew W, Bowcock AM, Krueger JG TRENDS IMMUNOL 2004 25 6 295-305
-
(2004)
Trends Immunol.
, vol.25
, Issue.6
, pp. 295-305
-
-
Lew, W.1
Bowcock, A.M.2
Krueger, J.G.3
-
41
-
-
0142053206
-
The immunological and genetic basis of inflammatory bowel disease
-
587805
-
587805 The immunological and genetic basis of inflammatory bowel disease. Bouma G, Strober W NAT IMMUNOL 2003 3 7 521-533
-
(2003)
Nat. Immunol.
, vol.3
, Issue.7
, pp. 521-533
-
-
Bouma, G.1
Strober, W.2
-
42
-
-
0033367045
-
A potent neutralizing monoclonal antibody can discriminate amongst IFNγ from various primates with greater specificity than can the human IFNγ receptor complex
-
587811
-
587811 A potent neutralizing monoclonal antibody can discriminate amongst IFNγ from various primates with greater specificity than can the human IFNγ receptor complex. Thakur AB, Landolfi NF MOL IMMUNOL 1999 36 15-16 1107-1115
-
(1999)
Mol. Immunol.
, vol.36
, Issue.15-16
, pp. 1107-1115
-
-
Thakur, A.B.1
Landolfi, N.F.2
-
43
-
-
0032903525
-
Comparison of the three-dimensional structures of a humanized and a chimeric Fab of an anti-γ-interferon antibody
-
587814
-
587814 Comparison of the three-dimensional structures of a humanized and a chimeric Fab of an anti-γ-interferon antibody. Fan ZC, Shan L, Goldsteen BZ, Guddat LW, Thakur A, Landolfi NF, Co MS, Vasquez M, Queen C, Ramsland PA, Edmundson AB J MOL RECOGNIT 1999 12 1 19-32
-
(1999)
J. Mol. Recognit.
, vol.12
, Issue.1
, pp. 19-32
-
-
Fan, Z.C.1
Shan, L.2
Goldsteen, B.Z.3
Guddat, L.W.4
Thakur, A.5
Landolfi, N.F.6
Co, M.S.7
Vasquez, M.8
Queen, C.9
Ramsland, P.A.10
Edmundson, A.B.11
-
44
-
-
16644376358
-
Three-dimensional structures of a humanized anti-IFNγ Fab (HuZAF) in two crystal forms
-
587821
-
587821 Three-dimensional structures of a humanized anti-IFNγ Fab (HuZAF) in two crystal forms. Bourne PC, Terzyan SS, Cloud G, Landolfi NF, Vasquez M, Edmundson AB ACTA CRYSTALLOGR D BIOL CRYSTALLOGR 2004 60 10 1761-1769
-
(2004)
Acta Crystallogr. D. Biol. Crystallogr.
, vol.60
, Issue.10
, pp. 1761-1769
-
-
Bourne, P.C.1
Terzyan, S.S.2
Cloud, G.3
Landolfi, N.F.4
Vasquez, M.5
Edmundson, A.B.6
-
45
-
-
0038341894
-
Antibody-mediated blockade of the CXCR3 chemokine receptor results in diminished recruitment of T helper 1 cells into sites of inflammation
-
587823
-
587823 Antibody-mediated blockade of the CXCR3 chemokine receptor results in diminished recruitment of T helper 1 cells into sites of inflammation. Xie JH, Nomura N, Lu M, Chen SL, Koch GE, Weng Y, Rosa R, Di Salvo J, Mudgett J, Peterson LB, Wicker LS, DeMartino JA J LEUKOCYTE BIOL 2003 73 6 771-780
-
(2003)
