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Volumn 40, Issue 3, 1997, Pages 320-327

CD4 antibody treatment in patients with active Crohn's disease: A phase 1 dose finding study

Author keywords

Crohn's disease; inflammatory bowel disease; monoclonal antibody treatment; T cells

Indexed keywords

CD4 ANTIGEN; CYTOKINE; MONOCLONAL ANTIBODY;

EID: 0030989417     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.40.3.320     Document Type: Article
Times cited : (110)

References (31)
  • 1
    • 0026575932 scopus 로고
    • The mechanism of action of cyclosporin a and FK506
    • Schreiber SL, Crabtree CR. The mechanism of action of cyclosporin A and FK506. Immunol Today 1992; 13: 136-42.
    • (1992) Immunol Today , vol.13 , pp. 136-142
    • Schreiber, S.L.1    Crabtree, C.R.2
  • 2
    • 0024429141 scopus 로고
    • A placebo-controlled, double-blind, randomized trial of cyclosporine therapy in active chronic Crohn's disease
    • Brynskov J, Freund L, Rasmussen SN, Lauritsen K, Schaffalitzky de Muckadell O, Williams N, et al. A placebo-controlled, double-blind, randomized trial of cyclosporine therapy in active chronic Crohn's disease. N Engl J Med 1989; 321: 845-50.
    • (1989) N Engl J Med , vol.321 , pp. 845-850
    • Brynskov, J.1    Freund, L.2    Rasmussen, S.N.3    Lauritsen, K.4    Schaffalitzky De Muckadell, O.W.N.5
  • 4
    • 0023696551 scopus 로고
    • CD4 positive Leu-8 negative helper-inducer T-cells predominate in the human intestinal lamina propria
    • Konoff ME, Strober W, Fiochi C, Zeitz M, James SP. CD4 positive Leu-8 negative helper-inducer T-cells predominate in the human intestinal lamina propria. J Immunol 1988; 14: 3029-36.
    • (1988) J Immunol , vol.14 , pp. 3029-3036
    • Konoff, M.E.1    Strober, W.2    Fiochi, C.3    Zeitz, M.4    James, S.P.5
  • 5
    • 0025615020 scopus 로고
    • Differential expression of CD25 (interleukin-2 receptor) on lamina propria T cells and macrophages in the intestinal lesions in Crohn's disease and ulcerative colitis
    • Choy MY, Walker-Smith JA, Williams CB, MacDonald TT. Differential expression of CD25 (interleukin-2 receptor) on lamina propria T cells and macrophages in the intestinal lesions in Crohn's disease and ulcerative colitis. Gut 1990; 31: 1365-70.
    • (1990) Gut , vol.31 , pp. 1365-1370
    • Choy, M.Y.1    Walker-Smith, J.A.2    Williams, C.B.3    MacDonald, T.T.4
  • 6
    • 0024260960 scopus 로고
    • Remission of Crohn's disease after human immunodeficiency virus infection
    • James SP. Remission of Crohn's disease after human immunodeficiency virus infection. Gastroenterology 1988; 95: 1667-69.
    • (1988) Gastroenterology , vol.95 , pp. 1667-1669
    • James, S.P.1
  • 7
    • 0023278475 scopus 로고
    • Reversal of advanced murine lupus in NZB/NZW F1 mice by treatment with monoclonal antibody to L3T4
    • Wofsy D, Seaman WE. Reversal of advanced murine lupus in NZB/NZW F1 mice by treatment with monoclonal antibody to L3T4. J Immunol 1987; 138: 3247-53.
    • (1987) J Immunol , vol.138 , pp. 3247-3253
    • Wofsy, D.1    Seaman, W.E.2
  • 8
    • 0022627666 scopus 로고
    • Immunotherapy for myasthenia gravis: A murine model
    • Christadoss P, Dauphinee MJ. Immunotherapy for myasthenia gravis: a murine model. J Immunol 1986; 136: 2437-40.
    • (1986) J Immunol , vol.136 , pp. 2437-2440
    • Christadoss, P.1    Dauphinee, M.J.2
  • 9
    • 43949169353 scopus 로고
    • Distinct roles for CD4 and CD8 as co-receptors in antigen receptor signaling
    • Julius M, Maroun CR, Haughn L. Distinct roles for CD4 and CD8 as co-receptors in antigen receptor signaling. Immunol Today 1993; 14: 177-87.
    • (1993) Immunol Today , vol.14 , pp. 177-187
    • Julius, M.1    Maroun, C.R.2    Haughn, L.3
  • 11
    • 0024356033 scopus 로고
