Valproic acid inhibits adhesion of vincristine- and cisplatin-resistant neuroblastoma tumour cells to endothelium

British Journal of Cancer

Volumn 96, Issue 11, 2007, Pages 1699-1706

  Blaheta, R A ^a   Michaelis, M ^a   Natsheh, I ^a   Hasenberg, C ^a   Weich, E ^a   Relja, B ^a   Jonas, D ^a   Doerr, H W ^a   Cinatl Jr , J ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

Adhesion; Chemoresistance; NCAM; Neuroblastoma; Valproic acid

Indexed keywords

CISPLATIN; DOXORUBICIN; ISOPROTEIN; NERVE CELL ADHESION MOLECULE; ONCOPROTEIN; PROTEIN P73; RNA; VALPROIC ACID; VINCRISTINE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CANCER RESISTANCE; CELL ADHESION; CONTROLLED STUDY; DOWN REGULATION; DRUG RESPONSE; ENDOTHELIUM; HUMAN; HUMAN CELL; IN VITRO STUDY; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTIGENS, SURFACE; ANTINEOPLASTIC AGENTS; CELL ADHESION; CISPLATIN; DRUG RESISTANCE, NEOPLASM; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASM INVASIVENESS; NEURAL CELL ADHESION MOLECULES; NEUROBLASTOMA; RNA, MESSENGER; TUMOR CELLS, CULTURED; VALPROIC ACID; VINCRISTINE;

EID: 34249796391     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6603777     Document Type: Article

References (37)