J. Leukocyte Biol.
, vol.73
, Issue.6
, pp. 771-780
-
-
Xie, J.H.1
Nomura, N.2
Lu, M.3
Chen, S.L.4
Koch, G.E.5
Weng, Y.6
Rosa, R.7
Di Salvo, J.8
Mudgett, J.9
Peterson, L.B.10
Wicker, L.S.11
DeMartino, J.A.12
-
46
-
-
0037018761
-
Maintenance infliximab for Crohn's disease: The ACCENT I randomised trial
-
587826 ACCENT I Study Group
-
587826 Maintenance infliximab for Crohn's disease: The ACCENT I randomised trial. Hanauer SB, Feagan BG, Lichtenstein GR, Mayer LF, Schreiber S, Colombel JF, Rachmilewitz D, Wolf DC, Olson A, Bao W, Rutgeerts P, ACCENT I Study Group LANCET 2002 359 9317 1541-1549
-
(2002)
Lancet
, vol.359
, Issue.9317
, pp. 1541-1549
-
-
Hanauer, S.B.1
Feagan, B.G.2
Lichtenstein, G.R.3
Mayer, L.F.4
Schreiber, S.5
Colombel, J.F.6
Rachmilewitz, D.7
Wolf, D.C.8
Olson, A.9
Bao, W.10
Rutgeerts, P.11
-
47
-
-
1842832738
-
Recent developments in the pharmacological treatment of Crohn's disease
-
587837
-
587837 Recent developments in the pharmacological treatment of Crohn's disease. Srinivasan R, Lichtenstein GR EXPERT OPIN INVESTIG DRUGS 2004 13 4 373-391
-
(2004)
Expert Opin. Investig. Drugs
, vol.13
, Issue.4
, pp. 373-391
-
-
Srinivasan, R.1
Lichtenstein, G.R.2
-
48
-
-
0037434552
-
Influence of immunogenicity on the long-term efficacy Of infliximab in Crohn's disease
-
587842
-
587842 Influence of immunogenicity on the long-term efficacy Of infliximab in Crohn's disease. Baert F, Noman M, Vermeire S, Van Assche G, D'Haens G, Carbonez A, Rutgeerts P N ENGL J MED 2003 348 7 601-608
-
(2003)
N. Engl. J. Med.
, vol.348
, Issue.7
, pp. 601-608
-
-
Baert, F.1
Noman, M.2
Vermeire, S.3
Van Assche, G.4
D'Haens, G.5
Carbonez, A.6
Rutgeerts, P.7
-
49
-
-
1542369183
-
Optimizing anti-tumor necrosis factor strategies in inflammatory bowel disease
-
587844
-
587844 Optimizing anti-tumor necrosis factor strategies in inflammatory bowel disease. Sandborn WJ CURR GASTROENTEROL REPORTS 2003 5 6 501-505
-
(2003)
Curr. Gastroenterol. Reports
, vol.5
, Issue.6
, pp. 501-505
-
-
Sandborn, W.J.1
-
50
-
-
10044276715
-
How future tumor necrosis factor antagonists and other compounds will meet the remaining challenges in Crohn's disease
-
587853
-
587853 How future tumor necrosis factor antagonists and other compounds will meet the remaining challenges in Crohn's disease. Sandbom WJ REV GASTROENTEROLOGICAL DISORDERS 2004 4 Suppl 3 S25-S33
-
(2004)
Rev. Gastroenterological Disorders
, vol.4
, Issue.SUPPL. 3
-
-
Sandbom, W.J.1
-
51
-
-
14844337460
-
Clinical implications of inflammatory bowel disease genetics on phenotype
-
587869
-
587869 Clinical implications of inflammatory bowel disease genetics on phenotype. Cummings JR, Jewell DP INFLAMM BOWEL DIS 2005 11 1 56-61
-
(2005)
Inflamm. Bowel Dis.
