PKC and PKA inhibitors reinstate morphine-induced behaviors in morphine tolerant mice

Pharmacological Research

Volumn 54, Issue 6, 2006, Pages 474-480

  Smith, Forrest L ^a   Javed, Ruby R ^a   Smith, Paul A ^a   Dewey, William L ^a   Gabra, Bichoy H ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Antinociception; Hypothermia; Morphine tolerance; Protein kinase A (PKA); Protein kinase C (PKC); Straub tail

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 4 CYANO 3 METHYLISOQUINOLINE; BISINDOLYLMALEIMIDE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; ISOQUINOLINE DERIVATIVE; KT 5720; MORPHINE; PROTEIN KINASE C INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANTINOCICEPTION; ARTICLE; BODY TEMPERATURE; BRAIN LEVEL; CONTROLLED STUDY; DRUG EFFECT; DRUG IMPLANTATION; DRUG PELLET; HOT PLATE TEST; HYPOTHERMIA; LATENT PERIOD; MALE; MORPHINE TOLERANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TAIL FLICK TEST;

ANALGESICS, OPIOID; ANIMALS; BEHAVIOR, ANIMAL; BODY TEMPERATURE; CARBAZOLES; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DRUG IMPLANTS; DRUG TOLERANCE; ENZYME INHIBITORS; HEAT; HYPOTHERMIA; INDOLES; INJECTIONS, INTRAVENTRICULAR; ISOQUINOLINES; MALE; MALEIMIDES; MICE; MORPHINE; PAIN; PROTEIN KINASE C; PYRROLES; REACTION TIME;

EID: 33845966383     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2006.09.007     Document Type: Article

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