1. Akeson R, Bernards R (1990) N-myc down regulates neural cell adhesion molecule expression in rat neuroblastoma. Mol Cell Biol 10: 2012-2016
2. Armstrong MB, Bian X, Liu Y, Subramanian C, Ratanaproeksa AB, Shao F, Yu VC, Kwok RP, Opipari Jr AW, Castle VP (2006) Signaling from p53 to NF-kappaB determines the chemotherapy responsiveness of neuroblastoma. Neoplasia 8: 967-977
3. Blaheta RA, Kronenberger B, Woitaschek D, Weber S, Scholz M, Schuldes H, Encke A, Markus BH (1998) Development of an ultrasensitive in vitro assay to monitor growth of primary cell cultures with reduced mitotic activity. J Immunol Methods 211: 159-169
4. Blaheta RA, Hundemer M, Mayer G, Vogel JU, Kornhuber B, Cinatl J, Markus BH, Driever PH, Cinatl Jr J (2002) Expression level of neural cell adhesion molecule (NCAM) inversely correlates with the ability of neuroblastoma cells to adhere to endothelium in vitro. Cell Commun Adhes 9: 131-147
5. Blaheta RA, Beecken WD, Engl T, Jonas D, Oppermann E, Hundemer M, Doerr HW, Scholz M, Cinatl J (2004) Human cytomegalovirus infection of tumor cells downregulates NCAM (CD56): a novel mechanism for virus-induced tumor invasiveness. Neoplasia 6: 323-331
6. Blaheta RA, Michaelis M, Driever PH, Cinatl Jr J (2005) Evolving anticancer drug valproic acid: insights into the mechanism and clinical studies. Med Res Rev 25: 383-397
7. Castro-Galache MD, Ferragut JA, Barbera VM, Martin-Orozco E, Gonzalez-Ros JM, Garcia-Morales P, Saceda M (2003) Susceptibility of multidrug resistance tumor cells to apoptosis induction by histone deacetylase inhibitors. Int J Cancer 104: 579-586
8. Cavallaro U, Niedermeyer J, Fuxa M, Christofori G (2001) N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling. Nat Cell Biol 3: 650-657
9. Cinatl Jr J, Cinatl J, Scholz M, Driever PH, Henrich D, Kabickova H, Vogel JU, Doerr HW, Kornhuber B (1996) Antitumor activity of sodium valproate in cultures of human neuroblastoma cells. Anticancer Drugs 7: 766-773
10. De Laurenzi V, Raschella G, Barcaroli D, Annicchiarico-Petruzzelli M, Ranalli M, Catani MV, Tanno B, Costanzo A, Levrero M, Melino G (2000) Induction of neuronal differentiation by p73 in a neuroblastoma cell line. J Biol Chem 275: 15226-15231
11. Driever PH, Wagner S, Hofstadter F, Wolff JE (2004) Valproic acid induces differentiation of a supratentorial primitive neuroectodermal tumor. Pediatr Hematol Oncol 21: 743-751
12. Edvardsen K, Pedersen P-H, Bjerkvig R, Hermann GG, Zeuthen J, Laerum OD, Walsh FS, Bock E (1994) Transfection of glioma cells with the neural-cell adhesion molecule NCAM: effect on glioma cell invasion and growth in vivo. Int J Cancer 58: 116-122
13. Hirokawa Y, Arnold M, Nakajima H, Zalcberg J, Maruta H (2005) Signal therapy of breast cancers by the HDAC inhibitor FK228 that blocks the activation of PAK1 and abrogates the tamoxifen-resistance. Cancer Biol Ther 4: 956-960
14. Huerta S, Srivatsan ES, Venkatesan N, Peters J, Moatamed F, Renner S, Livingston EH (2001) Alternative mRNA splicing in colon cancer causes loss of expression of neural cell adhesion molecule. Surgery 130: 834-843
15. Keshelava N, Seeger RC, Groshen S, Reynolds CP (1998) Drug resistance patterns of human neuroblastoma cell lines derived from patients at different phases of therapy. Cancer Res 58: 5396-5405
16. Kleinschmidt-DeMasters BK, Orr EA, Savelieva E, Owens GC, Kruse CA (1999) Paucity of retinoic acid receptor alpha (RAR alpha) nuclear immunostaining in gliomas and inability of retinoic acid to influence neural cell adhesion molecule (NCAM) expression. J Neurooncol 41: 31-42
17. Kotchetkov R, Cinatl J, Blaheta R, Vogel JU, Karaskova J, Squire J, Hernaiz Driever P, Klingebiel T, Cinatl Jr J (2003) Development of resistance to vincristine and doxorubicin in neuroblastoma alters malignant properties and induces additional karyotype changes: a preclinical model. Int J Cancer 104: 36-43
18. Kotchetkov R, Driever PH, Cinatl J, Michaelis M, Karaskova J, Blaheta R, Squire JA, Von Deimling A, Moog J, Cinatl Jr J (2005) Increased malignant behavior in neuroblastoma cells with acquired multi-drug resistance does not depend on P-gp expression. Int J Oncol 27: 1029-1037
19. Maiso P, Carvajal-Vergara X, Ocio EM, Lopez-Perez R, Mateo G, Gutierrez N, Atadja P, Pandiella A, San Miguel JF (2006) The histone deacetylase inhibitor LBH589 is a potent antimyeloma agent that overcomes drug resistance. Cancer Res 66: 5781-5789