, vol.11
, Issue.1
, pp. 56-61
-
-
Cummings, J.R.1
Jewell, D.P.2
-
52
-
-
0345358584
-
The IL-12 family of heterodimeric cytokines: New players in the regulation of T cell responses
-
587872
-
587872 The IL-12 family of heterodimeric cytokines: New players in the regulation of T cell responses. Trinchieri G, Pflanz S, Kastelein RA IMMUNITY 2003 19 5 641-644
-
(2003)
Immunity
, vol.19
, Issue.5
, pp. 641-644
-
-
Trinchieri, G.1
Pflanz, S.2
Kastelein, R.A.3
-
53
-
-
13244283212
-
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
-
587873
-
587873 IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. Langrish CL, Chen Y, Blumenschein WM, Mattson J, Basham B, Sedgwick JD, McClanahan T, Kastelein RA, Cua DJ J EXP MED 2005 201 2 233-240
-
(2005)
J. Exp. Med.
, vol.201
, Issue.2
, pp. 233-240
-
-
Langrish, C.L.1
Chen, Y.2
Blumenschein, W.M.3
Mattson, J.4
Basham, B.5
Sedgwick, J.D.6
McClanahan, T.7
Kastelein, R.A.8
Cua, D.J.9
-
54
-
-
0036434844
-
Paradoxical roqles of IFNγ in models of Th1-mediated autoimmunity
-
587874
-
587874 Paradoxical roqles of IFNγ in models of Th1-mediated autoimmunity. Rosloniec EF, Latham K, Guedez YB ARTHRITIS RES 2002 4 6 333-336
-
(2002)
Arthritis Res.
, vol.4
, Issue.6
, pp. 333-336
-
-
Rosloniec, E.F.1
Latham, K.2
Guedez, Y.B.3
-
55
-
-
1842782996
-
Anti-inflammatory properties of pro-inflammatory interferon-γ
-
587878
-
587878 Anti-inflammatory properties of pro-inflammatory interferon-γ. Muhl H, Pfeilschifter J INT IMMUNOPHARMACOL 2003 3 9 1247-1255
-
(2003)
Int. Immunopharmacol.
, vol.3
, Issue.9
, pp. 1247-1255
-
-
Muhl, H.1
Pfeilschifter, J.2
-
56
-
-
9644252669
-
New cytokine therapeutics for inflammatory bowel disease
-
587880
-
587878 New cytokine therapeutics for inflammatory bowel disease. Stokkers PC, Hommes DW CYTOKINE 2004 28 4-5 167-173
-
(2004)
Cytokine
, vol.28
, Issue.4-5
, pp. 167-173
-
-
Stokkers, P.C.1
Hommes, D.W.2
-
57
-
-
0041845066
-
Inhibition of IFNγ-inducible proteIn-10 abrogates colitis in IL-10-/-mice
-
587881
-
587881 Inhibition of IFNγ-inducible proteIn-10 abrogates colitis in IL-10-/-mice. Singh UP, Singh S, Taub DD, Lillard JW Jr J IMMUNOL 2003 171 3 1401-1406
-
(2003)
J. Immunol.
, vol.171
, Issue.3
, pp. 1401-1406
-
-
Singh, U.P.1
Singh, S.2
Taub, D.D.3
Lillard Jr., J.W.4
-
58
-
-
8744283162
-
Fontolizumab (HuZAF), a humanized anti-IFNγ antibody, has clinical activity and excellent tolerability in moderate to severe Crohn's disease
-
589547 Abs Late 5
-
589547 Fontolizumab (HuZAF), a humanized anti-IFNγ antibody, has clinical activity and excellent tolerability in moderate to severe Crohn's disease. Hommes D, Mikhajlova T, Stoinov S, Stimac D, Vucelic B, Lonovics J, Zakuiova M, D'Haens G, Van Asche G, Pearce T GASTROENTEROLOGY 2004 127 4 Suppl 2 Abs Late 5
-
(2004)
Gastroenterology
, vol.127
, Issue.4 SUPPL. 2
-
-
Hommes, D.1
Mikhajlova, T.2
Stoinov, S.3
Stimac, D.4
Vucelic, B.5
Lonovics, J.6
Zakuiova, M.7
D'Haens, G.8
Van Asche, G.9
Pearce, T.10
-
59
-
-
18144400844
-
-
