Pre-treatment with a PKC or PKA inhibitor prevents the development of morphine tolerance but not physical dependence in mice

Brain Research

Volumn 1217, Issue , 2008, Pages 70-77

  Gabra, Bichoy H ^a   Bailey, Chris P ^b   Kelly, Eamonn ^b   Smith, Forrest L ^c   Henderson, Graeme ^b   Dewey, William L ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c HARDING UNIVERSITY   (United States)

Author keywords

Antinociception; Morphine; Physical dependence; Protein kinase A; Protein kinase C; Tolerance

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; BISINDOLYLMALEIMIDE; BISINDOLYLMALEIMIDE I HYDROCHLORIDE; CYCLIC AMP DEPENDENT PROTEIN KINASE; MORPHINE; PROTEIN KINASE C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; BRAIN; CONTROLLED STUDY; DIARRHEA; DRUG DEPENDENCE; DRUG WITHDRAWAL; ENZYME ACTIVITY; GROOMING; JUMPING; LOCOMOTION; MALE; MORPHINE TOLERANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PTOSIS; REARING; TACHYPNEA; TREMOR; WET DOG SHAKES;

ANIMALS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DRUG TOLERANCE; ENZYME INHIBITORS; INJECTIONS, INTRAVENTRICULAR; MALE; MICE; MORPHINE; MORPHINE DEPENDENCE; PAIN THRESHOLD; PROTEIN KINASE C; SUBSTANCE WITHDRAWAL SYNDROME;

CANIS FAMILIARIS; MUS;

EID: 45449104616     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2008.04.036     Document Type: Article

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