20. Mattingly RR, Milstein ML, Mirkin BL (2001) Down-regulation of growth factor-stimulated MAP kinase signaling in cytotoxic drug-resistant human neuroblastoma cells. Cell Signal 13: 499-505
21. Okada T, Tanaka K, Nakatani F, Sakimura R, Matsunobu T, Li X, Hanada M, Nakamura T, Oda Y, Tsuneyoshi M, Iwamoto Y (2006) Involvement of P-glycoprotein and MRP1 in resistance to cyclic tetrapeptide subfamily of histone deacetylase inhibitors in the drug-resistant osteosarcoma and Ewing's sarcoma cells. Int J Cancer 118: 90-97
22. Owens GC, Orr EA, DeMasters BK, Muschel RJ, Berens ME, Kruse CA (1998) Overexpression of a transmembrane isoform of neural cell adhesion molecule alters the invasiveness of rat CNS-1 glioma. Cancer Res 58: 2020-2028
23. Pathil A, Armeanu S, Venturelli S, Mascagni P, Weiss TS, Gregor M, Lauer UM, Bitzer M (2006) HDAC inhibitor treatment of hepatoma cells induces both TRAIL-independent apoptosis and restoration of sensitivity to TRAIL. Hepatology 43: 425-434
24. Perl AK, Dahl U, Wilgenbus P, Cremer H, Semb H, Christofori G (1999) Reduced expression of neural cell adhesion molecule induces metastatic dissemination of pancreatic beta tumor cells. Nat Med 5: 286-291
25. Prag S, Lepekhin EA, Kolkova K, Hartmann-Petersen R, Kawa A, Walmod PS, Belman V, Gallagher HC, Berezin V, Bock E, Pedersen N (2002) NCAM regulates cell motility. J Cell Sci 115: 283-292
26. Reynolds CP, Biedler JL, Spengler BA, Reynolds DA, Ross RA, Frenkel EP, Smith RG (1986) Characterization of human neuroblastoma cell lines established before and after therapy. J Natl Cancer Inst 76: 375-387
27. Roesler J, Srivatsan E, Moatamed F, Peters J, Livingston EH (1997) Tumor suppressor activity of neural cell adhesion molecule in colon carcinoma. Am J Surg 174: 251-257
28. Ruefli AA, Bernhard D, Tainton KM, Kofler R, Smyth MJ, Johnstone RW (2002) Suberoylanilide hydroxamic acid (SAHA) overcomes multidrug resistance and induces cell death in P-glycoprotein-expressing cells. Int J Cancer 99: 292-298
29. Sampson-Johannes A, Wang W, Shtivelman E (1996) Colonization of human lung grafts in SCID-hu mice by human colon carcinoma cells. Int J Cancer 65: 864-869
30. Schuchmann M, Schulze-Bergkamen H, Fleischer B, Schattenberg JM, Siebler J, Weinmann A, Teufel A, Worns M, Fischer T, Strand S, Lohse AW, Galle PR (2006) Histone deacetylase inhibition by valproic acid down-regulates c-FLIP/CASH and sensitizes hepatoma cells towards CD95- and TRAIL receptor-mediated apoptosis and chemotherapy. Oncol Rep 15: 227-230
31. Servidei T, Riccardi A, Sanguinetti M, Dominici C, Riccardi R (2006) Increased sensitivity to the platelet-derived growth factor (PDGF) receptor inhibitor STI571 in chemoresistant glioma cells is associated with enhanced PDGF-BB-mediated signaling and STI571-induced Akt inactivation. J Cell Physiol 208: 220-228
32. Sonnemann J, Gange J, Pilz S, Stotzer C, Ohlinger R, Belau A, Lorenz G, Beck JF (2006) Comparative evaluation of the treatment efficacy of suberoylanilide hydroxamic acid (SAHA) and paclitaxel in ovarian cancer cell lines and primary ovarian cancer cells from patients. BMC Cancer 6: 183
33. Tabe Y, Konopleva M, Contractor R, Munsell M, Schober WD, Jin L, Tsutsumi-Ishii Y, Nagaoka I, Igari J, Andreeff M (2006) Up-regulation of MDR1 and induction of doxorubicin resistance by histone deacetylase inhibitor depsipeptide (FK228) and ATRA in acute promyelocytic leukemia cells. Blood 107: 1546-1554
34. Tang R, Faussat AM, Majdak P, Perrot JY, Chaoui D, Legrand O, Marie JP (2004) Valproic acid inhibits proliferation and induces apoptosis in acute myeloid leukemia cells expressing P-gp and MRP1. Leukemia 18: 1246-1251
35. Tezel E, Kawase Y, Takeda S, Oshima K, Nakao A (2001) Expression of neural cell adhesion molecule in pancreatic cancer. Pancreas 22: 122-125
36. Tsurutani J, Soda H, Oka M, Suenaga M, Doi S, Nakamura Y, Nakatomi K, Shiozawa K, Amada YY, Kamihira S, Kohno S (2003) Antiproliferative effects of the histone deacetylase inhibitor FR901228 on small-cell lung cancer lines and drug-resistant sublines. Int J Cancer 104: 238-242
37. Witt O, Schweigerer L, Driever PH, Wolff J, Pekrun A (2004) Valproic acid treatment of glioblastoma multiforme in a child. Pediatr Blood Cancer 43: 181