589575 PDL announces webcast of R&D update at 8:00AM Eastern Time, October 15. Protein Design Labs Inc PRESS RELEASE October 11
-
589575 PDL announces webcast of R&D update at 8:00AM Eastern Time, October 15. Protein Design Labs Inc PRESS RELEASE 2004 October 11
-
(2004)
-
-
-
60
-
-
0038109994
-
Autoimmunity associated with anti-tumor necrosis factor α treatment in Crohn's disease: A prospective cohort study
-
589588
-
589588 Autoimmunity associated with anti-tumor necrosis factor α treatment in Crohn's disease: A prospective cohort study. Vermeire S, Noman M, Van Assche G, Baert F, Van Steen K, Esters N, Joossens S, Bossuyt X, Rutgeerts P GASTROENTEROLOGY 2003 125 1 32-39
-
(2003)
Gastroenterology
, vol.125
, Issue.1
, pp. 32-39
-
-
Vermeire, S.1
Noman, M.2
Van Assche, G.3
Baert, F.4
Van Steen, K.5
Esters, N.6
Joossens, S.7
Bossuyt, X.8
Rutgeerts, P.9
-
61
-
-
18144407537
-
Protein Design Labs - Product development pipeline
-
589815 Protein Design Labs Inc COMPANY WORLD WIDE WEB SITE March 15
-
589815 Protein Design Labs - product development pipeline. Protein Design Labs Inc COMPANY WORLD WIDE WEB SITE 2005 March 15
-
(2005)
-
-
-
62
-
-
18144377668
-
Elan and Biogen Idec announce TYSABRI update
-
592477 Elan Corp plc PRESS RELEASE March 30
-
592477 Elan and Biogen Idec announce TYSABRI update. Elan Corp plc PRESS RELEASE 2005 March 30
-
(2005)
-
-
-
63
-
-
0032530697
-
IL-12, but not IFNγ, plays a major role in sustaining the chronic phase of colitis in IL-10-deficient mice
-
592581
-
592581 IL-12, but not IFNγ, plays a major role in sustaining the chronic phase of colitis in IL-10-deficient mice. Davidson NJ, Hudak SA, Lesley RE, Menon S, Leach MW, Rennick DM J IMMUNOL 1998 161 6 3143-3149
-
(1998)
J. Immunol.
, vol.161
, Issue.6
, pp. 3143-3149
-
-
Davidson, N.J.1
Hudak, S.A.2
Lesley, R.E.3
Menon, S.4
Leach, M.W.5
Rennick, D.M.6
-
64
-
-
0034033440
-
Hapten-induced colitis associated with maintained Th1 and inflammatory responses in IFNγ receptor-deficient mice
-
592584
-
592584 Hapten-induced colitis associated with maintained Th1 and inflammatory responses in IFNγ receptor-deficient mice. Camoglio L, te Velde AA, de Boer A, ten Kate FJ, Kopf M, van Deventer SJ EUR J IMMUNOL 2000 30 5 1486-1495
-
(2000)
Eur. J. Immunol.
, vol.30
, Issue.5
, pp. 1486-1495
-
-
Camoglio, L.1
te Velde, A.A.2
de Boer, A.3
ten Kate, F.J.4
Kopf, M.5
van Deventer, S.J.6
-
65
-
-
0038054271
-
Evidence for the critical role of interleukin-12 but not interferon-γ in the pathogenesis of experimental colitis in mice
-
592585
-
592585 Evidence for the critical role of interleukin-12 but not interferon-γ in the pathogenesis of experimental colitis in mice. Tozawa K, Hanai H, Sugimoto K, Baba S, Sugimura H, Aoshi T, Uchijima M, Nagata T, Koide Y J GASTROENTEROL HEPATOL 2003 18 5 578-587
-
(2003)
J. Gastroenterol. Hepatol.
, vol.18
, Issue.5
, pp. 578-587
-
-
Tozawa, K.1
Hanai, H.2
Sugimoto, K.3
Baba, S.4
Sugimura, H.5
Aoshi, T.6
Uchijima, M.7
Nagata, T.8
Koide, Y.9
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