Sodium valproate for painful diabetic neuropathy: A randomized double-blind placebo-controlled study

QJM: An International Journal of Medicine

Volumn 97, Issue 1, 2004, Pages 33-38

  Kochar, D K ^a,b   Rawat, N ^a   Agrawal, R P ^a   Vyas, A ^a   Beniwal, R ^a   Kochar, S K ^a   Garg, P ^a  

^a S P MEDICAL COLLEGE   (India)

^b NONE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALDOSE REDUCTASE INHIBITOR; ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; ASPARTATE AMINOTRANSFERASE; BACLOFEN; CAPSAICIN; CLONAZEPAM; GABAPENTIN; GAMMA LINOLENIC ACID; HEMOGLOBIN A1C; LAMOTRIGINE; LIDOCAINE; MEXILETINE; NERVE GROWTH FACTOR; NONSTEROID ANTIINFLAMMATORY AGENT; PLACEBO; VALPROIC ACID;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; ATAXIA; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIABETIC NEUROPATHY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; ELECTROPHYSIOLOGY; FEMALE; HUMAN; INFORMED CONSENT; LIVER FUNCTION TEST; MALE; MOTOR NERVE CONDUCTION; NAUSEA; NERVE CONDUCTION; NON INSULIN DEPENDENT DIABETES MELLITUS; NYSTAGMUS; PAIN ASSESSMENT; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SENSORY NERVE CONDUCTION; SIDE EFFECT; TABLET FORMULATION; VISUAL ANALOG SCALE; VOMITING;

EID: 1042269461     PISSN: 14602725     EISSN: None     Source Type: Journal    
DOI: 10.1093/qjmed/hch007     Document Type: Article

References (25)

1. Boulton AJM, Gries FA, Jervell J. Guidelines for the diagnosis and out patient management of diabetic peripheral neuropathy. Diabet Med 1998; 15:917-31.
2. Gallai V, Firenze C, Mazzotta G, Delegatto S. Neuropathy in children and adolescence with diabetes mellitus. Acta Neurol Scand 1988; 78:136-40.
3. Pirart J. Diabetes mellitus and its degenerative complications: a prospective study of 4400 patient observed between 1947 and 1973. Diabetes Care 1978; 1:168-88.
4. Partanen J, Niskanen L, Lehtinen J, et al. Natural history of peripheral neuropathy in patient with non-insulin dependent diabetes mellitus. N Engl J Med 1995; 333:89-94.
5. Fedele D, Comi G, Coscelli C, et al. A multicentre study on the prevalence of diabetic neuropathy in Italy. Diabetes Care 1997; 20:836-43.
6. Benbow S, Mac Farlane IA, William G. Painful diabetic neuropathy and its relationships to other painful neurogenic conditions. Pract Diabetes 1992; 9:62-5.
7. Boulton AJM, Knight G, Drury J, et al. The prevalence of symptomatic, diabetic neuropathy in an insulin treated population. Diabetes Care 1985; 8:125-8.
8. Low PA, Dotso RR: Symptomatic treatment of painful neuropathy (editorial). JAMA 1998; 280:1863.
9. Max MB, Culnane M, Schafer SC, et al. Amitriptyline relieves diabetic neuropathy pain in patients with normal or depressed mood. Neurology 1987; 37:589.
10. McQuay H, Carroll D, Jadad AR, Wiffen P, Moore A. Anticonvulsant drugs for management of pain: a systematic review. Br Med J 1995; 311:1047-52.
11. Kochar DK, Jain N, Agarwal RP, Srivastava T, Agarwal P, Gupta S. Sodium valproate in the management of painful neuropathy in type-2 diabetes - a randomized placebo control study. Acta Neurol Scand 2002; 106:248-52.
12. Ellenberg M. Treatment of diabetic neuropathy with diphenylhydantoin. NY State Med J 1968; 68:2653.
13. Saudek CD, Werns S, Reidenbert MM. Phenytoin in the treatment of lancinating pain. A comparison. Anaesthesia 1981; 36:1129.
14. Rull JA, Quibrera R, Gonzalez Millan H, et al. Symptomatic treatment of peripheral diabetic neuropathy with carbamazepine (Tegretol): Double blind crossover trial. Daibetologia 1969; 5:215.
15. Wilton TD. Tegretol in the treatment of diabetic neuropathy. S Afr Med J 19 74; 48:869.
16. Chakarbarti AK, Samantary SK. Diabetic peripheral neuropathy. Nerve conduction studies before, during and after carbamazepine therapy. Austral NZ Med 1976; 6:565.
17. Capsaicin Study Group. Effect of treatment with capsaicin on daily activities of patients with painful diabetic neuropathy. Diabetes Care 1992; 15:159.
18. Boulton AJM, Levin S, Comstock J. A multicentre trial of the alclose reductase inhibitor tolerastat in patients with symptomatic neuropathy. Diabetologia 1990; 33:431.
19. Crepaldi G, Fedele D, Tiengo A, et al. Ganglioside treatment in diabetic peripheral neuropathy: a multicenter trial. Acta Diabetol Lat 1983; 10:265.
20. Dejgard A, Petersen P, Kastrup J. Mexiletine for treatment of chronic painful diabetic neuropathy. Lancet 1988; 1:9.
21. Dyck PJ. Nerve growth factor and diabetic neuropathy. Lancet 1996; 348:1044-5.
22. Tandan R, Lewis GA, Krusinski PB. Topical capsaicin in painful diabetic neuropathy. Diabetes Care 1992; 15:8.
23. Backonja M, Beydown A, Edwards KR, et al. Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabtic mellitus. JAMA 1998; 280:1831-6.
24. Cutrer FM, Limmeroth V, Moskowitz MA. Possible mechanisms of valproate in migraine prophylaxis. Cephalalgia 1997; 17:93-100.
25. Chong MS, Smith TE, Hanna M. Anticonvulsants for the management of Pain. Euro Pain J 2002; 2:5-18.