    • Development and validation of an endoscopic index of the severity for Crohn's disease: A prospective multicentre study
    • Mary JY, Modigliani R, GETAID. Development and validation of an endoscopic index of the severity for Crohn's disease: a prospective multicentre study. Gut 1989; 30: 983-9.
    • (1989) Gut , vol.30 , pp. 983-989
    • Mary, J.Y.1    Modigliani, R.2
  • 13
    • 0027503243 scopus 로고
    • Use of a chimeric monoclonal anti-CD4 antibody in patients with refractory rheumatoid arthritis
    • Moreland LW, Bucy RP, Tilden A, Pratt PW, Lobuglio AF, Khazaeli M, et al. Use of a chimeric monoclonal anti-CD4 antibody in patients with refractory rheumatoid arthritis. Arthritis Rheum 1993; 36: 307-18.
    • (1993) Arthritis Rheum , vol.36 , pp. 307-318
    • Moreland, L.W.1    Bucy, R.P.2    Tilden, A.3    Pratt, P.W.4    Lobuglio, A.F.5    Khazaeli, M.6
  • 15
    • 0023903440 scopus 로고
    • Determination of the functional affinity of IgG1 and IgG4 antibodies to tetanus toxoid by isotype-specific solid-phase assays
    • Devey ME, Bleasdale K, Lee S, Rath S. Determination of the functional affinity of IgG1 and IgG4 antibodies to tetanus toxoid by isotype-specific solid-phase assays. J Immunol Methods 1988; 106: 119-25.
    • (1988) J Immunol Methods , vol.106 , pp. 119-125
    • Devey, M.E.1    Bleasdale, K.2    Lee, S.3    Rath, S.4
  • 16
    • 0025740571 scopus 로고
    • Evidence for different effects of soluble TNF-receptors on various TNF measurements in human biological fluids
    • Engelberts I, Stephens S, Francot GJM, van der Linden CJ, Buurman WA. Evidence for different effects of soluble TNF-receptors on various TNF measurements in human biological fluids. Lancet 1991; 338: 512.
    • (1991) Lancet , vol.338 , pp. 512
    • Engelberts, I.1    Stephens, S.2    Francot, G.J.M.3    Van Der Linden, C.J.4    Buurman, W.A.5
  • 18
    • 0025845509 scopus 로고
    • Sensitive ELISA for interleukin-6. Detection of IL-6 in biological fluids: Synovial fluids and sera
    • Helle M, Boeije L, de Groot E, de Vos A, Aarden L. Sensitive ELISA for interleukin-6. Detection of IL-6 in biological fluids: synovial fluids and sera. J Immunol Methods 1991; 138: 47-56.
    • (1991) J Immunol Methods , vol.138 , pp. 47-56
    • Helle, M.1    Boeije, L.2    De Groot, E.3    De Vos, A.4    Aarden, L.5
  • 20
    • 0027093377 scopus 로고
    • Treatment of rheumatoid arthritis with anti-CD4 monoclonal antibody. Open study of 25 patients with the B-F5 clone
    • Wendling D, Racadot E, Morel-Fourrier B, Wijdenes J. Treatment of rheumatoid arthritis with anti-CD4 monoclonal antibody. Open study of 25 patients with the B-F5 clone. Clin Rheumatol 1992; 11: 542-7.
    • (1992) Clin Rheumatol , vol.11 , pp. 542-547
    • Wendling, D.1    Racadot, E.2    Morel-Fourrier, B.3    Wijdenes, J.4
  • 21
    • 0024746393 scopus 로고
    • Anti-CD4 antibody treatment of patients with rheumatoid arthritis: I. Effect on clinical course and circulating T cells
    • Herzog C, Walker C, Müller W, Rieber P, Reiter C, Rietmüller G, et al. Anti-CD4 antibody treatment of patients with rheumatoid arthritis: I. Effect on clinical course and circulating T cells. J Autoimmunity 1989; 2: 627-12.
    • (1989) J Autoimmunity , vol.2 , pp. 627-712
    • Herzog, C.1    Walker, C.2    Müller, W.3    Rieber, P.4    Reiter, C.5    Rietmüller, G.6
  • 22
    • 0027280781 scopus 로고
    • Treatment with anti-CD4 monoclonal antibody and acute interstitial nephritis
    • Choy EH, Kingsley GH, Panayi GS. Treatment with anti-CD4 monoclonal antibody and acute interstitial nephritis. Arthritis Rheum 1993; 36: 723-4.
    • (1993) Arthritis Rheum , vol.36 , pp. 723-724
    • Choy, E.H.1    Kingsley, G.H.2    Panayi, G.S.3
  • 23
    • 0026656620 scopus 로고
    • Treatment of rheumatoid arthritis with single dose or weekly pulses of chimeric anti-CD4 monoclonal antibody
    • Choy EH, Chikanza IC, Kingsley GH, Corrigall V, Panayi GS. Treatment of rheumatoid arthritis with single dose or weekly pulses of chimeric anti-CD4 monoclonal antibody. Scand J Immunol 1992; 36: 291-8.
    • (1992) Scand J Immunol , vol.36 , pp. 291-298
    • Choy, E.H.1    Chikanza, I.C.2    Kingsley, G.H.3    Corrigall, V.4    Panayi, G.S.5
  • 24
    • 0026656809 scopus 로고
    • Downregulation of lymphocyte CD4 antigen expression by administration of anti-CD4 monoclonal antibodies
    • Morel P, Nicolas JF, Wijdenes J, Revillard JP. Downregulation of lymphocyte CD4 antigen expression by administration of anti-CD4 monoclonal antibodies. Clin Immunol Immunopathol 1992; 64: 248-53.
    • (1992) Clin Immunol Immunopathol , vol.64 , pp. 248-253
    • Morel, P.1    Nicolas, J.F.2    Wijdenes, J.3    Revillard, J.P.4
  • 26
    • 0028271154 scopus 로고
    • Treatment of rheumatoid arthritis with a chimeric CD4 monoclonal antibody (cM-T412): Immunopharmacological aspects and mechanisms of action
    • Van der Lubbe PA, Reiter C, Miltenburg AM, Kruger K, De Ruyter AN, Rieber EP, et al. Treatment of rheumatoid arthritis with a chimeric CD4 monoclonal antibody (cM-T412): immunopharmacological aspects and mechanisms of action. Scand J Immunol 1994; 39: 286-94.
    • (1994) Scand J Immunol , vol.39 , pp. 286-294
    • Van Der Lubbe, P.A.1    Reiter, C.2    Miltenburg, A.M.3    Kruger, K.4    De Ruyter, A.N.5    Rieber, E.P.6
  • 27
    • 0027175408 scopus 로고
    • Complement activation following first dose of OKT3 induces pulmonary sequestration of granulocytes: An explanation for respiratory side effects
    • Raasveld MHM, Bemelman FJ, Schellekens PThA, van Diepen FNJ, van Dongen A, van Royen EA, et al. Complement activation following first dose of OKT3 induces pulmonary sequestration of granulocytes: an explanation for respiratory side effects. Kidney Int 1993; 43: 1140-9.
    • (1993) Kidney Int , vol.43 , pp. 1140-1149
    • Raasveld, M.H.M.1    Bemelman, F.J.2    Schellekens, P.Th.A.3    Van Diepen, F.N.J.4    Van Dongen, A.5    Van Royen, E.A.6
  • 28
    • 0001656346 scopus 로고
    • Chimeric monoclonal anti-CD4 antibody therapy proves effective for inflammatory bowel disease
    • Deusch K, Reiter C, Mauthe B, Rietmüller G. Chimeric monoclonal anti-CD4 antibody therapy proves effective for inflammatory bowel disease [abstract]. Gastroenterology 1992; 102: A615.
    • (1992) Gastroenterology , vol.102
    • Deusch, K.1    Reiter, C.2    Mauthe, B.3    Rietmüller, G.4
  • 29
    • 0028179230 scopus 로고
    • Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity
    • Powrie F, Correa-Oliveira R, Mauze S, Coffman RL. Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity. J Exp Med 1994; 179: 589-600.
    • (1994) J Exp Med , vol.179 , pp. 589-600
    • Powrie, F.1    Correa-Oliveira, R.2    Mauze, S.3    Coffman, R.L.4
  • 30
    • 0022384860 scopus 로고
    • Inhibition of humoral immunity in vivo by monoclonal antibody to L3T4: Studies with soluble antigens in intact mice
    • Wofsy D, Mayes DC, Woodcock J, Seaman WE. Inhibition of humoral immunity in vivo by monoclonal antibody to L3T4: studies with soluble antigens in intact mice. J Immunol 1985; 135: 1698-701.
    • (1985) J Immunol , vol.135 , pp. 1698-1701
    • Wofsy, D.1    Mayes, D.C.2    Woodcock, J.3    Seaman, W.E.4
  • 31
    • 0022461975 scopus 로고
    • Long-term humoral unresponsiveness in vivo induced by treatment with monoclonal antibodies against L3T4
    • Gorozny J, Weyand CM, Fathman CG. Long-term humoral unresponsiveness in vivo induced by treatment with monoclonal antibodies against L3T4. J Exp Med 1986; 164: 911-25.
    • (1986) J Exp Med , vol.164 , pp. 911-925
    • Gorozny, J.1    Weyand, C.M.2    Fathman, C.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.